Abstract 2919: Discovery of small-molecule compounds targeting c-MYC using a novel cell-based screen by Mangatt, Biju, Pietra, Anthony D., Waszkiewicz, Anna, Jaworski, Jon-Paul, Ghidelli-Disse, Sonja, Berrodin, Thomas J., Sherk, Christian S., Meinhold, Derrick W., Rutkowska-Klute, Anna, Sundaram, Shanker K., Ganji, Gopinath, Halsey, Wendy S., Livi, George P., Li, William, Mack, James, Romeril, Stuart P., Minthorn, Elisabeth A., Kumar, Rakesh, Drewes, Gerard C., Heerding, Dirk A., Kallal, Lorena A., Buser, Carolyn A., Medina, Jesus R.

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Discovery of I‑BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition by Theodoulou, Natalie H, Bamborough, Paul, Bannister, Andrew J, Becher, Isabelle, Bit, Rino A, Che, Ka Hing, Chung, Chun-wa, Dittmann, Antje, Drewes, Gerard, Drewry, David H, Gordon, Laurie, Grandi, Paola, Leveridge, Melanie, Lindon, Matthew, Michon, Anne-Marie, Molnar, Judit, Robson, Samuel C, Tomkinson, Nicholas C. O, Kouzarides, Tony, Prinjha, Rab K, Humphreys, Philip G

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Click chemistry enables preclinical evaluation of targeted epigenetic therapies by Tyler, Dean S., Vappiani, Johanna, Cañeque, Tatiana, Lam, Enid Y. N., Ward, Aoife, Gilan, Omer, Chan, Yih-Chih, Hienzsch, Antje, Rutkowska, Anna, Werner, Thilo, Wagner, Anne J., Lugo, Dave, Gregory, Richard, Molina, Cesar Ramirez, Garton, Neil, Wellaway, Christopher R., Jackson, Susan, MacPherson, Laura, Figueiredo, Margarida, Stolzenburg, Sabine, Bell, Charles C., House, Colin, Dawson, Sarah-Jane, Hawkins, Edwin D., Drewes, Gerard, Prinjha, Rab K., Rodriguez, Raphaël, Grandi, Paola, Dawson, Mark A.

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Developing resilient supply chains in the Southern African Development Community: Lessons from the impact of COVID-19 by Pretorius, Ockert R., Drewes, Johannes E., Engelbrecht, Willy H., Malan, Gerard C.

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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery by Adams, David, Altucci, Lucia, Amit, Ido, Aparicio, Samuel, Arima, Takahiro, Asnafi, Vahid, Bae, Jae-Bum, Bassler, Kevin, Bilenky, Mikhail, Boehm, Bernhard, Bourque, Guillaume, Brors, Benedikt, Bussemakers, Marion J., Chadwick, Lisa, Chen, Wei, Cheung, Tom H., Choi, Nak Hyen, Chung, Ho-Ryun, Clarke, Laura, Dermitzakis, Manolis, Dylag, Tomasz, Eaves, Connie J., Ebert, Peter, Eils, Jürgen, Enver, Tariq, Ferguson-Smith, Anne, Fitzgibbon, Jude, Flicek, Paul, Fraser, Peter, Gasparoni, Nina, Gasparoni, Gilles, Heath, Simon, Helin, Kristian, Hitz, Benjamin C., Horsthemke, Bernhard, Ip, Nancy Y., Ito, Takashi, Jenuwein, Thomas, Joly, Yann, Kanai, Yae, Kang, Hee Gyung, Kiemer, Alexandra K., Kim, Song Cheol, Kim, Bong-Jo, Lehrach, Hans, Leitão, Elsa, Lengauer, Thomas, Lernmark, Åke, Leung, Gilberto K.K., Leung, Danny, Ma, Yussanne, Martin-Subero, Jose Ignacio, Maschke, Karen, Merten, Christoph, Minucci, Saverio, Mitsuyama, Totai, Moore, Richard A., Nordström, Karl, Norstedt, Irene, Ouellette, Francis, Pap, Thomas, Pelicci, Pier Giuseppe, Phillips, Anthony G., Polansky, Julia, Pospisilik, J. Andrew, Prabhakar, Shyam, Procaccini, Dena C., Radbruch, Andreas, Rajewsky, Nikolaus, Rakyan, Vardham, Richardson, David, Rothstein, Mark, Sasaki, Hiroyuki, Sauer, Sascha, Schmidt, Florian, Schultze, Joachim L., Schulyer, Ronald P., Schulz, Marcel, Siebert, Reiner, Sinha, Anupam, Soranzo, Nicole, Spivakov, Mikhail, Steidl, Christian, Suzuki, Narumi, Torrents, David, Tyson, Frederick L., Ullrich, Sebastian, Ushijima, Toshikazu, Valencia, Alfonso, Wallace, Chris, Weber, Stephanie, Weiler, Nina, Weng, Andrew, Wilder, Steven, Yamashita, Yasuhiro, Yap, Desmond Y., Yip, Kevin Y., Yip, Stephen, Zerbino, Daniel, Zipprich, Gideon

