AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-xL, Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia by Balachander, Srividya B., Criscione, Steven W., Byth, Kate F., Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W., Kurtz, Stephen E., McWeeney, Shannon K., Varnes, Jeffrey, Diebold, R. Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J., McCoull, William, Saeh, Jamal C., Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J., Jaaks, Patricia, Coker, Elizabeth A., Gregory, Gareth P., Newbold, Andrea, Johnstone, Ricky W., Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J. Paul, Davies, Barry R., Fawell, Stephen E., Gibbons, Francis D.

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Design and optimisation of dendrimer-conjugated Bcl-2/xL inhibitor, AZD0466, with improved therapeutic index for cancer therapy by Patterson, Claire M., Balachander, Srividya B., Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J., Gibbons, Francis D., Hennessy, Edward J., Kemmitt, Paul, Harmer, Alexander R., Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J. Paul, Schuller, Alwin G., Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E., Saeh, Jamal, Davies, Barry R., Owen, David J., Ashford, Marianne B.

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A novel BH3-mimetic, AZD0466, targeting BCL-XL and BCL-2 is effective in pre-clinical models of malignant pleural mesothelioma by Arulananda, Surein, O’Brien, Megan, Evangelista, Marco, Jenkins, Laura J., Poh, Ashleigh R., Walkiewicz, Marzena, Leong, Trishe, Mariadason, John M., Cebon, Jonathan, Balachander, Srividya B., Cidado, Justin R., Lee, Erinna F., John, Thomas, Fairlie, Walter D.

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Quantitative Evaluation of Dendritic Nanoparticles in Mice: Biodistribution Dynamics and Downstream Tumor Efficacy Outcomes by Vasalou, Christina, Ferguson, Douglas, Li, Weimin, Muse, Victorine, Gibbons, Francis D, Sonzini, Silvia, Zhang, Guangnong, Pop-Damkov, Petar, Gangl, Eric, Balachander, Srividya B, Wen, Shenghua, Schuller, Alwin G, Puri, Sanyogitta, Mazza, Mariarosa, Ashford, Marianne, Fretland, Adrian J, McGinnity, Dermot F, Jones, Rhys D. O

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Abstract 3075: Anti-leukemic activity of BCL-2/BCL-XL dual inhibitor - AZD0466 in T-acute lymphoblastic leukemia preclinical models by Kannan, Sankaranarayanan, Ghotbaldini, Sanaz, Wells, Julia E., Zhang, Qi, Balachander, Srividya, Cidado, Justin, Konopleva, Marina

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Abstract 56: AZD0466, a nanomedicine of a potent dual Bcl-2/Bcl-xL inhibitor, exhibits anti-tumor activity in a range of hematological and solid tumor models by Balachander, Srividya B., Tabatabai, Areya, Wen, Shenghua, Gibbons, Francis D., Fabbri, Giulia, Zhang, Guangnong Sunny, Cidado, Justin, Graham, Lorraine, Ashford, Marianne, Davies, Barry

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Abstract 1718: Design and optimization of a dendrimer-conjugated dual Bcl-2/Bcl-xL inhibitor, AZD0466, with improved therapeutic index by Ashford, Marianne B., Balachander, Srividya B., Graham, Lorraine, Grant, Iain, Gibbons, Francis D., Hill, Kathryn J., Harmer, Alexander R., Gales, Sonya, Redmond, Sean, Kelly, Brian, McCoull, William, Wen, Shenghua, Wild, Martin, Gangl, Eric, Owen, David J., Davies, Barry R.

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EZH2 Inhibitors Are Broadly Efficacious in Multiple Myeloma As Single Agent and in Combination with Standard of Care Therapeutics by Arora, Shilpi, Williamson, Kaylyn, Apte, Shruti, Balachander, Srividya, Busby, Jennifer, Hatton, Charlie, Bryant, Barbara, Trojer, Patrick

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Abstract 6150: AZD0466, a dual BCL-2/XL targeting nanomedicine, is active in small cell lung cancer models by Andersen, Courtney L., Fabbri, Giulia, Jenkins, David, Cader, Zumla, Sharma, Shringi, Tabatabai, Areya, Balachander, Srividya, Roebuck, Jordan, Galvin, Melanie, Simpson, Kathryn, Dive, Caroline, Ahnert, Jordi Rodon, Saeh, Jamal

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Anti-leukemia efficacy of the dual BCL2/BCL-XL inhibitor AZD0466 in acute lymphoblastic leukemia preclinical models by Kannan, Sankaranarayanan, Li, Yizhen, Baran, Natalia, Yang, Xu, Ghotbaldini, Sanaz, Tatarata, Qi Zhang, Yoshimura, Satoshi, Li, Zhenhua, Hsiao, Yu-Chih, Balachander, Srividya B, Andersen, Courtney L, Cidado, Justin, Yu, Jiyang, Jain, Nitin, Yang, Jun J, Konopleva, Marina Y

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Design and optimisation of dendrimer-conjugated Bcl-2/x L inhibitor, AZD0466, with improved therapeutic index for cancer therapy by Patterson, Claire M, Balachander, Srividya B, Grant, Iain, Pop-Damkov, Petar, Kelly, Brian, McCoull, William, Parker, Jeremy, Giannis, Michael, Hill, Kathryn J, Gibbons, Francis D, Hennessy, Edward J, Kemmitt, Paul, Harmer, Alexander R, Gales, Sonya, Purbrick, Stuart, Redmond, Sean, Skinner, Matthew, Graham, Lorraine, Secrist, J Paul, Schuller, Alwin G, Wen, Shenghua, Adam, Ammar, Reimer, Corinne, Cidado, Justin, Wild, Martin, Gangl, Eric, Fawell, Stephen E, Saeh, Jamal, Davies, Barry R, Owen, David J, Ashford, Marianne B

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AZD4320, A Dual Inhibitor of Bcl-2 and Bcl-x L , Induces Tumor Regression in Hematologic Cancer Models without Dose-limiting Thrombocytopenia by Balachander, Srividya B, Criscione, Steven W, Byth, Kate F, Cidado, Justin, Adam, Ammar, Lewis, Paula, Macintyre, Terry, Wen, Shenghua, Lawson, Deborah, Burke, Kathleen, Lubinski, Tristan, Tyner, Jeffrey W, Kurtz, Stephen E, McWeeney, Shannon K, Varnes, Jeffrey, Diebold, R Bruce, Gero, Thomas, Ioannidis, Stephanos, Hennessy, Edward J, McCoull, William, Saeh, Jamal C, Tabatabai, Areya, Tavana, Omid, Su, Nancy, Schuller, Alwin, Garnett, Mathew J, Jaaks, Patricia, Coker, Elizabeth A, Gregory, Gareth P, Newbold, Andrea, Johnstone, Ricky W, Gangl, Eric, Wild, Martin, Zinda, Michael, Secrist, J Paul, Davies, Barry R, Fawell, Stephen E, Gibbons, Francis D

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