Diagnosis and management of acquired aplastic anemia in childhood. Guidelines from the Marrow Failure Study Group of the Pediatric Haemato-Oncology Italian Association (AIEOP) by Guarina, A., Farruggia, P., Mariani, E., Saracco, P., Barone, A., Onofrillo, D., Cesaro, S., Angarano, R., Barberi, W., Bonanomi, S., Corti, P., Crescenzi, B., Dell'Orso, G., De Matteo, A., Giagnuolo, G., Iori, A.P., Ladogana, S., Lucarelli, A., Lupia, M., Martire, B., Mastrodicasa, E., Massaccesi, E., Arcuri, L., Giarratana, M.C., Menna, G., Miano, M., Notarangelo, L.D., Palazzi, G., Palmisani, E., Pestarino, S., Pierri, F., Pillon, M., Ramenghi, U., Russo, G., Saettini, F., Timeus, F., Verzegnassi, F., Zecca, M., Fioredda, F., Dufour, C.

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P739: THE EPI‐GENOMIC LANDSCAPE OF MONOSOMY 7 IN ADULT MDS/AML by Lema Fernandez, A. G., Nardelli, C., Di Battista, V., Quintini, M., Pellanera, F., Matteucci, C., Pierini, V., Crescenzi, B., Moretti, M., Bardelli, V., Gorello, P., Mecucci, C.

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Effects of Ubiquitin-Proteasome System Deregulation on the Vascular Senescence and Atherosclerosis Process in Elderly Patients by Marfella, Raffaele, Filippo, Clara Di, Laieta, Maria Teresa, Vestini, Rosanna, Barbieri, Michelangela, Sangiulo, Paolo, Crescenzi, Basilio, Ferraraccio, Franca, Rossi, Francesco, D'Amico, Michele, Paolisso, Giuseppe

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P-039 Insights on GNAS1 gene involvement in MDS by Di Giacomo, D, Pierini, T, Fernandez, A.G. Lema, Brandimarte, L, Pierini, V, Matteucci, C, Barba, G, Crescenzi, B, Mecucci, C

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252 NPM1 haploinsufficiency in human myeloid diseases with non-isolated −5/5q by Nofrini, V, La Starza, R, Crescenzi, B, Gorello, P, Brandimarte, L, Matteucci, C, Pierini, V, Arcioni, F, Berchicci, L, Musto, P, Rosati, R, Sambani, C, Santucci, A, Aventin, A, Mecucci, C

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253 Insights on centromeric breakpoints of 5q deletions by Nofrini, V, La Starza, R, Crescenzi, B, Pierini, V, Beacci, D, Matteucci, C, Arcioni, F, Berchicci, L, Romoli, S, Musto, P, Sambani, C, Aventin, A, Mecucci, C

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251 MN1-ETV6 fusion gene and −7: an unusual karyotypic evolution in AML after MDS with 5q by Nofrini, V, Berchicci, L, La Starza, R, Gorello, P, Di Giacomo, D, Arcioni, F, Pierini, V, Beacci, D, Crescenzi, B, Matteucci, C, Mecucci, C

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39 MK-5172: A NOVEL HCV NS3/4A PROTEASE INHIBITOR WITH POTENT ACTIVITY AGAINST KNOWN RESISTANCE MUTANTS by Carroll, S, McCauley, J, Ludmerer, S, Harper, S, Summa, V, Rowley, M, Rudd, M, Coleman, P, Liverton, N, Butcher, J, Mcintyre, C, Romano, J, Bush, K, Ferrara, M, Crescenzi, B, Petrocchi, A, Difilippo, M, Burlein, C, Dimuzio, J, Graham, D, Mchale, C, Stahlhut, M, Gates, A, Fandozzi, C, Trainor, N, Hazuda, D, Vacca, J, Olsen, D

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058 CLINICAL CHARACTERISTICS AND OUTCOME OF A CONSECUTIVE SERIES OF PATIENTS WITH VASCULAR PROSTHESIS INFECTION: A SINGLE CENTER REPORT by Durante-Mangoni, E, Caianiello, C, Cuccurullo, S, Albisinni, R, Sangiuolo, P, Ragone, E, Crescenzi, B, Utili, R

