Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS by Hodges, Timothy R, Abbott, Jason R, Little, Andrew J, Sarkar, Dhruba, Salovich, James M, Howes, Jennifer E, Akan, Denis T, Sai, Jiqing, Arnold, Allison L, Browning, Carrie, Burns, Michael C, Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A, Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, McConnell, Darryl B, Fesik, Stephen W

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Small Molecule-Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1 by Howes, Jennifer E, Akan, Denis T, Burns, Michael C, Rossanese, Olivia W, Waterson, Alex G, Fesik, Stephen W

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Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling by Abbott, Jason R, Hodges, Timothy R, Daniels, R. Nathan, Patel, Pratiq A, Kennedy, J. Phillip, Howes, Jennifer E, Akan, Denis T, Burns, Michael C, Sai, Jiqing, Sobolik, Tammy, Beesetty, Yugandhar, Lee, Taekyu, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W

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Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses by Akan, Denis T, Howes, Jennifer E, Sai, Jiqing, Arnold, Allison L, Beesetty, Yugandhar, Phan, Jason, Olejniczak, Edward T, Waterson, Alex G, Fesik, Stephen W

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Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS by Abbott, Jason R, Patel, Pratiq A, Howes, Jennifer E, Akan, Denis T, Kennedy, J. Phillip, Burns, Michael C, Browning, Carrie F, Sun, Qi, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, Fesik, Stephen W

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Abstract PR04: Small molecule-mediated activation of Ras elicits inhibition of MAPK and PI3K signaling though pathway feedback by Howes, Jennifer E., Akan, Denis T., Alicie, Bethany M., Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.

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Abstract 4447: Generation of an acquired resistance model to the novel AKT inhibitor CCT129254 by Akan, Denis T., Walton, Michael I., Garrett, Michelle D.

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Abstract 865: Small molecule-mediated modulation of Ras elicits inhibition of phospho ERK signaling through negative feedback on SOS1 by Howes, Jennifer E., Akan, Denis T., Burns, Michael C., Sun, Qi, Little, Andrew J., Camper, DeMarco V., Abbott, Jason R., Phan, Jason, Lee, Taekyu, Rossanese, Olivia W., Waterson, Alex G., Fesik, Stephen W.

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