Structure–Activity Relationships and Discovery of (S)‑5‑(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2′,1′:2,3]imidazo[4,5‑h]quinoline-3-carboxylic Ac... by Gotchev, Dimitar, Chen, Shuai, Dugan, Benjamin, Dorsey, Bruce D., Wang, Xu, Sheraz, Muhammad, Kowalski, Rose, Liu, Fei, Tang, Sunny, Chiu, Tim, Harasym, Troy, Graves, Ingrid E., Thi, Emily P., Mason, Jeremy D., Overholt, Nathan, Dugyala, Ravi, Lam, Angela M., Cole, Andrew G., Sofia, Michael J.

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Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161 by Lam, Angela M, Dugyala, Ravi R, Sheraz, Muhammed, Liu, Fei, Thi, Emily P, Graves, Ingrid E, Cuconati, Andrea, Steuer, Holly Micolochick, Ardzinski, Andrzej, Overholt, Nathan, Mason, Jeremy D, Gotchev, Dimitar, Cole, Andrew G, Harasym, Troy O, Sofia, Michael J

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Preclinical and clinical antiviral characterization of AB-836, a potent capsid assembly modulator against hepatitis B virus by Lam, Angela M., Mani, Nagraj, Ardzinski, Andrzej, Stever, Kim, Cuconati, Andrea, Micolochick Steuer, Holly, Thi, Emily P., Graves, Ingrid E., Espiritu, Christine L., Mesaros, Eugen, Kultgen, Steven G., Fan, Kristi, Cole, Andrew G., Harasym, Troy O., Rijnbrand, Rene, Brown, Joanne, Eley, Timothy, Varughese, Tilly, Gane, Edward, Picchio, Gaston, Sims, Karen D., Sofia, Michael J.

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Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic by Thi, Emily P., Ye, Xin, Snead, Nicholas M., Lee, Amy C. H., Micolochick Steuer, Holly M., Ardzinski, Andrzej, Graves, Ingrid E., Espiritu, Christine, Cuconati, Andrea, Abbott, Cory, Jarosz, Agnes, Teng, Xiaowei, Paratala, Bhavna, McClintock, Kevin, Harasym, Troy, Rijnbrand, Rene, Lam, Angela M., Sofia, Michael J.

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Pharmacodynamics of durable HBsAg suppression by AB-729 short interfering RNA correlates with pharmacokinetics of RNA-induced silencing complex (RISC) loading within liver by Thi, Emily P., Shubina, Maria, Graves, Ingrid, Lam, Angela M, Sofia, Michael J.

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Structure-Activity Relationships and Discovery of (S)-5-(tert-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido2',1':2,3imidazo4,5-hquinoline-3-carboxylic Acid (... by Gotchev, Dimitar, Chen, Shuai, Dugan, Benjamin, Dorsey, Bruce D, Wang, Xu, Sheraz, Muhammad, Kowalski, Rose, Liu, Fei, Tang, Sunny, Chiu, Tim, Harasym, Troy, Graves, Ingrid E, Thi, Emily P, Mason, Jeremy D, Overholt, Nathan, Dugyala, Ravi, Lam, Angela M, Cole, Andrew G, Sofia, Michael J

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Rational Design, Synthesis, and Structure–Activity Relationship of a Novel Isoquinolinone-Based Series of HBV Capsid Assembly Modulators Leading to the Identification of Clinical C... by Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Ardzinski, Andrzej, Stever, Kim, Dorsey, Bruce D., Mesaros, Eugen F., Thi, Emily P., Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lee, Amy C. H., Olland, Andrea, Suto, Robert K., Sofia, Michael J.

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Preclinical activity of small-molecule oral PD-L1 checkpoint inhibitors capable of reinvigorating T cell responses from chronic hepatitis B patients by Thi, Emily P., Cole, Andrew G., Heffernan, Gavin, Iott, Christina, Ozturk, Seyma, Ganchua, Sharie C, Nguyen, Dan, Graves, Ingrid, Ahuja, Vijay, Stever, Kim, Fan, Kristi, Quintero, Jorge G., Kultgen, Steven G., Shubina, Maria, Liu, Boya, Tang, Sunny, Harasym, Troy O., Lam, Angela M, Sofia, Michael J.

