An Abundance of Rare Functional Variants in 202 Drug Target Genes Sequenced in 14,002 People by Nelson, Matthew R., Wegmann, Daniel, Ehm, Margaret G., Kessner, Darren, St. Jean, Pamela, Verzilli, Claudio, Shen, Judong, Tang, Zhengzheng, Bacanu, Silviu-Alin, Fraser, Dana, Warren, Liling, Aponte, Jennifer, Zawistowski, Matthew, Liu, Xiao, Zhang, Hao, Zhang, Yong, Li, Jun, Li, Yun, Li Li, Woollard, Peter, Topp, Simon, Hall, Matthew D., Nangle, Keith, Wang, Jun, Abecasis, Gonçalo, Cardon, Lon R., Zöllner, Sebastian, Whittaker, John C., Chissoe, Stephanie L., Novembre, John, Mooser, Vincent

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Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families by Cruchaga, Carlos, Haller, Gabe, Chakraverty, Sumitra, Mayo, Kevin, Vallania, Francesco L M, Mitra, Robi D, Faber, Kelley, Williamson, Jennifer, Bird, Tom, Diaz-Arrastia, Ramon, Foroud, Tatiana M, Boeve, Bradley F, Graff-Radford, Neill R, St Jean, Pamela, Lawson, Michael, Ehm, Margaret G, Mayeux, Richard, Goate, Alison M

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FinnGen provides genetic insights from a well-phenotyped isolated population by Kurki, Mitja I., Karjalainen, Juha, Palta, Priit, Sipilä, Timo P., Donner, Kati M., Reeve, Mary P., Laivuori, Hannele, Kaunisto, Mari A., Loukola, Anu, Lahtela, Elisa, Mattsson, Hannele, Laiho, Päivi, Della Briotta Parolo, Pietro, Lehisto, Arto A., Kanai, Masahiro, Mars, Nina, Heyne, Henrike O., Veerapen, Kumar, Rüeger, Sina, Lemmelä, Susanna, Zhou, Wei, Ruotsalainen, Sanni, Pärn, Kalle, Hiekkalinna, Tero, Koskelainen, Sami, Llorens, Vincent, Gracia-Tabuenca, Javier, Siirtola, Harri, Reis, Kadri, Elnahas, Abdelrahman G., Aalto-Setälä, Katriina, Biswas, Shameek, Dada, Oluwaseun A., Ding, Zhihao, Ehm, Margaret G., Eklund, Kari, Färkkilä, Martti, Finucane, Hilary, Ganna, Andrea, Ghazal, Awaisa, Hakanen, Antti, Hu, Xinli, Hunkapiller, Julie, Jacob, Howard, Jensen, Jan-Nygaard, Joensuu, Heikki, John, Sally, Junttila, Juhani, Kähönen, Mika, Kallio, Lila, Kaprio, Jaakko, Kettunen, Johannes, Kilpeläinen, Elina, Kosma, Veli-Matti, Kuopio, Teijo, Laisk, Triin, Laukkanen, Jari, Liu, Aoxing, Mägi, Reedik, Mäkitie, Antti, Malarstig, Anders, Maranville, Joseph, Niemi, Mari E. K., Niemi, Marianna, Obeidat, Ma´en, Okafo, George, Palomäki, Antti, Palotie, Tuula, Pitkäranta, Anne, Pulford, David, Raghavan, Neha, Rahimov, Fedik, Riley-Gillis, Bridget, Rodosthenous, Rodosthenis, Salminen, Eveliina, Salomaa, Veikko, Schleutker, Johanna, Serpi, Raisa, Shen, Huei-yi, Siegel, Richard, Sul, Jae Hoon, Tachmazidou, Ioanna, Tienari, Pentti, Tukiainen, Taru, Vaura, Felix, Virolainen, Petri, Waring, Jeffrey, Waterworth, Dawn, Yang, Robert, Nelis, Mari, Metspalu, Andres, Milani, Lili, Fox, Caroline, Havulinna, Aki S., Perola, Markus, Jalanko, Anu, Plenge, Robert, Runz, Heiko, Daly, Mark J., Palotie, Aarno

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Phenome-wide association study using research participants' self-reported data provides insight into the Th17 and IL-17 pathway by Ehm, Margaret G, Aponte, Jennifer L, Chiano, Mathias N, Yerges-Armstrong, Laura M, Johnson, Toby, Barker, Jonathan N, Cook, Suzanne F, Gupta, Akanksha, Hinds, David A, Li, Li, Nelson, Matthew R, Simpson, Michael A, Tian, Chao, McCarthy, Linda C, Rajpal, Deepak K, Waterworth, Dawn M

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The influence of genomic context on mutation patterns in the human genome inferred from rare variants by Schaibley, Valerie M, Zawistowski, Matthew, Wegmann, Daniel, Ehm, Margaret G, Nelson, Matthew R, St Jean, Pamela L, Abecasis, Gonçalo R, Novembre, John, Zöllner, Sebastian, Li, Jun Z

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Contrasting Linkage-Disequilibrium Patterns between Cases and Controls as a Novel Association-Mapping Method by Zaykin, Dmitri V., Meng, Zhaoling, Ehm, Margaret G.

