The two pore potassium channel THIK‐1 regulates NLRP3 inflammasome activation by Drinkall, Samuel, Lawrence, Catherine B., Ossola, Bernadino, Russell, Samuel, Bender, Clare, Brice, Nicola B., Dawson, Lee A., Harte, Michael, Brough, David

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A Phase I, First-in-Human, Healthy Volunteer Study to Investigate the Safety, Tolerability, and Pharmacokinetics of CVN424, a Novel G Protein-Coupled Receptor 6 Inverse Agonist for... by Margolin, David H, Brice, Nicola L, Davidson, Antonia M, Matthews, Kim L, Carlton, Mark B L

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Mismatch negativity as an index of target engagement for excitation/inhibition-based treatment development: a double-blind, placebo-controlled, randomized, single-dose cross-over s... by Sehatpour, Pejman, Javitt, Daniel C, De Baun, Heloise M, Carlson, Marlene, Beloborodova, Anna, Margolin, David H, Carlton, Mark B L, Brice, Nicola L, Kantrowitz, Joshua T

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Discovery and first-time disclosure of CVN766, an exquisitely selective orexin 1 receptor antagonist by Glen, Angela, Bürli, Roland W., Livermore, David, Buffham, William, Merison, Stephanie, Rowland, Anna E., Newman, Robert, Fieldhouse, Charlotte, Miller, David J., Dawson, Lee A., Matthews, Kim, Carlton, Mark B., Brice, Nicola L.

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Characterisation of C101248: A novel selective THIK-1 channel inhibitor for the modulation of microglial NLRP3-inflammasome by Ossola, Bernardino, Rifat, Ali, Rowland, Anna, Hunter, Helen, Drinkall, Samuel, Bender, Clare, Hamlischer, Mayida, Teall, Martin, Burley, Russell, Barker, Daneil F., Cadwalladr, David, Dickson, Louise, Lawrence, Jason M.K., Harvey, Jenna R.M., Lizio, Marina, Xu, Xiao, Kavanagh, Edel, Cheung, Toni, Sheardown, Steve, Lawrence, Catherine B., Harte, Michael, Brough, David, Madry, Christian, Matthews, Kim, Doyle, Kevin, Page, Keith, Powell, Justin, Brice, Nicola L., Bürli, Roland W., Carlton, Mark B., Dawson, Lee A.

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Natural history of monoclonal B-cell lymphocytosis among relatives in CLL families by Slager, Susan L., Lanasa, Mark C., Marti, Gerald E., Achenbach, Sara J., Camp, Nicola J., Abbasi, Fatima, Kay, Neil E., Vachon, Celine M., Cerhan, James R., Johnston, James B., Call, Timothy G., Rabe, Kari G., Kleinstern, Geffen, Boddicker, Nicholas J., Norman, Aaron D., Parikh, Sameer A., Leis, Jose F., Banerji, Versha, Brander, Danielle M., Glenn, Martha, Ferrajoli, Alessandra, Curtin, Karen, Braggio, Esteban, Shanafelt, Tait D., McMaster, Mary L., Weinberg, J. Brice, Hanson, Curtis A., Caporaso, Neil E.

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Structural insights into the high basal activity and inverse agonism of the orphan receptor GPR6 implicated in Parkinson's disease by Barekatain, Mahta, Johansson, Linda C, Lam, Jordy H, Chang, Hao, Sadybekov, Anastasiia V, Han, Gye Won, Russo, Joseph, Bliesath, Joshua, Brice, Nicola L, Carlton, Mark B L, Saikatendu, Kumar S, Sun, Hukai, Murphy, Sean T, Monenschein, Holger, Schiffer, Hans H, Popov, Petr, Lutomski, Corinne A, Robinson, Carol V, Liu, Zhi-Jie, Hua, Tian, Katritch, Vsevolod, Cherezov, Vadim

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Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease by Brice, Nicola L., Schiffer, Hans H., Monenschein, Holger, Mulligan, Victoria J., Page, Keith, Powell, Justin, Xu, Xiao, Cheung, Toni, Burley, J. Russell, Sun, Huikai, Dickson, Louise, Murphy, Sean T., Kaushal, Nidhi, Sheardown, Steve, Lawrence, Jason, Chen, Yun, Bartkowski, Darian, Kanta, Anne, Russo, Joseph, Hosea, Natalie, Dawson, Lee A., Hitchcock, Stephen H., Carlton, Mark B.

