The “unnatural” history of colorectal cancer in Lynch syndrome: Lessons from colonoscopy surveillance by Ahadova, Aysel, Seppälä, Toni T., Engel, Christoph, Gallon, Richard, Burn, John, Holinski‐Feder, Elke, Steinke‐Lange, Verena, Möslein, Gabriela, Nielsen, Maartje, Broeke, Sanne W., Laghi, Luigi, Dominguez‐Valentin, Mev, Capella, Gabriel, Macrae, Finlay, Scott, Rodney, Hüneburg, Robert, Nattermann, Jacob, Hoffmeister, Michael, Brenner, Hermann, Bläker, Hendrik, Knebel Doeberitz, Magnus, Sampson, Julian R., Vasen, Hans, Mecklin, Jukka‐Pekka, Møller, Pål, Kloor, Matthias

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Delineating genotype and parent‐of‐origin effect on the phenotype in MSH6‐associated Lynch syndrome by Werf‐'t Lam, Anne‐Sophie, Rodriguez‐Girondo, Mar, Villasmil, Mandy, Tops, Carli M., Hest, Liselotte, Gille, Hans J. P., Duijkers, Floor A. M., Wagner, Anja, Eikenboom, Ellis, Letteboer, Tom G. W., Jong, Mirjam M., Bajwa‐ten Broeke, Sanne W., Bleeker, Fonnet, Gomez Garcia, Encarna B., Dominguez‐Valentin, Mev, Møller, Pal, Suerink, Manon, Nielsen, Maartje

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The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations by Helderman, Noah C., Bajwa - ten Broeke, Sanne W., Morreau, Hans, Suerink, Manon, Terlouw, Diantha, van der Werf-’ t Lam, Anne-Sophie, van Wezel, Tom, Nielsen, Maartje

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The coding microsatellite mutation profile of PMS2-deficient colorectal cancer by Bajwa - ten Broeke, Sanne W., Ballhausen, Alexej, Ahadova, Aysel, Suerink, Manon, Bohaumilitzky, Lena, Seidler, Florian, Morreau, Hans, van Wezel, Tom, Krzykalla, Julia, Benner, Axel, de Miranda, Noel F., von Knebel Doeberitz, Magnus, Nielsen, Maartje, Kloor, Matthias

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PMS2-associated Lynch syndrome: Past, present and future by Andini, Katarina D, Nielsen, Maartje, Suerink, Manon, Helderman, Noah C, Koornstra, Jan Jacob, Ahadova, Aysel, Kloor, Matthias, Mourits, Marian J E, Kok, Klaas, Sijmons, Rolf H, Bajwa-Ten Broeke, Sanne W

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Declining detection rates for APC and biallelic MUTYH variants in polyposis patients, implications for DNA testing policy by Terlouw, Diantha, Suerink, Manon, Singh, Sunny S, Gille, Hans J J P, Hes, Frederik J, Langers, Alexandra M J, Morreau, Hans, Vasen, Hans F A, Vos, Yvonne J, van Wezel, Tom, Tops, Carli M, Ten Broeke, Sanne W, Nielsen, Maartje

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Constitutional mismatch repair deficiency in a healthy child: On the spot diagnosis? by Suerink, M., Potjer, T.P., Versluijs, A.B., ten Broeke, S.W., Tops, C.M., Wimmer, K., Nielsen, M.

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Breaking Traditions: An Isotopic Study on the Changing Funerary Practices in the Dutch Iron Age (800–12 bc) by Kootker, L. M., Geerdink, C., Broeke, P. W., Kars, H., Davies, G. R.

