Translational PK-PD for targeted protein degradation by Bartlett, Derek W, Gilbert, Adam M

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Delineating the role of cooperativity in the design of potent PROTACs for BTK by Zorba, Adelajda, Nguyen, Chuong, Xu, Yingrong, Starr, Jeremy, Borzilleri, Kris, Smith, James, Zhu, Hongyao, Farley, Kathleen A., Ding, WeiDong, Schiemer, James, Feng, Xidong, Chang, Jeanne S., Uccello, Daniel P., Young, Jennifer A., Garcia-Irrizary, Carmen N., Czabaniuk, Lara, Schuff, Brandon, Oliver, Robert, Montgomery, Justin, Hayward, Matthew M., Coe, Jotham, Chen, Jinshan, Niosi, Mark, Luthra, Suman, Shah, Jaymin C., El-Kattan, Ayman, Qiu, Xiayang, West, Graham M., Noe, Mark C., Shanmugasundaram, Veerabahu, Gilbert, Adam M., Brown, Matthew F., Calabrese, Matthew F.

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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1‑((2S,5R)‑5-((7H‑Pyrrolo[2,3‑d]pyrimidin-4-yl)­amino)-2-methylpiperidin-1-yl)­prop-2-en-1-one (PF-06651600) Allowing for the I... by Thorarensen, Atli, Dowty, Martin E, Banker, Mary Ellen, Juba, Brian, Jussif, Jason, Lin, Tsung, Vincent, Fabien, Czerwinski, Robert M, Casimiro-Garcia, Agustin, Unwalla, Ray, Trujillo, John I, Liang, Sidney, Balbo, Paul, Che, Ye, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Leung, Louis, Yang, Xin, Soucy, Sarah, Hegen, Martin, Coe, Jotham, Langille, Jonathan, Vajdos, Felix, Chrencik, Jill, Telliez, Jean-Baptiste

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A kinetic proofreading model for bispecific protein degraders by Bartlett, Derek W., Gilbert, Adam M.

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Inducing protein-protein interactions with molecular glues by Che, Ye, Gilbert, Adam M., Shanmugasundaram, Veerabahu, Noe, Mark C.

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Chemical and Computational Methods for the Characterization of Covalent Reactive Groups for the Prospective Design of Irreversible Inhibitors by Flanagan, Mark E, Abramite, Joseph A, Anderson, Dennis P, Aulabaugh, Ann, Dahal, Upendra P, Gilbert, Adam M, Li, Chao, Montgomery, Justin, Oppenheimer, Stacey R, Ryder, Tim, Schuff, Brandon P, Uccello, Daniel P, Walker, Gregory S, Wu, Yan, Brown, Matthew F, Chen, Jinshan M, Hayward, Matthew M, Noe, Mark C, Obach, R. Scott, Philippe, Laurence, Shanmugasundaram, Veerabahu, Shapiro, Michael J, Starr, Jeremy, Stroh, Justin, Che, Ye

