Challenges relating to solid tumour brain metastases in clinical trials, part 1: patient population, response, and progression. A report from the RANO group by Lin, Nancy U, Dr, Lee, Eudocia Q, MD, Aoyama, Hidefumi, Prof, Barani, Igor J, MD, Baumert, Brigitta G, Prof, Brown, Paul D, Prof, Camidge, D Ross, MD, Chang, Susan M, Prof, Dancey, Janet, Prof, Gaspar, Laurie E, Prof, Harris, Gordon J, Prof, Hodi, F Stephen, MD, Kalkanis, Steven N, MD, Lamborn, Kathleen R, Prof, Linskey, Mark E, Prof, Macdonald, David R, MD, Margolin, Kim, Prof, Mehta, Minesh P, MD, Schiff, David, Prof, Soffietti, Riccardo, Prof, Suh, John H, Prof, van den Bent, Martin J, Prof, Vogelbaum, Michael A, Prof, Wefel, Jeffrey S, PhD, Wen, Patrick Y, Prof

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Challenges relating to solid tumour brain metastases in clinical trials, part 2: neurocognitive, neurological, and quality-of-life outcomes. A report from the RANO group by Lin, Nancy U, Dr, Wefel, Jeffrey S, PhD, Lee, Eudocia Q, MD, Schiff, David, Prof, van den Bent, Martin J, Prof, Soffietti, Riccardo, Prof, Suh, John H, Prof, Vogelbaum, Michael A, Prof, Mehta, Minesh P, MD, Dancey, Janet, Prof, Linskey, Mark E, Prof, Camidge, D Ross, MD, Aoyama, Hidefumi, Prof, Brown, Paul D, Prof, Chang, Susan M, Prof, Kalkanis, Steven N, MD, Barani, Igor J, MD, Baumert, Brigitta G, Prof, Gaspar, Laurie E, Prof, Hodi, F Stephen, MD, Macdonald, David R, MD, Wen, Patrick Y, Prof

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Stereotactic body radiation therapy for management of spinal metastases in patients without spinal cord compression: a phase 1–2 trial by Wang, Xin Shelley, Dr, Rhines, Laurence D, Prof, Shiu, Almon S, Prof, Yang, James N, PhD, Selek, Ugur, MD, Gning, Ibrahima, PhD, Liu, Ping, MS, Allen, Pamela K, PhD, Azeem, Syed S, MD, Brown, Paul D, Prof, Sharp, Hadley J, MD, Weksberg, David C, MD, Cleeland, Charles S, Prof, Chang, Eric L, Prof

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Response assessment criteria for brain metastases: proposal from the RANO group by Lin, Nancy U, Dr, Lee, Eudocia Q, MD, Aoyama, Hidefumi, Prof, Barani, Igor J, MD, Barboriak, Daniel P, Prof, Baumert, Brigitta G, MD, Bendszus, Martin, Prof, Brown, Paul D, Prof, Camidge, D Ross, MD, Chang, Susan M, Prof, Dancey, Janet, Prof, de Vries, Elisabeth G E, Prof, Gaspar, Laurie E, Prof, Harris, Gordon J, Prof, Hodi, F Stephen, MD, Kalkanis, Steven N, MD, Linskey, Mark E, Prof, Macdonald, David R, MD, Margolin, Kim, Prof, Mehta, Minesh P, Prof, Schiff, David, Prof, Soffietti, Riccardo, Prof, Suh, John H, Prof, van den Bent, Martin J, Prof, Vogelbaum, Michael A, Prof, Wen, Patrick Y, Prof

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Abiraterone acetate plus prednisone versus placebo plus prednisone in chemotherapy-naive men with metastatic castration-resistant prostate cancer (COU-AA-302): final overall surviv... by Ryan, Charles J, Prof, Smith, Matthew R, Prof, Fizazi, Karim, Prof, Saad, Fred, Prof, Mulders, Peter F A, Prof, Sternberg, Cora N, MD, Miller, Kurt, Prof, Logothetis, Christopher J, Prof, Shore, Neal D, MD, Small, Eric J, Prof, Carles, Joan, MD, Flaig, Thomas W, MD, Taplin, Mary-Ellen, MD, Higano, Celestia S, Prof, de Souza, Paul, Prof, de Bono, Johann S, Prof, Griffin, Thomas W, MD, De Porre, Peter, MD, Yu, Margaret K, MD, Park, Youn C, PhD, Li, Jinhui, PhD, Kheoh, Thian, PhD, Naini, Vahid, PharmD, Molina, Arturo, MD, Rathkopf, Dana E, MD

