Discovery and Characterization of Small Molecule Inhibitors of the BET Family Bromodomains by Chung, Chun-wa, Coste, Hervé, White, Julia H, Mirguet, Olivier, Wilde, Jonathan, Gosmini, Romain L, Delves, Chris, Magny, Sylvie M, Woodward, Robert, Hughes, Stephen A, Boursier, Eric V, Flynn, Helen, Bouillot, Anne M, Bamborough, Paul, Brusq, Jean-Marie G, Gellibert, Françoise J, Jones, Emma J, Riou, Alizon M, Homes, Paul, Martin, Sandrine L, Uings, Iain J, Toum, Jérôme, Clément, Catherine A, Boullay, Anne-Bénédicte, Grimley, Rachel L, Blandel, Florence M, Prinjha, Rab K, Lee, Kevin, Kirilovsky, Jorge, Nicodeme, Edwige

Get full text

From ApoA1 upregulation to BET family bromodomain inhibition: Discovery of I-BET151 by Mirguet, Olivier, Lamotte, Yann, Donche, Frédéric, Toum, Jérôme, Gellibert, Françoise, Bouillot, Anne, Gosmini, Romain, Nguyen, Van-Loc, Delannée, Delphine, Seal, Jonathan, Blandel, Florence, Boullay, Anne-Bénédicte, Boursier, Eric, Martin, Sandrine, Brusq, Jean-Marie, Krysa, Gael, Riou, Alizon, Tellier, Rémi, Costaz, Agnès, Huet, Pascal, Dudit, Yann, Trottet, Lionel, Kirilovsky, Jorge, Nicodeme, Edwige

Get full text

The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits by Bertrand, Sophie M, Ancellin, Nicolas, Beaufils, Benjamin, Bingham, Ryan P, Borthwick, Jennifer A, Boullay, Anne-Bénédicte, Boursier, Eric, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fouchet, Marie-Hélène, Fournier, Charlène, Francis, Peter L, Gummer, Laura A, Herry, Kenny, Hobbs, Andrew, Hobbs, Clare I, Homes, Paul, Jamieson, Craig, Nicodeme, Edwige, Pickett, Stephen D, Reid, Iain H, Simpson, Graham L, Sloan, Lisa A, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Valko, Klara, Washio, Yoshiaki, Young, Robert J

Get full text

Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2‑Aryl Benzimidazole BCATm Inhibitors by Deng, Hongfeng, Zhou, Jingye, Sundersingh, Flora, Messer, Jeffrey A, Somers, Donald O, Ajakane, Myriam, Arico-Muendel, Christopher C, Beljean, Arthur, Belyanskaya, Svetlana L, Bingham, Ryan, Blazensky, Emily, Boullay, Anne-Benedicte, Boursier, Eric, Chai, Jing, Carter, Paul, Chung, Chun-Wa, Daugan, Alain, Ding, Yun, Herry, Kenny, Hobbs, Clare, Humphries, Eric, Kollmann, Christopher, Nguyen, Van Loc, Nicodeme, Edwige, Smith, Sarah E, Dodic, Nerina, Ancellin, Nicolas

Get full text

Intestine-Specific Regulation of PPARα Gene Transcription by Liver X Receptors by Colin, Sophie, Bourguignon, Elodie, Boullay, Anne-Bénédicte, Tousaint, Jean-Jacques, Huet, Stéphane, Caira, Françoise, Staels, Bart, Lestavel, Sophie, Lobaccaro, Jean-Marc A, Delerive, Philippe

Get full text

Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment by Issandou, Marc, Guillard, Raphaëlle, Boullay, Anne-Benedicte, Linhart, Valerie, Lopez-Perez, Elvira

Get full text

Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity by Fouchet, Marie-Hélène, Donche, Frédéric, Martin, Christelle, Bouillot, Anne, Junot, Christophe, Boullay, Anne-Bénédicte, Potvain, Florent, Magny, Sylvie Demaria, Coste, Hervé, Walker, Max, Issandou, Marc, Dodic, Nérina

Get full text

Abstract 3228: Immune checkpoint blockade and autoimmune diseases: Development of a mouse model of colitis induced by anti-CTLA-4 by Nicodeme, Edwige, Blandel, Florence, Boullay, Valerie, Saintillan, Yannick, Krysa, Gael, Boullay, Anne-Benedicte, Tousaint, Jean-Jacques, Artus, Robin, Levenez, Laure, Odillard, Jeremy, Jacquet, Ingrid, Duchamp, Olivier, Viviani, Fabrice

Get full text

Intestine-specific regulation of PPARalpha gene transcription by liver X receptors by Colin, Sophie, Bourguignon, Elodie, Boullay, Anne-Bénédicte, Tousaint, Jean-Jacques, Huet, Stéphane, Caira, Françoise, Staels, Bart, Lestavel, Sophie, Lobaccaro, Jean-Marc A, Delerive, Philippe

Get full text

Intestine-Specific Regulation of PPARa Gene Transcription by Liver X Receptors by COLIN, Sophie, BOURGUIGNON, Elodie, BOULLAY, Anne-Bénédicte, TOUSAINT, Jean-Jacques, HUET, Stéphane, CAIRA, Francoise, STAELS, Bart, LESTAVEL, Sophie, LOBACCARO, Jean-Marc A, DELERIVE, Philippe

Get full text