Orphan drug development: an economically viable strategy for biopharma R&D by Meekings, Kiran N., Williams, Cory S.M., Arrowsmith, John E.

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Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents by Arrowsmith, John E, Campbell, Simon F, Cross, Peter E, Stubbs, John K, Burges, Roger A, Gardiner, Donald G, Blackburn, Kenneth J

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Selective class III antiarrhythmic agents. 1. Bis(arylalkyl)amines by Cross, Peter E, Arrowsmith, John E, Thomas, Geoffrey N, Gwilt, Michael, Burges, Roger A, Higgins, Alan J

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Long acting dihydropyridine calcium antagonists. 2. 2-[2-aminoheterocycloethoxy]methyl derivatives by Arrowsmith, John E, Campbell, Simon F, Cross, Peter E, Burges, Roger A, Gardiner, Donald G

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Reactions of anions of N-benzylidenebenzylamines and related compounds. A simple route to α-substituted benzylamines by Arrowsmith, John E., Cook, Michael J., Hardstone, David J.

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Early Homo at 2.8 Ma from Ledi-Geraru, Afar, Ethiopia by Villmoare, Brian, Kimbel, William H., Seyoum, Chalachew, Campisano, Christopher J., DiMaggio, Erin N., Rowan, John, Braun, David R., Arrowsmith, J Ramón, Reed, Kaye E.

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Near-Field Deformation from the El Mayor-Cucapah Earthquake Revealed by Differential LIDAR by Oskin, Michael E., Arrowsmith, J Ramon, Corona, Alejandro Hinojosa, Elliott, Austin J., Fletcher, John M., Fielding, Eric J., Gold, Peter O., Garcia, J. Javier Gonzalez, Hudnut, Ken W., Liu-Zeng, Jing, Teran, Orlando J.

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Late Pliocene fossiliferous sedimentary record and the environmental context of early Homo from Afar, Ethiopia by DiMaggio, Erin N., Campisano, Christopher J., Rowan, John, Dupont-Nivet, Guillaume, Deino, Alan L., Bibi, Faysal, Lewis, Margaret E., Souron, Antoine, Garello, Dominique, Werdelin, Lars, Reed, Kaye E., Arrowsmith, J Ramón

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Impact of pay for performance on prescribing of long-acting reversible contraception in primary care: an interrupted time series study by Arrowsmith, Myat E, Majeed, Azeem, Lee, John Tayu, Saxena, Sonia

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Phase I/II study of the combination of panobinostat and carfilzomib in patients with relapsed/refractory multiple myeloma by Berdeja, Jesus G, Hart, Lowell L, Mace, Joseph R, Arrowsmith, Edward R, Essell, James H, Owera, Rami S, Hainsworth, John D, Flinn, Ian W

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Atmospheric waves and global seismoacoustic observations of the January 2022 Hunga eruption, Tonga by Matoza, Robin S, Fee, David, Assink, Jelle D, Iezzi, Alexandra M, Green, David N, Kim, Keehoon, Toney, Liam, Lecocq, Thomas, Krishnamoorthy, Siddharth, Lalande, Jean-Marie, Nishida, Kiwamu, Gee, Kent L, Haney, Matthew M, Ortiz, Hugo D, Brissaud, Quentin, Martire, Léo, Rolland, Lucie, Vergados, Panagiotis, Nippress, Alexandra, Park, Junghyun, Shani-Kadmiel, Shahar, Witsil, Alex, Arrowsmith, Stephen, Caudron, Corentin, Watada, Shingo, Perttu, Anna B, Taisne, Benoit, Mialle, Pierrick, Le Pichon, Alexis, Vergoz, Julien, Hupe, Patrick, Blom, Philip S, Waxler, Roger, De Angelis, Silvio, Snively, Jonathan B, Ringler, Adam T, Anthony, Robert E, Jolly, Arthur D, Kilgour, Geoff, Averbuch, Gil, Ripepe, Maurizio, Ichihara, Mie, Arciniega-Ceballos, Alejandra, Astafyeva, Elvira, Ceranna, Lars, Cevuard, Sandrine, Che, Il-Young, De Negri, Rodrigo, Ebeling, Carl W, Evers, Läslo G, Franco-Marin, Luis E, Gabrielson, Thomas B, Hafner, Katrin, Harrison, R Giles, Komjathy, Attila, Lacanna, Giorgio, Lyons, John, Macpherson, Kenneth A, Marchetti, Emanuele, McKee, Kathleen F, Mellors, Robert J, Mendo-Pérez, Gerardo, Mikesell, T Dylan, Munaibari, Edhah, Oyola-Merced, Mayra, Park, Iseul, Pilger, Christoph, Ramos, Cristina, Ruiz, Mario C, Sabatini, Roberto, Schwaiger, Hans F, Tailpied, Dorianne, Talmadge, Carrick, Vidot, Jérôme, Webster, Jeremy, Wilson, David C

