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Crystal structure of human AKT1 with an allosteric inhibitor reveals a new mode of kinase inhibition
by
Wu, Wen-I
,
Voegtli, Walter C
,
Sturgis, Hillary L
,
Dizon, Faith P
,
Vigers, Guy P A
,
Brandhuber, Barbara J
Published in
PloS one
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Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors
by
Bencsik, Josef R.
,
Xiao, Dengming
,
Blake, James F.
,
Kallan, Nicholas C.
,
Mitchell, Ian S.
,
Spencer, Keith L.
,
Xu, Rui
,
Gloor, Susan L.
,
Martinson, Matthew
,
Risom, Tyler
,
Woessner, Richard D.
,
Dizon, Faith
,
Wu, Wen-I
,
Vigers, Guy P.A.
,
Brandhuber, Barbara J.
,
Skelton, Nicholas J.
,
Prior, Wei Wei
,
Murray, Lesley J.
Published in
Bioorganic & medicinal chemistry letters
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Bioorganic & Medicinal Chemistry Letters
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Plos One
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Subjects
Akt Protein
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Binding Sites
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Proto-Oncogene Proteins C-Akt - Antagonists & Inhibitors
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Science & Technology
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Akt
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Akt1 Protein
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Allosteric Properties
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Allosteric Regulation
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Amino Acid Sequence
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Animals
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Antineoplastic Agents
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Biochemistry
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Biochemistry/Biomacromolecule-Ligand Interactions
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Biochemistry/Cell Signaling And Trafficking Structures
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Cancer Treatment
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Backfile Package - Organic Chemistry (Legacy) [Yco]
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