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POLARBEAR constraints on cosmic birefringence and primordial magnetic fields by Ade, Peter A. R., Arnold, Kam, Atlas, Matt, Baccigalupi, Carlo, Barron, Darcy, Boettger, David, Borrill, Julian, Chapman, Scott, Chinone, Yuji, Cukierman, Ari, Dobbs, Matt, Ducout, Anne, Dunner, Rolando, Elleflot, Tucker, Errard, Josquin, Fabbian, Giulio, Feeney, Stephen, Feng, Chang, Gilbert, Adam, Goeckner-Wald, Neil, Groh, John, Hall, Grantland, Halverson, Nils W., Hasegawa, Masaya, Hattori, Kaori, Hazumi, Masashi, Hill, Charles, Holzapfel, William L., Hori, Yasuto, Howe, Logan, Inoue, Yuki, Jaehnig, Gregory C., Jaffe, Andrew H., Jeong, Oliver, Katayama, Nobuhiko, Kaufman, Jonathan P., Keating, Brian, Kermish, Zigmund, Keskitalo, Reijo, Kisner, Theodore, Kusaka, Akito, Le Jeune, Maude, Lee, Adrian T., Leitch, Erik M., Leon, David, Li, Yun, Linder, Eric, Lowry, Lindsay, Matsuda, Frederick, Matsumura, Tomotake, Miller, Nathan, Montgomery, Josh, Myers, Michael J., Navaroli, Martin, Nishino, Haruki, Okamura, Takahiro, Paar, Hans, Peloton, Julien, Pogosian, Levon, Poletti, Davide, Puglisi, Giuseppe, Raum, Christopher, Rebeiz, Gabriel, Reichardt, Christian L., Richards, Paul L., Ross, Colin, Rotermund, Kaja M., Schenck, David E., Sherwin, Blake D., Shimon, Meir, Shirley, Ian, Siritanasak, Praween, Smecher, Graeme, Stebor, Nathan, Steinbach, Bryan, Suzuki, Aritoki, Suzuki, Jun-ichi, Tajima, Osamu, Takakura, Satoru, Tikhomirov, Alexei, Tomaru, Takayuki, Whitehorn, Nathan, Wilson, Brandon, Yadav, Amit, Zahn, Alex, Zahn, Oliver

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Developing predictive assays: the phenotypic screening "rule of 3" by Vincent, Fabien, Loria, Paula, Pregel, Marko, Stanton, Robert, Kitching, Linda, Nocka, Karl, Doyonnas, Regis, Steppan, Claire, Gilbert, Adam, Schroeter, Thomas, Peakman, Marie-Claire

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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation by McAllister, Laura A, Butler, Christopher R, Mente, Scot, O’Neil, Steven V, Fonseca, Kari R, Piro, Justin R, Cianfrogna, Julie A, Foley, Timothy L, Gilbert, Adam M, Harris, Anthony R, Helal, Christopher J, Johnson, Douglas S, Montgomery, Justin I, Nason, Deane M, Noell, Stephen, Pandit, Jayvardhan, Rogers, Bruce N, Samad, Tarek A, Shaffer, Christopher L, da Silva, Rafael G, Uccello, Daniel P, Webb, Damien, Brodney, Michael A

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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition by Telliez, Jean-Baptiste, Dowty, Martin E, Wang, Lu, Jussif, Jason, Lin, Tsung, Li, Li, Moy, Erick, Balbo, Paul, Li, Wei, Zhao, Yajuan, Crouse, Kimberly, Dickinson, Caitlyn, Symanowicz, Peter, Hegen, Martin, Banker, Mary Ellen, Vincent, Fabien, Unwalla, Ray, Liang, Sidney, Gilbert, Adam M, Brown, Matthew F, Hayward, Matthew, Montgomery, Justin, Yang, Xin, Bauman, Jonathan, Trujillo, John I, Casimiro-Garcia, Agustin, Vajdos, Felix F, Leung, Louis, Geoghegan, Kieran F, Quazi, Amira, Xuan, Dejun, Jones, Lyn, Hett, Erik, Wright, Katherine, Clark, James D, Thorarensen, Atli

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Benchmarking in Vitro Covalent Binding Burden As a Tool To Assess Potential Toxicity Caused by Nonspecific Covalent Binding of Covalent Drugs by Dahal, Upendra P, Obach, R. Scott, Gilbert, Adam M

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Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms by Leung, Louis, Yang, Xin, Strelevitz, Timothy J., Montgomery, Justin, Brown, Matthew F., Zientek, Michael A., Banfield, Christopher, Gilbert, Adam M., Thorarensen, Atli, Dowty, Martin E.

