Now is the time for (2R,6R)-hydroxynorketamine to be viewed independently from its parent drug by Chaki, Shigeyuki, Yamaguchi, Jun-ichi

Get full text

Structure–activity relationships of novel piperazines as antagonists for the melanocortin-4 receptor by Nozawa, Dai, Okubo, Taketoshi, Ishii, Takaaki, Kakinuma, Hiroyuki, Chaki, Shigeyuki, Okuyama, Shigeru, Nakazato, Atsuro

Get full text

Group II metabotropic glutamate receptor agonists as a potential drug for schizophrenia: Metabotropic Glutamate Receptors and Cognition by CHAKI, Shigeyuki

Get full text

Electrophysiological effects of melanocortin receptor ligands on neuronal activities of monoaminergic neurons in rats by Kawashima, Naoya, Chaki, Shigeyuki, Okuyama, Shigeru

Get full text

Evaluation of the Safety, Tolerability, and Pharmacokinetic Profiles of TP0473292 (TS-161), A Prodrug of a Novel Orthosteric mGlu2/3 Receptor Antagonist TP0178894, in Healthy Subje... by Watanabe, Mai, Marcy, Brian, Hiroki, Ayano, Watase, Hirotaka, Kinoshita, Kohnosuke, Iijima, Michihiko, Marumo, Toshiyuki, Zarate, Carlos A, Chaki, Shigeyuki

Get full text

Safety and pharmacokinetic profiles of MGS0274 besylate (TS‐134), a novel metabotropic glutamate 2/3 receptor agonist prodrug, in healthy subjects by Watanabe, Mai, Marcy, Brian, Kinoshita, Kohnosuke, Fukasawa, Misako, Hikichi, Hirohiko, Chaki, Shigeyuki, Okuyama, Shigeru, Gevorkyan, Hakop, Yoshida, Shigeru

Get full text

Efficacy and safety of TS-121, a novel vasopressin V 1B receptor antagonist, as adjunctive treatment for patients with major depressive disorder: A randomized, double-blind, placeb... by Kamiya, Makoto, Sabia, Helene D, Marella, Julie, Fava, Maurizio, Nemeroff, Charles B, Umeuchi, Hideo, Iijima, Michihiko, Chaki, Shigeyuki, Nishino, Izumi

Get full text

A Novel Potent and Selective Histamine H 3 Receptor Antagonist Enerisant: In Vitro Profiles, In Vivo Receptor Occupancy, and Wake-Promoting and Procognitive Effects in Rodents by Hino, Noriko, Marumo, Toshiyuki, Kotani, Makiko, Shimazaki, Toshiharu, Kaku-Fukumoto, Ayaka, Hikichi, Hirohiko, Karasawa, Jun-Ichi, Tomishima, Yasumitsu, Komiyama, Hiroko, Tatsuda, Emi, Nozawa, Dai, Nakamura, Toshio, Chaki, Shigeyuki

Get full text

Efficacy and safety of TS-121, a novel vasopressin V1B receptor antagonist, as adjunctive treatment for patients with major depressive disorder: A randomized, double-blind, placebo... by Kamiya, Makoto, Sabia, Helene D., Marella, Julie, Fava, Maurizio, Nemeroff, Charles B., Umeuchi, Hideo, Iijima, Michihiko, Chaki, Shigeyuki, Nishino, Izumi

Get full text

Antidepressant and anxiolytic profiles of newly synthesized arginine vasopressin V1B receptor antagonists: TASP0233278 and TASP0390325 by Iijima, M, Yoshimizu, T, Shimazaki, T, Tokugawa, K, Fukumoto, K, Kurosu, S, Kuwada, T, Sekiguchi, Y, Chaki, S

Get full text

The pituitary mediates the anxiolytic-like effects of the vasopressin V 1B receptor antagonist, SSR149415, in a social interaction test in rats by Shimazaki, Toshiharu, Iijima, Michihiko, Chaki, Shigeyuki

Get full text

An arginine vasopressin V 1b antagonist, SSR149415 elicits antidepressant-like effects in an olfactory bulbectomy model by Iijima, Michihiko, Chaki, Shigeyuki

Get full text

Binding characteristics of [formula omitted]DAA1106, a novel and selective ligand for peripheral benzodiazepine receptors by Chaki, Shigeyuki, Funakoshi, Takeo, Yoshikawa, Ryoko, Okuyama, Shigeru, Okubo, Taketoshi, Nakazato, Atsuro, Nagamine, Masashi, Tomisawa, Kazuyuki

Get full text

In vitro and antinociceptive profile of HON0001, an orally active NMDA receptor NR2B subunit antagonist by Suetake-Koga, Sayoko, Shimazaki, Toshiharu, Takamori, Kazuaki, Chaki, Shigeyuki, Kanuma, Kosuke, Sekiguchi, Yoshinori, Suzuki, Tsutomu, Kikuchi, Toyohiko, Matsui, Yoshimitsu, Honda, Toshio

Get full text

Discovery of MGS0274, an ester prodrug of a metabotropic glutamate receptor 2/3 agonist with improved oral bioavailability by Urabe, Hiroki, Miyakoshi, Naoki, Ohtake, Norikazu, Nozoe, Akiko, Ochi, Motoki, Fukasawa, Misako, Kinoshita, Kohnosuke, Yamaguchi, Jun-ichi, Marumo, Toshiyuki, Hikichi, Hirohiko, Chaki, Shigeyuki, Hashihayata, Takashi

Get full text

No Sex-Specific Differences in the Acute Antidepressant Actions of (R)-Ketamine in an Inflammation Model by Chang, Lijia, Toki, Hidetoh, Qu, Youge, Fujita, Yuko, Mizuno-Yasuhira, Akiko, Yamaguchi, Jun-Ichi, Chaki, Shigeyuki, Hashimoto, Kenji

Get full text

Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-, and an N-methyl-D-aspartate receptor antagonist, ketamine, in... by Fukumoto, Kenichi, Iijima, Michihiko, Chaki, Shigeyuki

Get full text

Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2-(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propano i c acid... by Fukumoto, Kenichi, Iijima, Michihiko, Chaki, Shigeyuki

Get full text

Neuropharmacological profile of peripheral benzodiazepine receptor agonists, DAA1097 and DAA1106 by Okuyama, Shigeru, Chaki, Shigeyuki, Yoshikawa, Ryoko, Ogawa, Shin-ichi, Suzuki, Yoshiko, Okubo, Taketoshi, Nakazato, Atsuro, Nagamine, Masasi, Tomisawa, Kazuyuki

Get full text

An arginine vasopressin V1b antagonist, SSR149415 elicits antidepressant-like effects in an olfactory bulbectomy model by IIJIMA, Michihiko, CHAKI, Shigeyuki

Get full text