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Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study by Nalls, Mike A, PhD, McLean, Cory Y, PhD, Rick, Jacqueline, PhD, Eberly, Shirley, MS, Hutten, Samantha J, PhD, Gwinn, Katrina, MD, Sutherland, Margaret, PhD, Martinez, Maria, PhD, Heutink, Peter, PhD, Williams, Nigel M, PhD, Hardy, John, PhD, Gasser, Thomas, MD, Brice, Alexis, MD, Price, T Ryan, MS, Nicolas, Aude, PhD, Keller, Margaux F, PhD, Molony, Cliona, PhD, Gibbs, J Raphael, MS, Chen-Plotkin, Alice, MD, Suh, Eunran, PhD, Letson, Christopher, BS, Fiandaca, Massimo S, MD, Mapstone, Mark, PhD, Federoff, Howard J, MD, Noyce, Alastair J, MRCP, Morris, Huw, MD, Van Deerlin, Vivianna M, MD, Weintraub, Daniel, MD, Zabetian, Cyrus, MD, Hernandez, Dena G, MS, Lesage, Suzanne, PhD, Mullins, Meghan, BA, Conley, Emily Drabant, PhD, Northover, Carrie A M, PhD, Frasier, Mark, PhD, Marek, Ken, MD, Day-Williams, Aaron G, PhD, Stone, David J, PhD, Ioannidis, John P A, Prof, Singleton, Andrew B, Dr

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Neurofilament light levels predict clinical progression and death in multiple system atrophy by Chelban, Viorica, Nikram, Elham, Perez-Soriano, Alexandra, Wilke, Carlo, Foubert-Samier, Alexandra, Vijiaratnam, Nirosen, Guo, Tong, Jabbari, Edwin, Olufodun, Simisola, Gonzalez, Mariel, Senkevich, Konstantin, Laurens, Brice, Péran, Patrice, Rascol, Olivier, Le Traon, Anne Pavy, Todd, Emily G, Costantini, Alyssa A, Alikhwan, Sondos, Tariq, Ambreen, Ng, Bai Lin, Muñoz, Esteban, Painous, Celia, Compta, Yaroslau, Junque, Carme, Segura, Barbara, Zhelcheska, Kristina, Wellington, Henny, Schöls, Ludger, Jaunmuktane, Zane, Kobylecki, Christopher, Church, Alistair, Hu, Michele T M, Rowe, James B, Leigh, P Nigel, Massey, Luke, Burn, David J, Pavese, Nicola, Foltynie, Tom, Pchelina, Sofya, Wood, Nicholas, Heslegrave, Amanda J, Zetterberg, Henrik, Bocchetta, Martina, Rohrer, Jonathan D, Marti, Maria J, Synofzik, Matthis, Morris, Huw R, Meissner, Wassilios G, Houlden, Henry

