Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway by Kurppa, Kari J., Liu, Yao, To, Ciric, Zhang, Tinghu, Fan, Mengyang, Vajdi, Amir, Knelson, Erik H., Xie, Yingtian, Lim, Klothilda, Cejas, Paloma, Portell, Andrew, Lizotte, Patrick H., Ficarro, Scott B., Li, Shuai, Chen, Ting, Haikala, Heidi M., Wang, Haiyun, Bahcall, Magda, Gao, Yang, Shalhout, Sophia, Boettcher, Steffen, Shin, Bo Hee, Thai, Tran, Wilkens, Margaret K., Tillgren, Michelle L., Mushajiang, Mierzhati, Xu, Man, Choi, Jihyun, Bertram, Arrien A., Ebert, Benjamin L., Beroukhim, Rameen, Bandopadhayay, Pratiti, Awad, Mark M., Gokhale, Prafulla C., Kirschmeier, Paul T., Marto, Jarrod A., Camargo, Fernando D., Haq, Rizwan, Paweletz, Cloud P., Wong, Kwok-Kin, Barbie, David A., Long, Henry W., Gray, Nathanael S., Jänne, Pasi A.

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Altered chromosomal topology drives oncogenic programs in SDH-deficient GISTs by Flavahan, William A., Drier, Yotam, Johnstone, Sarah E., Hemming, Matthew L., Tarjan, Daniel R., Hegazi, Esmat, Shareef, Sarah J., Javed, Nauman M., Raut, Chandrajit P., Eschle, Benjamin K., Gokhale, Prafulla C., Hornick, Jason L., Sicinska, Ewa T., Demetri, George D., Bernstein, Bradley E.

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Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma by Iorgulescu, J Bryan, Gokhale, Prafulla C, Speranza, Maria C, Eschle, Benjamin K, Poitras, Michael J, Wilkens, Margaret K, Soroko, Kara M, Chhoeu, Chhayheng, Knott, Aine, Gao, Yan, Lim-Fat, Mary Jane, Baker, Gregory J, Bonal, Dennis M, Nguyen, Quang-Dé, Grant, Gareth R L, Ligon, Keith L, Sorger, Peter K, Chiocca, E Antonio, Anderson, Ana C, Kirschmeier, Paul T, Sharpe, Arlene H, Freeman, Gordon J, Reardon, David A

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Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis by Mathewson, Nathan D., Ashenberg, Orr, Tirosh, Itay, Gritsch, Simon, Perez, Elizabeth M., Marx, Sascha, Jerby-Arnon, Livnat, Chanoch-Myers, Rony, Hara, Toshiro, Richman, Alyssa R., Ito, Yoshinaga, Pyrdol, Jason, Friedrich, Mirco, Schumann, Kathrin, Poitras, Michael J., Gokhale, Prafulla C., Gonzalez Castro, L. Nicolas, Shore, Marni E., Hebert, Christine M., Shaw, Brian, Cahill, Heather L., Drummond, Matthew, Zhang, Wubing, Olawoyin, Olamide, Wakimoto, Hiroaki, Rozenblatt-Rosen, Orit, Brastianos, Priscilla K., Liu, X. Shirley, Jones, Pamela S., Cahill, Daniel P., Frosch, Matthew P., Louis, David N., Freeman, Gordon J., Ligon, Keith L., Marson, Alexander, Chiocca, E. Antonio, Reardon, David A., Regev, Aviv, Suvà, Mario L., Wucherpfennig, Kai W.

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Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity by Mahadevan, Navin R, Knelson, Erik H, Wolff, Jacquelyn O, Vajdi, Amir, Saigí, Maria, Campisi, Marco, Hong, Deli, Thai, Tran C, Piel, Brandon, Han, Saemi, Reinhold, Bruce B, Duke-Cohan, Jonathan S, Poitras, Michael J, Taus, Luke J, Lizotte, Patrick H, Portell, Andrew, Quadros, Victor, Santucci, Alison D, Murayama, Takahiko, Cañadas, Israel, Kitajima, Shunsuke, Akitsu, Aoi, Fridrikh, Maya, Watanabe, Hideo, Reardon, Brendan, Gokhale, Prafulla C, Paweletz, Cloud P, Awad, Mark M, Van Allen, Eliezer M, Lako, Ana, Wang, Xi-Tao, Chen, Benjamin, Hong, Fangxin, Sholl, Lynette M, Tolstorukov, Michael Y, Pfaff, Kathleen, Jänne, Pasi A, Gjini, Evisa, Edwards, Robin, Rodig, Scott, Reinherz, Ellis L, Oser, Matthew G, Barbie, David A