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Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international,... by Marina, Neyssa M, Prof, Smeland, Sigbjørn, Prof, Bielack, Stefan S, Prof, Bernstein, Mark, Prof, Jovic, Gordana, PhD, Krailo, Mark D, PhD, Hook, Jane M, MRCP, Arndt, Carola, Prof, van den Berg, Henk, MD, Brennan, Bernadette, MD, Brichard, Bénédicte, Prof, Brown, Ken L B, MD, Butterfass-Bahloul, Trude, MD, Calaminus, Gabriele, MD, Daldrup-Link, Heike E, MD, Eriksson, Mikael, MD, Gebhardt, Mark C, MD, Gelderblom, Hans, Prof, Gerss, Joachim, PhD, Goldsby, Robert, MD, Goorin, Allen, MD, Gorlick, Richard, Prof, Grier, Holcombe E, Prof, Hale, Juliet P, MD, Hall, Kirsten Sundby, MD, Hardes, Jendrik, Prof, Hawkins, Douglas S, MD, Helmke, Knut, Prof, Hogendoorn, Pancras C W, Prof, Isakoff, Michael S, MD, Janeway, Katherine A, MD, Jürgens, Heribert, Prof, Kager, Leo, MD, Kühne, Thomas, Prof, Lau, Ching C, MD, Leavey, Patrick J, Prof, Lessnick, Stephen L, Prof, Mascarenhas, Leo, MD, Meyers, Paul A, Prof, Mottl, Hubert, MD, Nathrath, Michaela, Prof, Papai, Zsuzsanna, Prof, Randall, R Lor, Prof, Reichardt, Peter, MD, Renard, Marleen, MD, Safwat, Akmal Ahmed, PhD, Schwartz, Cindy L, Prof, Stevens, Michael C G, Prof, Strauss, Sandra J, PhD, Teot, Lisa, MD, Werner, Mathias, MD, Sydes, Matthew R, MSc, Whelan, Jeremy S, Prof

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Adjuvant bevacizumab-containing therapy in triple-negative breast cancer (BEATRICE): primary results of a randomised, phase 3 trial by Cameron, David, Prof, Brown, Julia, Prof, Dent, Rebecca, MD, Jackisch, Christian, MD, Mackey, John, Prof, Pivot, Xavier, MD, Steger, Guenther G, Prof, Suter, Thomas M, Prof, Toi, Masakazu, Prof, Parmar, Mahesh, DPhil, Laeufle, Rita, MD, Im, Young-Hyuck, MD, Romieu, Gilles, MD, Harvey, Vernon, MD, Lipatov, Oleg, MD, Pienkowski, Tadeusz, MD, Cottu, Paul, MD, Chan, Arlene, Prof, Im, Seock-Ah, Prof, Hall, Peter S, PhD, Bubuteishvili-Pacaud, Lida, MD, Henschel, Volkmar, PhD, Deurloo, Regula J, PhD, Pallaud, Celine, PhD, Bell, Richard, Prof

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Crohn's disease management after intestinal resection: a randomised trial by De Cruz, Peter, PhD, Kamm, Michael A, Prof, Hamilton, Amy L, BSc, Ritchie, Kathryn J, RN, Krejany, Efrosinia O, MSc, Gorelik, Alexandra, MSc, Liew, Danny, Prof, Prideaux, Lani, PhD, Lawrance, Ian C, Prof, Andrews, Jane M, Prof, Bampton, Peter A, MD, Gibson, Peter R, Prof, Sparrow, Miles, MBBS, Leong, Rupert W, Prof, Florin, Timothy H, Prof, Gearry, Richard B, PhD, Radford-Smith, Graham, PhD, Macrae, Finlay A, Prof, Debinski, Henry, MD, Selby, Warwick, MD, Kronborg, Ian, MBBS, Johnston, Michael J, MBBS, Woods, Rodney, MBBS, Elliott, P Ross, MD, Bell, Sally J, MD, Brown, Steven J, PhD, Connell, William R, MD, Desmond, Paul V, MBBS

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Long-term outcomes after stenting versus endarterectomy for treatment of symptomatic carotid stenosis: the International Carotid Stenting Study (ICSS) randomised trial by Bonati, Leo H, MD, Dobson, Joanna, MSc, Featherstone, Roland L, PhD, Ederle, Jörg, PhD, van der Worp, H Bart, PhD, de Borst, Gert J, PhD, Mali, Willem P Th M, Prof, Beard, Jonathan D, ChM, Cleveland, Trevor, FRCR, Engelter, Stefan T, MD, Lyrer, Philippe A, MD, Ford, Gary A, Prof, Dorman, Paul J, FRCP, Brown, Martin M, Prof

