Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4 by Cheung, Mui, Bao, Weike, Behm, David J, Brooks, Carl A, Bury, Michael J, Dowdell, Sarah E, Eidam, Hilary S, Fox, Ryan M, Goodman, Krista B, Holt, Dennis A, Lee, Dennis, Roethke, Theresa J, Willette, Robert N, Xu, Xiaoping, Ye, Guosen, Thorneloe, Kevin S

Get full text

Potent, Selective and Orally Bioavailable Dihydropyrimidine Inhibitors of Rho Kinase (ROCK1) as Potential Therapeutic Agents for Cardiovascular Diseases by Sehon, Clark A, Wang, Gren Z, Viet, Andrew Q, Goodman, Krista B, Dowdell, Sarah E, Elkins, Patricia A, Semus, Simon F, Evans, Christopher, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

Get full text

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure by Thorneloe, Kevin S, Cheung, Mui, Bao, Weike, Alsaid, Hasan, Lenhard, Stephen, Jian, Ming-Yuan, Costell, Melissa, Maniscalco-Hauk, Kristeen, Krawiec, John A, Olzinski, Alan, Gordon, Earl, Lozinskaya, Irina, Elefante, Lou, Qin, Pu, Matasic, Daniel S, James, Chris, Tunstead, James, Donovan, Brian, Kallal, Lorena, Waszkiewicz, Anna, Vaidya, Kalindi, Davenport, Elizabeth A, Larkin, Jonathan, Burgert, Mark, Casillas, Linda N, Marquis, Robert W, Ye, Guosen, Eidam, Hilary S, Goodman, Krista B, Toomey, John R, Roethke, Theresa J, Jucker, Beat M, Schnackenberg, Christine G, Townsley, Mary I, Lepore, John J, Willette, Robert N

Get full text

Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4) by Brooks, Carl A, Barton, Linda S, Behm, David J, Eidam, Hilary S, Fox, Ryan M, Hammond, Marlys, Hoang, Tram H, Holt, Dennis A, Hilfiker, Mark A, Lawhorn, Brian G, Patterson, Jaclyn R, Stoy, Patrick, Roethke, Theresa J, Ye, Guosen, Zhao, Steve, Thorneloe, Kevin S, Goodman, Krista B, Cheung, Mui

Get full text

Development of Dihydropyridone Indazole Amides as Selective Rho-Kinase Inhibitors by Goodman, Krista B, Cui, Haifeng, Dowdell, Sarah E, Gaitanopoulos, Dimitri E, Ivy, Robert L, Sehon, Clark A, Stavenger, Robert A, Wang, Gren Z, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Semus, Simon F, Evans, Christopher, Fries, Harvey E, Jolivette, Larry J, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Bentley, Ross, Doe, Christopher P, Hu, Erding, Lee, Dennis

Get full text

Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity by Stavenger, Robert A, Cui, Haifeng, Dowdell, Sarah E, Franz, Robert G, Gaitanopoulos, Dimitri E, Goodman, Krista B, Hilfiker, Mark A, Ivy, Robert L, Leber, Jack D, Marino, Joseph P, Oh, Hye-Ja, Viet, Andrew Q, Xu, Weiwei, Ye, Guosen, Zhang, Daohua, Zhao, Yongdong, Jolivette, Larry J, Head, Martha S, Semus, Simon F, Elkins, Patricia A, Kirkpatrick, Robert B, Dul, Edward, Khandekar, Sanjay S, Yi, Tracey, Jung, David K, Wright, Lois L, Smith, Gary K, Behm, David J, Doe, Christopher P, Bentley, Ross, Chen, Zunxuan X, Hu, Erding, Lee, Dennis

Get full text

Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors by Goodman, Krista B., Bury, Michael J., Cheung, Mui, Cichy-Knight, Maria A., Dowdell, Sarah E., Dunn, Allison K., Lee, Dennis, Lieby, Jeffrey A., Moore, Michael L., Scherzer, Daryl A., Sha, Deyou, Suarez, Dominic P., Murphy, Dennis J., Harpel, Mark R., Manas, Eric S., McNulty, Dean E., Annan, Roland S., Matico, Rosalie E., Schwartz, Benjamin K., Trill, John J., Sweitzer, Thomas D., Wang, Da-yuan, Keller, Paul M., Krawiec, John A., Jaye, Michael C.

