Mesothelin-specific CAR-T cell therapy that incorporates an HLA-gated safety mechanism selectively kills tumor cells by Tokatlian, Talar, Asuelime, Grace E, Mock, Jee-Young, DiAndreth, Breanna, Sharma, Shruti, Toledo Warshaviak, Dora, Daris, Mark E, Bolanos, Kristian, Luna, Breanna L, Naradikian, Martin S, Deshmukh, Kiran, Hamburger, Agnes E, Kamb, Alexander

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Engineered T cells directed at tumors with defined allelic loss by Hamburger, Agnes E., DiAndreth, Breanna, Cui, Jiajia, Daris, Mark E., Munguia, Melanie L., Deshmukh, Kiran, Mock, Jee-Young, Asuelime, Grace E., Lim, Emily D., Kreke, Michelle R., Tokatlian, Talar, Kamb, Alexander

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Structure-function relationships of chimeric antigen receptors in acute T cell responses to antigen by Xu, Han, Hamburger, Agnes E., Mock, Jee-Young, Wang, Xueyin, Martin, Aaron D., Tokatlian, Talar, Oh, Julyun, Daris, Mark E., Negri, Kathleen R., Gabrelow, Grant B., Wu, Ming Lun, Nampe, Daniel P., Asuelime, Grace E., McElvain, Michele E., Sandberg, Mark L., Kamb, Alexander

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Design of TCR Structural Variants That Retain or Invert the Normal Activation Signal by Mock, Jee-Young, Oh, Julyun, Yi, Jason, Daris, Mark E., Hamburger, Agnes, Kamb, Alexander

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Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells by Spahr, Christopher S, Daris, Mark E, Graham, Kevin C, Soriano, Brian D, Stevens, Jennitte L, Shi, Stone D-H

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Chimeric Antigen Receptors Directed at Mutant KRAS Exhibit an Inverse Relationship Between Functional Potency and Neoantigen Selectivity by Tokatlian, Talar, Asuelime, Grace E, Naradikian, Martin S, Mock, Jee-Young, Daris, Mark E, Martin, Aaron D, Toledo Warshaviak, Dora, Kamb, Alexander, Hamburger, Agnes E

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Novel CAR T Modules (Tmod) to Target HLA-Class I Loss in Lymphoma by Hamburger, Agnes E., DiAndreth, Breanna, Daris, Mark E., Munguia, Melanie L., Deshmukh, Kiran, Mock, Jee-Young, Asuelime, Grace E., Lim, Emily D., Kreke, Michelle R., Tokatlian, Talar, Maloney, David, Go, William Y., Kamb, Alexander

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Discovery, characterization, and remediation of a C-terminal Fc-extension in proteins expressed in CHO cells by Spahr, Christopher S., Daris, Mark E., Graham, Kevin C., Soriano, Brian D., Stevens, Jennitte L., Shi, Stone D.-H.

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Dickkopf‐1 regulates bone formation in young growing rodents and upon traumatic injury by Li, Xiaodong, Grisanti, Mario, Fan, Wei, Asuncion, Frank J, Tan, Hong‐Lin, Dwyer, Denise, Han, Chun‐Ya, Yu, Longchuan, Lee, Jae, Lee, Edward, Barrero, Mauricio, Kurimoto, Pam, Niu, Qing‐Tian, Geng, Zhaopo, Winters, Aaron, Horan, Tom, Steavenson, Shirley, Jacobsen, Frederick, Chen, Qing, Haldankar, Raj, Lavallee, Jennifer, Tipton, Barbara, Daris, Mark, Sheng, Jackie, Lu, Hsieng S, Daris, Kristi, Deshpande, Rohini, Valente, Eliane G, Salimi‐Moosavi, Hossein, Kostenuik, Paul J, Li, Ji, Liu, Min, Li, Chaoyang, Lacey, David L, Simonet, W Scott, Ke, Hua Zhu, Babij, Philip, Stolina, Marina, Ominsky, Michael S, Richards, William G

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Geometric parameters that affect the behavior of logic-gated CAR T cells by Partin, Alexander C, Bruno, Richele, Shafaattalab, Sanam, Vander Mause, Erica, Winters, Aaron, Daris, Mark, Gahrs, Casey, Jette, Claudia A, DiAndreth, Breanna, Sandberg, Mark L, Hamburger, Agnes E, Kamb, Alexander, Riley, Timothy P

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proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates by Chan, Joyce C.Y, Piper, Derek E, Cao, Qiong, Liu, Dongming, King, Chadwick, Wang, Wei, Tang, Jie, Liu, Qiang, Higbee, Jared, Xia, Zhen, Di, Yongmei, Shetterly, Susan, Arimura, Ziva, Salomonis, Heather, Romanow, William G, Thibault, Stephen T, Zhang, Richard, Cao, Ping, Yang, Xiao-Ping, Yu, Timothy, Lu, Mei, Retter, Marc W, Kwon, Gayle, Henne, Kirk, Pan, Oscar, Tsai, Mei-Mei, Fuchslocher, Bryna, Yang, Evelyn, Zhou, Lei, Lee, Ki Jeong, Daris, Mark, Sheng, Jackie, Wang, Yan, Shen, Wenyan D, Yeh, Wen-Chen, Emery, Maurice, Walker, Nigel P.C, Shan, Bei, Schwarz, Margrit, Jackson, Simon M

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Abstract 2751: The modular Tmod dual_receptor system exploits tumor deletions to achieve robust tumor-selective cytotoxicity by Xu, Han, Hamburger, Agnes, Ando, Yuta, Asuelime, Grace, Bolanos, Kristian, Daris, Mark, DiAndreth, Breanna, Imun, Maria C., Lee, Wen-Hua, Li, Chuck Z., Luna, Breanna, Manry, Diane, Martin, Aaron D., McElvain, Michele E., Mock, Jee-Young, Naradikian, Martin, Sandberg, Mark L., Oh, Julyun, Shafaattalab, Sanam, Sharma, Shruti, Tokatlian, Talar, Wang, Xueyin, Wong, Lu Min, Kamb, Alexander

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Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1 H-indol-5-yl)-ethyl acrylamides by Wu, Yong-Jin, Sun, Li-Qiang, He, Huan, Chen, Jie, Starrett, John E, Dextraze, Pierre, Daris, Jean-Paul, Boissard, Christopher G, Pieschl, Rick L, Gribkoff, Valentin K, Natale, Joanne, Knox, Ronald J, Harden, David G, Thompson, Mark W, Fitzpatrick, William, Weaver, David, Wu, Dedong, Gao, Qi, Dworetzky, Steven I

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Synthesis and KCNQ2 opener activity of N-1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides by WU, Yong-Jin, SUN, Li-Qiang, NATALE, Joanne, KNOX, Ronald J, HARDEN, David G, THOMPSON, Mark W, FITZPATRICK, William, WEAVER, David, DEDONG WU, QI GAO, DWORETZKY, Steven I, HUAN HE, JIE CHEN, STARRETT, John E, DEXTRAZE, Pierre, DARIS, Jean-Paul, BOISSARD, Christopher G, PIESCHL, Rick L, GRIBKOFF, Valentin K

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