Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury by Wolenski, Francis S, Zhu, Andy Z X, Johnson, Mike, Yu, Shaoxia, Moriya, Yuu, Ebihara, Takuya, Csizmadia, Vilmos, Grieves, Jessica, Paton, Martin, Liao, Mingxiang, Gemski, Christopher, Pan, Liping, Vakilynejad, Majid, Dragan, Yvonne P, Chowdhury, Swapan K, Kirby, Patrick J

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Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS by Sun, Jinchun, Schnackenberg, Laura K., Holland, Ricky D., Schmitt, Thomas C., Cantor, Glenn H., Dragan, Yvonne P., Beger, Richard D.

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Mode of Action in Relevance of Rodent Liver Tumors to Human Cancer Risk by Holsapple, Michael P., Pitot, Henri C., Cohen, Samuel H., Boobis, Alan R., Klaunig, James E., Pastoor, Timothy, Dellarco, Vicki L., Dragan, Yvonne P.

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Current Therapeutic Landscape and Safety Roadmap for Targeting the Aryl Hydrocarbon Receptor in Inflammatory Gastrointestinal Indications by Faber, Samantha C, Lahoti, Tejas S, Taylor, Ewan R, Lewis, Lauren, Sapiro, Jessica M, Toledo Sales, Vicencia, Dragan, Yvonne P, Jeffy, Brandon D

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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury by Longo, Diane M, Woodhead, Jeffrey L, Walker, Paul, Herédi-Szabó, Krisztina, Mogyorósi, Károly, Wolenski, Francis S, Dragan, Yvonne P, Mosedale, Merrie, Siler, Scott Q, Watkins, Paul B, Howell, Brett A

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New phenotypic cytotoxicity assay for ROS-inducing compounds using rat renal epithelial cells by Uchiyama, Noriko, Yukawa, Tomoya, Dragan, Yvonne P., Wagoner, Matthew P., Naven, Russell T.

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Rat toxicogenomic study reveals analytical consistency across microarray platforms by Guo, Lei, Shi, Leming, Lobenhofer, Edward K, Wang, Charles, Shippy, Richard, Harris, Stephen C, Zhang, Lu, Mei, Nan, Chen, Tao, Herman, Damir, Goodsaid, Federico M, Hurban, Patrick, Phillips, Kenneth L, Xu, Jun, Deng, Xutao, Sun, Yongming Andrew, Tong, Weida, Dragan, Yvonne P

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Assessment of a 3D neural spheroid model to detect pharmaceutical-induced neurotoxicity by Wang, Qin, Cohen, Jennifer D, Yukawa, Tomoya, Estrella, Heather, Leonard, Chris, Nunes, Jairo, Choi, Colin, Mishra, Nibha, Lewis, Lauren, Baker, Kevin S, Kuga, Kazuhiro, Dragan, Yvonne P, Wagoner, Matthew P

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Cellular impedance assays for predictive preclinical drug screening of kinase inhibitor cardiovascular toxicity by Lamore, Sarah D, Kamendi, Harriet W, Scott, Clay W, Dragan, Yvonne P, Peters, Matthew F

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What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments? by Goodman, Jay I, Augustine, Karen A, Cunnningham, Michael L, Dixon, Darlene, Dragan, Yvonne P, Falls, James Greg, Rasoulpour, Reza J, Sills, Robert C, Storer, Richard D, Wolf, Douglas C, Pettit, Syril D

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Development of dietary soluble fibres by enzymatic synthesis and assessment of their digestibility in in vitro, animal and randomised clinical trial models by Hasselwander, Oliver, DiCosimo, Robert, You, Zheng, Cheng, Qiong, Rothman, Steven C., Suwannakham, Supaporn, Baer, Zachary C., Roesch, Brian M., Ruebling-Jass, Kristin D., Lai, Jian Ping, Hurteau, Richard E., Marquez, Mario L., Kopatsis, Alexander D., Ouwehand, Arthur C., Forssten, Sofia D., Mukerji, Pushkor, Caverly Rae, Jessica M., Dragan, Yvonne P., Damewood, James R., Tiihonen, Kirsti, Ibarra, Alvin

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Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor alpha agonists by Guo, Lei, Fang, Hong, Collins, Jim, Fan, Xiao-hui, Dial, Stacey, Wong, Alex, Mehta, Kshama, Blann, Ernice, Shi, Leming, Tong, Weida, Dragan, Yvonne P

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Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR gamma agonists on rat primary hepatocytes and human HepG2 cells by Guo, Lei, Zhang, Lu, Sun, Yongming, Muskhelishvili, Levan, Blann, Ernice, Dial, Stacey, Shi, Leming, Schroth, Gary, Dragan, Yvonne P