Get full text

CCR2 receptor antagonists: Optimization of biaryl sulfonamides to increase activity in whole blood by Wang, Gren Z., Haile, Pamela A., Daniel, Tom, Belot, Benjamin, Viet, Andrew Q., Goodman, Krista B., Sha, Deyou, Dowdell, Sarah E., Varga, Norbert, Hong, Xuan, Chakravorty, Subhas, Webb, Christine, Cornejo, Carla, Olzinski, Alan, Bernard, Roberta, Evans, Christopher, Emmons, Amanda, Briand, Jacques, Chung, Chun-Wa, Quek, Ruben, Lee, Dennis, Gough, Peter J., Sehon, Clark A.

Get full text

Aminomethylpiperazines as selective urotensin antagonists by Hilfiker, Mark A., Zhang, Daohua, Dowdell, Sarah E., Goodman, Krista B., McAtee, John J., Dodson, Jason W., Viet, Andrew Q., Wang, Gren Z., Sehon, Clark A., Behm, David J., Wu, Zining, Carballo, Luz H., Douglas, Stephen A., Neeb, Michael J.

Get full text

Development of potent and selective small-molecule human Urotensin-II antagonists by McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Sehon, Clark A., Sha, Deyou, Wang, Gren Z., Wang, Ning, Viet, Andrew Q., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Yuan, Catherine C.K., Douglas, Stephen A., Neeb, Michael J.

Get full text

Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles by McAtee, John J., Dodson, Jason W., Dowdell, Sarah E., Erhard, Karl, Girard, Gerald R., Goodman, Krista B., Hilfiker, Mark A., Jin, Jian, Sehon, Clark A., Sha, Deyou, Shi, Dongchuan, Wang, Feng, Wang, Gren Z., Wang, Ning, Wang, Yonghui, Viet, Andrew Q., Yuan, Catherine C.K., Zhang, Daohua, Aiyar, Nambi V., Behm, David J., Carballo, Luz H., Evans, Christopher A., Fries, Harvey E., Nagilla, Rakesh, Roethke, Theresa J., Xu, Xiaoping, Douglas, Stephen A., Neeb, Michael J.

Get full text

Relationship between neural responses to stress and mental health symptoms in psychogenic nonepileptic seizures after traumatic brain injury by Balachandran, Neha, Goodman, Adam M., Allendorfer, Jane B., Martin, Amber N., Tocco, Krista, Vogel, Valerie, LaFrance, W. Curt, Szaflarski, Jerzy P.

Get full text

Wastewater based surveillance can be used to reduce clinical testing intensity on a university campus by Amirali, Ayaaz, Babler, Kristina M., Sharkey, Mark E., Beaver, Cynthia C., Boone, Melinda M., Comerford, Samuel, Cooper, Daniel, Currall, Benjamin B., Goodman, Kenneth W., Grills, George S., Kobetz, Erin, Kumar, Naresh, Laine, Jennifer, Lamar, Walter E., Mason, Christopher E., Reding, Brian D., Roca, Matthew A., Ryon, Krista, Schürer, Stephan C., Shukla, Bhavarth S., Solle, Natasha Schaefer, Stevenson, Mario, Tallon, John J., Vidović, Dušica, Williams, Sion L., Yin, Xue, Solo-Gabriele, Helena M.

Get full text

White matter and neurite morphology differ in psychogenic nonepileptic seizures by Goodman, Adam M., Allendorfer, Jane B., Blum, Andrew S., Bolding, Mark S., Correia, Stephen, Ver Hoef, Lawrence W., Gaston, Tyler E., Grayson, Leslie E., Kraguljac, Nina V., Lahti, Adrienne C., Martin, Amber N., Monroe, William S., Philip, Noah S., Tocco, Krista, Vogel, Valerie, LaFrance, W. Curt, Szaflarski, Jerzy P.

Get full text

One-year follow-up of neurobehavioral therapy in functional seizures or epilepsy with traumatic brain injury: A nonrandomized controlled trial by Van Patten, Ryan, Blum, Andrew, Correia, Stephen, Philip, Noah S, Allendorfer, Jane B, Gaston, Tyler E, Goodman, Adam, Grayson, Leslie P, Tocco, Krista, Vogel, Valerie, Martin, Amber, Fry, Samantha, Bolding, Mark, Ver Hoef, Lawrence, Baird, Grayson L, Szaflarski, Jerzy P, LaFrance, Jr, W Curt

Get full text

Improvements in Montreal Cognitive Assessment scores after neurobehavioral therapy in adults with functional (nonepileptic) seizures and traumatic brain injury by Van Patten, Ryan, Chan, Lawrence, Tocco, Krista, Mordecai, Kristen, Altalib, Hamada, Twamley, Elizabeth W., Gaston, Tyler E., Grayson, Leslie P., Martin, Amber, Fry, Samantha, Goodman, Adam, Allendorfer, Jane B., Correia, Stephen, Szaflarski, Jerzy, LaFrance, W. Curt