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Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators by Mesaros, Eugen F, Cole, Andrew G, Kultgen, Steven G, Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J, Ardzinski, Andrzej, Stever, Kim, Micolochick Steuer, Holly M, Graves, Ingrid, Tang, Sunny, Harasym, Troy O, Lam, Angela M, Thi, Emily P, Dorsey, Bruce D, Sofia, Michael J

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Risk-adapted targeted intraoperative radiotherapy versus whole-breast radiotherapy for breast cancer: 5-year results for local control and overall survival from the TARGIT-A random... by Vaidya, Jayant S, Prof, Wenz, Frederik, Prof, Bulsara, Max, Prof, Tobias, Jeffrey S, Prof, Joseph, David J, Prof, Keshtgar, Mohammed, Prof, Flyger, Henrik L, MD, Massarut, Samuele, MD, Alvarado, Michael, MD, Saunders, Christobel, Prof, Eiermann, Wolfgang, Prof, Metaxas, Marinos, PhD, Sperk, Elena, MD, Sütterlin, Marc, Prof, Brown, Douglas, FRCS, Esserman, Laura, Prof, Roncadin, Mario, MD, Thompson, Alastair, Prof, Dewar, John A, Prof, Holtveg, Helle M R, MD, Pigorsch, Steffi, MD, Falzon, Mary, FRCPath, Harris, Eleanor, MD, Matthews, April, BSc, Brew-Graves, Chris, MSc, Potyka, Ingrid, PhD, Corica, Tammy, BSc, Williams, Norman R, PhD, Baum, Michael, Prof

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Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity by Meng, Bo, Abdullahi, Adam, Ferreira, Isabella A. T. M., Goonawardane, Niluka, Saito, Akatsuki, Kimura, Izumi, Yamasoba, Daichi, Gerber, Pehuén Pereyra, Fatihi, Saman, Rathore, Surabhi, Zepeda, Samantha K., Papa, Guido, Kemp, Steven A., Ikeda, Terumasa, Toyoda, Mako, Tan, Toong Seng, Kuramochi, Jin, Mitsunaga, Shigeki, Ueno, Takamasa, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Brevini, Teresa, Mallery, Donna L., Charles, Oscar J., Bowen, John E., Joshi, Anshu, Walls, Alexandra C., Jackson, Laurelle, Martin, Darren, Smith, Kenneth G. C., Bradley, John, Briggs, John A. G., Choi, Jinwook, Madissoon, Elo, Meyer, Kerstin B., Mlcochova, Petra, Ceron-Gutierrez, Lourdes, Doffinger, Rainer, Teichmann, Sarah A., Fisher, Andrew J., Pizzuto, Matteo S., de Marco, Anna, Corti, Davide, Hosmillo, Myra, Lee, Joo Hyeon, James, Leo C., Thukral, Lipi, Veesler, David, Sigal, Alex, Sampaziotis, Fotios, Goodfellow, Ian G., Matheson, Nicholas J., Sato, Kei, Gupta, Ravindra K.

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Pulmonary Metastasectomy versus Continued Active Monitoring in Colorectal Cancer (PulMiCC): a multicentre randomised clinical trial by Treasure, Tom, Farewell, Vern, Macbeth, Fergus, Monson, Kathryn, Williams, Norman R, Brew-Graves, Chris, Lees, Belinda, Grigg, Olivia, Fallowfield, Lesley

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Long term survival and local control outcomes from single dose targeted intraoperative radiotherapy during lumpectomy (TARGIT-IORT) for early breast cancer: TARGIT-A randomised cli... by Vaidya, Jayant S, Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik L, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R, Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Le Blanc-Onfroy, Magali, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J, Niewald, Marcus, Blohmer, Jens, McCready, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David J, Tobias, Jeffrey S

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An international randomised controlled trial to compare TARGeted Intraoperative radioTherapy (TARGIT) with conventional postoperative radiotherapy after breast-conserving surgery f... by Vaidya, Jayant S, Wenz, Frederik, Bulsara, Max, Tobias, Jeffrey S, Joseph, David J, Saunders, Christobel, Brew-Graves, Chris, Potyka, Ingrid, Morris, Stephen, Vaidya, Hrisheekesh J, Williams, Norman R, Baum, Michael

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Disruption of Ephx2 in cardiomyocytes but not endothelial cells improves functional recovery after ischemia-reperfusion in isolated mouse hearts by Edin, Matthew L., Gruzdev, Artiom, Bradbury, J. Alyce, Graves, Joan P., Lih, Fred B., DeGraff, Laura M., Fleming, Ingrid, Zeldin, Darryl C.

