New approach to the development of animal model of depression characterized by super-sensitivity of brain muscarinic cholinergic system by Nachkebia, N, Chkhartishvili, E, McHedlidze, O, Dzadzamia, S, Maglakelidze, N, Babilodze, M, Chijavadze, E

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Hippocampal repetitive local epileptic seizures improve learning and memory of spatial-conditioned sound discrimination in cats by Nachkebia, N, Chkhartishvili, E, Oniani, T

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Effect of induced hypoglycemia on sleep-waking cycle in rats by Chijavadze, E, Babilodze, M, Mchedlidze, O, Chkhartishvili, E, Nachkebia, N

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Repetitive intracerebroventricular (ICV) microinjection of orexina regulates sleep homeostasis and hastens recovery from deep barbiturate anesthesia induced sleep by Mchedlidze, O, Maglakelidze, N, Babilodze, M, Chkhartishvili, E, Dzadzamia, S, Tsomaia, V, Chijavadze, E, Nachkebia, N

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Serial electrical stimulations of hypothalamic orexin-containing neuronal regions lead to elevation of CSF OrexinA concentration and fasten the recovery of sleep-wakefulness cycle... by Maglakelidze, N, Chkhartishvili, E, Dzadzamia, S, Chijavadze, E, Babilodze, M, Nachkebia, N

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Malfunctioning of brain muscarinic cholinergic system in the period of early postnatal development leads to behavioral and sleep disturbances in adult age rats and changes in densi... by Nachkebia, N, Chkhartishvili, E, Mchedlidze, O, Dzadzamia, S, Maglakelidze, N, Chijavadze, E

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Serial electrical stimulations of hypothalamic Orexin-containing neuronal regions lead to elevation of CSF OrexinA concentration, shorten anesthesia time and fasten recovery of nor... by Mchedlidze, O, Chkhartishvili, E, Maglakelidze, N, Tsomaia, V, Rogava, N, Nachkebia, N

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Allergic Rhinitis and its Impact on Asthma (ARIA) Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology by Agache, Ioana, Bewick, Mickael, Bindslev-Jensen, Carsten, Correia de Sousa, Jaime, Demoly, Pascal, Illario, Maddalena, Lourenço, Olga, Mahboub, Bassam, Mullol, Joaquim, Namazova-Baranova, Leyla, Okamoto, Yoshitaka, Schunemann, Holger J., Stellato, Cristiana, Todo-Bom, Ana-Maria, Ventura, Maria-Teresa, Wang, De Yun, Waserman, Susan, Agache, I., Akdis, M., Almeida, R., Angles, R., Asarnoj, A., Bateman, E.D., Beghé, B., Bennoor, K.S., Bertorello, L., Bochenska Marciniak, M., Bonini, S., Bosnic-Anticevich, C.S., Panaitescu, C., Burguete Cabañas, M.T., Camargos, P.A.M., Cardona, V., Casale, T., Castellano, G., Cepeda Sarabia, A.M., Coll, J., Correia de Sousa, J., Costa, E., Czarlewski, W., Dahlen, S.E., Dedeu, T., Di Carluccio, N., Dray, G., Du Toit, G., Eklund, P., Farrell, J., Fuentes-Perez, J.M., Garcia-Aymerich, J., Gómez-Vera, J., Hourihane, J.O.'B., Illario, M., Keith, P.K., Kleine-Tebbe, J., Klimek, L., Lessa, M., Louis, R., Lourenço, O., Magnan, A., Mair, A., Matta Campos, J.J., Mihaltan, F., Moda, G., Momas, I., Moura Santo, P., Mullol, J., Nadif, R., Nalin, M., Napoli, L., Neffen, H., Niedeberger, V., Neou, A., Nieto, A., Nogueira-Silva, L., Ortega Cisneros, M., Ouedraogo, S., Persico, M., Picard, R., Pohl, W., Popov, T.A., Pugin, B., Rabe, K.F., Raciborski, F., Ribeirinho, I., Roller-Wirnsberger, R.E., Sanchez-Borges, M., Sheikh, A., Sierra, M., Spranger, O., Strozek, J., Szylling, A., Todo-Bom, A., Toppila-Salmi, S., van Eerd, M., Ventura, M.T., Walker, S., Wallace, D., Wickman, M., Williams, D.M., Yiallouros, P.K.

