The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile by Lyons, Jesse, Ghazi, Phaedra C, Starchenko, Alina, Tovaglieri, Alessio, Baldwin, Katherine R, Poulin, Emily J, Gierut, Jessica J, Genetti, Casie, Yajnik, Vijay, Breault, David T, Lauffenburger, Douglas A, Haigis, Kevin M

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Chloroquine Sensitizes GNAQ/11 -mutated Melanoma to MEK1/2 Inhibition by Truong, Amanda, Yoo, Jae Hyuk, Scherzer, Michael T, Sanchez, John Michael S, Dale, Kali J, Kinsey, Conan G, Richards, Jackson R, Shin, Donghan, Ghazi, Phaedra C, Onken, Michael D, Blumer, Kendall J, Odelberg, Shannon J, McMahon, Martin

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Simultaneous cytosolic delivery of a chemotherapeutic and siRNA using nanoparticle-stabilized nanocapsules by Hardie, Joseph, Jiang, Ying, Tetrault, Emily R, Ghazi, Phaedra C, Tonga, Gulen Yesilbag, Farkas, Michelle E, Rotello, Vincent M

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Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis by Lyons, Jesse, Brubaker, Douglas K, Ghazi, Phaedra C, Baldwin, Katherine R, Edwards, Amanda, Boukhali, Myriam, Strasser, Samantha Dale, Suarez-Lopez, Lucia, Lin, Yi-Jang, Yajnik, Vijay, Kissil, Joseph L, Haas, Wilhelm, Lauffenburger, Douglas A, Haigis, Kevin M

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Inhibition of MEK1/2 Forestalls the Onset of Acquired Resistance to Entrectinib in Multiple Models of NTRK1-Driven Cancer by Vaishnavi, Aria, Scherzer, Michael T., Kinsey, Conan G., Parkman, Gennie L., Truong, Amanda, Ghazi, Phaedra, Schuman, Sophia, Battistone, Benjamin, Garrido-Laguna, Ignacio, McMahon, Martin

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Substrate-based kinase activity inference identifies MK2 as driver of colitis by Strasser, Samantha Dale, Ghazi, Phaedra C, Starchenko, Alina, Boukhali, Myriam, Edwards, Amanda, Suarez-Lopez, Lucia, Lyons, Jesse, Changelian, Paul S, Monahan, Joseph B, Jacobsen, Jon, Brubaker, Douglas K, Joughin, Brian A, Yaffe, Michael B, Haas, Wilhelm, Lauffenburger, Douglas A, Haigis, Kevin M

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Tissue-Specific Oncogenic Activity of KRASA146T by Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian A., Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A., Westover, Kenneth D., Haigis, Kevin M.

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Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer by Ghazi, Phaedra C, O'Toole, Kayla T, Srinivas Boggaram, Sanjana, Scherzer, Michael T, Silvis, Mark R, Zhang, Yun, Bogdan, Madhumita, Smith, Bryan D, Lozano, Guillermina, Flynn, Daniel L, Snyder, Eric L, Kinsey, Conan G, McMahon, Martin

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Inhibition of ULK1/2 and KRASG12C controls tumor growth in preclinical models of lung cancer by Ghazi, Phaedra C, O'Toole, Kayla T, Srinivas Boggaram, Sanjana, Scherzer, Michael T, Silvis, Mark R, Zhang, Yun, Bogdan, Madhumita, Smith, Bryan D, Lozano, Guillermina, Flynn, Daniel L, Snyder, Eric L, Kinsey, Conan G, McMahon, Martin

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Abstract 1890: Chloroquine synergizes with MEK1/2 targeted therapy through dual YAP and lysosomal inhibition in GNAQ/11 mutant uveal melanoma by Truong, Amanda, Scherzer, Michael, Kinsey, Conan, Sanchez, John Michael, Yoo, Jae Hyuk, Richards, Jackson, Shin, Donghan, Ghazi, Phaedra, Onken, Michael, Blumer, Kendall, Odelberg, Shannon, McMahon, Martin

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Abstract PR03: Cooperative anti-tumor effects of combined inhibition of KRASG12C plus autophagy in preclinical models of KRASG12C-driven lung cancer by Ghazi, Phaedra C., Kinsey, Conan, Bogdan, Madhumita, Smith, Bryan D., Flynn, Daniel L., McMahon, Martin

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Inhibition of ULK1/2 and KRAS G12C controls tumor growth in preclinical models of lung cancer by Ghazi, Phaedra C, O'Toole, Kayla T, Srinivas Boggaram, Sanjana, Scherzer, Michael T, Silvis, Mark R, Zhang, Yun, Bogdan, Madhumita, Smith, Bryan D, Lozano, Guillermina, Flynn, Daniel L, Snyder, Eric L, Kinsey, Conan G, McMahon, Martin

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Abstract 3600: DCC-3116, a first-in-class selective inhibitor of ULK1/2 kinases and autophagy, synergizes with the KRASG12C inhibitor sotorasib resulting in tumor regression in KRA... by McMahon, Martin, Bogdan, Madhumita, Timson, Mary J., Al-Hashimi, Hikmat, Ghazi, Phaedra, Zhan, Yu, Smith, Bryan D., Kinsey, Conan G., Flynn, Daniel L.

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Integrated in vivo multi-omics analysis identifies p21-activated kinase signaling as a driver of colitis by Lyons, Jesse, Brubaker, Douglas K., Ghazi, Phaedra C., Baldwin, Katherine R., Edwards, Amanda, Boukhali, Myriam, Strasser, Samantha Dale, Suarez-Lopez, Lucia, Lin, Yi-Jang, Yajnik, Vijay, Kissil, Joseph L., Haas, Wilhelm, Lauffenburger, Douglas A., Haigis, Kevin M.

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Tissue-specific oncogenic activity of K-RasA146T by Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian A., Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A., Westover, Kenneth D., Haigis, Kevin M.

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Tissue-Specific Oncogenic Activity of KRAS A146T by Poulin, Emily J, Bera, Asim K, Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A, Huang, Tannie Q, Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A, Brubaker, Douglas K, Joughin, Brian A, Johnson, Christian W, DeStefanis, Rebecca A, Ghazi, Phaedra C, Gondi, Sudershan, Wales, Thomas E, Iacob, Roxana E, Bogdanova, Lana, Gierut, Jessica J, Li, Yina, Engen, John R, Perez-Mancera, Pedro A, Braun, Benjamin S, Gygi, Steven P, Lauffenburger, Douglas A, Westover, Kenneth D, Haigis, Kevin M

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