IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus by Drennan, S, D'Avola, A, Gao, Y, Weigel, C, Chrysostomou, E, Steele, A J, Zenz, T, Plass, C, Johnson, P W, Williams, A P, Packham, G, Stevenson, F K, Oakes, C C, Forconi, F

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Development and First Validation of a Disease Activity Score for Gout by Scirè, Carlo A., Carrara, Greta, Viroli, Cinzia, Cimmino, Marco A., Taylor, William J., Manara, Maria, Govoni, Marcello, Salaffi, Fausto, Punzi, Leonardo, Montecucco, Carlomaurizio, Matucci‐Cerinic, Marco, Minisola, Giovanni, Ariani, Alarico, Galossi, Alessandra, Lauriti, Ciro, Fracassi, Elena, Idolazzi, Luca, Bardelli, Marco, Selvi, Enrico, Tirri, Enrico, Furini, Federica, Inverardi, Flora, Calabrò, Andrea, Porta, Francesco, Bittelli, Raffaele, Venturino, Francesco, Capsoni, Franco, Prevete, Immacolata, Sebastiani, Giandomenico, Selmi, Carlo, Fabbriciani, Gianluigi, D'Avola, Giovanni, Botticella, Giulia, Serale, Francesca, Seminara, Giulia, D'Alessandro, Giuseppe, Santo, Leonardo, Longato, Lorena, Zaccara, Eleonora, Sinigaglia, Luigi, Atteritano, Marco, Broggini, Marco, Caprioli, Marta, Favero, Marta, Sallì, Salvatore, Scarati, Marco, Parisi, Simone, Malavolta, Nazzarena, Corvaglia, Stefania, Scarpato, Salvatore, Veneto, Vittorio

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High Surface IgM Levels Associate with Shorter Response Duration and Bypass of the BTK Blockade during Ibrutinib Therapy in CLL Patients by Chiodin, Giorgia, Dutton, David, Martino, Enrica Antonia, Drennan, Samantha, Tracy, Ian, Ondrisova, Laura, Henderson, Isla, D'Avola, Annalisa, Pitsillidou, Christina, Mraz, Marek, Johnson, Peter, Duncombe, Andrew, Packham, Graham, Steele, Andrew J, Parker, Helen, Bonfiglio, Silvia, Scarfo, Lydia, Sutton, Lesley-Ann, Ghia, Paolo, Rose-Zerilli, Matthew John Jerome, Strefford, Jonathan C, Stevenson, Freda K., Forconi, Francesco

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High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL by Chiodin, Giorgia, Drennan, Samantha, Martino, Enrica A, Ondrisova, Laura, Henderson, Isla, Del Rio, Luis, Tracy, Ian, D'Avola, Annalisa, Parker, Helen, Bonfiglio, Silvia, Scarfò, Lydia, Sutton, Lesley-Ann, Strefford, Jonathan C, Forster, Jade, Brake, Oliver, Potter, Kathleen N, Sale, Benjamin, Lanham, Stuart, Mraz, Marek, Ghia, Paolo, Stevenson, Freda K, Forconi, Francesco

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The Italian Observational Study on Severe Osteoporosis (ISSO): 24-month results on incidence of fractures and adherence to treatment by Idolazzi, Luca, Maugeri, Domenico, Monti, Salvatore, Massarotti, Marco, Osella, Giangiacomo, Barbagallo, Mario, Del Fiacco, Romano, Silvestri, Sandra

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Regional differences of vitamin D deficiency in rheumatoid arthritis patients in Italy by Rossini, M, D'Avola, G, Muratore, M, Malavolta, N, Silveri, F, Bianchi, G, Frediani, B, Minisola, G, Sorgi, M L, Varenna, M, Foti, R, Tartarelli, G, Orsolini, G, Adami, S

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Osteoporosis treatment and fracture incidence: the ICARO longitudinal study by Adami, S., Isaia, G., Luisetto, G., Minisola, S., Sinigaglia, L., Silvestri, S., Agnusdei, D., Gentilella, R., Nuti, R.