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Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA‐ARIA‐EPOS‐AIRWAYS ICP statement by Gevaert, P., Aberer, W, Akdis, CA, Asarnoj, A, Bateman, ED, Bedbrook, A, Bel, EH, Bergmann, KC, Bialoszewski, AZ, Bjermer, L, Blain, H, Blasi, F, Bonini, M, Bosse, I, Bousquet, J, Braido, F, Brightling, CE, Brozek, J, Carlsen, KH, Carr, W, Casale, T, Cepeda Sarabia, AM, Cervin, A, Chatzi, L, Chuchalin, AG, Cohen, N, Crooks, G, Dahl, R, Dahlen, SE, Dedeu, T, Dray, G, Du Toit, G, El‐Gamal, Y, Fink Wagner, A, Fiocchi, A, Forastiere, F, Goossens, H, Heinrich, J, Hopkins, C, Horak, F, Hourihane, JO, Humbert, M, Iaccarino, G, Jutel, M, Kaidashev, I, Kalogjera, L, Keil, T, Kerkhof, M, Kerstjens, HA, Khaitov, M, Klimek, L, Kowalski, M, Kowalski, ML, Laune, D, Le, LT, Li, J, Lieberman, P, Marshall, GD, Mathieu‐Dupas, E, Mercier, J, Miculinic, N, Millot‐Keurinck, J, Momas, I, Mösges, R, Niggemann, B, Nyembue, TD, Okubo, K, Pali‐Schöll, I, Palkonen, S, Panzner, P, Papadopoulos, NG, Passalacqua, G, Pedersen, S, Pfaar, O, Pigearias, B, Postma, D, Roberts, G, Rodenas, F, Ryan, D, Sanchez‐Borges, M, Simons, FER, Smit, HA, Solé, D, Spranger, O, Thijs, C, Todo‐Bom, A, Triggiani, M, Valenta, R, Valiulis, A, Valovirta, E, Ganse, E, Wick, RG, Varona, LL, Vazankari, T, Vontetsianos, T, Werfel, T, Wickman, M, Zar, HJ, Zernotti, ME, Zuberbier, T

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P.591 Orexin-A ameliorates lasting effects of postnatal dysfunctioning of muscarinic cholinergic system on sleep-wakefulness by Maglakelidze, N., Mchedlidze, O., Chkhartishvili, E., Babilodze, M., Bejanishvili, K., Rogava, N., Nachkebia, N.

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P.556 Orexin-A ameliorates lasting behavioral and sleep disturbances produced by early postnatal dysfunctioning of brain muscarinic cholinergic system by Maglakelidze, N., Mchedlidze, O., Chkhartishvili, E., Babilodze, M., Chijavadze, E., Nachkebia, N.

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Orexin-A ameliorates lasting behavioral and sleep disturbances produced by early postnatal dysfunctioning of brain muscarinic cholinergic system by Maglakelidze, N., Mchedlidze, O., Chkhartishvili, E., Babilodze, M., Chijavadze, E., Nachkebia, N.

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Correlation between work impairment, scores of rhinitis severity and asthma using the MASK‐air® App by Fokkens, Wytske J., Ivancevich, Juan C., Larenas‐Linnemann, Désirée, Samolinski, Boleslaw, Tomazic, Peter V., Toppila‐Salmi, Sanna, Basagaña, Xavier, Aberer, W, Agache, I, Akdis, CA, Almeida, R, Amat, F, Anto, JM, Asayag, E, Asarnoj, A, Barbagallo, M, Bewick, M, Bourret, R, Briedis, V, Panaitescu, C, Caimmi, D, Carlsen, KH, Carr, W, Cecchi, L, Chavannes, NH, Chiron, R, Chuchalin, AG, Chung, KF, Colas, L, Colgan, E, Darsow, U, Deleanu, D, Denburg, JA, Devillier, P, Garcia‐Cruz, MH, Jung, KS, Keith, PK, Khaltaev, N, Kowalski, ML, Lacwik, P, Lauri, D, Le, LTT, Lieberman, P, Lodrup Carlsen, KC, Louis, R, Mahboub, B, Mandajieva, E, Melo‐Gomes, E, Menditto, E, Moda, G, Mohammad, Y, Montefort, S, Mora Bogado, D, Nekam, K, Okubo, K, Onorato, GL, Pali‐Schöll, I, Papi, A, Pereira, AM, Picard, R, Pin, I, Popov, TA, Potter, P, Price, D, Prokopakis, EP, Puy, R, Pugin, B, Pulido Ross, RE, Przemecka, M, Ribeirinho, I, Rizzo, JA, Rodo, X, Rodriguez‐Mañas, L, Roller‐Wirnsberger, RE, Ryan, D, Salimäki, J, Sanchez‐Borges, M, Sastre‐Dominguez, J, Sarquis Serpa, F, Sierra, M, Simons, FER, Solé, D, Sondermann, M, Sorensen, M, Stelmach, R, Szylling, A, Todo‐Bom, A, Triggiani, M, Suppli Ulrik, C, Valenta, R, Valovirta, E, van Ganse, E, Vezzani, G, Vatrella, A, Viart, F, Vontetsianos, T, Wagenmann, M, Wang, DY, Wilson, N, Zhong, N