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Effect of case and control definitions on genome‐wide association study (GWAS) findings by Isgut, Monica, Song, Kijoung, Ehm, Margaret G., Wang, May Dongmei, Davitte, Jonathan

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The Benefits of Using Genetic Information to Design Prevention Trials by Hu, Youna, Li, Li, Ehm, Margaret G., Bing, Nan, Song, Kijoung, Nelson, Matthew R., Talmud, Philippa J., Hingorani, Aroon D., Kumari, Meena, Kivimäki, Mika, Xu, Chun-Fang, Waterworth, Dawn M., Whittaker, John C., Abecasis, Gonçalo R., Spino, Cathie, Kang, Hyun Min

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Integration of Real‐World Data and Genetics to Support Target Identification and Validation by Davitte, Jonathan M., Stott‐Miller, Marni, Ehm, Margaret G., Cunnington, Marianne C., Reynolds, Robert F.

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A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease by Scott, Robert A, Freitag, Daniel F, Li, Li, Chu, Audrey Y, Surendran, Praveen, Young, Robin, Grarup, Niels, Stancáková, Alena, Chen, Yuning, Varga, Tibor V, Yaghootkar, Hanieh, Luan, Jian'an, Zhao, Jing Hua, Willems, Sara M, Wessel, Jennifer, Wang, Shuai, Maruthur, Nisa, Michailidou, Kyriaki, Pirie, Ailith, van der Lee, Sven J, Gillson, Christopher, Al Olama, Ali Amin, Amouyel, Philippe, Arriola, Larraitz, Arveiler, Dominique, Aviles-Olmos, Iciar, Balkau, Beverley, Barricarte, Aurelio, Barroso, Inês, Garcia, Sara Benlloch, Bis, Joshua C, Blankenberg, Stefan, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Borecki, Ingrid B, Bork-Jensen, Jette, Bowden, Sarah, Caldas, Carlos, Caslake, Muriel, Cupples, L Adrienne, Cruchaga, Carlos, Czajkowski, Jacek, den Hoed, Marcel, Dunn, Janet A, Earl, Helena M, Ehret, Georg B, Ferrannini, Ele, Ferrieres, Jean, Foltynie, Thomas, Ford, Ian, Forouhi, Nita G, Gianfagna, Francesco, Gonzalez, Carlos, Grioni, Sara, Hiller, Louise, Jansson, Jan-Håkan, Jørgensen, Marit E, Jukema, J Wouter, Kaaks, Rudolf, Kee, Frank, Kerrison, Nicola D, Key, Timothy J, Kontto, Jukka, Kote-Jarai, Zsofia, Kraja, Aldi T, Kuulasmaa, Kari, Kuusisto, Johanna, Linneberg, Allan, Liu, Chunyu, Marenne, Gaëlle, Mohlke, Karen L, Morris, Andrew P, Muir, Kenneth, Müller-Nurasyid, Martina, Munroe, Patricia B, Navarro, Carmen, Nielsen, Sune F, Nilsson, Peter M, Nordestgaard, Børge G, Packard, Chris J, Palli, Domenico, Panico, Salvatore, Peloso, Gina M, Perola, Markus, Peters, Annette, Poole, Christopher J, Quirós, J Ramón, Rolandsson, Olov, Sacerdote, Carlotta, Salomaa, Veikko, Sánchez, María-José, Sattar, Naveed, Sharp, Stephen J, Sims, Rebecca, Slimani, Nadia, Smith, Jennifer A, Thompson, Deborah J, Trompet, Stella, Tumino, Rosario

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Assessment of rosacea symptom severity by genome-wide association study and expression analysis highlights immuno-inflammatory and skin pigmentation genes by Aponte, Jennifer L, Chiano, Mathias N, Yerges-Armstrong, Laura M, Hinds, David A, Tian, Chao, Gupta, Akanksha, Guo, Cong, Fraser, Dana J, Freudenberg, Johannes M, Rajpal, Deepak K, Ehm, Margaret G, Waterworth, Dawn M

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Genome-wide meta-analysis conducted in three large biobanks expands the genetic landscape of lumbar disc herniations by Salo, Ville, Määttä, Juhani, Sliz, Eeva, Reimann, Ene, Mägi, Reedik, Reis, Kadri, Elhanas, Abdelrahman G., Reigo, Anu, Palta, Priit, Esko, Tõnu, Karppinen, Jaro, Kettunen, Johannes

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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata by Sliz, Eeva, Tyrmi, Jaakko S., Rahmioglu, Nilufer, Zondervan, Krina T., Becker, Christian M., Uimari, Outi, Kettunen, Johannes

