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JAK1/STAT3 activation directly inhibits IL-12 production in dendritic cells by preventing CDK9/P-TEFb recruitment to the p35 promoter
by
Wagner, Andreas H.
,
Conzelmann, Michael
,
Fitzer, Franziska
,
Giese, Thomas
,
Gülow, Karsten
,
Falk, Christine S.
,
Krämer, Oliver H.
,
Dietrich, Sascha
,
Hecker, Markus
,
Luft, Thomas
Published in
Biochemical pharmacology
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Biochemical Pharmacology
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Subjects
Cdk9
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Cells, Cultured
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Cyclin-Dependent Kinase 9 - Metabolism
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Dendritic Cells
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Dendritic Cells - Metabolism
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Humans
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Interleukin-12
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Interleukin-12 - Biosynthesis
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Interleukin-12 - Genetics
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Jak Inhibitor
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Jak-Stat Pathway
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Janus Kinase 1 - Antagonists & Inhibitors
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Janus Kinase 1 - Metabolism
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Life Sciences & Biomedicine
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Pharmacology & Pharmacy
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Positive Transcriptional Elongation Factor B - Metabolism
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Promoter Regions, Genetic
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Pyrazoles - Pharmacology
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Reactive Oxygen Species - Metabolism
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Science & Technology
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Elsevier Sciencedirect Journals
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Elsevier
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