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The Apparent Genetic Anticipation in PMS2-Associated Lynch Syndrome Families Is Explained by Birth-cohort Effect by Ten Broeke, Sanne W, Rodríguez-Girondo, Mar, Suerink, Manon, Aretz, Stefan, Bernstein, Inge, Capellá, Gabriel, Engel, Christoph, Gomez-Garcia, Encarna B, van Hest, Liselot P, von Knebel Doeberitz, Magnus, Lagerstedt-Robinson, Kristina, Letteboer, Tom G W, Moller, Pal, van Os, Theo A, Pineda, Marta, Rahner, Nils, Olderode-Berends, Maran J W, von Salomé, Jenny, Schackert, Hans K, Spruijt, Liesbeth, Steinke-Lange, Verena, Wagner, Anja, Tops, Carli M J, Nielsen, Maartje

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Mutational Signature Analysis Reveals NTHL1 Deficiency to Cause a Multi-tumor Phenotype by Grolleman, Judith E., de Voer, Richarda M., Elsayed, Fadwa A., Nielsen, Maartje, Weren, Robbert D.A., Palles, Claire, Ligtenberg, Marjolijn J.L., Vos, Janet R., ten Broeke, Sanne W., de Miranda, Noel F.C.C., Kuiper, Renske A., Kamping, Eveline J., Jansen, Erik A.M., Vink-Börger, M. Elisa, Popp, Isabell, Lang, Alois, Spier, Isabel, Hüneburg, Robert, James, Paul A., Li, Na, Staninova, Marija, Lindsay, Helen, Cockburn, David, Spasic-Boskovic, Olivera, Clendenning, Mark, Sweet, Kevin, Capellá, Gabriel, Sjursen, Wenche, Høberg-Vetti, Hildegunn, Jongmans, Marjolijn C., Neveling, Kornelia, Geurts van Kessel, Ad, Morreau, Hans, Hes, Frederik J., Sijmons, Rolf H., Schackert, Hans K., Ruiz-Ponte, Clara, Dymerska, Dagmara, Lubinski, Jan, Rivera, Barbara, Foulkes, William D., Tomlinson, Ian P., Valle, Laura, Buchanan, Daniel. D., Kenwrick, Sue, Adlard, Julian, Dimovski, Aleksandar J., Campbell, Ian G., Aretz, Stefan, Schindler, Detlev, van Wezel, Tom, Hoogerbrugge, Nicoline, Kuiper, Roland P.

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Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database by Dominguez-Valentin, Mev, Sampson, Julian R, Seppälä, Toni T, ten Broeke, Sanne W, Plazzer, John-Paul, Nakken, Sigve, Engel, Christoph, Aretz, Stefan, Jenkins, Mark A, Sunde, Lone, Bernstein, Inge, Capella, Gabriel, Balaguer, Francesc, Thomas, Huw, Evans, D. Gareth, Burn, John, Greenblatt, Marc, Hovig, Eivind, de Vos tot Nederveen Cappel, Wouter H, Sijmons, Rolf H, Bertario, Lucio, Tibiletti, Maria Grazia, Cavestro, Giulia Martina, Lindblom, Annika, Della Valle, Adriana, López-Köstner, Francisco, Gluck, Nathan, Katz, Lior H, Heinimann, Karl, Vaccaro, Carlos A, Büttner, Reinhard, Görgens, Heike, Holinski-Feder, Elke, Morak, Monika, Holzapfel, Stefanie, Hüneburg, Robert, von Knebel Doeberitz, Magnus, Loeffler, Markus, Rahner, Nils, Schackert, Hans K, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Hopper, John L, Win, Aung Ko, Haile, Robert W, Lindor, Noralane M, Gallinger, Steven, Le Marchand, Loïc, Newcomb, Polly A, Figueiredo, Jane C, Thibodeau, Stephen N, Wadt, Karin, Therkildsen, Christina, Okkels, Henrik, Ketabi, Zohreh, Moreira, Leticia, Sánchez, Ariadna, Serra-Burriel, Miquel, Pineda, Marta, Navarro, Matilde, Blanco, Ignacio, Green, Kate, Lalloo, Fiona, Crosbie, Emma J, Hill, James, Denton, Oliver G, Frayling, Ian M, Rødland, Einar Andreas, Vasen, Hans, Mints, Miriam, Neffa, Florencia, Esperon, Patricia, Alvarez, Karin, Kariv, Revital, Rosner, Guy, Pinero, Tamara Alejandra, Gonzalez, Maria Laura, Kalfayan, Pablo, Tjandra, Douglas, Winship, Ingrid M, Macrae, Finlay, Möslein, Gabriela, Mecklin, Jukka-Pekka, Nielsen, Maartje, Møller, Pål