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Dual inhibition of MDM2 and MDM4 in virus-positive Merkel cell carcinoma enhances the p53 response by Park, Donglim Esther, Cheng, Jingwei, Berrios, Christian, Montero, Joan, Cortés-Cros, Marta, Ferretti, Stéphane, Arora, Reety, Tillgren, Michelle L., Gokhale, Prafulla C., DeCaprio, James A.

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Comparison of effects of midostaurin, crenolanib, quizartinib, gilteritinib, sorafenib and BLU‐285 on oncogenic mutants of KIT, CBL and FLT3 in haematological malignancies by Weisberg, Ellen, Meng, Chengcheng, Case, Abigail E., Sattler, Martin, Tiv, Hong L., Gokhale, Prafulla C., Buhrlage, Sara J., Liu, Xiaoxi, Yang, Jing, Wang, Jinhua, Gray, Nathanael, Stone, Richard M., Adamia, Sophia, Dubreuil, Patrice, Letard, Sebastien, Griffin, James D.

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Glioblastoma Eradication Following Immune Checkpoint Blockade in an Orthotopic, Immunocompetent Model by Reardon, David A, Gokhale, Prafulla C, Klein, Sarah R, Ligon, Keith L, Rodig, Scott J, Ramkissoon, Shakti H, Jones, Kristen L, Conway, Amy Saur, Liao, Xiaoyun, Zhou, Jun, Wen, Patrick Y, Van Den Abbeele, Annick D, Hodi, F Stephen, Qin, Lei, Kohl, Nancy E, Sharpe, Arlene H, Dranoff, Glenn, Freeman, Gordon J

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Combined targeting of the BRD4-NUT-p300 axis in NUT midline carcinoma by dual selective bromodomain inhibitor, NEO2734 by Morrison-Smith, Chevaun D, Knox, Tatiana M, Filic, Ivona, Soroko, Kara M, Eschle, Benjamin K, Wilkens, Margaret K, Gokhale, Prafulla C, Giles, Francis, Griffin, Andrew, Brown, Bill, Shapiro, Geoffrey I, Zucconi, Beth E, Cole, Philip A, Lemieux, Madeleine E, French, Christopher A

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EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd by Haikala, Heidi M, Lopez, Timothy, Köhler, Jens, Eser, Pinar O, Xu, Man, Zeng, Qing, Teceno, Tyler J, Ngo, Kenneth, Zhao, Yutong, Ivanova, Elena V, Bertram, Arrien A, Leeper, Brittaney A, Chambers, Emily S, Adeni, Anika E, Taus, Luke J, Kuraguchi, Mari, Kirschmeier, Paul T, Yu, Channing, Shiose, Yoshinobu, Kamai, Yasuki, Qiu, Yang, Paweletz, Cloud P, Gokhale, Prafulla C, Jänne, Pasi A