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Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study by Kuppermann, Nathan, Prof, Holmes, James F, Prof, Dayan, Peter S, MD, Hoyle, John D, MD, Atabaki, Shireen M, MD, Holubkov, Richard, PhD, Nadel, Frances M, MD, Monroe, David, MD, Stanley, Rachel M, MD, Borgialli, Dominic A, DO, Badawy, Mohamed K, MD, Schunk, Jeff E, Prof, Quayle, Kimberly S, MD, Mahajan, Prashant, MD, Lichenstein, Richard, MD, Lillis, Kathleen A, MD, Tunik, Michael G, MD, Jacobs, Elizabeth S, MD, Callahan, James M, MD, Gorelick, Marc H, Prof, Glass, Todd F, MD, Lee, Lois K, MD, Bachman, Michael C, MD, Cooper, Arthur, Prof, Powell, Elizabeth C, MD, Gerardi, Michael J, MD, Melville, Kraig A, MD, Muizelaar, J Paul, Prof, Wisner, David H, Prof, Zuspan, Sally Jo, RN, Dean, J Michael, Prof, Wootton-Gorges, Sandra L, Prof

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Tenofovir alafenamide versus tenofovir disoproxil fumarate, coformulated with elvitegravir, cobicistat, and emtricitabine, for initial treatment of HIV-1 infection: two randomised,... by Sax, Paul E, Dr Prof, Wohl, David, MD, Yin, Michael T, Prof, Post, Frank, MD, DeJesus, Edwin, MD, Saag, Michael, MD, Pozniak, Anton, MD, Thompson, Melanie, MD, Podzamczer, Daniel, MD, Molina, Jean Michel, Prof, Oka, Shinichi, MD, Koenig, Ellen, MD, Trottier, Benoit, MD, Andrade-Villanueva, Jaime, MD, Crofoot, Gordon, MD, Custodio, Joseph M, PharmD, Plummer, Andrew, MS, Zhong, Lijie, PhD, Cao, Huyen, MD, Martin, Hal, MD, Callebaut, Christian, PhD, Cheng, Andrew K, MD, Fordyce, Marshall W, MD, McCallister, Scott, MD

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Abiraterone acetate for treatment of metastatic castration-resistant prostate cancer: final overall survival analysis of the COU-AA-301 randomised, double-blind, placebo-controlled... by Fizazi, Karim, Prof Dr, Scher, Howard I, Prof, Molina, Arturo, MD, Logothetis, Christopher J, Prof, Chi, Kim N, MD, Jones, Robert J, PhD, Staffurth, John N, MD, North, Scott, MD, Vogelzang, Nicholas J, MD, Saad, Fred, Prof, Mainwaring, Paul, MD, Harland, Stephen, MD, Goodman, Oscar B, MD, Sternberg, Cora N, MD, Li, Jin Hui, PhD, Kheoh, Thian, PhD, Haqq, Christopher M, MD, de Bono, Johann S, Prof

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Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT... by Kwo, Paul Y, Dr, Lawitz, Eric J, MD, McCone, Jonathan, MD, Schiff, Eugene R, Prof, Vierling, John M, Prof, Pound, David, MD, Davis, Mitchell N, DO, Galati, Joseph S, MD, Gordon, Stuart C, MD, Ravendhran, Natarajan, MD, Rossaro, Lorenzo, Prof, Anderson, Frank H, MD, Jacobson, Ira M, Prof, Rubin, Raymond, MD, Koury, Kenneth, PhD, Pedicone, Lisa D, PhD, Brass, Clifford A, MD, Chaudhri, Eirum, MD, Albrecht, Janice K, PhD

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Metabolic syndrome and salt sensitivity of blood pressure in non-diabetic people in China: a dietary intervention study by Chen, Jing, Dr, Gu, Dongfeng, Prof, Huang, Jianfeng, MD, Rao, Dabeeru C, Prof, Jaquish, Cashell E, PhD, Hixson, James E, Prof, Chen, Chung-Shiuan, MS, Chen, Jichun, MD, Lu, Fanghong, Prof, Hu, Dongsheng, Prof, Rice, Treva, PhD, Kelly, Tanika N, PhD, Hamm, L Lee, Prof, Whelton, Paul K, Prof, He, Jiang, Prof

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Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3, randomised controlled trial by Adelson, P David, Prof, Wisniewski, Stephen R, Prof, Beca, John, MD, Brown, S Danielle, MS, Bell, Michael, MD, Muizelaar, J Paul, Prof, Okada, Pamela, MD, Beers, Sue R, PhD, Balasubramani, Goundappa K, PhD, Hirtz, Deborah, MD