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia by Dawson, Mark A., Prinjha, Rab K., Dittmann, Antje, Giotopoulos, George, Bantscheff, Marcus, Chan, Wai-In, Robson, Samuel C., Chung, Chun-wa, Hopf, Carsten, Savitski, Mikhail M., Huthmacher, Carola, Gudgin, Emma, Lugo, Dave, Beinke, Soren, Chapman, Trevor D., Roberts, Emma J., Soden, Peter E., Auger, Kurt R., Mirguet, Olivier, Doehner, Konstanze, Delwel, Ruud, Burnett, Alan K., Jeffrey, Phillip, Drewes, Gerard, Lee, Kevin, Huntly, Brian J. P., Kouzarides, Tony

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Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis by Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick R. C., Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.

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Correction: Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells by Martino, Julieta, Siri, Sebastián Omar, Calzetta, Nicolás Luis, Paviolo, Natalia Soledad, Garro, Cintia, Pansa, Maria F, Carbajosa, Sofía, Brown, Aaron C, Bocco, José Luis, Gloger, Israel, Drewes, Gerard, Madauss, Kevin P, Soria, Gastón, Gottifredi, Vanesa

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Inhibitors of Rho kinases (ROCK) induce multiple mitotic defects and synthetic lethality in BRCA2-deficient cells by Martino, Julieta, Siri, Sebastián Omar, Calzetta, Nicolás Luis, Paviolo, Natalia Soledad, Garro, Cintia, Pansa, Maria F, Carbajosa, Sofía, Brown, Aaron C, Bocco, José Luis, Gloger, Israel, Drewes, Gerard, Madauss, Kevin P, Soria, Gastón, Gottifredi, Vanesa

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Functional organization of the yeast proteome by systematic analysis of protein complexes by Gavin, Anne-Claude, Superti-Furga, Giulio, Bösche, Markus, Krause, Roland, Grandi, Paola, Marzioch, Martina, Bauer, Andreas, Schultz, Jörg, Rick, Jens M, Michon, Anne-Marie, Cruciat, Cristina-Maria, Remor, Marita, Höfert, Christian, Schelder, Malgorzata, Brajenovic, Miro, Ruffner, Heinz, Merino, Alejandro, Klein, Karin, Hudak, Manuela, Dickson, David, Rudi, Tatjana, Gnau, Volker, Bauch, Angela, Bastuck, Sonja, Huhse, Bettina, Leutwein, Christina, Heurtier, Marie-Anne, Copley, Richard R, Edelmann, Angela, Querfurth, Erich, Rybin, Vladimir, Drewes, Gerard, Raida, Manfred, Bouwmeester, Tewis, Bork, Peer, Seraphin, Bertrand, Kuster, Bernhard, Neubauer, Gitte

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The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages by Arendse, Lauren B, Murithi, James M, Qahash, Tarrick, Pasaje, Charisse Flerida A, Godoy, Luiz C, Dey, Sumanta, Gibhard, Liezl, Ghidelli-Disse, Sonja, Drewes, Gerard, Bantscheff, Marcus, Lafuente-Monasterio, Maria J, Fienberg, Stephen, Wambua, Lynn, Gachuhi, Samuel, Coertzen, Dina, van der Watt, Mariëtte, Reader, Janette, Aswat, Ayesha S, Erlank, Erica, Venter, Nelius, Mittal, Nimisha, Luth, Madeline R, Ottilie, Sabine, Winzeler, Elizabeth A, Koekemoer, Lizette L, Birkholtz, Lyn-Marie, Niles, Jacquin C, Llinás, Manuel, Fidock, David A, Chibale, Kelly

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The structure based design of dual HDAC/BET inhibitors as novel epigenetic probes by Atkinson, Stephen J., Soden, Peter E., Angell, Davina C., Bantscheff, Marcus, Chung, Chun-wa, Giblin, Kathryn A., Smithers, Nicholas, Furze, Rebecca C., Gordon, Laurie, Drewes, Gerard, Rioja, Inmaculada, Witherington, Jason, Parr, Nigel J., Prinjha, Rab K.

