CD137 (4-1BB) Costimulation Modifies DNA Methylation in CD8 + T Cell-Relevant Genes by Aznar, M Angela, Labiano, Sara, Diaz-Lagares, Angel, Molina, Carmen, Garasa, Saray, Azpilikueta, Arantza, Etxeberria, Iñaki, Sanchez-Paulete, Alfonso R, Korman, Alan J, Esteller, Manel, Sandoval, Juan, Melero, Ignacio

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Hypoxia-induced soluble CD137 in malignant cells blocks CD137L-costimulation as an immune escape mechanism by Labiano, Sara, Palazón, Asis, Bolaños, Elixabet, Azpilikueta, Arantza, Sánchez-Paulete, Alfonso R., Morales-Kastresana, Aizea, Quetglas, Jose I., Perez-Gracia, José L., Gúrpide, Alfonso, Rodriguez-Ruiz, Maria, Aznar, M. Angela, Jure-Kunkel, Maria, Berraondo, Pedro, Melero, Ignacio

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Abstract 628: Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies by Glez-Vaz, Javier, Azpilikueta, Arantza, Olivera, Irene, Cirella, Assunta, Teijeira, Álvaro, Ochoa, Carmen, Álvarez, Maite, Eguren, Iñaki, Luri-Rey, Carlos, Sanmamed, Miguel F., Melero, Ignacio

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Abstract 614: CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects by Glez-Vaz, Javier, Azpilikueta, Arantza, Ochoa, Maria Carmen, Olivera, Irene, Gomis, Gabriel, Cirella, Asunta, Luri-Rey, Carlos, Álvarez, Maite, Ciordia, Sergio, Berraondo, Pedro, Teijeira, Álvaro, Corrales, Fernando, Zapata, Juan M, Melero, Ignacio

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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma by Ochoa, Maria Carmen, Sanchez-Gregorio, Sandra, de Andrea, Carlos E., Garasa, Saray, Alvarez, Maite, Olivera, Irene, Glez-Vaz, Javier, Luri-Rey, Carlos, Etxeberria, Iñaki, Cirella, Assunta, Azpilikueta, Arantza, Berraondo, Pedro, Argemi, Josepmaria, Sangro, Bruno, Teijeira, Alvaro, Melero, Ignacio

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CD137 (4-1BB) requires physically associated cIAPs for signal transduction and antitumor effects by Glez-Vaz, Javier, Azpilikueta, Arantza, Ochoa, María C, Olivera, Irene, Gomis, Gabriel, Cirella, Asunta, Luri-Rey, Carlos, Álvarez, Maite, Pérez-Gracia, Jose L, Ciordia, Sergio, Eguren-Santamaria, Iñaki, Alexandru, Raluca, Berraondo, Pedro, de Andrea, Carlos, Teijeira, Álvaro, Corrales, Fernando, Zapata, Juan M, Melero, Ignacio

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Intratumoral injection of interferon‐α and systemic delivery of agonist anti‐CD137 monoclonal antibodies synergize for immunotherapy by Dubrot, Juan, Palazón, Asis, Alfaro, Carlos, Azpilikueta, Arantza, Ochoa, María Carmen, Rouzaut, Ana, Martinez‐Forero, Iván, Teijeira, Alvaro, Berraondo, Pedro, Le Bon, Agnes, Hervás‐Stubbs, Sandra, Melero, Ignacio

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Abstract 4012: Improving radiotherapy abscopal effects with anti-PD1 and anti-CD137-based immunotherapy by Rodríguez-Ruiz, MariaE, Rodriguez, Inmaculada, Garasa, Saray, Barbes, Benigno, Solorzano, Jose Luis, Perez Gracia, Jose Luis, Labiano, Sara, Azpilikueta, Arantza, Bolanos, Elixabet, R. Sanchez-Paulete, Alfonso, Aznar, M. Angela, Rouzaut, Ana, Jure-Kunkel, Maria, Etxeberria, Iñaki, Alfaro, Carlos, Oñate, Carmen, Ponz, Mariano, Melero, Ignacio

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Abstract 4908: Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells by Sánchez-Paulete, Alfonso R., Cueto, Francisco J., Martínez-López, María, Labiano, Sara, Morales-Kastresana, Aizea, Rodríguez-Ruiz, Maria E., Jure-Kunkel, Maria, Azpilikueta, Arantza, Quetglas, José I., Sancho, David, Melero, Ignacio

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Abstract 3826: A therapeutically actionable pro-tumoral axis of cytokines involving interleukin-8, TNFα and IL-1β by Olivera, Irene, Sanz-Pamplona, Rebeca, Bolaños, Elixabet, Rodriguez, Inmaculada, Etxeberria, Iñaki, Cirella, Assunta, Garasa, Saray, Migueliz, Itziar, Eguren, Iñaki, Sanmamed, Miguel F., Glez-Vaz, Javier, Azpilikueta, Arantza, Alvarez, Maite, Ochoa, Maria C., De Andrea, Carlos E., Berraondo, Pedro, Teijeira, Álvaro, Melero, Ignacio

