Selinexor Combined with Ibrutinib Demonstrates Tolerability and Safety in Advanced B-Cell Malignancies: A Phase I Study by Stephens, Deborah M, Huang, Ying, Ruppert, Amy S, Walker, Janek S, Canfield, Daniel, Cempre, Casey B, Fu, Qiang, Baker, Sharyn, Hu, Boyu, Shah, Harsh, Vadeboncoeur, Renee, Rogers, Kerry A, Bhat, Seema, Jaglowski, Samantha M, Lockman, Hank, Lapalombella, Rosa, Byrd, John C, Woyach, Jennifer A

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Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter’s transformation by Hing, Zachary A., Walker, Janek S., Whipp, Ethan C., Brinton, Lindsey, Cannon, Matthew, Zhang, Pu, Sher, Steven, Cempre, Casey B., Brown, Fiona, Smith, Porsha L., Agostinelli, Claudio, Pileri, Stefano A., Skinner, Jordan N., Williams, Katie, Phillips, Hannah, Shaffer, Jami, Beaver, Larry P., Pan, Alexander, Shin, Kyle, Gregory, Charles T., Ozer, Gulcin H., Yilmaz, Selen A., Harrington, Bonnie K., Lehman, Amy M., Yu, Lianbo, Coppola, Vincenzo, Yan, Pearlly, Scherle, Peggy, Wang, Min, Pitis, Philip, Xu, Chaoyi, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer, Blachly, James S., Alinari, Lapo, Yang, Yiping, Byrd, John C., Baiocchi, Robert A., Blaser, Bradley W., Lapalombella, Rosa

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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia by Walker, Janek S, Hing, Zachary A, Harrington, Bonnie, Baumhardt, Jordan, Ozer, Hatice Gulcin, Lehman, Amy, Giacopelli, Brian, Beaver, Larry, Williams, Katie, Skinner, Jordan N, Cempre, Casey B, Sun, Qingxiang, Shacham, Sharon, Stromberg, Benjamin R, Summers, Matthew K, Abruzzo, Lynne V, Rassenti, Laura, Kipps, Thomas J, Parikh, Sameer, Kay, Neil E, Rogers, Kerry A, Woyach, Jennifer A, Coppola, Vincenzo, Chook, Yuh Min, Oakes, Christopher, Byrd, John C, Lapalombella, Rosa

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Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Pan, Alexander, Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrózek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Yan, Pearlly, Byrd, John C., Blachly, James S., Lapalombella, Rosa

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Targeting OXPHOS de novo purine synthesis as the nexus of FLT3 inhibitor-mediated synergistic antileukemic actions by Zhang, Pu, Brinton, Lindsey T, Gharghabi, Mehdi, Sher, Steven, Williams, Katie, Cannon, Matthew, Walker, Janek S, Canfield, Daniel, Beaver, Larry, Cempre, Casey B, Phillips, Hannah, Chen, Xuyong, Yan, Pearlly, Lehman, Amy, Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert, Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S, Lapalombella, Rosa

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Simultaneous Disruption of XPO1 and A20 in Murine B Cells Influences Both B and T Cell Repertoire by Walker, Janek S., Cempre, Casey B., Skinner, Jordan N., Walker, Brandi R., Byrd, John C., Lapalombella, Rosa

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LP-118, a Selective Bcl-2 Inhibitor with Tuned Bcl-Xl Activity, Causes Myeloid Differentiation and Cell Death in Acute Myeloid Leukemia (AML) by Koenig, Kristin L, Brame, Colin, Sher, Steven, Beaver, Larry, Cempre, Casey B., Williams, Katie, Purcell, Matthew, Harrington, Bonnie, Chen, Yi, Tan, Felai, Anthony, Stephen P., Chen, Yu, Shen, Yue, Byrd, John C., Lapalombella, Rosa

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Genome-Wide CRISPR/Cas9 Knockout Screen Reveals Novel Gilteritinib Combinations Targeting Oxidative Phosphorylation and De-Novo Purine Biosynthesis Pathways for FLT3-ITD+ Acute Mye... by Sher, Steven, Zhang, Pu, Brinton, Lindsey, Gharghabi, Mehdi, Williams, Katie, Cannon, Matthew, Walker, Janek S., Canfield, Daniel, Beaver, Larry, Cempre, Casey B., Phillips, Hannah, Chen, Xuyong, Yan, Pearlly S., Lehman, Amy M., Scherle, Peggy, Wang, Min, Vaddi, Kris, Baiocchi, Robert A., Wang, Ruoning, Sampath, Deepa, Alinari, Lapo, Blachly, James S., Lapalombella, Rosa

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Dysregulation of PRMT5 in Chronic Lymphocytic Leukemia Supports Transformation to Diffuse Large B-Cell Lymphoma by Whipp, Ethan, Hing, Zachary A, Walker, Janek S., Sher, Steven, Cempre, Casey B., Brown, Fiona, Agostinelli, Claudio, Pileri, Stefano A, Williams, Katie, Beaver, Larry, Pan, Alexander, Gregory, Charles T., Yan, Pearlly S., Scherle, Peggy, Wang, Min, Vaddi, Kris, Chen-Kiang, Selina, Woyach, Jennifer A., Blachly, James S., Alinari, Lapo, Yang, Yiping, Baiocchi, Robert A., Blaser, Bradley W, Lapalombella, Rosa

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Abstract 2260: Evaluating a rare t(X;14)(q28;q32) translocation reveals MTCP1 as a driving factor in chronic lymphocytic leukemia by Walker, Janek S., Hing, Zachary A., Sher, Steven, Cronin, James, Williams, Katie, Harrington, Bonnie, Skinner, Jordan N., Cempre, Casey B., Gregory, Charles T., Yano, Max, Beaver, Larry P., Walker, Brandi R., Labanowska, Jadwiga M., Heerema, Nyla A., Mrozek, Krzysztof, Woyach, Jennifer A., Ruppert, Amy S., Lehman, Amy, Ozer, Hatice Gulcin, Coppola, Vincenzo, Byrd, John C., Blachly, James S., Lapalombella, Rosa

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PRMT5 Initiates an Epigenetic Program That Promotes Progression of Chronic Lymphocytic Leukemia by Hing, Zachary A, Skinner, Jordan N., Beaver, Larry P., Lai, Tzung-Huei, Cempre, Casey B., Harrington, Bonnie K., Sampath, Deepa, Lehman, Amy M., Yu, Lianbo, Alinari, Lapo, Byrd, John C., Baiocchi, Robert A, Lapalombella, Rosa

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