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Targeted Prostate Cancer Screening in BRCA1 and BRCA2 Mutation Carriers: Results from the Initial Screening Round of the IMPACT Study by Bancroft, Elizabeth K, Page, Elizabeth C, Castro, Elena, Lilja, Hans, Vickers, Andrew, Sjoberg, Daniel, Assel, Melissa, Foster, Christopher S, Drew, Kate, Mæhle, Lovise, Axcrona, Karol, Evans, D. Gareth, Bulman, Barbara, Eccles, Diana, van Asperen, Christi, Vasen, Hans, Kiemeney, Lambertus A, Ringelberg, Janneke, Cybulski, Cezary, Wokolorczyk, Dominika, Selkirk, Christina, Hulick, Peter J, Bojesen, Anders, Skytte, Anne-Bine, Lam, Jimmy, Taylor, Louise, Oldenburg, Rogier, Verhaegh, Gerald, van Zelst-Stams, Wendy A, Oosterwijk, Jan C, Blanco, Ignacio, Salinas, Monica, Cook, Jackie, Rosario, Derek J, Buys, Saundra, Conner, Tom, Ausems, Margreet G, Ong, Kai-ren, Hoffman, Jonathan, Domchek, Susan, Teixeira, Manuel R, Maia, Sofia, Foulkes, William D, Taherian, Nassim, Ruijs, Marielle, den Enden, Apollonia T. Helderman-van, Izatt, Louise, Davidson, Rosemarie, Adank, Muriel A, Walker, Lisa, Schmutzler, Rita, Tucker, Kathy, Kirk, Judy, Hodgson, Shirley, Harris, Marion, Douglas, Fiona, Lindeman, Geoffrey J, Zgajnar, Janez, Tischkowitz, Marc, Susman, Rachel, Ramón y Cajal, Teresa, Patcher, Nicholas, Spigelman, Allan, Liljegren, Annelie, Side, Lucy, Brewer, Carole, Donaldson, Alan, Stefansdottir, Vigdis, Chen-Shtoyerman, Rakefet, Amor, David J, Barwell, Julian, Giri, Veda N, Murthy, Vedang, Nicolai, Nicola, Teo, Soo-Hwang, Greenhalgh, Lynn, Strom, Sara, Henderson, Alex, McGrath, John, Gallagher, David, Aaronson, Neil, Ardern-Jones, Audrey, Bangma, Chris, Dearnaley, David, Eyfjord, Jorunn, Rothwell, Jeanette, Falconer, Alison, Gronberg, Henrik, Johannsson, Oskar, Kote-Jarai, Zsofia, Axcrona, Ulrika, Melia, Jane, McKinley, Joanne, Mitra, Anita V, Moynihan, Clare, Rennert, Gad, Suri, Mohnish, Wilson, Penny, Killick, Emma, Moss, Sue

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Mutations in the DJ-1 Gene Associated with Autosomal Recessive Early-Onset Parkinsonism by Bonifati, Vincenzo, Rizzu, Patrizia, van Baren, Marijke J., Schaap, Onno, Breedveld, Guido J., Krieger, Elmar, Marieke C. J. Dekker, Squitieri, Ferdinando, Ibanez, Pablo, Joosse, Marijke, van Dongen, Jeroen W., Vanacore, Nicola, van Swieten, John C., Brice, Alexis, Meco, Giuseppe, van Duijn, Cornelia M., Oostra, Ben A., Heutink, Peter

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Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis by Kleinstern, Geffen, Camp, Nicola J., Goldin, Lynn R., Vachon, Celine M., Vajdic, Claire M., de Sanjose, Silvia, Weinberg, J. Brice, Benavente, Yolanda, Casabonne, Delphine, Liebow, Mark, Nieters, Alexandra, Hjalgrim, Henrik, Melbye, Mads, Glimelius, Bengt, Adami, Hans-Olov, Boffetta, Paolo, Brennan, Paul, Maynadie, Marc, McKay, James, Cocco, Pier Luigi, Shanafelt, Tait D., Call, Timothy G., Norman, Aaron D., Hanson, Curtis, Robinson, Dennis, Chaffee, Kari G., Brooks-Wilson, Angela R., Monnereau, Alain, Clavel, Jacqueline, Glenn, Martha, Curtin, Karen, Conde, Lucia, Bracci, Paige M., Morton, Lindsay M., Cozen, Wendy, Severson, Richard K., Chanock, Stephen J., Spinelli, John J., Johnston, James B., Rothman, Nathaniel, Skibola, Christine F., Leis, Jose F., Kay, Neil E., Smedby, Karin E., Berndt, Sonja I., Cerhan, James R., Caporaso, Neil, Slager, Susan L.

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Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing by Jansen, Iris E, Ye, Hui, Heetveld, Sasja, Lechler, Marie C, Michels, Helen, Seinstra, Renée I, Lubbe, Steven J, Drouet, Valérie, Lesage, Suzanne, Majounie, Elisa, Gibbs, J Raphael, Nalls, Mike A, Ryten, Mina, Botia, Juan A, Vandrovcova, Jana, Simon-Sanchez, Javier, Castillo-Lizardo, Melissa, Rizzu, Patrizia, Blauwendraat, Cornelis, Chouhan, Amit K, Li, Yarong, Yogi, Puja, Amin, Najaf, van Duijn, Cornelia M, Morris, Huw R, Brice, Alexis, Singleton, Andrew B, David, Della C, Nollen, Ellen A, Jain, Shushant, Shulman, Joshua M, Heutink, Peter