Get full text

Ability To Serologically Confirm Recent Zika Virus Infection in Areas with Varying Past Incidence of Dengue Virus Infection in the United States and U.S. Territories in 2016 by Lindsey, Nicole P, Staples, J Erin, Powell, Krista, Rabe, Ingrid B, Fischer, Marc, Powers, Ann M, Kosoy, Olga I, Mossel, Eric C, Munoz-Jordan, Jorge L, Beltran, Manuela, Hancock, W Thane, Toews, Karrie-Ann E, Ellis, Esther M, Ellis, Brett R, Panella, Amanda J, Basile, Alison J, Calvert, Amanda E, Laven, Janeen, Goodman, Christin H, Gould, Carolyn V, Martin, Stacey W, Thomas, Jennifer D, Villanueva, Julie, Mataia, Mary L, Sciulli, Rebecca, Gose, Remedios, Whelen, A Christian, Hills, Susan L

Get full text

Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer by Ryan, Bríd M., Zanetti, Krista A., Robles, Ana I., Schetter, Aaron J., Goodman, Julie, Hayes, Richard B., Huang, Wen‐Yi, Gunter, Mark J., Yeager, Meredith, Burdette, Laurie, Berndt, Sonja I., Harris, Curtis C.

Get full text

Discovery and fine-mapping of height loci via high-density imputation of GWASs in individuals of African ancestry by Graff, Mariaelisa, Young, Kristin L., Marouli, Eirini, Fine, Rebecca S., Lim, Elise, Buchanan, Victoria, Rand, Kristin, Wojczynski, Mary K., Yanek, Lisa R., Aldrich, Melinda C., Ambrosone, Christine B., Atwood, Larry, Bandera, Elisa V., Berndt, Sonja I., Bernstein, Leslie, Bowden, Donald W., Burke, Gregory, Cai, Qiuyin, Carlson, Chris, Casey, Graham, Chanock, Stephen J., Chen, Guanjie, Chen, Minhui, Conti, David V., Cooper, Richard S., Cushman, Mary, Dimitrov, Latchezar, Evans, Michele K., Freedman, Barry I., Gillanders, Elizabeth M., Gottesman, Omri, Henderson, Brian E., Hernandez, Dena G., Hsing, Ann W., Hsu, Yu-Han H., Huo, Dezheng, Irvin, Marguerite R., John, Esther M., Johnson, Karen C., Jordan, Joanne M., Kabagambe, Edmond K., Keating, Brendan J., Kittles, Rick A., Leonard, Hampton, Lettre, Guillaume, Li, Yun, Li, Jin, Liu, Yongmei, Liu, Youfang, Liu, Simin, Lohman, Kurt, Maixner, William, McKnight, Barbara, Meng, Yan, Monda, Keri L., Moore, Jason H., Murphy, Adam B., Nalls, Mike A., Nathanson, Katherine L., Neuhouser, Marian L., Nyante, Sarah, Ochs-Balcom, Heather, Ogundiran, Temidayo O., Ogunniyi, Adesola, Padhukasahasram, Badri, Pettaway, Curtis A., Peyser, Patricia A., Rao, D.C., Rasmussen-Torvik, Laura J., Reiner, Alex P., Rhie, Suhn K., Rodriguez-Gil, Jorge L., Schwartz, Ann G., Shriner, Daniel A., Siscovick, David S., Smith, Shad, Spitz, Margaret, Stevens, Victoria L., Stram, Alex, Strom, Sara S., Sucheston, Lara, Sun, Yan V., Tajuddin, Salman M., Tayo, Bamidele O., Thun, Michael J., Vaidya, Dhananjay, Vedantam, Sailaja, Vitolins, Mara, Wang, Zhaoming, Wassertheil-Smoller, Sylvia, Weir, David R., Wilson, James G., Wrensch, Margaret, Wu, Xifeng, Zakai, Neil, Zonderman, Alan B., Psaty, Bruce M., Borecki, Ingrid B., Liu, Ching-Ti, North, Kari E.

Get full text

Innate immunity gene polymorphisms and the risk of colorectal neoplasia by Chang, Cindy M, Chia, Victoria M, Gunter, Marc J, Zanetti, Krista A, Ryan, Bríd M, Goodman, Julie E, Harris, Curtis C, Weissfeld, Joel, Huang, Wen-Yi, Chanock, Stephen, Yeager, Meredith, Hayes, Richard B, Berndt, Sonja I

Get full text