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A Dutch MYH7 founder mutation, p.(Asn1918Lys), is associated with early onset cardiomyopathy and congenital heart defects by van der Linde, I. H. M., Hiemstra, Y. L., Bökenkamp, R., van Mil, A. M., Breuning, M. H., Ruivenkamp, C., ten Broeke, S. W., Veldkamp, R. F., van Waning, J. I., van Slegtenhorst, M. A., van Spaendonck-Zwarts, K. Y., Lekanne Deprez, R. H., Herkert, J. C., Boven, L., van der Zwaag, P. A., Jongbloed, J. D. H., Bootsma, M., Barge-Schaapveld, D. Q. C. M.

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Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders by Stolz, Jacob R., Foote, Kendall M., Veenstra-Knol, Hermine E., Pfundt, Rolph, ten Broeke, Sanne W., de Leeuw, Nicole, Roht, Laura, Pajusalu, Sander, Part, Reelika, Rebane, Ionella, Õunap, Katrin, Stark, Zornitza, Kirk, Edwin P., Lawson, John A., Lunke, Sebastian, Christodoulou, John, Louie, Raymond J., Rogers, R. Curtis, Davis, Jessica M., Innes, A. Micheil, Wei, Xing-Chang, Keren, Boris, Mignot, Cyril, Lebel, Robert Roger, Sperber, Steven M., Sakonju, Ai, Dosa, Nienke, Barge-Schaapveld, Daniela Q.C.M., Peeters-Scholte, Cacha M.P.C.D., Ruivenkamp, Claudia A.L., van Bon, Bregje W., Kennedy, Joanna, Low, Karen J., Ellard, Sian, Pang, Lewis, Junewick, Joseph J., Mark, Paul R., Carvill, Gemma L., Swanson, Geoffrey T.

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Evaluation of current prediction models for Lynch syndrome: updating the PREMM5 model to identify PMS2 mutation carriers by Goverde, A., Spaander, M. C. W., Nieboer, D., van den Ouweland, A. M. W., Dinjens, W. N. M., Dubbink, H. J., Tops, C. J., ten Broeke, S. W., Bruno, M. J., Hofstra, R. M. W., Steyerberg, E. W., Wagner, A.

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Survival by colon cancer stage and screening interval in Lynch syndrome: a prospective Lynch syndrome database report by Dominguez-Valentin, Mev, Seppälä, Toni T, Sampson, Julian R, Macrae, Finlay, Winship, Ingrid, Evans, D Gareth, Scott, Rodney J, Burn, John, Möslein, Gabriela, Bernstein, Inge, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Lepistö, Anna, Lindblom, Annika, Plazzer, John-Paul, Tjandra, Douglas, Thomas, Huw, Green, Kate, Lalloo, Fiona, Crosbie, Emma J, Hill, James, Capella, Gabriel, Pineda, Marta, Navarro, Matilde, Vidal, Joan Brunet, Rønlund, Karina, Nielsen, Randi Thyregaard, Yilmaz, Mette, Elvang, Louise Laurberg, Katz, Lior, Nielsen, Maartje, Ten Broeke, Sanne W, Nakken, Sigve, Hovig, Eivind, Sunde, Lone, Kloor, Matthias, Knebel Doeberitz, Magnus V, Ahadova, Aysel, Lindor, Noralane, Steinke-Lange, Verena, Holinski-Feder, Elke, Mecklin, Jukka-Pekka, Møller, Pål

