Development of a Robust High-Throughput Screening Platform for Inhibitors of the Striatal-Enriched Tyrosine Phosphatase (STEP) by Lambert, Lester J, Grotegut, Stefan, Celeridad, Maria, Gosalia, Palak, Backer, Laurent Js De, Bobkov, Andrey A, Salaniwal, Sumeet, Chung, Thomas Dy, Zeng, Fu-Yue, Pass, Ian, Lombroso, Paul J, Cosford, Nicholas Dp, Tautz, Lutz

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Novel potent azetidine-based compounds irreversibly inhibit Stat3 activation and induce antitumor response against human breast tumor growth in vivo by Yue, Peibin, Zhu, Yinsong, Brotherton-Pleiss, Christine, Fu, Wenzhen, Verma, Nagendra, Chen, Jasmine, Nakamura, Kayo, Chen, Weiliang, Chen, Yue, Alonso-Valenteen, Felix, Mikhael, Simoun, Medina-Kauwe, Lali, Kershaw, Kathleen M., Celeridad, Maria, Pan, Songqin, Limpert, Allison S., Sheffler, Douglas J., Cosford, Nicholas D.P., Shiao, Stephen L., Tius, Marcus A., Lopez-Tapia, Francisco, Turkson, James

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Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) by Sidique, Shyama, Ardecky, Robert, Su, Ying, Narisawa, Sonoko, Brown, Brock, Millán, José Luis, Sergienko, Eduard, Cosford, Nicholas D.P.

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The mGluR2 Positive Allosteric Modulator BINA Decreases Cocaine Self-Administration and Cue-Induced Cocaine-Seeking and Counteracts Cocaine-Induced Enhancement of Brain Reward Func... by Jin, Xinchun, Semenova, Svetlana, Yang, Li, Ardecky, Robert, Sheffler, Douglas J, Dahl, Russell, Conn, P Jeffrey, Cosford, Nicholas DP, Markou, Athina

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Structure–activity relationship and improved hydrolytic stability of pyrazole derivatives that are allosteric inhibitors of West Nile Virus NS2B-NS3 proteinase by Sidique, Shyama, Shiryaev, Sergey A., Ratnikov, Boris I., Herath, Ananda, Su, Ying, Strongin, Alex Y., Cosford, Nicholas D.P.

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Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP by Ardecky, Robert J., Welsh, Kate, Finlay, Darren, Lee, Pooi San, González-López, Marcos, Ganji, Santhi Reddy, Ravanan, Palaniyandi, Mace, Peter D., Riedl, Stefan J., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D.P.

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Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP by González-Lόpez, Marcos, Welsh, Kate, Finlay, Darren, Ardecky, Robert J., Ganji, Santhi Reddy, Su, Ying, yuan, Hongbin, Teriete, Peter, Mace, Peter D., Riedl, Stefan J., Vuori, Kristiina, Reed, John C., Cosford, Nicholas D.P.

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Radiosynthesis and preclinical evaluation of a carbon-11 labeled PET ligand for imaging metabotropic glutamate receptor 7 by Li, Yinlong, Xiao, Zhiwei, Mori, Wakana, Sun, Jiyun, Yamasaki, Tomoteru, Rong, Jian, Fujinaga, Masayuki, Chen, Jiahui, Kumata, Katsushi, Zhao, Chunyu, Zhang, Yiding, Collier, Thomas L, Hu, Kuan, Xie, Lin, Zhou, Xin, Zhang, Wei, Song, Zhendong, Gao, Yabiao, Sun, Zhenkun, Zhang, Kuo, Patel, Jimmy S, Ran, Chongzhao, Chaudhary, Ahmad, Sheffler, Douglas J, Cosford, Nicholas Dp, Zhang, Linqi, Zhai, Chuangyan, Haider, Ahmed, Yuan, Hongjie, Zhang, Ming-Rong, Liang, Steven H

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Development of a novel, CNS-penetrant, metabotropic glutamate receptor 3 (mGlu3) NAM probe (ML289) derived from a closely related mGlu5 PAM by Sheffler, Douglas J., Wenthur, Cody J., Bruner, Joshua A., Carrington, Sheridan J.S., Vinson, Paige N., Gogi, Kiran K., Blobaum, Anna L., Morrison, Ryan D., Vamos, Mitchell, Cosford, Nicholas D.P., Stauffer, Shaun R., Scott Daniels, J., Niswender, Colleen M., Jeffrey Conn, P., Lindsley, Craig W.

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Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists by Chua, Peter C., Nagasawa, Johnny Y., Bleicher, Leo S., Munoz, Benito, Schweiger, Edwin J., Tehrani, Lida, Anderson, Jeffrey J., Cramer, Merryl, Chung, Janice, Green, Mitchell D., King, Chris D., Reyes-Manalo, Grace, Cosford, Nicholas D.P.

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Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids by Wang, Huabo, Teriete, Peter, Hu, Angela, Raveendra-Panickar, Dhanya, Pendelton, Kelsey, Lazo, John S, Eiseman, Julie, Holien, Toril, Misund, Kristine, Oliynyk, Ganna, Arsenian-Henriksson, Marie, Cosford, Nicholas DP, Sundan, Anders, Prochownik, Edward V

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Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity by Smith, Nicholas D., Poon, Steve F., Huang, Dehua, Green, Mitchell, King, Christopher, Tehrani, Lida, Roppe, Jeffrey R., Chung, Janice, Chapman, Deborah P., Cramer, Merryl, Cosford, Nicholas D.P.

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