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New clinical and biological insights from the international TARGIT-A randomised trial of targeted intraoperative radiotherapy during lumpectomy for breast cancer by Vaidya, Jayant S., Bulsara, Max, Baum, Michael, Wenz, Frederik, Massarut, Samuele, Pigorsch, Steffi, Alvarado, Michael, Douek, Michael, Saunders, Christobel, Flyger, Henrik, Eiermann, Wolfgang, Brew-Graves, Chris, Williams, Norman R., Potyka, Ingrid, Roberts, Nicholas, Bernstein, Marcelle, Brown, Douglas, Sperk, Elena, Laws, Siobhan, Sütterlin, Marc, Corica, Tammy, Lundgren, Steinar, Holmes, Dennis, Vinante, Lorenzo, Bozza, Fernando, Pazos, Montserrat, Blanc-Onfroy, Magali Le, Gruber, Günther, Polkowski, Wojciech, Dedes, Konstantin J., Niewald, Marcus, Blohmer, Jens, McReady, David, Hoefer, Richard, Kelemen, Pond, Petralia, Gloria, Falzon, Mary, Joseph, David, Tobias, Jeffrey S.

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The SmartTarget Biopsy Trial: A Prospective, Within-person Randomised, Blinded Trial Comparing the Accuracy of Visual-registration and Magnetic Resonance Imaging/Ultrasound Image-f... by Hamid, Sami, Donaldson, Ian A., Hu, Yipeng, Rodell, Rachael, Villarini, Barbara, Bonmati, Ester, Tranter, Pamela, Punwani, Shonit, Sidhu, Harbir S., Willis, Sarah, van der Meulen, Jan, Hawkes, David, McCartan, Neil, Potyka, Ingrid, Williams, Norman R., Brew-Graves, Chris, Freeman, Alex, Moore, Caroline M., Barratt, Dean, Emberton, Mark, Ahmed, Hashim U.

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SARS-CoV-2 spike N-terminal domain modulates TMPRSS2-dependent viral entry and fusogenicity by Meng, Bo, Choi, Jinwook, Baker, Stephen, Dougan, Gordon, Hess, Christoph, Kingston, Nathalie, Lehner, Paul J., Lyons, Paul A., Matheson, Nicholas J., Owehand, Willem H., Saunders, Caroline, Summers, Charlotte, Thaventhiran, James E.D., Toshner, Mark, Weekes, Michael P., Maxwell, Patrick, Shaw, Ashley, Calder, Jo, Canna, Laura, Domingo, Jason, Fuller, Stewart, Harris, Julie, Hewitt, Sarah, Kennet, Jane, Jose, Sherly, Kourampa, Jenny, Meadows, Anne, O’Brien, Criona, Price, Jane, Publico, Cherry, Rastall, Rebecca, Ribeiro, Carla, Rowlands, Jane, Ruffolo, Valentina, Tordesillas, Hugo, Dunmore, Benjamin J., Gräf, Stefan, Hodgson, Josh, Huang, Christopher, Hunter, Kelvin, Jones, Emma, Legchenko, Ekaterina, Matara, Cecilia, Martin, Jennifer, O’Donnell, Ciara, Pointon, Linda, Shih, Joy, Sutcliffe, Rachel, Tilly, Tobias, Treacy, Carmen, Tong, Zhen, Wylot, Marta, Betancourt, Ariana, Bower, Georgie, Cossetti, Chiara, De Sa, Aloka, Epping, Madeline, Gleadall, Nick, Hinch, Andrew, Jackson, Sarah, Jarvis, Isobel, Krishna, Ben, Omarjee, Ommar, Perera, Marianne, Potts, Martin, Richoz, Nathan, Romashova, Veronika, Stefanucci, Luca, Strezlecki, Mateusz, Turner, Lori, De Bie, Eckart M.D.D., Bunclark, Katherine, Josipovic, