Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors by Foster, Jessica B, Griffin, Crystal, Rokita, Jo Lynne, Stern, Allison, Brimley, Cameron, Rathi, Komal, Lane, Maria V, Buongervino, Samantha N, Smith, Tiffany, Madsen, Peter J, Martinez, Daniel, Delaidelli, Alberto, Sorensen, Poul H, Wechsler-Reya, Robert J, Karikó, Katalin, Storm, Phillip B, Barrett, David M, Resnick, Adam C, Maris, John M, Bosse, Kristopher R

Get full text

Serial Profiling of Circulating Tumor DNA Identifies Dynamic Evolution of Clinically Actionable Genomic Alterations in High-Risk Neuroblastoma by Bosse, Kristopher R, Giudice, Anna Maria, Lane, Maria V, McIntyre, Brendan, Schürch, Patrick M, Pascual-Pasto, Guillem, Buongervino, Samantha N, Suresh, Sriyaa, Fitzsimmons, Alana, Hyman, Adam, Gemino-Borromeo, Maria, Saggio, Jennifer, Berko, Esther R, Daniels, Alexander A, Stundon, Jennifer, Friedrichsen, Megan, Liu, Xin, Margolis, Matthew L, Li, Marilyn M, Tierno, Marni Brisson, Oxnard, Geoffrey R, Maris, John M, Mossé, Yael P

Get full text

GPC2 antibody–drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies by Pascual-Pasto, Guillem, McIntyre, Brendan, Shraim, Rawan, Buongervino, Samantha N, Erbe, Amy K, Zhelev, Doncho V, Sadirova, Shakhnozakhon, Giudice, Anna M, Martinez, Daniel, Garcia-Gerique, Laura, Dimitrov, Dimiter S, Sondel, Paul M, Bosse, Kristopher R

Get full text

A GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope by Raman, Swetha, Buongervino, Samantha N, Lane, Maria V, Zhelev, Doncho V, Zhu, Zhongyu, Cui, Hong, Martinez, Benjamin, Martinez, Daniel, Wang, Yanping, Upton, Kristen, Patel, Khushbu, Rathi, Komal S, Navia, Carmen T, Harmon, Daniel B, Li, Yimei, Pawel, Bruce, Dimitrov, Dimiter S, Maris, John M, Julien, Jean-Philippe, Bosse, Kristopher R

Get full text

GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity by Heitzeneder, Sabine, Bosse, Kristopher R., Zhu, Zhongyu, Zhelev, Doncho, Majzner, Robbie G., Radosevich, Molly T., Dhingra, Shaurya, Sotillo, Elena, Buongervino, Samantha, Pascual-Pasto, Guillem, Garrigan, Emily, Xu, Peng, Huang, Jing, Salzer, Benjamin, Delaidelli, Alberto, Raman, Swetha, Cui, Hong, Martinez, Benjamin, Bornheimer, Scott J., Sahaf, Bita, Alag, Anya, Fetahu, Irfete S., Hasselblatt, Martin, Parker, Kevin R., Anbunathan, Hima, Hwang, Jennifer, Huang, Min, Sakamoto, Kathleen, Lacayo, Norman J., Klysz, Dorota D., Theruvath, Johanna, Vilches-Moure, José G., Satpathy, Ansuman T., Chang, Howard Y., Lehner, Manfred, Taschner-Mandl, Sabine, Julien, Jean-Phillipe, Sorensen, Poul H., Dimitrov, Dimiter S., Maris, John M., Mackall, Crystal L.

Get full text

Antibody-Drug Conjugate Efficacy in Neuroblastoma: Role of Payload, Resistance Mechanisms, Target Density, and Antibody Internalization by Buongervino, Samantha, Lane, Maria V, Garrigan, Emily, Zhelev, Doncho V, Dimitrov, Dimiter S, Bosse, Kristopher R

Get full text

IMMU-16. TARGETING GLYPICAN 2 (GPC2) ON PEDIATRIC MALIGNANT BRAIN TUMORS WITH MRNA CAR T CELLS by Foster, Jessica, Griffin, Crystal, Stern, Allison, Brimley, Cameron, Buongervino, Samantha, Storm, Phillip, Barrett, David, Maris, John, Resnick, Adam, Bosse, Kristopher

Get full text

Abstract A26: Characterization and development of a GPC2 ADC for neuroblastoma and other cancers by Bosse, Kristopher R., Raman, Swetha, Buongervino, Samantha, Lane, Maria, Upton, Kristen, Cui, Hong, Martinez, Benjamin, Martinez, Daniel, Zhelev, Doncho V., Pawel, Bruce, Dimitrov, Dimiter S., Julien, Jean-Philippe, Maris, John M.

Get full text

Abstract 1548: Potent activity of CAR T cells targeting the oncofetal protein GPC2 engineered to recognize low antigen density in neuroblastoma by Heitzeneder, Sabine, Bosse, Kristopher R., Zhu, Zhongyu, Jelev, Dontcho, Dhingra, Shaurya, Majzner, Robbie, Sotillo-Pineiro, Elena, Buongervino, Samantha, Xu, Peng, Huang, Jing, Delaidelli, Alberto, Hasselblatt, Martin, Parker, Kevin, Anbunathan, Hima, Alag, Anya, Hwang, Jennifer, Huang, Min, Klysz, Dorota D., Theruvath, Johanna L., Vilches-Moure, Jose G., Satpathy, Ansuman T., Sorensen, Poul H., Dimitrov, Dimiter S., Maris, John M., Mackall, Crystal L.

Get full text

IMMU-04. DEVELOPMENT OF GPC2-DIRECTED CHIMERIC ANTIGEN RECEPTOR THERAPY FOR PEDIATRIC BRAIN TUMORS WITH IN VITRO TRANSCRIBED mRNA by Foster, Jessica B, Griffin, Crystal, Stern, Allison, Brimley, Cameron, Lane, Maria, Buongervino, Samantha, Dimitrov, Dimiter S, Barrett, David M, Resnick, Adam C, Maris, John M, Bosse, Kristopher R

Get full text

Abstract 3105: Serial profiling of ctDNA identifies clinically actionable genomic evolution in high-risk neuroblastoma by Bosse, Kristopher R., Buongervino, Samantha, Lane, Maria, Hyman, Adam, Gemino-borromeo, Maria, Saggio, Jennifer, Fitzsimmons, Alana, Forcier, Brady, Murphy, Anne, Wick, John, Cooke, Matthew, Webster, Jennifer, Madison, Russell, Welsh, Alley, Miller, Vincent A., Ali, Siraj M., Maris, John M., Mosse, Yael P.

Get full text

1189 A GPC2 antibody-drug conjugate reprograms the neuroblastoma immune milieu to enhance macrophage-driven therapies by Pascual-Pasto, Guillem, McIntyre, Brendan, Shraim, Rawan, Buongervino, Samantha, Erbe, Amy, Jelev, Dontcho, Giudice, Anna, Martinez, Daniel, Garcia-Gerique, Laura, Dimitrov, Dimiter, Sondel, Paul, Bosse, Kristopher

Get full text