Glutamate dehydrogenase as a biomarker for mitotoxicity; insights from furosemide hepatotoxicity in the mouse by Church, Rachel J, Schomaker, Shelli J, Eaddy, J Scott, Boucher, Germaine G, Kreeger, John M, Aubrecht, Jiri, Watkins, Paul B

Get full text

Liver Microvascular Injury and Thrombocytopenia of Antibody-Calicheamicin Conjugates in Cynomolgus Monkeys-Mechanism and Monitoring by Guffroy, Magali, Falahatpisheh, Hadi, Biddle, Kathleen, Kreeger, John, Obert, Leslie, Walters, Karen, Goldstein, Richard, Boucher, Germaine, Coskran, Timothy, Reagan, William, Sullivan, Danielle, Huang, Chunli, Sokolowski, Sharon, Giovanelli, Richard, Gerber, Hans-Peter, Finkelstein, Martin, Khan, Nasir

Get full text

Selective Activation of AMPK β1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy by Salatto, Christopher T., Miller, Russell A., Cameron, Kimberly O., Cokorinos, Emily, Reyes, Allan, Ward, Jessica, Calabrese, Matthew F., Kurumbail, Ravi G., Rajamohan, Francis, Kalgutkar, Amit S., Tess, David A., Shavnya, Andre, Genung, Nathan E., Edmonds, David J., Jatkar, Aditi, Maciejewski, Benjamin S, Amaro, Marina, Gandhok, Harmeet, Monetti, Mara, Cialdea, Katherine, Bollinger, Eliza, Kreeger, John M., Coskran, Timothy M., Opsahl, Alan C., Boucher, Germaine G., Birnbaum, Morris J., DaSilva-Jardine, Paul, Rolph, Tim

Get full text

Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, β‑Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation by O’Neill, Brian T, Beck, Elizabeth M, Butler, Christopher R, Nolan, Charles E, Gonzales, Cathleen, Zhang, Lei, Doran, Shawn D, Lapham, Kimberly, Buzon, Leanne M, Dutra, Jason K, Barreiro, Gabriela, Hou, Xinjun, Martinez-Alsina, Luis A, Rogers, Bruce N, Villalobos, Anabella, Murray, John C, Ogilvie, Kevin, LaChapelle, Erik A, Chang, Cheng, Lanyon, Lorraine F, Steppan, Claire M, Robshaw, Ashley, Hales, Katherine, Boucher, Germaine G, Pandher, Karamjeet, Houle, Christopher, Ambroise, Claude W, Karanian, David, Riddell, David, Bales, Kelly R, Brodney, Michael A

Get full text

An in vitro alveolar epithelial cell model recapitulates LRRK2 inhibitor-induced increases in lamellar body size observed in preclinical models by Harney, Julie, Bajaj, Piyush, Finley, James E., Kopec, Anna K., Koza-Taylor, Petra H., Boucher, Germaine G., Lanz, Thomas A., Doshna, Colleen M., Somps, Christopher J., Adkins, Karissa, Houle, Christopher

Get full text

No Evidence of Neurogenesis in Adult Rat Sympathetic Ganglia Following Guanethidine-Induced Neuronal Loss by Walters, Karen M., Boucher, Magalie, Boucher, Germaine G., Opsahl, Alan C., Mouton, Peter R., Liu, Chang-Ning, Ritenour, Casey R., Kawabe, Thomas T., Pryski, Hayley N., Somps, Christopher J.

Get full text

Selective Activation of AMPK β 1-Containing Isoforms Improves Kidney Function in a Rat Model of Diabetic Nephropathy by Salatto, Christopher T, Miller, Russell A, Cameron, Kimberly O, Cokorinos, Emily, Reyes, Allan, Ward, Jessica, Calabrese, Matthew F, Kurumbail, Ravi G, Rajamohan, Francis, Kalgutkar, Amit S, Tess, David A, Shavnya, Andre, Genung, Nathan E, Edmonds, David J, Jatkar, Aditi, Maciejewski, Benjamin S, Amaro, Marina, Gandhok, Harmeet, Monetti, Mara, Cialdea, Katherine, Bollinger, Eliza, Kreeger, John M, Coskran, Timothy M, Opsahl, Alan C, Boucher, Germaine G, Birnbaum, Morris J, DaSilva-Jardine, Paul, Rolph, Tim

Get full text

High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/faCP rats, a model of type 2 diabetic nephropathy by Dower, Ken, Zhao, Shanrong, Schlerman, Franklin J, Savary, Leigh, Campanholle, Gabriela, Johnson, Bryce G, Xi, Li, Nguyen, Vuong, Zhan, Yutian, Lech, Matthew P, Wang, Ju, Nie, Qing, Karsdal, Morten A, Genovese, Federica, Boucher, Germaine, Brown, Thomas P, Zhang, Baohong, Homer, Bruce L, Martinez, Robert V

Get full text

The Development of Subcutaneous Sarcomas in Rodents Exposed to Peroxisome Proliferators Agonists: Hypothetical Mechanisms of Action and De-Risking Attitude by Pruimboom-Brees, Ingrid M., Francone, Omar, Pettersen, John C., Kerlin, Roy L., Will, Yvonne, Amacher, David E., Boucher, Germaine G., Morton, Daniel

Get full text

Renal Dysplasia in Beagle Dogs: Four Cases by Bruder, Marc C., Shoieb, Ahmed M., Shirai, Norimitsu, Boucher, Germaine G., Brodie, Thomas A.

Get full text

Abstract LB-202: Liver microvascular injury and thrombocytopenia of antibody-calicheamicin conjugates: mechanism and monitoring by Guffroy, Magali, Falahatpisheh, Hadi, Biddle, Kathleen, Kreeger, John, Obert, Leslie, Walters, Karen, Goldstein, Richard, Boucher, Germaine, Coskran, Timothy, Reagan, William, Sullivan, Danielle, Sokolowski, Sharon, Giovanelli, Richard, Gerber, Hans-Peter, Finkelstein, Martin, Khan, Nasir

Get full text

High resolution molecular and histological analysis of renal disease progression in ZSF1 fa/fa.sup.CP rats, a model of type 2 diabetic nephropathy by Dower, Ken, Zhao, Shanrong, Schlerman, Franklin J, Savary, Leigh, Campanholle, Gabriela, Johnson, Bryce G, Xi, Li, Nguyen, Vuong, Zhan, Yutian, Lech, Matthew P, Wang, Ju, Nie, Qing, Karsdal, Morten A, Genovese, Federica, Boucher, Germaine, Brown, Thomas P, Zhang, Baohong, Homer, Bruce L, Martinez, Robert V

Get full text