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Implications of apoptosis for toxicity, carcinogenicity, and risk assessment : Fumonisin B1 as an example by DRAGAN, Yvonne P, BIDLACK, Wayne R, COHEN, Samuel M, GOLDSWORTHY, Thomas L, HARD, Gordon C, HOWARD, Paul C, RILEY, Ronald T, VOSS, Kenneth A

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Evaluation of NMR spectral data of urine in conjunction with measured clinical chemistry and histopathology parameters to assess the effects of liver and kidney toxicants by Schnackenberg, Laura K, Dragan, Yvonne P, Reily, Michael D, Robertson, Donald G, Beger, Richard D

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The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements by Shi, Leming, Reid, Laura H, Jones, Wendell D, Shippy, Richard, Warrington, Janet A, Baker, Shawn C, Collins, Patrick J, de Longueville, Francoise, Kawasaki, Ernest S, Lee, Kathleen Y, Luo, Yuling, Sun, Yongming Andrew, Willey, James C, Setterquist, Robert A, Fischer, Gavin M, Tong, Weida, Dragan, Yvonne P, Dix, David J, Frueh, Felix W, Goodsaid, Frederico M, Herman, Damir, Jensen, Roderick V, Johnson, Charles D, Lobenhofer, Edward K, Puri, Raj K, Schrf, Uwe, Thierry-Mieg, Jean, Wang, Charles, Wilson, Mike, Wolber, Paul K, Zhang, Lu, Amur, Shashi, Bao, Wenjun, Barbacioru, Catalin C, Lucas, Anne Bergstrom, Bertholet, Vincent, Boysen, Cecilie, Bromley, Bud, Brown, Donna, Brunner, Alan, Canales, Roger, Cao, Xiaoxi Megan, Cebula, Thomas A, Chen, James J, Cheng, Jing, Chu, Tzu-Ming, Chudin, Eugene, Corson, John, Corton, J Christopher, Croner, Lisa J, Davies, Christopher, Davison, Timothy S, Delenstarr, Glenda, Deng, Xutao, Dorris, David, Eklund, Aron C, Fan, Xiao-hui, Fang, Hong, Fulmer-Smentek, Stephanie, Fuscoe, James C, Gallagher, Kathryn, Ge, Weigong, Guo, Lei, Guo, Xu, Hager, Janet, Haje, Paul K, Han, Jing, Han, Tao, Harbottle, Heather C, Harris, Stephen C, Hatchwell, Eli, Hauser, Craig A, Hester, Susan, Hong, Huixiao, Hurban, Patrick, Jackson, Scott A, Ji, Hanlee, Knight, Charles R, Kuo, Winston P, LeClerc, J Eugene, Levy, Shawn, Li, Quan-Zhen, Liu, Chunmei, Liu, Ying, Lombardi, Michael J, Ma, Yunqing, Magnuson, Scott R, Maqsodi, Botoul, McDaniel, Tim, Mei, Nan, Myklebost, Ola, Ning, Baitang, Novoradovskaya, Natalia, Orr, Michael S, Osborn, Terry W, Papallo, Adam, Patterson, Tucker A, Perkins, Roger G, Peters, Elizabeth H, Peterson, Ron

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Improved cell typing by charge-state deconvolution of matrix-assisted laser desorption/ionization mass spectra by Wilkes, Jon G., Buzatu, Dan A., Dare, Diane J., Dragan, Yvonne P., Chiarelli, M. Paul, Holland, Ricky D., Beaudoin, Michael, Heinze, Thomas M., Nayak, Rajesh, Shvartsburg, Alexandre A.

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Immunohistochemical localization and semi-quantitation of hepatic tamoxifen–DNA adducts in rats exposed orally to tamoxifen by Divi, Rao L., Dragan, Yvonne P., Pitot, Henry C., Poirier, Miriam C.

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Alterations in specific gene expression and focal neoplastic growth during spontaneous hepatocarcinogenesis in albumin-SV40 T antigen transgenic rats by Dragan, Yvonne P., Sargent, Linda M., Babcock, Karlee, Kinunen, Nina, Pitot, Henry C.

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Tamoxifen induces hepatic aneuploidy and mitotic spindle disruption after a single in vivo administration to female Sprague-Dawley rats by SARGENT, L. M, DRAGAN, Y. P, BAHNUB, N, WILEY, J. E, SATTLER, C. A, SCHROEDER, P, SATTLER, G. L, JORDAN, V. C, PITOT, H. C

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