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Estimating the effectiveness of routine asymptomatic PCR testing at different frequencies for the detection of SARS-CoV-2 infections by Hellewell, Joel, Russell, Timothy W, Beale, Rupert, Kelly, Gavin, Houlihan, Catherine, Nastouli, Eleni, Kucharski, Adam J

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Pandemic peak SARS-CoV-2 infection and seroconversion rates in London frontline health-care workers by Houlihan, Catherine F, Kelly, Gavin, Spyer, Moira J, Nastouli, Eleni, Allen, Zoe, Ambrose, Karen, Barns-Jenkins, Caitlin, Basu, Souradeep, Buck, Michael D, Cardoso, Ana, Carter, Nick, Carvalho, Luiz, Chen, Qu, Churchward, Laura, Cottrell, Sally, Davison, Dara, Debaisieux, Solene, Diaz-Romero, Monica, Diring, Jessica, Driscoll, Paul C, Edwards, Amelia, Evangelopoulos, Dimitrios, Ferron, Aaron, Fitz, Dan, Fleming, James, Gaiba, Alessandra, Goldstone, Robert, Halldorsson, Steinar, Hoskins, Beth, Houlihan, Catherine F, Hoyle, Jacqueline, Htun, Mint R, Hubank, Michael, Hughes, Deborah, Instrell, Rachael, Jamal-Hanjani, Mariam, Johnson, Mark, Kotzampaltiris, Paul, Kousis, Konstantinos, Kucharska, Ania, Lee, Stacey-Ann, Lu, Wei-Ting, MacRae, James I, McCoy, Laura E, Minutti, Carlos M, Molina-Arcas, Miriam, Moore, David, Moraiti, Anastasia, Nutan, Savita, Oedekoven, Caroline, O'Neill, Olga, Osborne, Neil, Papayannopoulos, Venizelos, Patel, Yogen, Paun, Oana, Perez Caballero, Ana, Perez-Lloret, Jimena, Pollitt, Marc, Shah Punatar, Rajvee, Ramaprasad, Abhinay, Richardson, Kayleigh, Ridewood, Sophie, Rossi, Alice, Rowan, Andrew, Sahai, Erik, Sawyer, Chelsea, Spyer, Moira J, Steel, Louisa, Strange, Amy, Swanton, Charles, Tautz-Davis, Zoe H, Taylor, Gunes, Toolan-Kerr, Patrick, Torelli, Francesca, Toteva, Tea, Ule, Jernej, Wenman, Catharina, Williams, Matthew J, Wright, Joshua, Xiang, Zheng, Matthews, Rebecca, Severn, Abigail, Michie, Susan, Shahmanesh, Maryam, Lukha, Hinal, Davies, Claudia, Williams, Bethany, Riddell, Andrew, Bartolovic, Kerol, Russell, Emma, Carr, Lotte, Crayton, Elise, Meyer, Carly, Vora, Nina, Stoltenberg, Andrea, Byrne, Tom, Gilson, Richard, Kelly, Gavin, Roberts, Fiona, Hatipoglu, Emine

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Cutaneous Human Papillomaviruses as Recurrence Factor in Actinic Keratoses by Dianzani, C., Pierangeli, A., Chiricozzi, A., Avola, A., Degener, A.M.

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Scalable and robust SARS-CoV-2 testing in an academic center by Aitken, Jim, Ambrose, Karen, Barrell, Sam, Beale, Rupert, Bineva-Todd, Ganka, Biswas, Dhruva, Byrne, Richard, Caidan, Simon, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Crawford, Margaret, Cubitt, Laura, Dearing, Vicky, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Fidanis, Efthymios, Gaiba, Alessandra, Gamblin, Steve, Gandhi, Sonia, Goldman, Jacki, Goldstone, Robert, Grant, Paul R., Greco, Maria, Heaney, Judith, Hindmarsh, Steve, Houlihan, Catherine F., Howell, Michael, Hubank, Michael, Hughes, Deborah, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kirk, Stuart, Kjaer, Svend, Levett, Andrew, Levett, Lisa, Levi, Marcel, Lu, Wei-Ting, MacRae, James I., Matthews, John, McCoy, Laura E., Moore, Catherine, Moore, David, Nastouli, Eleni, Nicod, Jerome, Nightingale, Luke, Olsen, Jessica, O’Reilly, Nicola, Pabari, Amar, Papayannopoulos, Venizelos, Patel, Namita, Peat, Nigel, Pollitt, Marc, Ratcliffe, Peter, Reis e Sousa, Caetano, Rosa, Annachiara, Rosenthal, Rachel, Roustan, Chloe, Rowan, Andrew, Shin, Gee Yen, Snell, Daniel M., Song, Ok-Ryul, Spyer, Moira J., Strange, Amy, Swanton, Charles, Turner, James M. A., Turner, Melanie, Wack, Andreas, Walker, Philip A., Ward, Sophia, Wong, Wai Keong, Wright, Joshua, Wu, Mary