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Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids by Jenkins, Russell W, Aref, Amir R, Lizotte, Patrick H, Ivanova, Elena, Stinson, Susanna, Zhou, Chensheng W, Bowden, Michaela, Deng, Jiehui, Liu, Hongye, Miao, Diana, He, Meng Xiao, Walker, William, Zhang, Gao, Tian, Tian, Cheng, Chaoran, Wei, Zhi, Palakurthi, Sangeetha, Bittinger, Mark, Vitzthum, Hans, Kim, Jong Wook, Merlino, Ashley, Quinn, Max, Venkataramani, Chandrasekar, Kaplan, Joshua A, Portell, Andrew, Gokhale, Prafulla C, Phillips, Bart, Smart, Alicia, Rotem, Asaf, Jones, Robert E, Keogh, Lauren, Anguiano, Maria, Stapleton, Lance, Jia, Zhiheng, Barzily-Rokni, Michal, Cañadas, Israel, Thai, Tran C, Hammond, Marc R, Vlahos, Raven, Wang, Eric S, Zhang, Hua, Li, Shuai, Hanna, Glenn J, Huang, Wei, Hoang, Mai P, Piris, Adriano, Eliane, Jean-Pierre, Stemmer-Rachamimov, Anat O, Cameron, Lisa, Su, Mei-Ju, Shah, Parin, Izar, Benjamin, Thakuria, Manisha, LeBoeuf, Nicole R, Rabinowits, Guilherme, Gunda, Viswanath, Parangi, Sareh, Cleary, James M, Miller, Brian C, Kitajima, Shunsuke, Thummalapalli, Rohit, Miao, Benchun, Barbie, Thanh U, Sivathanu, Vivek, Wong, Joshua, Richards, William G, Bueno, Raphael, Yoon, Charles H, Miret, Juan, Herlyn, Meenhard, Garraway, Levi A, Van Allen, Eliezer M, Freeman, Gordon J, Kirschmeier, Paul T, Lorch, Jochen H, Ott, Patrick A, Hodi, F Stephen, Flaherty, Keith T, Kamm, Roger D, Boland, Genevieve M, Wong, Kwok-Kin, Dornan, David, Paweletz, Cloud Peter, Barbie, David A

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Cotargeting a MYC/eIF4A-survival axis improves the efficacy of KRAS inhibitors in lung cancer by Nardi, Francesca, Perurena, Naiara, Schade, Amy E, Li, Ze-Hua, Ngo, Kenneth, Ivanova, Elena V, Saldanha, Aisha, Li, Chendi, Gokhale, Prafulla C, Hata, Aaron N, Barbie, David A, Paweletz, Cloud P, Jänne, Pasi A, Cichowski, Karen

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MET-Induced CD73 Restrains STING-Mediated Immunogenicity of EGFR-Mutant Lung Cancer by Yoshida, Ryohei, Saigi, Maria, Tani, Tetsuo, Springer, Benjamin F, Shibata, Hirofumi, Kitajima, Shunsuke, Mahadevan, Navin R, Campisi, Marco, Kim, William, Kobayashi, Yoshihisa, Thai, Tran C, Haratani, Koji, Yamamoto, Yurie, Sundararaman, Shriram K, Knelson, Erik H, Vajdi, Amir, Canadas, Israel, Uppaluri, Ravindra, Paweletz, Cloud P, Miret, Juan J, Lizotte, Patrick H, Gokhale, Prafulla C, Jänne, Pasi A, Barbie, David A

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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer by Kitajima, Shunsuke, Tani, Tetsuo, Springer, Benjamin F., Campisi, Marco, Osaki, Tatsuya, Haratani, Koji, Chen, Minyue, Knelson, Erik H., Mahadevan, Navin R., Ritter, Jessica, Yoshida, Ryohei, Köhler, Jens, Ogino, Atsuko, Nozawa, Ryu-Suke, Sundararaman, Shriram K., Thai, Tran C., Homme, Mizuki, Piel, Brandon, Kivlehan, Sophie, Obua, Bonje N., Purcell, Connor, Yajima, Mamiko, Barbie, Thanh U., Lizotte, Patrick H., Jänne, Pasi A., Paweletz, Cloud P., Gokhale, Prafulla C., Barbie, David A.

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Silent mutations reveal therapeutic vulnerability in RAS Q61 cancers by Kobayashi, Yoshihisa, Chhoeu, Chhayheng, Li, Jiaqi, Price, Kristin S., Kiedrowski, Lesli A., Hutchins, Jamie L., Hardin, Aaron I., Wei, Zihan, Hong, Fangxin, Bahcall, Magda, Gokhale, Prafulla C., Jänne, Pasi A.

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Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer by Buck, Elizabeth, Gokhale, Prafulla C, Koujak, Susan, Brown, Eric, Eyzaguirre, Alexandra, Tao, Nianjun, Rosenfeld-Franklin, Maryland, Lerner, Lorena, Chiu, M Isabel, Wild, Robert, Epstein, David, Pachter, Jonathan A, Miglarese, Mark R

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Preclinical characterization of OSI-027, a potent and selective inhibitor of mTORC1 and mTORC2: distinct from rapamycin by Bhagwat, Shripad V, Gokhale, Prafulla C, Crew, Andrew P, Cooke, Andy, Yao, Yan, Mantis, Christine, Kahler, Jennifer, Workman, Jennifer, Bittner, Mark, Dudkin, Lorina, Epstein, David M, Gibson, Neil W, Wild, Robert, Arnold, Lee D, Houghton, Peter J, Pachter, Jonathan A

