Preclinical evaluation of the simultaneous inhibition of MCL-1 and BCL-2 with the combination of S63845 and venetoclax in multiple myeloma by Algarín, Esperanza M, Díaz-Tejedor, Andrea, Mogollón, Pedro, Hernández-García, Susana, Corchete, Luis A, San-Segundo, Laura, Martín-Sánchez, Montserrat, González-Méndez, Lorena, Schoumacher, Marie, Banquet, Sebastien, Kraus-Berthier, Laurence, Kloos, Ioana, Derreal, Alix, Halilovic, Ensar, Maacke, Heiko, Gutiérrez, Norma C, Mateos, María-Victoria, Paíno, Teresa, Garayoa, Mercedes, Ocio, Enrique M

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Combination Therapy of FLT3 Tyrosine Kinase Inhibitors and BH3 Mimetics Targeting Antiapoptotic MCL-1 Synergistically Eliminates FLT3-ITD Acute Myeloid Leukemia Cells in Vitro and... by Skwarska, Anna, Moujalled, Donia M, Panis, Paul F, Patel, Shraddha, Zhang, Qi, Herbrich, Shelley, Kurvilla, Vinitha, Baran, Natalia, Pomilio, Giovanna, Halilovic, Ensar, Mistry, Prakash, Ruvolo, Vivian, Ruvolo, Peter P., Derréal, Alix, Banquet, Sebastien, Niemira, Magdalena, Kretowski, Adam, Daver, Naval, Andreeff, Michael, Wei, Andrew H., Konopleva, Marina

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Cytokine-like protein 1–induced survival of monocytes suggests a combined strategy targeting MCL1 and MAPK in CMML by Sevin, Margaux, Debeurme, Franck, Laplane, Lucie, Badel, Séverine, Morabito, Margot, Newman, Hanna L., Torres-Martin, Miguel, Yang, Qin, Badaoui, Bouchra, Wagner-Ballon, Orianne, Saada, Véronique, Sélimoglu-Buet, Dorothée, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Fenaux, Pierre, Itzykson, Raphael, Braun, Thorsten, Etienne, Gabriel, Berthon, Celine, Thépot, Sylvain, Kepp, Oliver, Kroemer, Guido, Padron, Eric, Figueroa, Maria E., Droin, Nathalie, Solary, Eric

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Abstract 257: Targeting AML through apoptosis activation using Bcl-2/Mcl-1 or Bcl-2/Hdm2 inhibitor combination therapies by Wang, Youzhen, Qui, Shumei, Sanghavi, Sneha, Mulford, Iain, Lysiak, Gaëlle, Chanrion, Maïa, Mistry, Prakash, Pfaar, Ulrike, Schoumacher, Marie, Claperon, Audrey, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Fabre, Claire, Maacke, Heiko, Colland, Frédéric, Geneste, Olivier, Morris, Erick, Halilovic, Ensar

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Abstract 4477: MIK665/S64315, a novel Mcl-1 inhibitor, in combination with Bcl-2 inhibitors exhibits strong synergistic antitumor activity in a range of hematologic malignancies by Halilovic, Ensar, Chanrion, Maïa, Mistry, Prakash, Wartmann, Markus, Qiu, Shumei, Sanghavi, Sneha, Chen, Yan, Lysiak, Gaëlle, Maragno, Ana Leticia, Pfaar, Ulrike, Huth, Felix, Schoumacher, Marie, Claperon, Audrey, Kraus-Berthier, Laurence, Banquet, Sébastien, Derreal, Alix, Maacke, Heiko, Colland, Frédéric, Geneste, Olivier, Morris, Erick, Wang, Youzhen

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Abstract 4482: S64315 (MIK665) is a potent and selective Mcl1 inhibitor with strong antitumor activity across a diverse range of hematologic tumor models by Maragno, Ana Leticia, Mistry, Prakash, Kotschy, András, Szlavik, Zoltán, Murray, James, Davidson, James, Toumelin-Braizat, Gaëtane Le, Chanrion, Maïa, Bruno, Alain, Claperon, Audrey, Maacke, Heiko, Morris, Erick, Wang, Youzhen, Derreal, Alix, Csekei, Márton, Paczal, Attila, Szabo, Zoltán, Sipos, Szabolcs, Proszenyak, Agnes, Balint, Balázs, Surgenor, Allan, Dokurno, Pawel, Matassova, Natalia, Chen, Ijen, Lysiak-Auvity, Gaëlle, Girard, Anne-Marie, Grave, Fabienne, Colland, Frédéric, Halilovic, Ensar, Geneste, Olivier

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Synergistic Activity of the MCL-1 Inhibitor S63845 with Midostaurin in Preclinical Human Models of FLT3-ITD Mutated Acute Myeloid Leukemia (AML) by Skwarska, Anna, Panis, Paul, Zhang, Qi, Herbrich, Shelley, Kurvilla, Vinitha M., Baran, Natalia, Halilovic, Ensar, Ruvolo, Peter, Ruvolo, Vivian, Morris, Erick, Wei, Andrew, Moujalled, Donia, Derreal, Alix, Banquet, Sebastien, Andreeff, Michael, Konopleva, Marina

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