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In vivo depletion of DC impairs the anti-tumor effect of agonistic anti-CD137 mAb by Murillo, Oihana, Dubrot, Juan, Palazón, Asís, Arina, Ainhoa, Azpilikueta, Arantza, Alfaro, Carlos, Solano, Sarai, Ochoa, María C, Berasain, Carmen, Gabari, Izaskun, Pérez-Gracia, José.L, Berraondo, Pedro, Hervás-Stubbs, Sandra, Melero, Ignacio

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Abstract 261: Nivolumab and urelumab enhance antitumor activity of human T lymphocytes engrafted in Rag2-/-IL2Rγnull immunodeficient mice by Sanmamed, Miguel F., Rodriguez, Inmaculada, Oñate, Carmen, Azpilikueta, Arantza, Rodriguez-Ruiz, Maria E., Morales-Kastresana, Aizea, Labiano, Sara, Perez-Gracia, Jose L., Martín-Algarra, Salvador, Alfaro, Carlos, Schalper, Kurt A., Mazzolini, Guillermo, Sarno, Francesca, Hidalgo, Manuel, Korman, Alan J., Jure-Kunkel, Maria, Melero, Ignacio

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Abstract LB-330: Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hep... by Morales-Kastresana, Aizea, Sanmamed, Miguel F., Rodriguez, Inmaculada, Palazon, Asis, Martinez-Forero, Ivan, Labiano, Sara, Hervas-Stubbs, Sandra, Sangro, Bruno, Ochoa, Carmen, Azpilikueta, Arantza, Bolaños, Elixabet, Gütgemann, Ines, Melero, Ignacio

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Essential complicity of perforin-granzyme and FAS-L mechanisms to achieve tumor rejection following treatment with anti-CD137 mAb by Morales-Kastresana, Aizea, Catalán, Elena, Hervás-Stubbs, Sandra, Palazón, Asis, Azpilikueta, Arantza, Bolaños, Elixabet, Anel, Alberto, Pardo, Julián, Melero, Ignacio

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The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFNγ by Arina, Ainhoa, Murillo, Oihana, Hervás‐Stubbs, Sandra, Azpilikueta, Arantza, Dubrot, Juan, Tirapu, Iñigo, Huarte, Eduardo, Alfaro, Carlos, Pérez‐Gracia, Jose L., González‐Aseguinolaza, Gloria, Sarobe, Pablo, Lasarte, Juan J., Jamieson, Amanda, Prieto, Jesús, Raulet, David H., Melero, Ignacio

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Innate Functions of Immunoglobulin M Lessen Liver Gene Transfer with Helper-Dependent Adenovirus: e85432 by Unzu, Carmen, Melero, Ignacio, Morales-Kastresana, Aizea, Sampedro, Ana, Serrano-Mendioroz, Irantzu, Azpilikueta, Arantza, Ochoa, Maria Carmen, Dubrot, Juan, Martinez-Anso, Eduardo, Fontanellas, Antonio

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Therapeutic anti-tumor efficacy of anti-CD137 agonistic monoclonal antibody in mouse models of myeloma by Murillo, Oihana, Arina, Ainhoa, Hervas-Stubbs, Sandra, Gupta, Anjana, McCluskey, Brandon, Dubrot, Juan, Palazón, Asís, Azpilikueta, Arantza, Ochoa, Maria C., Alfaro, Carlos, Solano, Sarai, Pérez-Gracia, José L., Oyajobi, Babatunde O., Melero, Ignacio

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Therapeutic activity of a combination of immunostimulatory monoclonal antibodies (anti-B7-H1, CD137 and OX40) on a c-myc-driven spontaneous transgenic model of hepatocellular carci... by Morales-Kastresana, Aizea, Miguel, Sanmamed F, Rodriguez, Inmaculada, Palazon, Asis, Martinez-Forero, Ivan, Labiano, Sara, Hervas-Stubbs, Sandra, Sangro, Bruno, Ochoa, Carmen, Rouzaut, Ana, Azpilikueta, Arantza, Bolaños, Elixabet, Jure-Kunkel, Maria, Gutgemann, Ines, Melero, Ignacio

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106 Interferon-Producing Killer Dendritic Cells and Natural Killer Cells Response to Interleukin-15 Liver Gene Transfer by Murillo, Oihana, Arina, Ainhoa, Dubrot, Juan, Azpilikueta, Arantza, Gabari, Izaskun, Alfaro, Carlos, Berasain, Carmen, Hervas-Stubbs, Sandra, Perez Gracia, José L., Prieto, Jesús, Melero, Ignacio, Ferrini, Silvano

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The combined actions of NK and T lymphocytes are necessary to reject an EGFP+ mesenchymal tumor through mechanisms dependent on NKG2D and IFNy by ARINA, Ainhoa, MURILLO, Oihana, SAROBE, Pablo, LASARTE, Juan J, JAMIESON, Amanda, PRIETO, Jesus, RAULET, David H, MELERO, Ignacio, HERVAS-STUBBS, Sandra, AZPILIKUETA, Arantza, DUBROT, Juan, TIRAPU, Inigo, HUARTE, Eduardo, ALFARO, Carlos, PEREZ-GRACIA, Jose L, GONZALEZ -ASEGUINOLAZA, Gloria

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