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OC.04.6 FECAL AND MUCOSAL MICROBIOTA PROFILING IN IRRITABLE BOWEL SYNDROME AND INFLAMMATORY BOWEL DISEASE: A FOCUS ON AKKERMANSIA MUCINIPHILA by Lo Presti, A., Zorzi, F., Del Chierico, F., Altomare, A., Cocca, S., Avola, A., Cella, E., Calabrese, E., Biancone, L., Monteleone, G., Cicala, M., Angeletti, S., Ciccozzi, M., Putignani, L., Guarino, M.P.L.

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Clinical outcomes of COVID-19 in long-term care facilities for people with epilepsy by Balestrini, Simona, Anders-Cannon, Jonny, Silvennoinen, Katri, Zagaglia, Sara, Pardington, Rosemarie, Ambrose, Karen, Avola, Alida, Barr, Genevieve, Bineva-Todd, Ganka, Bonnet, Dominique, Buck, Michael D., Busby, Louise, Byott, Matthew, Caidan, Simon, Carvalho, Luiz, Chandler, Natalie, Clayton, Bobbi, Collins, Zena, Cullup, Tom, Davies, Heledd, Davis, Patrick, Diaz-Romero, Monica, D'Avola, Annalisa, Edwards, Amelia, Faraway, Rupert, Fleming, James, Frederico, Bruno, Gaul, Liam, Goldman, Jacki, Goldstone, Robert, Grant, Paul R., Guedan, Anabel, Hall, Ross, Harris, Suzanne, Heaney, Judith, Hirani, Rajnika, Hope, Joshua, Howell, Michael, Howitt, Louise, Htun, Mint R., Hughes, Jane, Jenkins, Lucy, Kanu, Nnennaya, Kjaer, Svend, Knuepfer, Ellen, Lappin, Michelle, Marczak, Julie A., Martensson, Mimmi, Matthews, John, McCall, Samuel, Minutti, Carlos M., Montaner, Beatriz, Moore, Catherine, Moreira-Teixeira, Lucia, Naceur-Lombardelli, Cristina, Nelson, Aileen, Nicod, Jerome, Nightingale, Luke, Nofal, Stephanie, O'Reilly, Nicola, Patel, Namita, Patel, Yogen, Caballero, Ana Perez, Perrault, Magali S., Prieto-Godino, Lucia, Proust, Alize, Puvirajasinghe, Clinda, Queval, Christophe, Roberts, Fiona, Rodgers, Angela, Romero Clavijo, Pablo, Roustan, Chloe, Rowan, Andrew, Sait, Aaron, Sala, Katarzyna, Sanchez, Emilie, Santucci, Pierre, Sardar, Fatima, Shahmanesh, Maryam, Spyer, Moira J., Steel, Louisa, Sullivan, Adrienne E., Tautz-Davis, Zoe H., Taylor, Gunes, Taylor, Harriet B., Torelli, Francesca, Treeck, Moritz, Tsai, Ming-Han C., Venkatesan, Subramanian, Wang, Yiran, Wenman, Catharina, Williams, Luke, Williams, Matthew J., Zecchin, Davide, Zillwood, Rachel, Sisodiya, Sanjay M., Norris, Sarah, Rugg-Gunn, Fergus, Shaya, Gabriel, Singh, Priyanka

