Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase by Lingel, Andreas, Sendzik, Martin, Huang, Ying, Shultz, Michael D, Cantwell, John, Dillon, Michael P, Fu, Xingnian, Fuller, John, Gabriel, Tobias, Gu, Justin, Jiang, Xiangqing, Li, Ling, Liang, Fang, McKenna, Maureen, Qi, Wei, Rao, Weijun, Sheng, Xijun, Shu, Wei, Sutton, James, Taft, Benjamin, Wang, Long, Zeng, Jue, Zhang, Hailong, Zhang, Maya, Zhao, Kehao, Lindvall, Mika, Bussiere, Dirksen E

Get full text

Total Synthesis of (−)-Jiadifenin by Yang, Yang, Fu, Xingnian, Chen, Jianwei, Zhai, Hongbin

Get full text

Facile Construction of the Pentacyclic Framework of Subincanadine B. Synthesis of 20-Deethylenylated Subincanadine B and 19,20-Dihydrosubincanadine B by Liu, Yanqin, Luo, Shengjun, Fu, Xingnian, Fang, Zhuang, Zeyang, Xiong, Wanting, Jia, Xueshun, Zhai, Hongbin

Get full text

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy by Huang, Ying, Zhang, Jeff, Yu, Zhengtian, Zhang, Hailong, Wang, Youzhen, Lingel, Andreas, Qi, Wei, Gu, Justin, Zhao, Kehao, Shultz, Michael D, Wang, Long, Fu, Xingnian, Sun, Yongfeng, Zhang, Qiong, Jiang, Xiangqing, Zhang, Jiangwei, Zhang, Chunye, Li, Ling, Zeng, Jue, Feng, Lijian, Zhang, Chao, Liu, Yueqin, Zhang, Man, Zhang, Lijun, Zhao, Mengxi, Gao, Zhenting, Liu, Xianghui, Fang, Douglas, Guo, Haibing, Mi, Yuan, Gabriel, Tobias, Dillon, Michael P, Atadja, Peter, Oyang, Counde

Get full text

Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies by Huang, Ying, Sendzik, Martin, Zhang, Jeff, Gao, Zhenting, Sun, Yongfeng, Wang, Long, Gu, Justin, Zhao, Kehao, Yu, Zhengtian, Zhang, Lijun, Zhang, Qiong, Blanz, Joachim, Chen, Zijun, Dubost, Valérie, Fang, Douglas, Feng, Lijian, Fu, Xingnian, Kiffe, Michael, Li, Ling, Luo, Fangjun, Luo, Xiao, Mi, Yuan, Mistry, Prakash, Pearson, David, Piaia, Alessandro, Scheufler, Clemens, Terranova, Remi, Weiss, Andreas, Zeng, Jue, Zhang, Hailong, Zhang, Jiangwei, Zhao, Mengxi, Dillon, Michael P, Jeay, Sebastien, Qi, Wei, Moggs, Jonathan, Pissot-Soldermann, Carole, Li, En, Atadja, Peter, Lingel, Andreas, Oyang, Counde

Get full text

Abstract 6279: CTS2190, a next-generation epigenetic inhibitor for targeting type I PRMT deregulated human tumors by Shi, Hui, Fu, Xingnian, Ouyang, Qiugeng, Huang, Jiaxin, Wang, Yiqin, Wang, Youzhen, Xu, Guoliang, Mi, Yuan, Wu, Haiping

Get full text

Abstract 6278: Combination therapeutic strategy with type I PRMT inhibition in cancer treatment by Shi, Hui, Fu, Xingnian, Liu, Yilin, Ouyang, Qiugeng, Wang, Meng, Huang, Jiaxin, Wang, Long, Wang, Youzhen, Mi, Yuan, Wu, Haiping

Get full text

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase by Lingel, Andreas, Sendzik, Martin, Huang, Ying, Shultz, Michael D., Cantwell, John, Dillon, Michael P., Fu, Xingnian, Fuller, John, Gabriel, Tobias, Gu, Justin, Jiang, Xiangqing, Li, Ling, Liang, Fang, McKenna, Maureen, Qi, Wei, Rao, Weijun, Sheng, Xijun, Shu, Wei, Sutton, James, Taft, Benjamin, Wang, Long, Zeng, Jue, Zhang, Hailong, Zhang, Maya, Zhao, Kehao, Lindvall, Mika, Bussiere, Dirksen E.

Get full text

Total Synthesis of (−)-Jiadifenin by Yang, Yang, Fu, Xingnian, Chen, Jianwei, Zhai, Hongbin

Get full text

Total Synthesis of (−)‐Jiadifenin by Yang, Yang, Fu, Xingnian, Chen, Jianwei, Zhai, Hongbin

Get full text