SY21BIOMARKERS AND DRUG TARGETS IN ALCOHOL ABUSE AND DEPENDENCESY21-1INCREASE IN BLOOD-BRAIN BARRIER PERMEABILITY IN POST-MORTEM ALCOHOLIC BRAIN: INVOLVEMENT OF TLR4 by Rubio-Araiz, A., Porcu, F., García-Gutiérrez, M. S., Pérez-Hernández, M., Aracil-Fernández, M. A., Gutiérrez-López, M. D., Guerri, C., Manzanares, J., O'Shea, E., Colado, M. I.

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Cannabinoid CB1 and CB2 Receptors, and Monoacylglycerol Lipase Gene Expression Alterations in the Basal Ganglia of Patients with Parkinson’s Disease by Navarrete, Francisco, García-Gutiérrez, M. Salud, Aracil-Fernández, Auxiliadora, Lanciego, José L., Manzanares, Jorge

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Might basophils be a reliable biomarker in severe asthma? by García Ródenas, María del Mar, Aracil, Cleofé Fernández, Marco de la Calle, Francisco M.

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Role of CB2 Cannabinoid Receptors in the Rewarding, Reinforcing, and Physical Effects of Nicotine by NAVARRETE, Francisco, RODRIGUEZ-ARIAS, Marta, MANZANARES, Jorge, MARTIN-GARCIA, Elena, NAVARRO, Daniela, GARCIA-GUTIERREZ, María S, AGUILAR, María A, ARACIL-FERNANDEZ, Auxiliadora, BERBEL, Pere, MINARRO, José, MAIDONADO, Rafael

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P.6.c.007 Deletion or blockade of cannabinoid CB2 receptors modifies the reinforcing, motivational and physiological actions of nicotine in mice by Rueda, F. Navarrete, Rodríguez-Arias, M, Martín-García, E, Navarro, D, García-Gutiérrez, M.S, Aracil-Fernández, A, Berbel, P, Miñarro, J, Maldonado, R, Manzanares, J

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Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice by Blanco-Gandía, M. Carmen, Cantacorps, Lídia, Aracil-Fernández, Auxiliadora, Montagud-Romero, Sandra, Aguilar, María A., Manzanares, Jorge, Valverde, Olga, Miñarro, José, Rodríguez-Arias, Marta

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Changes in gene expression and sensitivity of cocaine reward produced by a continuous fat diet by Blanco-Gandía, M. Carmen, Aracil-Fernández, Auxiliadora, Montagud-Romero, Sandra, Aguilar, Maria A., Manzanares, Jorge, Miñarro, José, Rodríguez-Arias, Marta

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Decreased Cocaine Motor Sensitization and Self-Administration in Mice Overexpressing Cannabinoid CB2 Receptors by ARACIL-FERNANDEZ, Auxiliadora, M TRIGO, José, S GARCIA-GUTIERREZ, Maria, ORTEGA-ALVARO, Antonio, TERNIANOV, Alexander, NAVARRO, Daniela, ROBLEDO, Patricia, BERBEL, Pere, MALDONADO, Rafael, MANZANARES, Jorge

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The rewarding effects of ethanol are modulated by binge eating of a high-fat diet during adolescence by Blanco-Gandía, M. Carmen, Ledesma, Juan Carlos, Aracil-Fernández, Auxiliadora, Navarrete, Francisco, Montagud-Romero, Sandra, Aguilar, Maria A., Manzanares, Jorge, Miñarro, José, Rodríguez-Arias, Marta

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Opioid and Cannabinoid Systems as Therapeutic Targets for the Treatment of Alcohol Dependence: From Animal Models to Clinical Practice by Femenia, Teresa, Portillo, Pablo, Perez-Ortiz, Jose M., Aracil-Fernandez, Auxiliadora, Rubio, Gabriel, Manzanares, Jorge

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Machine learning to predict major bleeding during anticoagulation for venous thromboembolism: possibilities and limitations by Mateo, Jorge, Bikdeli, Behnood, Demelo‐Rodriguez, Pablo, Sadeghipour, Parham, Adarraga, MD, Alberich‐Conesa, A, Alonso‐Carrillo, J, Amado, C, Amorós, S, Arcelus, JI, Ballaz, A, Barba, R, Barbagelata, C, Barrón‐Andrés, B, Blanco‐Molina, A, Casado, I, Demelo‐Rodríguez, P, Díaz‐Peromingo, JA, Dubois‐Silva, A, Farfán‐Sedano, AI, Fernández‐Aracil, C, Fernández‐Capitán, C, Fernández‐Jiménez, B, Fernández‐Reyes, JL, Francisco, I, García, MA, García de Herreros, M, García‐Bragado, F, García‐González, C, Gil‐De Gómez, M, Gómez‐Cuervo, C, Hernández‐Blasco, L, Jaras, MJ, Jiménez, D, Lacruz, B, Lainez‐Justo, S, Lecumberri, R, López‐Núñez, JJ, López‐Sáez, JB, Lorente, MA, Maestre, A, Martín‐Guerra, JM, Martín‐Martos, F, Monreal, M, Muñoz‐Gamito, G, Nieto, JA, Otalora, S, Pérez‐Ductor, C, Pesce, ML, Poyo‐Molina, J, Puchades, R, Rivera‐Civico, F, Rivera‐Gallego, A, Roca, M, Rodríguez‐Cobo, A, Rubio, CM, Ruiz‐Ruiz, J, Salgueiro, G, Sancho, T, Sendín, V, Sigüenza, P, Suriñach, JM, Tiberio, G, Uresandi, F, Usandizaga, E, Vela, JR, Vidal, G, Villalobos, A, Verhamme, P, Arguello, JD, Roa, J, Malý, R, Accassat, S, Bura‐Riviere, A, Catella, J, Couturaud, F, Espitia, O, Grange, C, Le Mao, R, Mahé, I, Najib, D, Tzoran, I, Bilora, F, Ciammaichella, M, De Angelis, A, Dentali, F, Di Micco, P, Grandone, E, Merla, S, Siniscalchi, C, Visonà, A, Vo Hong, N, Zalunardo, B, Kigitovica, D, Skride, A, Fonseca, S, Bosevski, M, Zdraveska, M, Mazzolai, L, Bui, HM

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Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice by Gómez-Milanés, Iván, Almela, Pilar, García-Carmona, Juan-Antonio, Salud García-Gutiérrez, M., Aracil-Fernández, Auxiliadora, Manzanares, Jorge, Victoria Milanés Maquilón, M., Luisa Laorden, M.

