Fast estimation of genetic correlation for biobank-scale data by Wu, Yue, Burch, Kathryn S., Ganna, Andrea, Pajukanta, Päivi, Pasaniuc, Bogdan, Sankararaman, Sriram

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F2. CAUSAL RELATIONSHIPS BETWEEN CHILDHOOD MALTREATMENT AND ADULT HEALTH AND SOCIOECONOMIC OUTCOMES USING TWO-SAMPLE MENDELIAN RANDOMIZATION by Chen, Tzu-Ting, Chen, Chia-Yen, Liu, Chao-Yu, Lee, Jiwoo, Ganna, Andrea, Feng, Yen-Chen, Lin, Yen-Feng

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Enabling Efficient and Confident Annotation of LC−MS Metabolomics Data through MS1 Spectrum and Time Prediction by Broeckling, Corey D, Ganna, Andrea, Layer, Mark, Brown, Kevin, Sutton, Ben, Ingelsson, Erik, Peers, Graham, Prenni, Jessica E

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Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease by Zanoni, Paolo, Khetarpal, Sumeet A., Larach, Daniel B., Hancock-Cerutti, William F., Millar, John S., Cuchel, Marina, DerOhannessian, Stephanie, Kontush, Anatol, Surendran, Praveen, Saleheen, Danish, Trompet, Stella, Jukema, J. Wouter, De Craen, Anton, Deloukas, Panos, Sattar, Naveed, Ford, Ian, Packard, Chris, Majumder, Abdullah al Shafi, Alam, Dewan S., Di Angelantonio, Emanuele, Abecasis, Goncalo, Chowdhury, Rajiv, Erdmann, Jeanette, Nordestgaard, Børge G., Nielsen, Sune F., Tybjærg-Hansen, Anne, Schmidt, Ruth Frikke, Kuulasmaa, Kari, Liu, Dajiang J., Perola, Markus, Blankenberg, Stefan, Salomaa, Veikko, Männistö, Satu, Amouyel, Philippe, Arveiler, Dominique, Ferrieres, Jean, Müller-Nurasyid, Martina, Ferrario, Marco, Kee, Frank, Willer, Cristen J., Samani, Nilesh, Schunkert, Heribert, Butterworth, Adam S., Howson, Joanna M. M., Peloso, Gina M., Stitziel, Nathan O., Danesh, John, Kathiresan, Sekar, Rader, Daniel J.

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The impact of rare variation on gene expression across tissues by Li, Xin, Kim, Yungil, Tsang, Emily K., Davis, Joe R., Damani, Farhan N., Chiang, Colby, Hess, Gaelen T., Zappala, Zachary, Strober, Benjamin J., Scott, Alexandra J., Li, Amy, Ganna, Andrea, Bassik, Michael C., Merker, Jason D., Hall, Ira M., Battle, Alexis, Montgomery, Stephen B.

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The role of polygenic risk and susceptibility genes in breast cancer over the course of life by Mars, Nina, Widén, Elisabeth, Kerminen, Sini, Meretoja, Tuomo, Pirinen, Matti, della Briotta Parolo, Pietro, Palta, Priit, Palotie, Aarno, Kaprio, Jaakko, Joensuu, Heikki, Daly, Mark, Ripatti, Samuli

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HAPNEST: efficient, large-scale generation and evaluation of synthetic datasets for genotypes and phenotypes by Wharrie, Sophie, Yang, Zhiyu, Raj, Vishnu, Monti, Remo, Gupta, Rahul, Wang, Ying, Martin, Alicia, O’Connor, Luke J, Kaski, Samuel, Marttinen, Pekka, Palamara, Pier Francesco, Lippert, Christoph, Ganna, Andrea

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A MULTIDISCIPLINARY APPROACH TO BETTER UNDERSTAND TREATMENT RESISTANT DEPRESSION by Yi, Lu, Xiong, Ying, Krebs, Kristi, Jermy, Bradley, Ganna, Andrea, Sullivan, Patrick, Lehto, Kelli, Landen, Mikael

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Genetic architecture of human plasma lipidome and its link to cardiovascular disease by Tabassum, Rubina, Rämö, Joel T., Ripatti, Pietari, Koskela, Jukka T., Kurki, Mitja, Karjalainen, Juha, Palta, Priit, Hassan, Shabbeer, Nunez-Fontarnau, Javier, Kiiskinen, Tuomo T. J., Söderlund, Sanni, Matikainen, Niina, Gerl, Mathias J., Surma, Michal A., Klose, Christian, Stitziel, Nathan O., Laivuori, Hannele, Havulinna, Aki S., Service, Susan K., Salomaa, Veikko, Pirinen, Matti, Jauhiainen, Matti, Daly, Mark J., Freimer, Nelson B., Palotie, Aarno, Taskinen, Marja-Riitta, Simons, Kai, Ripatti, Samuli

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Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances by Salihovic, Samira, Fall, Tove, Ganna, Andrea, Broeckling, Corey D., Prenni, Jessica E., Hyötyläinen, Tuulia, Kärrman, Anna, Lind, P. Monica, Ingelsson, Erik, Lind, Lars