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Author Correction: Scalable and robust SARS-CoV-2 testing in an academic center by Aitken, Jim, Ambrose, Karen, Barrell, Sam, Beale, Rupert, Bineva-Todd, Ganka, Biswas, Dhruva, Byrne, Richard, Caidan, Simon, Cherepanov, Peter, Churchward, Laura, Clark, Graham, Crawford, Margaret, Cubitt, Laura, Dearing, Vicky, Earl, Christopher, Edwards, Amelia, Ekin, Chris, Fidanis, Efthymios, Gaiba, Alessandra, Gamblin, Steve, Gandhi, Sonia, Goldman, Jacki, Goldstone, Robert, Grant, Paul R., Greco, Maria, Heaney, Judith, Hindmarsh, Steve, Houlihan, Catherine F., Howell, Michael, Hubank, Michael, Hughes, Deborah, Instrell, Rachael, Jackson, Deborah, Jamal-Hanjani, Mariam, Jiang, Ming, Johnson, Mark, Jones, Leigh, Kanu, Nnennaya, Kassiotis, George, Kirk, Stuart, Kjaer, Svend, Levett, Andrew, Levett, Lisa, Levi, Marcel, Lu, Wei-Ting, MacRae, James I., Matthews, John, McCoy, Laura E., Moore, Catherine, Moore, David, Nastouli, Eleni, Nicod, Jerome, Nightingale, Luke, Olsen, Jessica, O’Reilly, Nicola, Pabari, Amar, Papayannopoulos, Venizelos, Patel, Namita, Peat, Nigel, Pollitt, Marc, Ratcliffe, Peter, Reis e Sousa, Caetano, Rosa, Annachiara, Rosenthal, Rachel, Roustan, Chloe, Rowan, Andrew, Shin, Gee Yen, Snell, Daniel M., Song, Ok-Ryul, Spyer, Moira J., Strange, Amy, Swanton, Charles, Turner, James M. A., Turner, Melanie, Wack, Andreas, Walker, Philip A., Ward, Sophia, Wong, Wai Keong, Wright, Joshua, Wu, Mary

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S844 KDM5 INHIBITION OFFERS A NOVEL THERAPEUTIC STRATEGY FOR THE TREATMENT OF KMT2D MUTANT LYMPHOMAS by Heward, J., Koniali, L., D’Avola, A., Close, K., Yeomans, A., Johnson, P., Okosun, J., Neve, R., Gribben, J., Oppermann, U., Packham, G., Fitzgibbon, J.

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Phase I open label liver-directed gene therapy clinical trial for acute intermittent porphyria by D’Avola, Delia, López-Franco, Esperanza, Sangro, Bruno, Pañeda, Astrid, Grossios, Nadina, Gil-Farina, Irene, Benito, Alberto, Twisk, Jaap, Paz, María, Ruiz, Juan, Schmidt, Manfred, Petry, Harald, Harper, Pauline, de Salamanca, Rafael Enríquez, Fontanellas, Antonio, Prieto, Jesús, González-Aseguinolaza, Gloria

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Recombinant AAV Integration Is Not Associated With Hepatic Genotoxicity in Nonhuman Primates and Patients by Gil-Farina, Irene, Fronza, Raffaele, Kaeppel, Christine, Lopez-Franco, Esperanza, Ferreira, Valerie, D'Avola, Delia, Benito, Alberto, Prieto, Jesus, Petry, Harald, Gonzalez-Aseguinolaza, Gloria, Schmidt, Manfred

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The importance of liver functional reserve in the non-surgical treatment of hepatocellular carcinoma by D’Avola, Delia, Granito, Alessandro, Torre-Aláez, Manuel de la, Piscaglia, Fabio

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Mutations in circulating tumor DNA predict primary resistance to systemic therapies in advanced hepatocellular carcinoma by von Felden, Johann, Craig, Amanda J., Garcia-Lezana, Teresa, Labgaa, Ismail, Haber, Philipp K., D’Avola, Delia, Asgharpour, Amon, Dieterich, Douglas, Bonaccorso, Antoinette, Torres-Martin, Miguel, Sia, Daniela, Sung, Max W., Tabrizian, Parissa, Schwartz, Myron, Llovet, Josep M., Villanueva, Augusto

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Intratumoral heterogeneity and clonal evolution in liver cancer by Losic, Bojan, Craig, Amanda J., Villacorta-Martin, Carlos, Martins-Filho, Sebastiao N., Akers, Nicholas, Chen, Xintong, Ahsen, Mehmet E., von Felden, Johann, Labgaa, Ismail, DʹAvola, Delia, Allette, Kimaada, Lira, Sergio A., Furtado, Glaucia C., Garcia-Lezana, Teresa, Restrepo, Paula, Stueck, Ashley, Ward, Stephen C., Fiel, Maria I., Hiotis, Spiros P., Gunasekaran, Ganesh, Sia, Daniela, Schadt, Eric E., Sebra, Robert, Schwartz, Myron, Llovet, Josep M., Thung, Swan, Stolovitzky, Gustavo, Villanueva, Augusto

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