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Might Basophils Be a Reliable Biomarker in Severe Asthma? by García Ródenas, María Del Mar, Fernández Aracil, Cleofé, Marco de la Calle, Francisco M

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Outcomes during anticoagulation in patients with symptomatic vs. incidental splanchnic vein thrombosis by Tufano, Antonella, Ageno, Walter, Di Micco, Pierpaolo, Niglio, Alferio, Rosa, Vladimir, Ballaz, Aitor, Braester, Andrei, Rubio, Carmen Mª., Isern, Virginia, Imbalzano, Egidio, Monreal, Manuel

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Outcomes of venous thromboembolism in patients with inherited thrombophilia treated with direct oral anticoagulants: insights from the RIETE registry by Cohen, Omri, Kenet, Gili, Levy-Mendelovich, Sarina, Tzoran, Inna, Brenner, Benjamin, De Ancos, Cristina, López-Miguel, Patricia, Varona, José F., Catella, Judith, Monreal, Manuel

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Real‐life Use of Anticoagulants in Venous Thromboembolism With a Focus on Patients With Exclusion Criteria for Direct Oral Anticoagulants by Moustafa, Farès, Pesavento, Raffaele, di Micco, Pierpaolo, González‐Martínez, José, Quintavalla, Roberto, Peris, Maria‐Luisa, Porras, José Antonio, Falvo, Nicolas, Baños, Pilar, Monreal, Manuel

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Age-Related Differences in the Presentation, Management, and Clinical Outcomes of 100,000 Patients With Venous Thromboembolism in the RIETE Registry by Ortega, Alberto García, Pedro-Tudela, Ana, Pérez-Ductor, Cristina, Skride, Andris, Siniscalchi, Carmine, Adarraga, M.D., Amado, C., Ballaz, A., Barbagelata, C., Bascuñana, J., Blanco-Molina, A., De Ancos, C., Demelo-Rodríguez, P., De Juana-Izquierdo, C., Díaz-Brasero, A.M., Díaz-Peromingo, J.A., Dubois-Silva, A., Falgá, C., Farfán-Sedano, A.I., Fernández-Aracil, C., Fidalgo, M.A., Francisco, I., Gabara, C., Galeano-Valle, F., García-Ortega, A., Gavín-Sebastián, O., Gil De Gómez, M.A., Gil-Díaz, A., Gómez-Cuervo, C., Gutiérrez, J., Hernández-Blasco, L., Jiménez, D., Jou, I., Joya, M.D., Lainez-Justo, S., Lobo, J.L., López-Miguel, P., Madridano, O., Maestre, A., Martín del Pozo, M., Mena, E., Mercado, M.I., Moisés, J., Monreal, M., Olid, M., Ordieres-Ortega, L., Ortiz, M., Otero, R., Palomeque, A.C., Paredes, E., Parra-Rosado, P., Pérez-Pinar, M., Porras, J.A., Rosa, V., Salgueiro, G., Sancho, T., Sendín, V., Sigüenza, P., Soler, S., Suárez-Fernández, S., Trujillo-Santos, J., Uresandi, F., Varona, J.F., Villares, P., Ay, C., Vanassche, T., Verhamme, P., Yoo, H.H.B., Montenegro, A.C., Roa, J., Malý, R., Catella, J., Couturaud, F., Espitia, O., Grange, C., Moustafa, F., Sarlon-Bartoli, G., Schellong, S., Brenner, B., Tzoran, I., Rashidi, F., Abenante, A., Barillari, G., Bilora, F., Bortoluzzi, C., Colaizzo, D., Dentali, F., Di Micco, P., Lambertenghi-Deliliers, D., Poz, A., Siniscalchi, C., Paluga, R., Kigitovica, D., Fonseca, S., Marques, R., Pinto, S., Trajkova, M., Aujayeb, A., Caprini, J.A., Bui, H.M.

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Correction to: REal worlD Effectiveness and Safety of Mepolizumab in a Multicentric Spanish Cohort of Asthma Patients Stratified by Eosinophils: The REDES Study by Domingo Ribas, Christian, Carrillo Díaz, Teresa, Blanco Aparicio, Marina, Martínez Moragón, Eva, Banas Conejero, David, Sánchez Herrero, M. Guadalupe

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Right ventricular-pulmonary artery coupling for prognostication in acute pulmonary embolism by Lyhne, Mads Dam, Bikdeli, Behnood, Jiménez, David, Kabrhel, Christopher, Dudzinski, David M, Moisés, Jorge, Lobo, José Luis, Armestar, Fernando, Guirado, Leticia, Ballaz, Aitor, Monreal, Manuel

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SY21-2ROLE OF CANNABINOID CB2 RECEPTOR IN THE REINFORCING ACTIONS OF ETHANOL by García-Gutiérrez, M. S., Navarrete, F., Aracil-Fernández, A., Ortega-Álvaro, A., Ternianov, A., Manzanares, J.

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