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Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling by Fan, Mengyang, Lu, Wenchao, Che, Jianwei, Kwiatkowski, Nicholas P, Gao, Yang, Seo, Hyuk-Soo, Ficarro, Scott B, Gokhale, Prafulla C, Liu, Yao, Geffken, Ezekiel A, Lakhani, Jimit, Song, Kijun, Kuljanin, Miljan, Ji, Wenzhi, Jiang, Jie, He, Zhixiang, Tse, Jason, Boghossian, Andrew S, Rees, Matthew G, Ronan, Melissa M, Roth, Jennifer A, Mancias, Joseph D, Marto, Jarrod A, Dhe-Paganon, Sirano, Zhang, Tinghu, Gray, Nathanael S

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Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma by Bandopadhayay, Pratiti, Piccioni, Federica, O’Rourke, Ryan, Ho, Patricia, Gonzalez, Elizabeth M., Buchan, Graham, Qian, Kenin, Gionet, Gabrielle, Girard, Emily, Coxon, Margo, Rees, Matthew G., Brenan, Lisa, Dubois, Frank, Shapira, Ofer, Greenwald, Noah F., Pages, Melanie, Balboni Iniguez, Amanda, Paolella, Brenton R., Meng, Alice, Sinai, Claire, Roti, Giovanni, Dharia, Neekesh V., Creech, Amanda, Tanenbaum, Benjamin, Khadka, Prasidda, Tracy, Adam, Tiv, Hong L., Hong, Andrew L., Coy, Shannon, Rashid, Rumana, Lin, Jia-Ren, Cowley, Glenn S., Lam, Fred C., Goodale, Amy, Lee, Yenarae, Schoolcraft, Kathleen, Vazquez, Francisca, Hahn, William C., Tsherniak, Aviad, Bradner, James E., Yaffe, Michael B., Milde, Till, Pfister, Stefan M., Qi, Jun, Schenone, Monica, Carr, Steven A., Ligon, Keith L., Kieran, Mark W., Santagata, Sandro, Olson, James M., Gokhale, Prafulla C., Jaffe, Jacob D., Root, David E., Stegmaier, Kimberly, Johannessen, Cory M., Beroukhim, Rameen

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Next-generation characterization of the Cancer Cell Line Encyclopedia by Ghandi, Mahmoud, Huang, Franklin W., Jané-Valbuena, Judit, Kryukov, Gregory V., Lo, Christopher C., McDonald, E. Robert, Barretina, Jordi, Gelfand, Ellen T., Bielski, Craig M., Li, Haoxin, Hu, Kevin, Andreev-Drakhlin, Alexander Y., Kim, Jaegil, Hess, Julian M., Haas, Brian J., Aguet, François, Weir, Barbara A., Rothberg, Michael V., Paolella, Brenton R., Lawrence, Michael S., Akbani, Rehan, Lu, Yiling, Tiv, Hong L., Gokhale, Prafulla C., de Weck, Antoine, Mansour, Ali Amin, Oh, Coyin, Shih, Juliann, Hadi, Kevin, Rosen, Yanay, Bistline, Jonathan, Venkatesan, Kavitha, Reddy, Anupama, Sonkin, Dmitriy, Liu, Manway, Lehar, Joseph, Korn, Joshua M., Porter, Dale A., Jones, Michael D., Golji, Javad, Caponigro, Giordano, Taylor, Jordan E., Dunning, Caitlin M., Creech, Amanda L., Warren, Allison C., McFarland, James M., Zamanighomi, Mahdi, Kauffmann, Audrey, Stransky, Nicolas, Imielinski, Marcin, Maruvka, Yosef E., Cherniack, Andrew D., Tsherniak, Aviad, Vazquez, Francisca, Jaffe, Jacob D., Lane, Andrew A., Weinstock, David M., Johannessen, Cory M., Morrissey, Michael P., Stegmeier, Frank, Schlegel, Robert, Hahn, William C., Getz, Gad, Mills, Gordon B., Boehm, Jesse S., Golub, Todd R., Garraway, Levi A., Sellers, William R.

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