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No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2 : A Prospective Lynch Syndrome Database Study by Dominguez-Valentin, Mev, Plazzer, John-Paul, Sampson, Julian R, Engel, Christoph, Aretz, Stefan, Jenkins, Mark A, Sunde, Lone, Bernstein, Inge, Capella, Gabriel, Balaguer, Francesc, Macrae, Finlay, Winship, Ingrid M, Thomas, Huw, Evans, Dafydd Gareth, Burn, John, Greenblatt, Marc, de Vos Tot Nederveen Cappel, Wouter H, Sijmons, Rolf H, Nielsen, Maartje, Bertario, Lucio, Bonanni, Bernardo, Tibiletti, Maria Grazia, Cavestro, Giulia Martina, Lindblom, Annika, Valle, Adriana Della, Lopez-Kostner, Francisco, Alvarez, Karin, Gluck, Nathan, Katz, Lior, Heinimann, Karl, Vaccaro, Carlos A, Nakken, Sigve, Hovig, Eivind, Green, Kate, Lalloo, Fiona, Hill, James, Vasen, Hans F A, Perne, Claudia, Büttner, Reinhard, Görgens, Heike, Holinski-Feder, Elke, Morak, Monika, Holzapfel, Stefanie, Hüneburg, Robert, von Knebel Doeberitz, Magnus, Loeffler, Markus, Rahner, Nils, Weitz, Jürgen, Steinke-Lange, Verena, Schmiegel, Wolff, Vangala, Deepak, Crosbie, Emma J, Pineda, Marta, Navarro, Matilde, Brunet, Joan, Moreira, Leticia, Sánchez, Ariadna, Serra-Burriel, Miquel, Mints, Miriam, Kariv, Revital, Rosner, Guy, Piñero, Tamara Alejandra, Pavicic, Walter Hernán, Kalfayan, Pablo, Broeke, Sanne W Ten, Mecklin, Jukka-Pekka, Pylvänäinen, Kirsi, Renkonen-Sinisalo, Laura, Lepistö, Anna, Peltomäki, Päivi, Hopper, John L, Win, Aung Ko, Buchanan, Daniel D, Lindor, Noralane M, Gallinger, Steven, Marchand, Loïc Le, Newcomb, Polly A, Figueiredo, Jane C, Thibodeau, Stephen N, Therkildsen, Christina, Hansen, Thomas V O, Lindberg, Lars, Rødland, Einar Andreas, Neffa, Florencia, Esperon, Patricia, Tjandra, Douglas, Möslein, Gabriela, Seppälä, Toni T, Møller, Pål

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SNP association study in PMS2-associated Lynch syndrome by ten Broeke, Sanne W., Elsayed, Fadwa A., Pagan, Lisa, Olderode-Berends, Maran J. W., Garcia, Encarna Gomez, Gille, Hans J. P., van Hest, Liselot P., Letteboer, Tom G. W., van der Kolk, Lizet E., Mensenkamp, Arjen R., van Os, Theo A., Spruijt, Liesbeth, Redeker, Bert J. W., Suerink, Manon, Vos, Yvonne J., Wagner, Anja, Wijnen, Juul T., Steyerberg, E. W., Tops, Carli M. J., van Wezel, Tom, Nielsen, Maartje

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Dominantly inherited micro-satellite instable cancer - the four Lynch syndromes - an EHTG, PLSD position statement by Møller, Pal, Seppälä, Toni T, Ahadova, Aysel, Crosbie, Emma J, Holinski-Feder, Elke, Scott, Rodney, Haupt, Saskia, Möslein, Gabriela, Winship, Ingrid, Broeke, Sanne W Bajwa-Ten, Kohut, Kelly E, Ryan, Neil, Bauerfeind, Peter, Thomas, Laura E, Evans, D Gareth, Aretz, Stefan, Sijmons, Rolf H, Half, Elizabeth, Heinimann, Karl, Horisberger, Karoline, Monahan, Kevin, Engel, Christoph, Cavestro, Giulia Martina, Fruscio, Robert, Abu-Freha, Naim, Zohar, Levi, Laghi, Luigi, Bertario, Lucio, Bonanni, Bernardo, Tibiletti, Maria Grazia, Lino-Silva, Leonardo S, Vaccaro, Carlos, Valle, Adriana Della, Rossi, Benedito Mauro, da Silva, Leandro Apolinário, de Oliveira Nascimento, Ivana Lucia, Rossi, Norma Teresa, Dębniak, Tadeusz, Mecklin, Jukka-Pekka, Bernstein, Inge, Lindblom, Annika, Sunde, Lone, Nakken, Sigve, Heuveline, Vincent, Burn, John, Hovig, Eivind, Kloor, Matthias, Sampson, Julian R, Dominguez-Valentin, Mev