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Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study by Kerola, Anne M, Palomäki, Antti, Laivuori, Hannele, Laitinen, Tarja, Färkkilä, Martti, Eklund, Kari K, Ripatti, Samuli, Perola, Markus, Ganna, Andrea, Lindbohm, Joni V, Mars, Nina

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Non-targeted metabolomics combined with genetic analyses identifies bile acid synthesis and phospholipid metabolism as being associated with incident type 2 diabetes by Fall, Tove, Salihovic, Samira, Brandmaier, Stefan, Nowak, Christoph, Ganna, Andrea, Gustafsson, Stefan, Broeckling, Corey D., Prenni, Jessica E., Kastenmüller, Gabi, Peters, Annette, Magnusson, Patrik K., Wang-Sattler, Rui, Giedraitis, Vilmantas, Berne, Christian, Gieger, Christian, Pedersen, Nancy L., Ingelsson, Erik, Lind, Lars

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A second update on mapping the human genetic architecture of COVID-19 by Jansen, Philip, Nakanishi, Tomoko, Priest, James, Turebayeva, Gulsimzhan, Bouab, Meriem, Bourque, Guillaume, Tse, Sze Man, Faucon, Annika B, Jensen, Björn-Erik Ole, Bals, Robert, Noor, Abdul, Liontos, Angelos, Azuure, Clinton, Blanco-Grau, Albert, Casalone, Elisabetta, Bellelli, Giuseppe, Kurihara, Hayato, Farré, Xavier, Hunkapiller, Julie, Kim, Jin Yong, Lee, Ji Yeon, Jung, Keum Ji, Bretherick, Andrew D, Ostermann, Marlies, Ryan, Lucy, Briton, Kate, Cutler, Sean, Springle, Philippa, Goodwin, Emma, Tibke, Clare, Farley, Sean, Bradley-Potts, Joanne, Whileman, Amanda, Kaye, Callum, Preston, Stephen, Cupitt, Jason, Jakkula, Srinivas, Lamb, Thomas, Hudson, Anne, Clark, Richard, Hudig, Lisa, Roberts, Abigail, Slevin, Kathryn, Thomas, Vicky, Chisholm, Catherine, Scanlon, Jeremy, Jones, Helen, Riches, Joanne, Anderson, Susan, Davies, Rhys, Tebbutt, Julie, Conyngham, Jo-Anna, Hobden, Gillian, Collier, Dawn, Durga, Latha, Wilson, Alison, Finnell, Jez, Serrano-Ruiz, Alfredo, Turner, Patricia, Turney, Sharon, Tutt, Gabriella, Varghese, Mathew, Stuart, Carmel, Wood, Stephen, Cother, Naiara, Brady, Ailbhe, Arden, Tracie, Capps, Nigel, Lennon, Liz, Joseph, Sibet, Jennings, Claire, Revill, Adam, Fletcher, Jo, Sutherland, Isobel, Kaye, Duncan, Whitbread, Jennifer, Hector, Gemma, Goddard, Peter, Lauder, Christen, Oosthuyzen, Wilna, Szoor-Mcelhinney, Helen, Upadhyay, Kamlesh J, Joshi, Chaitanya G, Kabata, Hiroki, Mikami, Yohei, Sonobe, Kazunari, Tateno, Hiroki, Yoshihara, Tomoyuki, Kuwahara, Naota, Sugiura, Hisatoshi, Ishihara, Sayoko, Ismail, Said I, Feng, Yen-Chen Anne, Castano, Luis, Ceballos, Francisco C, Aguado, Jose María, Carbonell, Cristina, Werge, Thomas, Wilson, Daniel J, Serra-Llovich, Alex

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Rediscovery rate estimation for assessing the validation of significant findings in high-throughput studies by Ganna, Andrea, Lee, Donghwan, Ingelsson, Erik, Pawitan, Yudi

