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(.+-.)-9-Amino-1,2,3,4-tetrahydroacridin-1-ol. A potential Alzheimer's disease therapeutic of low toxicity
by
Shutske, Gregory M
,
Pierrat, Frank A
,
Cornfeldt, Michael L
,
Szewczak, Mark R
,
Huger, Francis P
,
Bores, Gina M
,
Haroutunian, Vahram
,
Davis, Kenneth L
Published in
Journal of medicinal chemistry
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9-Amino-1,2,3,4-tetrahydroacridin-1-ols. Synthesis and evaluation as potential Alzheimer's disease therapeutics
by
Shutske, Gregory M
,
Pierrat, Frank A
,
Kapples, Kevin J
,
Cornfeldt, Michael L
,
Szewczak, Mark R
,
Huger, Francis P
,
Bores, Gina M
,
Haroutunian, Vahram
,
Davis, Kenneth L
Published in
Journal of medicinal chemistry
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Synthesis and Evaluation of 5-Amino-5,6,7,8-tetrahydroquinolinones as Potential Agents for the Treatment of Alzheimer's Disease
by
Fink, David M
,
Bores, Gina M
,
Effland, Richard C
,
Huger, Francis P
,
Kurys, Barbara E
,
Rush, Douglas K
,
Selk, David E
Published in
Journal of medicinal chemistry
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Imino 1,2,3,4-tetrahydrocyclopent[b]indole carbamates as dual inhibitors of acetylcholinesterase and monoamine oxidase
by
Fink, David M.
,
Palermo, M.G.
,
Bores, Gina M.
,
Huger, Francis P.
,
Kurys, Barbara E.
,
Merriman, Michael C.
,
Olsen, Gordon E.
,
Petko, Wayne
,
O'Malley, Gerard J.
Published in
Bioorganic & medicinal chemistry letters
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Pharmacological activity and safety profile of P10358, a novel, orally active acetylcholinesterase inhibitor for Alzheimer's disease
by
Smith, C P
,
Bores, G M
,
Petko, W
,
Li, M
,
Selk, D E
,
Rush, D K
,
Camacho, F
,
Winslow, J T
,
Fishkin, R
,
Cunningham, D M
,
Brooks, K M
,
Roehr, J
,
Hartman, H B
,
Davis, L
,
Vargas, H M
Published in
The Journal of pharmacology and experimental therapeutics
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Synthesis and preliminary structure-activity relationships of 1-[(3-fluoro-4-pyridinyl)amino]-3-methyl-1H-indol-5-yl methyl carbamate (P10358), a novel acetylcholinesterase inhibit...
by
Martin, Lawrence L.
,
Davis, Larry
,
Klein, Joseph T.
,
Nemoto, Peter
,
Olsen, Gordon E.
,
Bores, Gina M.
,
Camacho, Fernando
,
Petko, Wayne W.
,
Rush, Douglas K.
,
Selk, David
,
Smith, Craig P.
,
Vargas, Hugo M.
,
Winslow, James T.
,
Effland, Richard C.
,
Fink, David M.
Published in
Bioorganic & medicinal chemistry letters
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Pharmacological Activity and Safety Profile of P10358, a Novel, Orally Active Acetylcholinesterase Inhibitor for Alzheimerâs Disease
by
Craig P. Smith
,
Gina M. Bores
,
Wayne Petko
,
Mary Li
,
David E. Selk
,
Douglas K. Rush
,
Fernando Camacho
,
James T. Winslow
,
Rod Fishkin
,
Dana M. Cunningham
,
Karen M. Brooks
,
Joachim Roehr
,
Harold B. Hartman
,
Larry Davis
,
Hugo M. Vargas
Published in
The Journal of pharmacology and experimental therapeutics
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Synthesis and in vitro acetylcholinesterase inhibitory activity of some 1-substituted analogues of velnacrine
by
Kapples, Kevin J.
,
Shutske, Gregory M.
,
Bores, Gina M.
,
Huger, Francis P.
Published in
Bioorganic & medicinal chemistry letters
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Serotonergic activity of HP 184 : Does spontaneous release have a role ?
by
SMITH, C. P
,
WOODS-KETTELBERGER, A. T
,
CORBETT, R
,
CHESSON, S. M
,
BORES, G. M
,
PETKO, W. W
,
ROEHR, J. E
,
KONGSAMUT, S
Published in
Neurochemical research
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Synthesis and biological activity of putative mono-hydroxylated metabolites of velnacrine
by
Shutske, Gregory M.
,
Bores, Gina M.
,
Bradshaw, Katherine C.
,
Huger, Francis P.
,
Kapples, Kevin J.
,
Larsen, Raymond D.
,
Rush, Douglas K.
,
Tomer, John D.
Published in
Bioorganic & medicinal chemistry letters
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Aminopyridine Carbamic Acid Esters: Synthesis and Potential as Acetylcholinesterase Inhibitors and Acetylcholine Releasers
by
Shutske, Gregory M.
,
Tomer, John D.
,
Kapples, Kevin J.
,
Hrib, Nicholas J.
,
Jurcak, John G.
,
Bores, Gina M.
,
Huger, Francis P.
,
Petko, Wayne
,
Smith, Craig P.
Published in
Journal of pharmaceutical sciences
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