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Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors by Yu, Wenyu, Chory, Emma J., Wernimont, Amy K., Tempel, Wolfram, Scopton, Alex, Federation, Alexander, Marineau, Jason J., Qi, Jun, Barsyte-Lovejoy, Dalia, Yi, Joanna, Marcellus, Richard, Iacob, Roxana E., Engen, John R., Griffin, Carly, Aman, Ahmed, Wienholds, Erno, Li, Fengling, Pineda, Javier, Estiu, Guillermina, Shatseva, Tatiana, Hajian, Taraneh, Al-awar, Rima, Dick, John E., Vedadi, Masoud, Brown, Peter J., Arrowsmith, Cheryl H., Bradner, James E., Schapira, Matthieu

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MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin by Gallo, Marco, Coutinho, Fiona J., Vanner, Robert J., Gayden, Tenzin, Mack, Stephen C., Murison, Alex, Remke, Marc, Li, Ren, Takayama, Naoya, Desai, Kinjal, Lee, Lilian, Lan, Xiaoyang, Park, Nicole I., Barsyte-Lovejoy, Dalia, Smil, David, Sturm, Dominik, Kushida, Michelle M., Head, Renee, Cusimano, Michael D., Bernstein, Mark, Clarke, Ian D., Dick, John E., Pfister, Stefan M., Rich, Jeremy N., Arrowsmith, Cheryl H., Taylor, Michael D., Jabado, Nada, Bazett-Jones, David P., Lupien, Mathieu, Dirks, Peter B.

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Discovery of a Potent and Selective Targeted NSD2 Degrader for the Reduction of H3K36me2 by Hanley, Ronan P., Nie, David Y., Tabor, John R., Li, Fengling, Sobh, Amin, Xu, Chenxi, Barker, Natalie K., Dilworth, David, Hajian, Taraneh, Gibson, Elisa, Szewczyk, Magdalena M., Brown, Peter J., Barsyte-Lovejoy, Dalia, Herring, Laura E., Wang, Gang Greg, Licht, Jonathan D., Vedadi, Masoud, Arrowsmith, Cheryl H., James, Lindsey I.

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The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage by Kitevski-LeBlanc, Julianne, Fradet-Turcotte, Amélie, Kukic, Predrag, Wilson, Marcus D, Portella, Guillem, Yuwen, Tairan, Panier, Stephanie, Duan, Shili, Canny, Marella D, van Ingen, Hugo, Arrowsmith, Cheryl H, Rubinstein, John L, Vendruscolo, Michele, Durocher, Daniel, Kay, Lewis E

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Coseismic fault zone deformation revealed with differential lidar: Examples from Japanese Mw ∼7 intraplate earthquakes by Nissen, Edwin, Maruyama, Tadashi, Ramon Arrowsmith, J, Elliott, John R., Krishnan, Aravindhan K., Oskin, Michael E., Saripalli, Srikanth

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Biological and structural basis for Aha1 regulation of Hsp90 ATPase activity in maintaining proteostasis in the human disease cystic fibrosis by Koulov, Atanas V, LaPointe, Paul, Lu, Bingwen, Razvi, Abbas, Coppinger, Judith, Dong, Meng-Qiu, Matteson, Jeanne, Laister, Rob, Arrowsmith, Cheryl, Yates, 3rd, John R, Balch, William E

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Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled... by Fizazi, Karim, Prof Dr, Scher, Howard I, Prof, Molina, Arturo, MD, Logothetis, Christopher J, Prof, Chi, Kim N, MD, Jones, Robert J, PhD, Staffurth, John N, MD, North, Scott, MD, Vogelzang, Nicholas J, MD, Saad, Fred, Prof, Mainwaring, Paul, MD, Harland, Stephen, MD, Goodman, Oscar B, MD, Sternberg, Cora N, MD, Li, Jin Hui, PhD, Kheoh, Thian, PhD, Haqq, Christopher M, MD, de Bono, Johann S, Prof

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Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival by Morgan, Paul, Van Der Graaf, Piet H., Arrowsmith, John, Feltner, Doug E., Drummond, Kira S., Wegner, Craig D., Street, Steve D.A.

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Structural and Functional Comparison of the RING Domains of Two p53 E3 Ligases, Mdm2 and Pirh2 by Shloush, Jonathan, Vlassov, John E., Engson, Ian, Duan, Shili, Saridakis, Vivian, Dhe-paganon, Sirano, Raught, Brian, Sheng, Yi, Arrowsmith, Cheryl H.

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