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Abstract 3242: New chemical tools for disrupting the MDM2/p53 protein-protein interaction: Identification, synthesis and biological evaluation of a novel class of MDM2/p53 inhibito...
by
Pernazza, Daniele
,
Li, Xiaolong
,
Lawrence, Harshani R.
,
Guida, Wayne C.
,
DuBoulay, Courtney J.
,
Watts, Shawn
,
Sebti, Saïd M.
,
Chen, Jiandong
,
Lawrence, Nicholas J.
Published in
Cancer research (Chicago, Ill.)
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Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction
by
Kim, Young B.
,
Balasis, Maria E.
,
Doi, Kenichiro
,
Berndt, Norbert
,
DuBoulay, Courtney
,
Hu, Chih-Chi Andrew
,
Guida, Wayne
,
Wang, Hong-Gang
,
Sebti, Saïd M.
,
Del Valle, Juan R.
Published in
Bioorganic & medicinal chemistry letters
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Bioorganic & Medicinal Chemistry Letters
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Cancer Research
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Anticancer Agents
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Antineoplastic Agents - Chemistry
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Apoptosis Regulatory Proteins - Antagonists & Inhibitors
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Apoptosis Regulatory Proteins - Metabolism
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Bcl-2
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Bcl-2-Like Protein 11
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Breast Neoplasms
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Cell Proliferation - Drug Effects
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Chemistry, Medicinal
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Enzyme-Linked Immunosorbent Assay
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Humans
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Indexing In Process
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Inhibitory Concentration 50
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Life Sciences & Biomedicine
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