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Deletions of the long arm of chromosome 5 define subgroups of T-cell acute lymphoblastic leukemia by La Starza, Roberta, Barba, Gianluca, Demeyer, Sofie, Pierini, Valentina, Di Giacomo, Danika, Gianfelici, Valentina, Schwab, Claire, Matteucci, Caterina, Vicente, Carmen, Cools, Jan, Messina, Monica, Crescenzi, Barbara, Chiaretti, Sabina, Foà, Robin, Basso, Giuseppe, Harrison, Christine J, Mecucci, Cristina

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PO022 Autoimmune phenomena, myelodysplastic syndromes, cytogenetics: a case report by Crescenzi, B, Berchicci, L, Aversa, F, Ballanti, S, La Starza, R, Lupattelli, G

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Cryptic chromosome 9q34 deletion generates TAF-I{alpha}/CAN and TAF-I{beta}/CAN fusion transcripts in acute myeloid leukemia by Rosati, Roberto, La Starza, Roberta, Barba, Gianluca, Gorello, Paolo, Pierini, Valentina, Matteucci, Caterina, Roti, Giovanni, Crescenzi, Barbara, Romoli, Silvia, Aloisi, Teresa, Aversa, Franco, Martelli, Massimo Fabrizio, Mecucci, Cristina

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C018 Del (20q), a benign clonal abnormality, involves totipotent stem cells in Shwachman Diamond Syndrome by Crescenzi, B, La Starza, R, Sambani, C, Parcharidou, A, Brandimarte, L, Matteucci, C, Martelli, M.F, Mecucci, C

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P074 Molecular cytogenetic delineation of del (4q) in myelodysplastic syndromes with peripheral blood monocytosis by La Starza, R, Cei, M, Crescenzi, B, Matteucci, C, Brandimarte, L, Barba, G, Gorello, P, Martelli, M.F, Mecucci, C

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Molecular Delineation of 13q Deletion Boundaries in 20 Patients With Myeloid Malignancies by La Starza, R., Wlodarska, I., Aventin, A., Falzetti, D., Crescenzi, B., Martelli, M.F., Van den Berghe, H., Mecucci, C.

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SQSTM1-NUP214: a new gene fusion in adult T-cell acute lymphoblastic leukemia by GORELLO, Paolo, LA STARZA, Roberta, DI GIACOMO, Danika, MESSINA, Monica, CRISTINA PUZZOLO, Maria, CRESCENZI, Barbara, SANTORO, Alessandra, CHIARETTI, Sabina, MECUCCI, Cristina

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C022 NPM1 monoallelic deletion in a subgroup of MDS/AML with del (5q) or monosomy 5 and complex karyotype by La Starza, R, Roti, G, Brandimarte, L, Varasano, E, Arcioni, F, Pierini, A, Crescenzi, B, Diverio, D, Guglielmini, G, Martelli, M.F, Aventin, A, Mecucci, C

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Different boundaries characterize isolated and non-isolated 5q deletions in myelodysplastic syndromes and acute myeloid leukemias by NOFRINI, Valeria, LA STARZA, Roberta, CRESCENZI, Barbara, PIERINI, Valentina, BARBA, Gianluca, MECUCCI, Cristina

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Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults by GORELLO, Paolo, LA STARZA, Roberta, MESSINA, Monica, GRAMMATICO, Sara, MANCINI, Marco, MATTEUCCI, Caterina, BARDI, Antonella, GUARINI, Anna, MARTELLI, Massimo Fabrizio, FOA, Robin, MECUCCI, Cristina, VARASANO, Emanuela, CHIARETTI, Sabina, ELIA, Loredana, PIERINI, Valentina, BARBA, Gianluca, BRANDIMARTE, Lucia, CRESCENZI, Barbara, VITALE, Antonella

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AML1/MTG16 fusion gene from a t(16;21)(q24;q22) translocation in treatment-induced leukemia after breast cancer by LA STARZA, Roberta, SAMBANI, Constantina, CRESCENZI, Barbara, MATTEUCCI, Caterina, MARTELLI, Massimo F, MECUCCI, Cristina

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