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Polo-like Kinase 1 Inhibition as a Therapeutic Approach to Selectively Target BRCA1-Deficient Cancer Cells by Synthetic Lethality Induction by Carbajosa, Sofía, Pansa, María Florencia, Paviolo, Natalia S, Castellaro, Andrés M, Andino, Diego L, Nigra, Ayelén D, García, Iris Alejandra, Racca, Ana C, Rodriguez-Berdini, Lucía, Angiolini, Virginia, Guantay, Laura, Villafañez, Florencia, Federico, María Belén, Rodríguez-Baili, María Celeste, Caputto, Beatriz L, Drewes, Gerard, Madauss, Kevin P, Gloger, Israel, Fernandez, Elmer, Gil, Germán A, Bocco, José Luis, Gottifredi, Vanesa, Soria, Gastón

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Author Correction: Cyclin-dependent kinase 12 is a drug target for visceral leishmaniasis by Wyllie, Susan, Thomas, Michael, Patterson, Stephen, Crouch, Sabrinia, De Rycker, Manu, Lowe, Rhiannon, Gresham, Stephanie, Urbaniak, Michael D., Otto, Thomas D., Stojanovski, Laste, Simeons, Frederick R. C., Manthri, Sujatha, MacLean, Lorna M., Zuccotto, Fabio, Homeyer, Nadine, Pflaumer, Hannah, Boesche, Markus, Sastry, Lalitha, Connolly, Paul, Albrecht, Sebastian, Berriman, Matt, Drewes, Gerard, Gray, David W., Ghidelli-Disse, Sonja, Dixon, Susan, Fiandor, Jose M., Wyatt, Paul G., Ferguson, Michael A. J., Fairlamb, Alan H., Miles, Timothy J., Read, Kevin D., Gilbert, Ian H.

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The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages by Arendse, Lauren B, Murithi, James M, Qahash, Tarrick, Pasaje, Charisse Flerida A, Godoy, Luiz C, Dey, Sumanta, Gibhard, Liezl, Ghidelli-Disse, Sonja, Drewes, Gerard, Bantscheff, Marcus, Lafuente-Monasterio, Maria J, Fienberg, Stephen, Wambua, Lynn, Gachuhi, Samuel, Coertzen, Dina, Van Der Watt, Mariëtte, Reader, Janette, Aswat, Ayesha S, Erlank, Erica, Venter, Nelius, Mittal, Nimisha, Luth, Madeline R, Ottilie, Sabine, Winzeler, Elizabeth A, Koekemoer, Lizette L, Birkholtz, Lyn-Marie, Niles, Jacquin C, Llinás, Manuel, Fidock, David A, Chibale, Kelly

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CDK12 inhibition reduces abnormalities in cells from patients with myotonic dystrophy and in a mouse model by Ketley, Ami, Wojciechowska, Marzena, Ghidelli-Disse, Sonja, Bamborough, Paul, Ghosh, Tushar K, Morato, Marta Lopez, Sedehizadeh, Saam, Malik, Naveed Altaf, Tang, Zhenzhi, Powalowska, Paulina, Tanner, Matthew, Billeter-Clark, Rudolf, Trueman, Rebecca C, Geiszler, Philippine C, Agostini, Alessandra, Othman, Othman, Bösche, Markus, Bantscheff, Marcus, Rüdiger, Martin, Mossakowska, Danuta E, Drewry, David H, Zuercher, William J, Thornton, Charles A, Drewes, Gerard, Uings, Iain, Hayes, Christopher J, Brook, J David