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Author Correction: FinnGen provides genetic insights from a well-phenotyped isolated population by Kurki, Mitja I., Karjalainen, Juha, Palta, Priit, Sipilä, Timo P., Donner, Kati M., Reeve, Mary P., Laivuori, Hannele, Kaunisto, Mari A., Loukola, Anu, Lahtela, Elisa, Mattsson, Hannele, Laiho, Päivi, Della Briotta Parolo, Pietro, Lehisto, Arto A., Kanai, Masahiro, Mars, Nina, Heyne, Henrike O., Veerapen, Kumar, Rüeger, Sina, Lemmelä, Susanna, Zhou, Wei, Ruotsalainen, Sanni, Pärn, Kalle, Hiekkalinna, Tero, Koskelainen, Sami, Llorens, Vincent, Gracia-Tabuenca, Javier, Siirtola, Harri, Reis, Kadri, Elnahas, Abdelrahman G., Aalto-Setälä, Katriina, Biswas, Shameek, Dada, Oluwaseun A., Ding, Zhihao, Ehm, Margaret G., Eklund, Kari, Färkkilä, Martti, Finucane, Hilary, Ganna, Andrea, Ghazal, Awaisa, Hakanen, Antti, Hu, Xinli, Hunkapiller, Julie, Jacob, Howard, Jensen, Jan-Nygaard, Joensuu, Heikki, John, Sally, Junttila, Juhani, Kähönen, Mika, Kallio, Lila, Kaprio, Jaakko, Kettunen, Johannes, Kilpeläinen, Elina, Kosma, Veli-Matti, Kuopio, Teijo, Laisk, Triin, Laukkanen, Jari, Liu, Aoxing, Mägi, Reedik, Mäkitie, Antti, Malarstig, Anders, Maranville, Joseph, Niemi, Mari E. K., Niemi, Marianna, Obeidat, Ma´en, Okafo, George, Palomäki, Antti, Palotie, Tuula, Pitkäranta, Anne, Pulford, David, Raghavan, Neha, Rahimov, Fedik, Riley-Gillis, Bridget, Rodosthenous, Rodosthenis, Salminen, Eveliina, Salomaa, Veikko, Schleutker, Johanna, Serpi, Raisa, Shen, Huei-yi, Siegel, Richard, Sul, Jae Hoon, Tachmazidou, Ioanna, Tienari, Pentti, Tukiainen, Taru, Vaura, Felix, Virolainen, Petri, Waring, Jeffrey, Waterworth, Dawn, Yang, Robert, Nelis, Mari, Metspalu, Andres, Milani, Lili, Fox, Caroline, Havulinna, Aki S., Perola, Markus, Jalanko, Anu, Plenge, Robert, Runz, Heiko, Daly, Mark J., Palotie, Aarno

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The Population Reference Sample, POPRES: A Resource for Population, Disease, and Pharmacological Genetics Research by Nelson, Matthew R., Bryc, Katarzyna, King, Karen S., Indap, Amit, Boyko, Adam R., Novembre, John, Briley, Linda P., Maruyama, Yuka, Waterworth, Dawn M., Waeber, Gérard, Vollenweider, Peter, Oksenberg, Jorge R., Hauser, Stephen L., Stirnadel, Heide A., Kooner, Jaspal S., Chambers, John C., Jones, Brendan, Mooser, Vincent, Bustamante, Carlos D., Roses, Allen D., Burns, Daniel K., Ehm, Margaret G., Lai, Eric H.

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Analysis of rare variant population structure in Europeans explains differential stratification of gene-based tests by Zawistowski, Matthew, Reppell, Mark, Wegmann, Daniel, St Jean, Pamela L, Ehm, Margaret G, Nelson, Matthew R, Novembre, John, Zöllner, Sebastian

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Testing Association of Statistically Inferred Haplotypes with Discrete and Continuous Traits in Samples of Unrelated Individuals by Zaykin, Dmitri V., Westfall, Peter H., Young, S. Stanley, Karnoub, Maha A., Wagner, Michael J., Ehm, Margaret G.

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Selection of Genetic Markers for Association Analyses, Using Linkage Disequilibrium and Haplotypes by Meng, Zhaoling, Zaykin, Dmitri V., Xu, Chun-Fang, Wagner, Michael, Ehm, Margaret G.

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Comparing variant calling algorithms for target-exon sequencing in a large sample by Lo, Yancy, Kang, Hyun M, Nelson, Matthew R, Othman, Mohammad I, Chissoe, Stephanie L, Ehm, Margaret G, Abecasis, Gonçalo R, Zöllner, Sebastian

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An Autosomal Genomic Scan for Loci Linked to Type II Diabetes Mellitus and Body-Mass Index in Pima Indians by Hanson, Robert L., Ehm, Margaret G., Pettitt, David J., Prochazka, Michal, Thompson, D. Bruce, Timberlake, David, Foroud, Tatiana, Kobes, Sayuko, Baier, Leslie, Burns, Daniel K., Almasy, Laura, Blangero, John, Garvey, W. Timothy, Bennett, Peter H., Knowler, William C.

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