287 The discovery and optimization of small molecule antagonists of the WDR5–MLL interaction by Al-Awar, R, Al-Awar, R.S, Getlik, M, Smil, D, Bolshan, Y, Poda, G, Senisterra, G, Wu, H, Allali-Hassani, A, Wasney, G.A, Barsyte-Lovejoy, D, Dombrovski, L, Dong, A, He, H, Seitova, A, Chau, I, Li, F, Couture, J.F, Kuznetsova, E, Marcellus, R

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