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Effectiveness of nail bed repair in children with or without replacing the fingernail: NINJA multicentre randomized clinical trial by Jain, Abhilash, Greig, Aina V H, Jones, Amy, Cooper, Cushla, Davies, Loretta, Greshon, Akiko, Fletcher, Heidi, Sierakowski, Adam, Dritsaki, Melina, Nguyen, Thi Thu An, Png, May Ee, Stokes, Jamie R, Dakin, Helen, Cook, Jonathan A, Beard, David J, Gardiner, Matthew D

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A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium by Costas, Laura, Lambert, Brice H, Birmann, Brenda M, Moysich, Kirsten B, De Roos, Anneclaire J, Hofmann, Jonathan N, Baris, Dalsu, Wang, Sophia S, Camp, Nicola J, Tricot, Guido, Atanackovic, Djordje, Brennan, Paul, Cocco, Pierluigi, Nieters, Alexandra, Becker, Nikolaus, Maynadié, Marc, Foretová, Lenka, Boffetta, Paolo, Staines, Anthony, Brown, Elisabeth E, de Sanjosé, Silvia

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Cost-effectiveness of replacing versus discarding the nail in children with nail bed injury by Dakin, Helen A, Nguyen, Thi Thu An, Dritsaki, Melina, Greig, Aina V H, Stokes, Jamie R, Cook, Jonathan A, Beard, David J, Davies, Loretta, Gardiner, Matthew D, Jain, Abhilash

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Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction by ANTONIOU, Antonis C, BEESLEY, Jonathan, ISAACS, Claudine, GANZ, Patricia A, TOMLINSON, Gail, OLOPADE, Olufunmilayo I, COUCH, Fergus J, XIANSHU WANG, LINDOR, Noralane M, PANKRATZ, Vernon S, RADICE, Paolo, MANOUKIAN, Siranoush, MCGUFFOG, Lesley, PEISSEL, Bernard, ZAFFARONI, Daniela, BARILE, Monica, VIEL, Alessandra, ALLAVENA, Anna, DALL' OLIO, Valentina, PETERLONGO, Paolo, SZABO, Csilla I, ZIKAN, Michal, CLAES, Kathleen, SINILNIKOVA, Olga M, POPPE, Bruce, FORETOVA, Lenka, MAI, Phuong L, GREENE, Mark H, RENNERT, Gad, LEJBKOWICZ, Flavio, GLENDON, Gord, OZCELIK, Hilmi, ANDRULIS, Irene L, THOMASSEN, Mads, HEALEY, Sue, GERDES, Anne-Marie, SUNDE, Lone, CRUGER, Dorthe, JENSEN, Uffe Birk, CALIGO, Maria, FRIEDMAN, Eitan, KAUFMAN, Bella, LAITMAN, Yael, MILGROM, Roni, DUBROVSKY, Maya, NEUHAUSEN, Susan L, COHEN, Shimrit, BORG, Ake, JERNSTRÖM, Helena, LINDBLOM, Annika, RANTALA, Johanna, STENMARK-ASKMALM, Marie, MELIN, Beatrice, NATHANSON, Kate, DOMCHEK, Susan, JAKUBOWSKA, Ania, YUAN CHUN DING, REBBECK, Timothy R, WEITZEL, Jeffrey N, LYNCH, Henry T

