A phase 3 double-blind study of the addition of tocilizumab vs placebo to cyclosporin/methotrexate GVHD prophylaxis by Kennedy, Glen A., Tey, Siok-Keen, Buizen, Luke, Varelias, Antiopi, Gartlan, Kate H., Curley, Cameron, Olver, Stuart D., Chang, Karshing, Butler, Jason P., Misra, Ashish, Subramoniapillai, Elango, Morton, A. James, Durrant, Simon, Henden, Andrea S., Moore, John, Ritchie, David, Gottlieb, David, Cooney, Julian, Paul, Sanjoy K., Hill, Geoffrey R.

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IL-6 dysregulation originates in dendritic cells and mediates graft-versus-host disease via classical signaling by Wilkinson, Andrew N., Chang, Karshing, Kuns, Rachel D., Henden, Andrea S., Minnie, Simone A., Ensbey, Kathleen S., Clouston, Andrew D., Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Gartlan, Kate H., Hill, Geoffrey R.

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Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract by Gartlan, Kate H., Koyama, Motoko, Lineburg, Katie E., Chang, Karshing, Ensbey, Kathleen S., Kuns, Rachel D., Henden, Andrea S., Samson, Luke D., Clouston, Andrew D., Lopez, Angel F., MacDonald, Kelli P.A., Hill, Geoffrey R.

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Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT by Gartlan, Kate H., Varelias, Antiopi, Koyama, Motoko, Robb, Renee J., Markey, Kate A., Chang, Karshing, Wilkinson, Andrew N., Smith, David, Ullah, Md Ashik, Kuns, Rachel D., Raffelt, Neil C., Olver, Stuart D., Lineburg, Katie E., Teal, Bianca E., Cheong, Melody, Teng, Michele W.L., Smyth, Mark J., Tey, Siok-Keen, MacDonald, Kelli P.A., Hill, Geoffrey R.

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IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease by Henden, Andrea S, Koyama, Motoko, Robb, Renee J, Forero, Adriana, Kuns, Rachel D, Chang, Karshing, Ensbey, Kathleen S, Varelias, Antiopi, Kazakoff, Stephen H, Waddell, Nicole, Clouston, Andrew D, Giri, Rabina, Begun, Jakob, Blazar, Bruce R, Degli-Esposti, Mariapia A, Kotenko, Sergei V, Lane, Steven W, Bowerman, Kate L, Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H, Hill, Geoffrey R

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IFN-λ therapy prevents severe gastrointestinal graft-versus-host disease by Henden, Andrea S., Koyama, Motoko, Robb, Renee J., Forero, Adriana, Kuns, Rachel D., Chang, Karshing, Ensbey, Kathleen S., Varelias, Antiopi, Kazakoff, Stephen H., Waddell, Nicole, Clouston, Andrew D., Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A., Kotenko, Sergei V., Lane, Steven W., Bowerman, Kate L., Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H., Hill, Geoffrey R.

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Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation by Pearson, Frances E, Chang, Karshing, Minoda, Yoshihito, Rojas, Ingrid M Leal, Haigh, Oscar L, Daraj, Ghazal, Tullett, Kirsteen M, Radford, Kristen J

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Diverse IL-6 signalling modalities drive pathogenic T cell differentiation and graft-versus-host-disease after allotransplantation by Gartlan, Kate H, Wilkinson, Andrew, Chang, Karshing, Kuns, Rachel D, Henden, Andrea, Minnie, Simone A, Ensbey, Kathleen S, Clouston, Andrew, Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Hill, Geoffrey R

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Inhibition of the Cytolytic Protein Perforin Prevents Rejection of Transplanted Bone Marrow Stem Cells in Vivo by Spicer, Julie A, Miller, Christian K, O’Connor, Patrick D, Jose, Jiney, Giddens, Anna C, Jaiswal, Jagdish K, Jamieson, Stephen M. F, Bull, Matthew R, Denny, William A, Akhlaghi, Hedieh, Trapani, Joseph A, Hill, Geoff R, Chang, Karshing, Gartlan, Kate H

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A Critical Role for Donor-Derived IL-22 in Cutaneous Chronic Gvhd by Gartlan, Kate H, Bommiasamy, Hemamalini, Paz, Katelyn, Wilkinson, Andrew, Owen, Mary, Reichenbach, Dawn, Banovic, Tatjana, Wehner, Kimberly, Buchanan, Faith, Varelias, Antiopi, Kuns, Rachel, Chang, Karshing, Fedoriw, Yuri, Shea, Thomas C., Coghill, James M., Zaiken, Michael, Plank, Maximilian, Foster, Paul, Clouston, Andrew, Blazar, Bruce, Serody, Jonathan S, Hill, Geoffrey R

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Preclinical Activity and Pharmacokinetic/Pharmacodynamic Relationship for a Series of Novel Benzenesulfonamide Perforin Inhibitors by Gartlan, Kate H., Jaiswal, Jagdish K., Bull, Matthew R., Akhlaghi, Hedieh, Sutton, Vivien R., Alexander, Kylie A., Chang, Karshing, Hill, Geoffrey R., Miller, Christian K., O’Connor, Patrick D., Jose, Jiney, Trapani, Joseph A., Charman, Susan A., Spicer, Julie A., Jamieson, Stephen M. F.

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ASC Modulates CTL Cytotoxicity and Transplant Outcome Independent of the Inflammasome by Cheong, Melody, Gartlan, Kate H, Lee, Jason S, Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D, Andoniou, Christopher E, Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R, Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A, Boyle, Glen M, Smyth, Mark J, Engwerda, Christian R, MacDonald, Kelli P A, Trapani, Joseph A, Degli-Esposti, Mariapia A, Koyama, Motoko, Hill, Geoffrey R

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Interferon Lambda Protects Gastrointestinal Stem Cells from Acute Gvhd by Henden, Andrea S, Robb, Renee, Forero, Adriana, Kuns, Rachel D, Ensbey, Kathleen S, Chang, Karshing, Varelias, Antiopi, Kazakoff, Stephen H, Waddell, Nic, Clouston, Andrew D, Giri, Rabina, Begun, Jakob, Blazar, Bruce R., Degli-Esposti, Mariapia A, Kotenko, Sergei V, Lane, Steven W, Bowerman, Kate L, Savan, Ram, Hugenholtz, Philip, Gartlan, Kate H, Hill, Geoffrey

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