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Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease by Zhou, Wei, Tsuo, Kristin, Hirbo, Jibril B., Wang, Ying, Bhattacharya, Arjun, Zhao, Huiling, Surakka, Ida, Wolford, Brooke N., Lo Faro, Valeria, Lopera-Maya, Esteban A., Läll, Kristi, Favé, Marie-Julie, Chapman, Sinéad B., Karjalainen, Juha, Maasha, Mutaamba, Chavan, Sameer, Daya, Michelle, Ding, Yi, Feng, Yen-Chen A., Guare, Lindsay A., Gignoux, Christopher R., Graham, Sarah E., Ingold, Nathan, Ismail, Said I., Laisk, Triin, Lin, Kuang, Millwood, Iona Y., Moreno-Grau, Sonia, Nam, Kisung, Palta, Priit, Saad, Chadi, Setia-Verma, Shefali, Thorsteinsdottir, Unnur, Verma, Anurag, Zawistowski, Matthew, Afifi, Nahla, Al-Dabhani, Kawthar M., Campbell, Archie, Crooks, Kristy, Fritsche, Lars G., Fthenou, Eleni, Guo, Yu, Hunt, Karen A., Ioannidis, Alexander, Jansonius, Nomdo M., Konuma, Takahiro, Lee, Ming Ta Michael, Lopez-Pineda, Arturo, Matsuda, Yuta, Marioni, Riccardo E., Numakura, Kensuke, Patil, Snehal, Richmond, Anne, Rojas-Muñoz, Agustin, Shortt, Jonathan A., Tao, Ran, Vanderwerff, Brett, Vernekar, Manvi, Veturi, Yogasudha, Barnes, Kathleen C., Chen, Zhengming, Smith, George Davey, Finucane, Hilary K., Gamazon, Eric R., Gaunt, Tom R., Ge, Tian, Katsanis, Nicholas, Koskela, Jukka T., Law, Matthew H., Li, Liming, Loos, Ruth J.F., Matsuda, Koichi, Olsen, Catherine M., Shavit, Jordan A., Snieder, Harold, Takano, Tomohiro, Vonk, Judith M., Wicks, Stephen J., Wijmenga, Cisca, Wright, John, Zhou, Xiang, Awadalla, Philip, Boehnke, Michael, Bustamante, Carlos D., Fatumo, Segun, Hayward, Caroline, Hveem, Kristian, Kenny, Eimear E., Lee, Seunggeun, Mbarek, Hamdi, Mägi, Reedik, Martin, Hilary C., Medland, Sarah E., Palotie, Aarno V., Pasaniuc, Bogdan, Rader, Daniel J., Ritchie, Marylyn D., Smoller, Jordan W., Stefansson, Kari, Martin, Alicia R.

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Proteomic profiles before and during weight loss: Results from randomized trial of dietary intervention by Figarska, Sylwia M., Rigdon, Joseph, Ganna, Andrea, Elmståhl, Sölve, Lind, Lars, Gardner, Christopher D., Ingelsson, Erik

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Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance by Nowak, Christoph, Hetty, Susanne, Salihovic, Samira, Castillejo-Lopez, Casimiro, Ganna, Andrea, Cook, Naomi L., Broeckling, Corey D., Prenni, Jessica E., Shen, Xia, Giedraitis, Vilmantas, Ärnlöv, Johan, Lind, Lars, Berne, Christian, Sundström, Johan, Fall, Tove, Ingelsson, Erik

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47. UNVEILING THE HIDDEN HEALTH RISKS: PHENOME-WIDE ASSOCIATIONS IN SEX CHROMOSOME TRISOMIES FROM THREE INTERNATIONAL COHORTS by Davis, Shanlee, Liu, Aoxing, Lapato, Dana, Teerlink, Craig, Gentry, Amanda, Lancaster, Eva, Singh, Madhurbain, Genovese, Giulio, Gorman, Bryan, Bigdeli, Tim, Lynch, Julie, Ross, Judith, Ganna, Andrea, Hauger, Richard, Peterson, Roseann

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Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry by Ahmad, Shafqat, Rukh, Gull, Varga, Tibor V, Ali, Ashfaq, Kurbasic, Azra, Shungin, Dmitry, Ericson, Ulrika, Koivula, Robert W, Chu, Audrey Y, Rose, Lynda M, Ganna, Andrea, Qi, Qibin, Stančáková, Alena, Sandholt, Camilla H, Elks, Cathy E, Curhan, Gary, Jensen, Majken K, Tamimi, Rulla M, Allin, Kristine H, Jørgensen, Torben, Brage, Soren, Langenberg, Claudia, Aadahl, Mette, Grarup, Niels, Linneberg, Allan, Paré, Guillaume, Magnusson, Patrik K E, Pedersen, Nancy L, Boehnke, Michael, Hamsten, Anders, Mohlke, Karen L, Pasquale, Louis T, Pedersen, Oluf, Scott, Robert A, Ridker, Paul M, Ingelsson, Erik, Laakso, Markku, Hansen, Torben, Qi, Lu, Wareham, Nicholas J, Chasman, Daniel I, Hallmans, Göran, Hu, Frank B, Renström, Frida, Orho-Melander, Marju, Franks, Paul W

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Abstract 18244: A Multi-Ancestry GWAS of Calcific Aortic Stenosis Among 2.7 Million Individuals by Small, Aeron M, Dufresne, Line, Farber-Eger, Eric, Abner, Erik, Corey, Kristin, Stefánsson, Kári, Nadauld, Lincoln, Bundgaard, Henning, Lee, Jiwoo, Schumacher, Johannes, Trenkwalder, Teresa, Soderberg, Stefan, Ganna, Andrea, Rader, Daniel J, Moksnes, Marta Riise, Lin, Meng, Laporte, Fabien, Larsson, Susanna, Smith, Gustav, Do, Ron, Ito, Kaoru, Holm, Hilma, Sun, Yan, Kim, Kelly, WILSON, PETER, Odonnell, Christopher J, Peloso, Gina, Engert, Jamie C, Thanassoulis, George, Natarajan, Pradeep

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