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Structure-Based Approach To Identify 5‑[4-Hydroxyphenyl]­pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators by Unwalla, Ray, Mousseau, James J, Fadeyi, Olugbeminiyi O, Choi, Chulho, Parris, Kevin, Hu, Baihua, Kenney, Thomas, Chippari, Susan, McNally, Christopher, Vishwanathan, Karthick, Kilbourne, Edward, Thompson, Catherine, Nagpal, Sunil, Wrobel, Jay, Yudt, Matthew, Morris, Carl A, Powell, Dennis, Gilbert, Adam M, Chekler, Eugene L. Piatnitski

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Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity by Zhang, Qingzhou, Jiang, Fan, Zhao, Bingchuan, Lin, Huacan, Tian, Yuan, Xie, Mingsheng, Bai, Guoyun, Gilbert, Adam M., Goetz, Gilles H., Liras, Spiros, Mathiowetz, Alan A., Price, David A., Song, Kun, Tu, Meihua, Wu, Yujie, Wang, Tao, Flanagan, Mark E., Wu, Yun-Dong, Li, Zigang

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ADX47273 [S-(4-Fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: A Novel Metabotropic Glutamate Receptor 5-Selective Positive Allosteric Mo... by Liu, Feng, Grauer, Steve, Kelley, Cody, Navarra, Rachel, Graf, Radka, Zhang, Guoming, Atkinson, Peter J, Popiolek, Michael, Wantuch, Caitlin, Khawaja, Xavier, Smith, Deborah, Olsen, Michael, Kouranova, Evguenia, Lai, Margaret, Pruthi, Farhana, Pulicicchio, Claudine, Day, Mark, Gilbert, Adam, Pausch, Mark H, Brandon, Nicholas J, Beyer, Chad E, Comery, Tom A, Logue, Sheree, Rosenzweig-Lipson, Sharon, Marquis, Karen L

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The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? by Sukoff Rizzo, Stacey J, Leonard, Sarah K, Gilbert, Adam, Dollings, Paul, Smith, Deborah L, Zhang, Mei-Yi, Di, Li, Platt, Brian J, Neal, Sarah, Dwyer, Jason M, Bender, Corey N, Zhang, Jean, Lock, Tim, Kowal, Dianne, Kramer, Angela, Randall, Andrew, Huselton, Christine, Vishwanathan, Karthick, Tse, Susanna Y, Butera, John, Ring, Robert H, Rosenzweig-Lipson, Sharon, Hughes, Zoë A, Dunlop, John

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Analysis of CLL Voltage-Output Resonant Converters Using Describing Functions by FOSTER, Martin P, GOULD, Christopher R, GILBERT, Adam J, STONE, David A, BINGHAM, Christopher M

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines by Bai, Guoyun, O’Connell, Thomas N, Brodney, Michael A, Butler, Christopher R, Czabaniuk, Lara C, Gilbert, Adam M, LaChapelle, Erik A, Li, Chao, McAllister, Laura A, Ogilvie, Kevin, Philippe, Laurence, Salomon-Ferrer, Romelia, Shapiro, Michael J, Starr, Jeremy T, Uccello, Daniel P, Withka, Jane M, Yan, Jiangli, Brown, Matthew F

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Pyrazolidine-3,5-diones and 5-Hydroxy-1H-pyrazol-3(2H)-ones, Inhibitors of UDP-N-acetylenolpyruvyl Glucosamine Reductase by Gilbert, Adam M, Failli, Amedeo, Shumsky, Jay, Yang, Youjun, Severin, Anatoly, Singh, Guy, Hu, William, Keeney, David, Petersen, Peter J, Katz, Alan H

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Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism by Ahn, Kay, Boehm, Markus, Brown, Matthew F, Calloway, Jessica, Che, Ye, Chen, Jinshan, Fennell, Kimberly F, Geoghegan, Kieran F, Gilbert, Adam M, Gutierrez, Jemy A, Kalgutkar, Amit S, Lanba, Adhiraj, Limberakis, Chris, Magee, Thomas V, O’Doherty, Inish, Oliver, Robert, Pabst, Brandon, Pandit, Jayvardhan, Parris, Kevin, Pfefferkorn, Jeffrey A, Rolph, Timothy P, Patel, Rushi, Schuff, Brandon, Shanmugasundaram, Veerabahu, Starr, Jeremy T, Varghese, Alison H, Vera, Nicholas B, Vernochet, Cecile, Yan, Jiangli

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