Interpretation and Considerations on the Safety Evaluation of Human Drug Metabolites by Atrakchi, Aisar H

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Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies an... by Guo, Xiaoqing, Seo, Ji-Eun, Xu, Hannah, Yan, Jian, Malhi, Pritpal, Atrakchi, Aisar H, McGovern, Timothy, Davis Bruno, Karen L, Heflich, Robert H, Chen, Tao

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Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays by Li, Xilin, Le, Yuan, Seo, Ji-Eun, Guo, Xiaoqing, Li, Yuxi, Chen, Si, Mittelstaedt, Roberta A., Moore, Nyosha, Guerrero, Sharon, Sims, Audrey, King, Sruthi T., Atrakchi, Aisar H., McGovern, Timothy J., Davis-Bruno, Karen L., Keire, David A., Elespuru, Rosalie K., Heflich, Robert H., Mei, Nan

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Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s by Li, Xilin, He, Xiaobo, Le, Yuan, Guo, Xiaoqing, Bryant, Matthew S., Atrakchi, Aisar H., McGovern, Timothy J., Davis-Bruno, Karen L., Keire, David A., Heflich, Robert H., Mei, Nan

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Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells by Li, Xilin, Le, Yuan, Guo, Xiaoqing, King, Sruthi T., Dorsam, Robert T., Atrakchi, Aisar H., McGovern, Timothy J., Davis-Bruno, Karen L., Keire, David A., Heflich, Robert H., Mei, Nan

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Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models by Seo, Ji-Eun, Yu, Joshua Z., Xu, Hannah, Li, Xilin, Atrakchi, Aisar H., McGovern, Timothy J., Bruno, Karen L. Davis, Mei, Nan, Heflich, Robert H., Guo, Xiaoqing

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Optimizing the detection of N-nitrosamine mutagenicity in the Ames test by Heflich, Robert H., Bishop, Michelle E., Mittelstaedt, Roberta A., Yan, Jian, Guerrero, Sharon K., Sims, Audrey M., Mitchell, Kamela, Moore, Nyosha, Li, Xilin, Mei, Nan, Elespuru, Rosalie K., King, Sruthi T., Keire, David A., Kruhlak, Naomi L., Dorsam, Robert T., Raw, Andre S., Davis Bruno, Karen L., McGovern, Timothy J., Atrakchi, Aisar H.

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Current and Future Application of Genetic Toxicity Assays: The Role and Value of In Vitro Mammalian Assays by Elespuru, Rosalie K., Agarwal, Rajiv, Atrakchi, Aisar H., Bigger, C. Anita H., Heflich, Robert H., Jagannath, Devaraya R., Levy, Dan D., Moore, Martha M., Ouyang, Yanli, Robison, Timothy W., Sotomayor, Rene E., Cimino, Michael C., Dearfield, Kerry L.

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Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of four small-molecule nitrosamines with different carcinogenic potencies... by Guo, Xiaoqing, Seo, Ji-Eun, Xu, Hannah, Yan, Jian, Malhi, Pritpal, Atrakchi, Aisar H, Mcgovern, Timothy, Davis Bruno, Karen L, Heflich, Robert H, Chen, Tao

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Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related... by Robison, Timothy W., Heflich, Robert H., Manjanatha, Mugimane G., Elespuru, Rosalie, Atrakchi, Aisar, Mei, Nan, Ding, Wei

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A Regulatory Perspective on Issues and Approaches in Characterizing Human Metabolites by Davis-Bruno, Karen L., Atrakchi, Aisar

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Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A by Valentin, Jean-Pierre, Bass, Alan S., Atrakchi, Aisar, Olejniczak, Klaus, Kannosuke, Fujimori

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Calcium Currents Recorded from a Vertebrate Presynaptic Nerve Terminal are Resistant to the Dihydropyridine Nifedipine by Stanley, Elis F., Atrakchi, Aisar H.

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