S139: BCOR DELETION SUSTAINS NOTCH1 SIGNALLING ACTIVATION TO ACCELERATE CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) PROGRESSION TOWARD RICHTER TRANSFORMATION IN MICE by Rompietti, C., Sorcini, D., De Falco, F., Dorillo, E., Adamo, F. M., Silva Barcelos, E. C., Stella, A., Scialdone, A., Esposito, A., Arcaleni, R., Bigerna, B., Martino, G., Moretti, L., Mameli, M. G., Geraci, C., Sandoletti, L., Cipiciani, A., Rosati, E., Falini, B., Sportoletti, P.

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IL-17-producing double-negative T cells are expanded in the peripheral blood, infiltrate the salivary gland and are partially resistant to corticosteroid therapy in patients with S... by Alunno, A, Bistoni, O, Bartoloni Bocci, E, Caterbi, S, Bigerna, B, Pucciarini, A, Tabarrini, A, Mannucci, R, Beghelli, D, Falini, B, Gerli, R

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Selective Silencing of the NPM1 Mutant Protein and Apoptosis Induction upon ATRA In Vitro Treatment of AML Cells Carrying NPM1 Mutations by Martelli, M.P., Pettirossi, V., Manes, N., Liso, A., Mezzasoma, F., Cecchetti, F., De Marco, M.F., Bigerna, B., Pucciarini, A., Nicoletti, I., Martelli, M.F., Falini, B.

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PF228 DIAGNOSTIC VALUE OF PU.1 LOCALIZATION IN ACUTE MYELOID LEUKEMIA WITH MUTATED NPM1 by Pianigiani, G., Betti, C., Rossi, R., Bigerna, B., Brunetti, L.

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A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells by Falini, Brunangelo, Fizzotti, Marco, Pucciarini, Alessandra, Bigerna, Barbara, Marafioti, Teresa, Gambacorta, Marcello, Pacini, Roberta, Alunni, Cristina, Natali–Tanci, Laura, Ugolini, Barbara, Sebastiani, Carla, Cattoretti, Giorgio, Pileri, Stefano, Dalla-Favera, Riccardo, Stein, Harald

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Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: impact on WHO classification by Pasqualucci, Laura, Liso, Arcangelo, Martelli, Maria Paola, Bolli, Niccolò, Pacini, Roberta, Tabarrini, Alessia, Carini, Manola, Bigerna, Barbara, Pucciarini, Alessandra, Mannucci, Roberta, Nicoletti, Ildo, Tiacci, Enrico, Meloni, Giovanna, Specchia, Giorgina, Cantore, Nicola, Di Raimondo, Francesco, Pileri, Stefano, Mecucci, Cristina, Mandelli, Franco, Martelli, Massimo Fabrizio, Falini, Brunangelo

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Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT) by Falini, Brunangelo, Tiacci, Enrico, Pucciarini, Alessandra, Bigerna, Barbara, Kurth, Julia, Hatzivassiliou, Georgia, Droetto, Sara, Galletti, Barbara Verducci, Gambacorta, Marcello, Orazi, Attilio, Pasqualucci, Laura, Miller, Ira, Küppers, Ralf, Dalla-Favera, Riccardo, Cattoretti, Giorgio

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Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice by Falini, Brunangelo, Martelli, Maria Paola, Mecucci, Cristina, Liso, Arcangelo, Bolli, Niccolo, Bigerna, Barbara, Pucciarini, Alessandra, Pileri, Stefano, Meloni, Giovanna, Martelli, Massimo F, Haferlach, Torsten, Schnittger, Susanne

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PB1882 DECONSTRUCTING RICHTER SYNDROME TUMOR NICHE: JAGGED‐1 LIGAND LEADS THE WAY by Marra, A., Laurenti, M.E., Baldoni, S., Sorcini, D., Pasquino, S., Giansanti, M., Bigerna, B., Rompietti, C., De Falco, F., Del Papa, B., Martino, G., Ascani, S., Mecucci, C., Rosati, E., Sportoletti, P.

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Immunotoxin therapy of hematological malignancies by PASQUALUCCI, L, FLENGHI, L, TERENZI, A, BOLOGNESI, A, STIRPE, F, BIGERNA, B, FALINI, B

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Tumor protein D52 (TPD52): a novel B-cell/plasma-cell molecule with unique expression pattern and Ca2+-dependent association with annexin VI by Tiacci, Enrico, Orvietani, Pier-Luigi, Bigerna, Barbara, Pucciarini, Alessandra, Corthals, Garry L., Pettirossi, Valentina, Martelli, Maria P., Liso, Arcangelo, Benedetti, Roberta, Pacini, Roberta, Bolli, Niccolò, Pileri, Stefano, Pulford, Karen, Gambacorta, Marcello, Carbone, Antonino, Pasquarello, Carla, Scherl, Alexander, Robertson, Helen, Sciurpi, Maria Teresa, Alunni-Bistocchi, Giovanni, Binaglia, Luciano, Byrne, Jennifer A., Falini, Brunangelo

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Detection of normal and chimeric nucleophosmin in human cells by CORDELL, J. L, PULFORD, K. A. F, BIGERNA, B, RONCADOR, G, BANHAM, A, COLOMBO, E, PELICCI, P.-G, MASON, D. Y, FALINI, B

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Distinctive Expression Pattern of the BCL-6 Protein in Nodular Lymphocyte Predominance Hodgkin's Disease by Falini, Brunangelo, Bigerna, Barbara, Pasqualucci, Laura, Fizzotti, Marco, Martelli, Massimo F., Pileri, Stefano, Pinto, Antonio, Carbone, Antonino, Venturi, Stefania, Pacini, Roberta, Cattoretti, Giorgio, Pescarmona, Edoardo, Coco, Francesco Lo, Pelicci, Pier-Giuseppe, Anagnastopoulos, loannis, Dalla-Favera, Riccardo, Flenghi, Leonardo

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML by Falini, Brunangelo, Bolli, Niccolò, Shan, Jing, Martelli, Maria Paola, Liso, Arcangelo, Pucciarini, Alessandra, Bigerna, Barbara, Pasqualucci, Laura, Mannucci, Roberta, Rosati, Roberto, Gorello, Paolo, Diverio, Daniela, Roti, Giovanni, Tiacci, Enrico, Cazzaniga, Giovanni, Biondi, Andrea, Schnittger, Suzanne, Haferlach, Torsten, Hiddemann, Wolfgang, Martelli, Massimo F., Gu, Wei, Mecucci, Cristina, Nicoletti, Ildo

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