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Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study by Dowty, James G., Lee, Grant, Templeton, Allyson S., Alvarez, Karin, Ankathil, Ravindran, Austin, Rachel, Barca-Tierno, Verónica, Berthet, Pascaline, Boisjoli, Talya, Briollais, Laurent, Brunet, Joan, Bucksch, Karolin, Buettner, Reinhard, Burn, John, Caldés, Trinidad, Casey, Graham, Chew, Min H., Choi, Yun-hee, Church, James, Clendenning, Mark, Colas, Chrystelle, Coupier, Isabelle, de la Chapelle, Albert, Dębniak, Tadeusz, Della Valle, Adriana, Dominguez-Valentin, Mev, Engel, Christoph, Esperon, Patricia, Foulkes, William, Frebourg, Thierry, Gallinger, Steven, Garre, Pilar, Genuardi, Maurizio, Giraud, Sophie, Goodwin, Annabel, Green, Kate, Guindalini, Rodrigo S.C., Half, Elizabeth E., Hampel, Heather, Ho, Judy W.C., Hoogerbrugge, Nicoline, Hüneburg, Robert, Huntley, Vanessa, Jensen, Uffe B, Juhari, Wan K.W., Kloor, Matthias, Kupfer, Sonia S., Lagerstedt-Robinson, Kristina, Lalloo, Fiona, Lautrup, Charlotte K., Leggett, Barbara A., Lejeune, Sophie, Lindor, Noralane, Loeffler, Markus, Lucassen, Anneke M, Lynch, Patrick M., Møller, Pål, Navarro, Matilde, Neffa, Florencia, Neklason, Deborah, Nixon, Dawn M., Palmero, Edenir I., Pande, Mala, Parry, Susan, Pineda, Marta, Qiu, Jay, Ramesar, Raj, Rasmussen, Lene J., Redler, Silke, Ricciardiello, Luigi, Schulmann, Karsten, Schuster, Helène, Senter, Leigha, Seppälä, Toni T, Shtoyerman, Rakefet, Sijmons, Rolf H., Soto, Jose Luis, Spigelman, Allan, Steinke-Lange, Verena, Stoffel, Elena M., Strassburg, Christian P., Sunde, Lone, Therkildsen, Christina, Thibodeau, Steve, Tucker, Katherine M., Tunca, Berrin, Uhrhammer, Nancy, Vaccaro, Carlos, van Duijnhoven, Fränzel J.B., van Wanzeele, Meghan J., Vasen, Hans F.A., von Knebel Doeberitz, Magnus, von Salomé, Jenny, Ward, Robyn L., Wise, Paul E., Yamaguchi, Tatsuro, Zahary, Mohd N., Hopper, John L., Haile, Robert W., Jenkins, Mark A.

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Clustered mutations in the GRIK2 kainate receptor subunit gene underlie diverse neurodevelopmental disorders by Stolz, Jacob R., Foote, Kendall M., Veenstra-Knol, Hermine E., Pfundt, Rolph, ten Broeke, Sanne W., de Leeuw, Nicole, Roht, Laura, Pajusalu, Sander, Part, Reelika, Rebane, Ionella, Õunap, Katrin, Stark, Zornitza, Kirk, Edwin P., Lawson, John A., Lunke, Sebastian, Christodoulou, John, Louie, Raymond J., Rogers, R. Curtis, Davis, Jessica M., Innes, A. Micheil, Wei, Xing-Chang, Keren, Boris, Mignot, Cyril, Lebel, Robert Roger, Sperber, Steven M., Sakonju, Ai, Dosa, Nienke, Barge-Schaapveld, Daniela Q.C.M., Peeters-Scholte, Cacha M.P.C.D., Ruivenkamp, Claudia A.L., van Bon, Bregje W., Kennedy, Joanna, Low, Karen J., Ellard, Sian, Pang, Lewis, Junewick, Joseph J., Mark, Paul R., Carvill, Gemma L., Swanson, Geoffrey T.

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