Abstract 5621: Single-walled carbon nanotubes for delivery of siRNA: Antitumor efficacy comparing formulated complexes in EGFR overexpressing A431 xenografts by Kirkpatrick, D. Lynn, Gliko, Olga, Weiss, Michelle, Owusu, Iris, Naumov, Anton

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Abstract 1975: PHuDock®, a computational discovery and development platform for novel PH domain-binding agents, identifies a novel antitumor AKT/PDPK1 inhibitor, PHT- 427 by Zhang, Shuxing, Meuillet, Emmanuelle, Powis, Garth, Kirkpatrick, D. Lynn

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Abstract 4481: Topical application of the dual PDPK1/AKT inhibitor PHT-427 inhibits signaling and growth of human breast cancer cutaneous metastases in mice by Kirkpatrick, D. Lynn, Johnson, Jenny L.H., Lemos, Robert, Abdelemelek, Mena, Ihle, Nathan, Powis, Garth

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Mechanisms of Inhibition of the Thioredoxin Growth Factor System by Antitumor 2-Imidazolyl Disulfides by Kirkpatrick, D.Lynn, Kuperus, Miles, Dowdeswell, Marla, Potier, Noelle, Donald, Lynda J, Kunkel, Mark, Berggren, Margareta, Angulo, Miguel, Powis, Garth

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Thioredoxin redox control of cell growth and death and the effects of inhibitors by Powis, Garth, Kirkpatrick, D.Lynn, Angulo, Miguel, Baker, Amanda

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Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 while oncogenic Ras is a dominant predictor for resistance by Ihle, NathanT, Lemos, Robert, Wipf, Peter, Yacoub, Adly, Mitchell, Clint, Siwak, Doris, Mills, Gordon B., Dent, Paul, Kirkpatrick, D Lynn, Powis, Garth

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Molecular pharmacology and antitumor activity of PHT-427 a novel AKT/PDPK1 pleckstrin homology domain inhibitor by Meuillet, Emmanuelle J., Zuohe, Song, Lemos, Robert, Ihle, Nathan, Kingston, John, Watkins, Ryan, Moses, Sylvestor A., Zhang, Shuxing, Cuny, Lei Du, Herbst, Roy, Jacoby, Jörg J., Zhou, Li Li, Ahad, Ali M., Mash, Eugene A, Kirkpatrick, D Lynn, Powis, Garth

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Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha by Koh, Mei Y, Spivak-Kroizman, Taly, Venturini, Sara, Welsh, Sarah, Williams, Ryan R, Kirkpatrick, D Lynn, Powis, Garth

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Evaluation of nafamostat mesylate safety and inhibition of SARS-CoV-2 replication using a 3-dimensional human airway epithelia model by Kirkpatrick, D Lynn, Millard, Jeffrey

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The phosphoinositide-3-kinase inhibitor PX-866 overcomes resistance to the EGFR inhibitor gefitinib in A-549 human non small cell lung cancer xenografts by Ihle, Nathan T., Paine-Murrieta, Gillian, Berggren, Margareta I., Baker, Amanda, Tate, Wendy R., Wipf, Peter, Abraham, Robert T., Kirkpatrick, D. Lynn, Powis, Garth

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The thioredoxin redox inhibitors 1-methylpropyl 2-imidazolyl disulfide and pleurotin inhibit hypoxia-induced factor 1alpha and vascular endothelial growth factor formation by Welsh, Sarah J, Williams, Ryan R, Birmingham, Anne, Newman, David J, Kirkpatrick, D Lynn, Powis, Garth

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Modification of antitumor disulfide cytotoxicity by glutathione depletion in murine cells by KIRKPATRICK, D. L

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(o- and p-Nitrobenzyloxycarbonyl)-5-fluorouracil derivatives as potential conjugated bioreductive alkylating agents by Lin, Tai Shun, Wang, Lin, Antonini, Ippolito, Cosby, Lucille A, Shiba, David A, Kirkpatrick, D. Lynn, Sartorelli, Alan C

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High-performance liquid chromatographic method for the separation of chlorambucil and its N-oxide prodrug by Chandler, Katherine J., McCabe, James B., Kirkpatrick, D.Lynn

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Pediatric Cardiology Provider Attitudes About Palliative Care: A Multicenter Survey Study by Balkin, Emily Morell, Kirkpatrick, James N., Kaufman, Beth, Swetz, Keith M., Sleeper, Lynn A., Wolfe, Joanne, Blume, Elizabeth D.

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Factors associated with methamphetamine withdrawal symptoms among people who inject drugs by Zhao, Johnathan, Kral, Alex H., Simpson, Kelsey A., Ceasar, Rachel Carmen, Wenger, Lynn D., Kirkpatrick, Matt, Bluthenthal, Ricky N.

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Abbreviated closure for remote damage control laparotomy in extreme environments: A randomized trial of sutures versus wound clamps comparing terrestrial and weightless conditions by Kirkpatrick, Andrew W., Major, McKee, Jessica Lynn, MSc, Tien, Colonel Homer, CD MD FRCSC, LaPorta, Anthony J., Colonel (Ret), Lavell, Kit, DFC, Leslie, Tim, MSc, McBeth, Paul B., MD FRCSC, Roberts, Derek J., MD PhD, Ball, Chad G., MD MSC FRCSC FACS

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Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling by Ihle, Nathan T, Williams, Ryan, Chow, Sherry, Chew, Wade, Berggren, Margareta I, Paine-Murrieta, Gillian, Minion, Daniel J, Halter, Robert J, Wipf, Peter, Abraham, Robert, Kirkpatrick, Lynn, Powis, Garth

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randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination by Ramanathan, Ramesh K, Abbruzzese, James, Dragovich, Tomislav, Kirkpatrick, Lynn, Guillen, Jose M, Baker, Amanda F, Pestano, Linda A, Green, Sylvan, Von Hoff, Daniel D

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Abstract 1736: A novel Mer tyrosine kinase inhibitor mediates increased cell killing in combination with FGFR inhibition by Newton, Timothy P., Cummings, Christopher T., Kirkpatrick, Gregory D., Hinz, Trista K., DeRyckere, Deborah, Zhang, Weihe, Wang, Xiaodong, Frye, Stephen, Earp, H. Shelton, Heasley, Lynn, Graham, Douglas K.

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