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Identification of IL6R and chromosome 11q13.5 as risk loci for asthma by Ferreira, Manuel AR, Dr, Matheson, Melanie C, PhD, Duffy, David L, PhD, Marks, Guy B, Prof, Hui, Jennie, PhD, Le Souëf, Peter, Prof, Danoy, Patrick, PhD, Baltic, Svetlana, PhD, Nyholt, Dale R, PhD, Jenkins, Mark, PhD, Hayden, Catherine, PhD, Willemsen, Gonneke, PhD, Ang, Wei, MSc, Kuokkanen, Mikko, PhD, Beilby, John, PhD, Cheah, Faang, BSc, de Geus, Eco JC, PhD, Ramasamy, Adaikalavan, DPhil, Vedantam, Sailaja, PhD, Salomaa, Veikko, PhD, Madden, Pamela A, PhD, Heath, Andrew C, Prof, Hopper, John L, Prof, Visscher, Peter M, PhD, Musk, Bill, Prof, Leeder, Stephen R, Prof, Jarvelin, Marjo-Riitta, Prof, Pennell, Craig, PhD, Boomsma, Dorret I, Prof, Hirschhorn, Joel N, Prof, Walters, Haydn, Prof, Martin, Nicholas G, Prof, James, Alan, FRACP, Jones, Graham, PhD, Abramson, Michael J, Prof, Robertson, Colin F, FRACP, Dharmage, Shyamali C, PhD, Brown, Matthew A, Prof, Montgomery, Grant W, PhD, Thompson, Philip J, Prof

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Adenoma surveillance and colorectal cancer incidence: a retrospective, multicentre, cohort study by Atkin, Wendy, Prof, Wooldrage, Kate, MSc, Brenner, Amy, MSc, Martin, Jessica, MSc, Shah, Urvi, MSc, Perera, Sajith, MSc, Lucas, Fiona, PhD, Brown, Jeremy P, MSc, Kralj-Hans, Ines, PhD, Greliak, Paul, BA, Pack, Kevin, BSc, Wood, Jill, MPH, Thomson, Ann, MSc, Veitch, Andrew, MD, Duffy, Stephen W, Prof, Cross, Amanda J, PhD

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Celecoxib plus hormone therapy versus hormone therapy alone for hormone-sensitive prostate cancer: first results from the STAMPEDE multiarm, multistage, randomised controlled trial by James, Nicholas D, Prof, Sydes, Matthew R, CSci, Mason, Malcolm D, Prof, Clarke, Noel W, Prof, Anderson, John, MD, Dearnaley, David P, Prof, Dwyer, John, FRIC, Jovic, Gordana, PhD, Ritchie, Alastair WS, FRCSEd, Russell, J Martin, FRCR, Sanders, Karen, BSc, Thalmann, George N, Prof, Bertelli, Gianfilippo, MD, Birtle, Alison J, FRCR, O'Sullivan, Joe M, Prof, Protheroe, Andrew, PhD, Sheehan, Denise, FRCR, Srihari, Narayanan, FRCR, Parmar, Mahesh KB, Prof

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Intercontinental dissemination of azithromycin-resistant shigellosis through sexual transmission: a cross-sectional study by Baker, Kate S, PhD, Dallman, Timothy J, PhD, Ashton, Philip M, PhD, Day, Martin, BSc, Hughes, Gwenda, PhD, Crook, Paul D, MSc, Gilbart, Victoria L, MSc, Zittermann, Sandra, PhD, Allen, Vanessa G, MD, Howden, Benjamin P, Prof, Tomita, Takehiro, PhD, Valcanis, Mary, MPH, Harris, Simon R, PhD, Connor, Thomas R, PhD, Sintchenko, Vitali, PhD, Howard, Peter, BSc, Brown, Jeremy D, MBBS, Petty, Nicola K, PhD, Gouali, Malika, PharmD, Thanh, Duy Pham, MSc, Keddy, Karen H, BSc (Med), Smith, Anthony M, PhD, Talukder, Kaisar A, PhD, Faruque, Shah M, PhD, Parkhill, Julian, Prof, Baker, Stephen, Prof, Weill, François-Xavier, PhD, Jenkins, Claire, PhD, Thomson, Nicholas R, Prof

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Simvastatin in aneurysmal subarachnoid haemorrhage (STASH): a multicentre randomised phase 3 trial by Kirkpatrick, Peter J, FMedSci, Turner, Carole L, MSc, Smith, Christopher, PhD, Hutchinson, Peter J, Prof, Murray, Gordon D, Prof

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