Synthesis of 4-Substituted Chlorophthalazines, Dihydrobenzoazepinediones, 2-Pyrazolylbenzoic Acid, and 2-Pyrazolylbenzohydrazide via 3-Substituted 3-Hydroxyisoindolin-1-ones by Nguyen, Hanh Nho, Cee, Victor J, Deak, Holly L, Du, Bingfan, Faber, Kathleen Panter, Gunaydin, Hakan, Hodous, Brian L, Hollis, Steven L, Krolikowski, Paul H, Olivieri, Philip R, Patel, Vinod F, Romero, Karina, Schenkel, Laurie B, Geuns-Meyer, Stephanie D

Get full text

Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor by Hodous, Brian L, Geuns-Meyer, Stephanie D, Hughes, Paul E, Albrecht, Brian K, Bellon, Steve, Bready, James, Caenepeel, Sean, Cee, Victor J, Chaffee, Stuart C, Coxon, Angela, Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Hoffman, Doug, Johnson, Rebecca E, Kendall, Richard, Kim, Joseph L, Long, Alexander M, Morrison, Michael, Olivieri, Philip R, Patel, Vinod F, Polverino, Anthony, Rose, Paul, Tempest, Paul, Wang, Ling, Whittington, Douglas A, Zhao, Huilin

Get full text

Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity by DiMauro, Erin F, Newcomb, John, Nunes, Joseph J, Bemis, Jean E, Boucher, Christina, Buchanan, John L, Buckner, William H, Cee, Victor J, Chai, Lilly, Deak, Holly L, Epstein, Linda F, Faust, Ted, Gallant, Paul, Geuns-Meyer, Stephanie D, Gore, Anu, Gu, Yan, Henkle, Brad, Hodous, Brian L, Hsieh, Faye, Huang, Xin, Kim, Joseph L, Lee, Josie H, Martin, Matthew W, Masse, Craig E, McGowan, David C, Metz, Daniela, Mohn, Deanna, Morgenstern, Kurt A, Oliveira-dos-Santos, Antonio, Patel, Vinod F, Powers, David, Rose, Paul E, Schneider, Stephen, Tomlinson, Susan A, Tudor, Yan-Yan, Turci, Susan M, Welcher, Andrew A, White, Ryan D, Zhao, Huilin, Zhu, Li, Zhu, Xiaotian

Get full text

Synthesis, structural analysis, and SAR studies of triazine derivatives as potent, selective Tie-2 inhibitors by Hodous, Brian L., Geuns-Meyer, Stephanie D., Hughes, Paul E., Albrecht, Brian K., Bellon, Steve, Caenepeel, Sean, Cee, Victor J., Chaffee, Stuart C., Emery, Maurice, Fretland, Jenne, Gallant, Paul, Gu, Yan, Johnson, Rebecca E., Kim, Joseph L., Long, Alexander M., Morrison, Michael, Olivieri, Philip R., Patel, Vinod F., Polverino, Anthony, Rose, Paul, Wang, Ling, Zhao, Huilin

Get full text

Discovery of a Potent, Selective, and Orally Bioavailable Pyridinyl-Pyrimidine Phthalazine Aurora Kinase Inhibitor by Cee, Victor J, Schenkel, Laurie B, Hodous, Brian L, Deak, Holly L, Nguyen, Hanh N, Olivieri, Philip R, Romero, Karina, Bak, Annette, Be, Xuhai, Bellon, Steve, Bush, Tammy L, Cheng, Alan C, Chung, Grace, Coats, Steve, Eden, Patrick M, Hanestad, Kelly, Gallant, Paul L, Gu, Yan, Huang, Xin, Kendall, Richard L, Lin, Min-Hwa Jasmine, Morrison, Michael J, Patel, Vinod F, Radinsky, Robert, Rose, Paul E, Ross, Sandra, Sun, Ji-Rong, Tang, Jin, Zhao, Huilin, Payton, Marc, Geuns-Meyer, Stephanie D

Get full text

Optimization of a Novel Quinazolinone-Based Series of Transient Receptor Potential A1 (TRPA1) Antagonists Demonstrating Potent in Vivo Activity by Schenkel, Laurie B, Olivieri, Philip R, Boezio, Alessandro A, Deak, Holly L, Emkey, Renee, Graceffa, Russell F, Gunaydin, Hakan, Guzman-Perez, Angel, Lee, Josie H, Teffera, Yohannes, Wang, Weiya, Youngblood, Beth D, Yu, Violeta L, Zhang, Maosheng, Gavva, Narender R, Lehto, Sonya G, Geuns-Meyer, Stephanie

Get full text

Selective antagonism of TRPA1 produces limited efficacy in models of inflammatory- and neuropathic-induced mechanical hypersensitivity in rats by Lehto, Sonya G, Weyer, Andy D, Youngblood, Beth D, Zhang, Maosheng, Yin, Ruoyuan, Wang, Weiya, Teffera, Yohannes, Cooke, Melanie, Stucky, Cheryl L, Schenkel, Laurie, Geuns-Meyer, Stephanie, Moyer, Bryan D, Wild, Kenneth D, Gavva, Narender R

Get full text

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of NaV1.7 inhibition by Boezio, Alessandro A., Andrews, Kristin, Boezio, Christiane, Chu-Moyer, Margaret, Copeland, Katrina W., DiMauro, Erin F., Foti, Robert S., Fremeau, Robert T., Gao, Hua, Geuns-Meyer, Stephanie, Graceffa, Russell F., Gunaydin, Hakan, Huang, Hongbing, La, Daniel S., Ligutti, Joseph, Moyer, Bryan D., Peterson, Emily A., Yu, Violeta, Weiss, Matthew M.

Get full text

1,2,4-Triazolsulfone: A novel isosteric replacement of acylsulfonamides in the context of Na V 1.7 inhibition by Boezio, Alessandro A, Andrews, Kristin, Boezio, Christiane, Chu-Moyer, Margaret, Copeland, Katrina W, DiMauro, Erin F, Foti, Robert S, Fremeau, Jr, Robert T, Gao, Hua, Geuns-Meyer, Stephanie, Graceffa, Russell F, Gunaydin, Hakan, Huang, Hongbing, La, Daniel S, Ligutti, Joseph, Moyer, Bryan D, Peterson, Emily A, Yu, Violeta, Weiss, Matthew M

Get full text