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Lasting effects of early postnatal malfunctioning of brain muscarinic cholinergic system are ameliorated by icv microinjection of Orexin-a (Hypocretin-1) and Orexin-b (Hypocretin-2... by Nachkebia, N., Maglakelidze, N., Mchedlidze, O., Chkhartishvili, E., Chijavadze, E., Babilodze, M., Bejanishvili, K.

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L0020 Changes in blood glucose level and sleep disturbances in these conditions by Chijavadze, E, Babilodze, M, Chkhartishvili, E, Mchedlidze, O, Nachkebia, N

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Guidance to 2018 good practice: ARIA digitally‐enabled, integrated, person‐centred care for rhinitis and asthma by Mathieu‐Dupas, E., Todo‐Bom, A., Canonica, G. W., Napoli, L., Chavannes, N. H., Fuentes Perez, J. M., Huerta‐Villalobos, Y. R., Rodriguez‐Zagal, E., Dubakiene, R., Devillier, P., Rolland, C., Cardona, V., Klimek, L., Gemicioğlu, B., Palkonen, S., Dykewick, M., Murray, R., Hellings, P. W., Aberer, W., Agache, I., Angles, R., Bjermer, L., Bochenska Marciniak, M., Bogus‐Buczynska, I., Bonini, S., Bosnic‐Anticevich, C. S., Boulet, L. P., Bousquet, P. J., Briedis, V., Burguete Cabañas, M. T., Camargos, P. A. M., Camuzat, T., Castellano, G., Chavannes, N. H., Chiron, R., Coll, J., Czarlewski, W., Dedeu, T., Demoly, P., Di Carluccio, N., Dray, G., Du Toit, G., El‐Gamal, Y., Eklund, P., Farrell, J., Fonseca, J. A., Gutter, Z., Illario, M., Kalyoncu, A. F., Karjalainen, J., Keith, P. K., Khaitov, M., Kvedariene, V., Lacwik, P., Lavrut, J., Lessa, M., Lourenço, O., Malva, J., Matta Campos, J. J., Matos, A. L., Maurer, M., Medina‐Avalos, M. A., Mihaltan, F., Moda, G., Mösges, R., Mota‐Pinto, A., Moura Santo, P., Nadif, R., Namazova‐Baranova, L., Niedeberger, V., Nekam, K., Nieto, A., Onorato, G. L., Ouedraogo, S., Panzner, P., Pereira, A. M., Pfaar, O., Pugin, B., Rodriguez‐Mañas, L., Rolland, C., Rodriguez‐Zagal, E., Rolla, G., Salimäki, J., Scadding, G. K., Serpa, F. S., Sierra, M., Solé, D., Sondermann, M., Sunyer, J., Strozek, J., Szylling, A., To, T., Tomazic, P. V., Ganse, E., Hague, M., Wang, D. Y., Werfel, T., Wickman, M., Yorgancioglu, A., Zar, H. J.

