Ligand-Bound Structures of the Dengue Virus Protease Reveal the Active Conformation by Noble, Christian G, Seh, Cheah Chen, Chao, Alexander T, Shi, Pei Yong

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Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling by Lim, Siew Pheng, Noble, Christian Guy, Seh, Cheah Chen, Soh, Tingjin Sherryl, El Sahili, Abbas, Chan, Grace Kar Yarn, Lescar, Julien, Arora, Rishi, Benson, Timothy, Nilar, Shahul, Manjunatha, Ujjini, Wan, Kah Fei, Dong, Hongping, Xie, Xuping, Shi, Pei-Yong, Yokokawa, Fumiaki

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Identifying Initiation and Elongation Inhibitors of Dengue Virus RNA Polymerase in a High-Throughput Lead-Finding Campaign by Smith, Thomas M., Lim, Siew Pheng, Yue, Kimberley, Busby, Scott A., Arora, Rishi, Seh, Cheah Chen, Wright, S. Kirk, Nutiu, Razvan, Niyomrattanakit, Pornwaratt, Wan, Kah Fei, Beer, David, Shi, Pei-Yong, Benson, Timothy E.

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NS5 from Dengue Virus Serotype 2 Can Adopt a Conformation Analogous to That of Its Zika Virus and Japanese Encephalitis Virus Homologues by El Sahili, Abbas, Soh, Tingjin Sherryl, Schiltz, Jonas, Gharbi-Ayachi, Aïcha, Seh, Cheah Chen, Shi, Pei-Yong, Lim, Siew Pheng, Lescar, Julien

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NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models by Moquin, Stephanie A, Simon, Oliver, Karuna, Ratna, Lakshminarayana, Suresh B, Yokokawa, Fumiaki, Wang, Feng, Saravanan, Chandra, Zhang, Jin, Day, Craig W, Chan, Katherine, Wang, Qing-Yin, Lu, Siyan, Dong, Hongping, Wan, Kah Fei, Lim, Siew Pheng, Liu, Wei, Seh, Cheah Chen, Chen, Yen-Liang, Xu, Haoying, Barkan, David T, Kounde, Cyrille S, Sim, Wei Lin Sandra, Wang, Gang, Yeo, Hui-Quan, Zou, Bin, Chan, Wai Ling, Ding, Mei, Song, Jae-Geun, Li, Min, Osborne, Colin, Blasco, Francesca, Sarko, Christopher, Beer, David, Bonamy, Ghislain M C, Sasseville, Vito G, Shi, Pei-Yong, Diagana, Thierry T, Yeung, Bryan K S, Gu, Feng

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Two RNA Tunnel Inhibitors Bind in Highly Conserved Sites in Dengue Virus NS5 Polymerase: Structural and Functional Studies by Arora, Rishi, Liew, Chong Wai, Soh, Tingjin Sherryl, Otoo, Dorcas Adobea, Seh, Cheah Chen, Yue, Kimberley, Nilar, Shahul, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian G, Chen, Yen Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas M, Benson, Timothy E, Lim, Siew Pheng

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A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation... by Lim, Siew Pheng, Koh, Jolene Hong Kiew, Seh, Cheah Chen, Liew, Chong Wai, Davidson, Andrew D., Chua, Leng Shiew, Chandrasekaran, Ramya, Cornvik, Tobias C., Shi, Pei-Yong, Lescar, Julien

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Structure-activity relationship of uridine-based nucleoside phosphoramidate prodrugs for inhibition of dengue virus RNA-dependent RNA polymerase by Wang, Gang, Lim, Siew Pheng, Chen, Yen-Liang, Hunziker, Jürg, Rao, Ranga, Gu, Feng, Seh, Cheah Chen, Ghafar, Nahdiyah Abdul, Xu, Haoying, Chan, Katherine, Lin, Xiaodong, Saunders, Oliver L., Fenaux, Martijn, Zhong, Weidong, Shi, Pei-Yong, Yokokawa, Fumiaki

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A Cyclic Phosphoramidate Prodrug of 2'-Deoxy-2'-Fluoro-2'- C -Methylguanosine for the Treatment of Dengue Virus Infection by Karuna, Ratna, Yokokawa, Fumiaki, Wang, Keshi, Zhang, Jin, Xu, Haoying, Wang, Gang, Ding, Mei, Chan, Wai Ling, Abdul Ghafar, Nahdiyah, Leonardi, Andrea, Seh, Cheah Chen, Seah, Peck Gee, Liu, Wei, Srinivasa, Rao P S, Lim, Siew Pheng, Lakshminarayana, Suresh B, Growcott, Ellie, Babu, Sreehari, Fenaux, Martijn, Zhong, Weidong, Gu, Feng, Shi, Pei-Yong, Blasco, Francesca, Chen, Yen-Liang

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240 Humanized CD30 chimeric antigen receptor T cells with a novel 4–1BB derived spacer have improved activity and safety against CD30-positive lymphomas by Kua, Lindsay, Ng, Chee Hoe, Jin Wei Tan, Ong, Richard, Cheah, Chen Seh, Wong, Fiona, Sim, Don, Horak, Ivan David, Low, Lionel, Tan, Kar Wai

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Stabilization of dengue virus polymerase in de novo initiation assay provides advantages for compound screening by Niyomrattanakit, Pornwaratt, Wan, Kah Fei, Chung, Ka Yan, Abas, Siti Nurdiana, Seh, Cheah Chen, Dong, Hongping, Lim, Chin Chin, Chao, Alexander Theodore, Lee, Chang Bok, Nilar, Shahul, Lescar, Julien, Shi, Pei-Yong, Beer, David, Lim, Siew Pheng

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A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening by Noble, Christian G., Lim, Siew Pheng, Arora, Rishi, Yokokawa, Fumiaki, Nilar, Shahul, Seh, Cheah Chen, Wright, S.Kirk, Benson, Timothy E., Smith, Paul W., Shi, Pei-Yong

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HSP90 is required for TAK1 stability but not for its activation in the pro-inflammatory signaling pathway by Liu, Xin Yu, Seh, Cheah Chen, Cheung, Peter C.F.

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Crystallographic structure of ubiquitin in complex with cadmium ions by Qureshi, Insaf A, Ferron, Francois, Seh, Cheah Chen, Cheung, Peter, Lescar, Julien

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