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Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers by Kuchenbaecker, Karoline B, Neuhausen, Susan L, Robson, Mark, Barrowdale, Daniel, McGuffog, Lesley, Mulligan, Anna Marie, Andrulis, Irene L, Spurdle, Amanda B, Schmidt, Marjanka K, Schmutzler, Rita K, Engel, Christoph, Wappenschmidt, Barbara, Nevanlinna, Heli, Thomassen, Mads, Southey, Melissa, Radice, Paolo, Ramus, Susan J, Domchek, Susan M, Nathanson, Katherine L, Lee, Andrew, Healey, Sue, Nussbaum, Robert L, Rebbeck, Timothy R, Arun, Banu K, James, Paul, Karlan, Beth Y, Lester, Jenny, Cass, Ilana, Terry, Mary Beth, Daly, Mary B, Goldgar, David E, Buys, Saundra S, Janavicius, Ramunas, Tihomirova, Laima, Tung, Nadine, Dorfling, Cecilia M, van Rensburg, Elizabeth J, Steele, Linda, v O Hansen, Thomas, Ejlertsen, Bent, Gerdes, Anne-Marie, Nielsen, Finn C, Dennis, Joe, Cunningham, Julie, Hart, Steven, Slager, Susan, Osorio, Ana, Benitez, Javier, Duran, Mercedes, Weitzel, Jeffrey N, Tafur, Isaac, Hander, Mary, Peterlongo, Paolo, Manoukian, Siranoush, Peissel, Bernard, Roversi, Gaia, Scuvera, Giulietta, Bonanni, Bernardo, Mariani, Paolo, Volorio, Sara, Dolcetti, Riccardo, Varesco, Liliana, Papi, Laura, Tibiletti, Maria Grazia, Giannini, Giuseppe, Fostira, Florentia, Konstantopoulou, Irene, Garber, Judy, Hamann, Ute, Donaldson, Alan, Brewer, Carole, Foo, Claire, Evans, D Gareth, Frost, Debra, Eccles, Diana, Douglas, Fiona, Brady, Angela, Cook, Jackie, Tischkowitz, Marc, Adlard, Julian, Barwell, Julian, Ong, Kai-ren, Walker, Lisa, Izatt, Louise, Side, Lucy E, Kennedy, M John, Rogers, Mark T, Porteous, Mary E, Morrison, Patrick J, Platte, Radka, Eeles, Ros, Davidson, Rosemarie, Hodgson, Shirley, Ellis, Steve, Godwin, Andrew K, Rhiem, Kerstin, Meindl, Alfons, Ditsch, Nina, Arnold, Norbert, Plendl, Hansjoerg

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Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers by Antoniou, Antonis C., Sinilnikova, Olga M., McGuffog, Lesley, Healey, Sue, Nevanlinna, Heli, Chen, Xiaoqing, Neuhausen, Susan L., Ding, Yuan C., Couch, Fergus J., Wang, Xianshu, Fredericksen, Zachary, Peterlongo, Paolo, Peissel, Bernard, Viel, Alessandra, Radice, Paolo, Szabo, Csilla I., Foretova, Lenka, Zikan, Michal, Claes, Kathleen, Greene, Mark H., Mai, Phuong L., Ozcelik, Hilmi, Thomassen, Mads, Sunde, Lone, Caligo, Maria A., Laitman, Yael, Kontorovich, Tair, Kaufman, Bella, Dagan, Efrat, Baruch, Ruth Gershoni, Harbst, Katja, Barbany-Bustinza, Gisela, Rantala, Johanna, Domchek, Susan M., Nathanson, Katherine L., Osorio, Ana, Blanco, Ignacio, Lasa, Adriana, Hamann, Ute, Rookus, Matti A., Collee, J. Margriet, Devilee, Peter, van der Luijt, Rob B., Waisfisz, Quinten, Wijnen, Juul, van Roozendaal, Cornelis E.P., Peock, Susan, Cook, Margaret, Frost, Debra, Oliver, Clare, Platte, Radka, Evans, D. Gareth, Eeles, Rosalind, Izatt, Louise, Eccles, Diana, Cole, Trevor, Hodgson, Shirley, Buecher, Bruno, Léoné, Mélanie, Remenieras, Audrey, Caron, Olivier, Lenoir, Gilbert M., Sevenet, Nicolas, Longy, Michel, Ferrer, Sandra Fert, Prieur, Fabienne, Goldgar, David, Miron, Alexander, John, Esther M., Daly, Mary B., Hopper, John L., Gschwantler-Kaulich, Daphne, Staudigl, Christine, Hansen, Thomas v. O., Barkardottir, Rosa Bjork, Kirchhoff, Tomas, Pal, Prodipto, Kosarin, Kristi, Offit, Kenneth, Piedmonte, Marion, Rodriguez, Gustavo C., Wakeley, Katie, Boggess, John F., Schwartz, Peter E., Montagna, Marco, Imyanitov, Evgeny N., Allavena, Anna, Schmutzler, Rita K., Versmold, Beatrix, Engel, Christoph, Ditsch, Nina, Niederacher, Dieter, Deißler, Helmut, Fiebig, Britta, Suttner, Christian, Schönbuchner, Ines, Gadzicki, Dorothea, Caldes, Trinidad, Pooley, Karen A., Chenevix-Trench, Georgia

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