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MASK 2017: ARIA digitally‐enabled, integrated, person‐centred care for rhinitis and asthma multimorbidity using real‐world‐evidence by Mathieu‐Dupas, E., Pépin, J. L., Lourenço, O., Cruz, A. A., Serpa, F. S., De Feo, G., Fuentes Perez, M., Huerta Villabolos, Y. R., Rodriguez‐Zagal, E., Bosse, I., Devillier, P., Fontaine, J. F., Samolinski, B., Valiulis, A., Tomazic, P., Gemicioğlu, B., Bosnic‐Anticevich, S., Bachert, C., Waserman, S., Eerd, M., Casale, T., Naclerio, R. N., Agache, I., Alberti, M. R., Asayag, E., Avolio, F., Baroni, I., Barreto, B. A., Bel, E. H., Blain, H., Blasi, F., Bosse, I., Caballero‐Fonseca, F., Cepeda Sarabia, A. M., Chuchalin, A. G., Chung, K. F., Conforti, D., Costa‐Dominguez, M. C., Dahlen, S. E., Fátima Emerson, M., De Vries, G., Paula Motta Rubini, N., Eller, E., Gemicioglu, B., Genova, S., George, C., Gomez, R. M., Guidacci, M., Guldemond, N. A., Guzmán, M. A., Haahtela, T., Hajjam, J., Johnston, S. L., Joos, G., Kaidashev, I., Kalayci, O., Kalyoncu, A. F., Karjalainen, J., Khaitov, M., Kuna, P., Lauri, D., Levato, G., Mahboub, B., Maspero, J. F., Menditto, E., Mercier, J., Miculinic, N., Mora Bogado, D., Muraro, A., Murray, R., Odzhakova, C., Ohta, K., Panzner, P., Pépin, J. L., Pfaar, O., Portejoie, F., Pozzi, A. C., Puy, R., Rajabian‐Soderlund, R., Rivero‐Yeverino, D., Ryan, D., Samolinski, B., Sisul, J. C., Somekh, D., Sooronbaev, T., Sorensen, M., Stukas, R., Triggiani, M., Urrutia‐Pereira, M., Valero, A., Hague, M., Vandenplas, O., Viegi, M., Wilson, N., Wroczynski, P., Zhang, L., Zhong, N., Zernotti, M. E., Zidarn, M., Zubrinich, C.

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Unmet needs in severe chronic upper airway disease (SCUAD) by Bousquet, Jean, MD, Bachert, Claus, MD, Canonica, Giorgio W., MD, Casale, Thomas B., MD, Cruz, Alvaro A., MD, Lockey, Richard J., MD, Zuberbier, Torsten, MD

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Next‐generation ARIA care pathways for rhinitis and asthma: a model for multimorbid chronic diseases by Erhola, Marina, Agache, Ioana, Brusselle, Guy, Klimek, Ludger, Lourenço, Olga M., Papadopoulos, Nikos, Pham‐Thi, Nhân, Toppila‐Salmi, Sanna, Bonniaud, Philippe, Briedis, Vitalis, Cartier, Christine, Chkhartishvili, Eka, Custovic, Adnan, Dantas, Carina, Dubakiene, Ruta, Eller, Esben, Gemicioğlu, Bilun, Gotua, Maia, Kardas, Przemyslaw, Khaltaev, Nikolai, Kowalski, Marek L., Lieberman, Philip, Lipworth, Brian, Lodrup Carlsen, Karin C., Loureiro, Claudia C., Mathieu‐Dupas, Eve, Meltzer, Eli O., Moda, Giuliana, Mösges, Ralf, Panzner, Peter, Pfaar, Oliver, Phillips, Jim, Picard, Robert, Plavec, Davor, Rodo, Xavier, Somekh, David, Sova, Milan, Thibaudon, Michel, Valero, Antonio A., Vandenplas, Olivier, Wroczynski, Piotr, Zeng, Stéphane, Zhong, Nan S., Asayag, E., Avolio, F., Bacci, E., Barbagallo, M., Baroni, I., Barreto, B. A., Bateman, E. D., Bewick, M., Bel, E. H., Bouchard, J., Caballero‐Fonseca, F., Carriazo, A. M., Cepeda, A. M., Chivato, T., Cingi, C., Colas, L., Corti, F., Dahlen, S. E., De Carlo, G., Motta Rubina, N. P., Di Capua Ercolano, S., Dykewicz, M. S., Forti, S., Wijk, R. Gerth, González Diaz, S., Ispayeva, Z., Jares, E. J., Jung, K. S., Kuitunen, M., Lipiec, A., Meltzer, E. O., Morais‐Almeida, M., Morato‐Castro, F. F., Nyembue, T. D., Palkonen, S., Park, H. S., Papi, A., Pulido Ross, R. E., Reitsma, S., Rizzo, J. A., Rizzo, M. C., Rodenas, F., Roller‐Wirnsberger, R. E., Rosado‐Pinto, J., Schmid‐Grendelmeier, P., Sova, M., Stellato, C., Tebyriçá, J. N., Thibaudon, M., Valiulis, A., Eerd, M., Vicheva, D., Vontetsianos, T., Westman, M., Williams, S., Yusuf, O. M., Zuberbier, T.

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L0017 Additional evidence concerning the role of brain adrenergic system in the regulation of paradoxical sleep by Nachkebia, N, Chkhartishvili, E, Nachkebia, A, Chijavadze, E, Babilodze, M, Dzadzamia, S

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