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Novel Antitubercular 6‑Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure–Activity Relationship and Target I... by Wilson, Colin R, Gessner, Richard K, Moosa, Atica, Seldon, Ronnett, Warner, Digby F, Mizrahi, Valerie, Soares de Melo, Candice, Simelane, Sandile B, Nchinda, Aloysius, Abay, Efrem, Taylor, Dale, Njoroge, Mathew, Brunschwig, Christel, Lawrence, Nina, Boshoff, Helena I. M, Barry, Clifton E, Sirgel, Frederick A, van Helden, Paul, Harris, C. John, Gordon, Richard, Ghidelli-Disse, Sonja, Pflaumer, Hannah, Boesche, Markus, Drewes, Gerard, Sanz, Olalla, Santos, Gracia, Rebollo-Lopez, Maria José, Urones, Beatriz, Selenski, Carolyn, Lafuente-Monasterio, Maria Jose, Axtman, Matthew, Lelièvre, Joël, Ballell, Lluis, Mueller, Rudolf, Street, Leslie J, Ghorpade, Sandeep R, Chibale, Kelly

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Proteome survey reveals modularity of the yeast cell machinery by Gavin, A.C, Aloy, P, Grandi, P, Krause, R, Boesche, M, Marzioch, M, Rau, C, Jensen, L.J, Bastuck, S, Dümpelfeld, B

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Human Proteinpedia enables sharing of human protein data by Lefevre, Michael, Molina, Henrik, Mehrle, Alexander, Jung, Peter, Muddiman, David C, Hochstrasser, Denis F, Nalli, Anuradha, Mann, Matthias, Zhou, Ming, Fenselau, Catherine, Cagney, Gerard, DeSouza, Leroi V, Sirdeshmukh, Ravi, Björling, Erik, Pepperkok, Rainer, Rice, Robert H, Zurbig, Petra, Chaerkady, Raghothama, Purvine, Samuel O, Pandey, Akhilesh, Sullivan, Matthew, Balgley, Brian M, Bantscheff, Marcus, Figeys, Daniel, Michael Siu, K W, Vidal-Taboada, José-Manuel, Gimble, Jeffrey M, Hjernø, Karin, Cantin, Greg T, Hanash, Samir M, Petricoin, Emanuel F, Crockett, David, Dunn, Michael J, Lim, Megan S, Drewes, Gerard, Gromov, Pavel, Costello, Catherine E, Deutsch, Eric W, Gnad, Florian, Takatalo, Maarit, Alexandre, Hainard, Celis, Julio E, Vihinen, Mauno, Morgan, James D, Andrews, Philip C, Ahn, Natalie G, Korf, Ulrike, Kwon, Min-Seok, James, Peter, Wiemann, Stefan, Veenstra, Timothy D, Helsens, Kenny, Menon, Rajasree, Sheng, Shi Jun, Gelfi, Cecilia, Kheterpal, Indu, Lee, Young-Jin, Zhu, Yunping, Chu, Feixia, Mathivanan, Suresh, Horn, David M, Bennett, Keiryn L, Hofmann, Oliver, Pennington, Kyla, Ramachandran, Prasanna, Jensen, Pia Hønnerup, Löbke, Christian, Zhong, Jun, Moritz, Robert, Loo, Joseph A, Ohara, Osamu, Martinez-Heredia, Juan, Seshi, Beerelli, Hancock, William S, Simpson, Richard J, Shivakumar, K, Neubert, Thomas A, Goel, Renu, Rick, Jens, Ewing, Rob M, Sayd, Thierry, Oliva, Rafael, Thongboonkerd, Visith, Bustelo, Xosé R, Sanchez, Jean-Charles, De Marzo, Angelo M, Dransfield, Eric, Paik, Young-Ki, Hruban, Ralph H, Harsha, HC, He, Fuchu, Fang, Xiangming, Amanchy, Ramars, Hermeking, Heiko, Gagné, Pierre, Kikuno, Reiko F, Smith, Jeffrey C, Xu, Tao, Oyama, Masaaki, Gevaert, Kris

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1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis by Singh, Vinayak, Grzegorzewicz, Anna E., Fienberg, Stephen, Müller, Rudolf, Khonde, Lutete Peguy, Sanz, Olalla, Alfonso, Salvatore, Urones, Beatriz, Drewes, Gerard, Bantscheff, Marcus, Ghidelli-Disse, Sonja, Ioerger, Thomas R., Angala, Bhanupriya, Liu, Jiuyu, Lee, Richard E., Sacchettini, James C., Krieger, Inna V., Jackson, Mary, Chibale, Kelly, Ghorpade, Sandeep R.

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