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The plant diterpene epoxysiderol targets Hsp70 in cancer cells, affecting its ATPase activity and reducing its translocation to plasma membrane
by
Fiengo, L.
,
Lauro, G.
,
Bellone, M.L.
,
Bifulco, G.
,
Dal Piaz, F.
,
De Tommasi, N.
Published in
International journal of biological macromolecules
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International Journal Of Biological Macromolecules
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Adenosine Triphosphatases - Metabolism
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Apoptosis - Drug Effects
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Biochemistry & Molecular Biology
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Biological Products - Chemistry
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Biological Products - Pharmacology
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Cell Cycle - Drug Effects
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Cell Line, Tumor
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Cell Membrane - Drug Effects
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Cell Membrane - Metabolism
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Chemical Proteomics
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Chemistry
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Chemistry, Applied
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Diterpenes - Chemistry
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Diterpenes - Pharmacology
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Docking
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Drug Screening Assays, Antitumor
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Hsp70 Heat-Shock Proteins - Metabolism
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Hsp70 Inhibitor
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Humans
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Life Sciences & Biomedicine
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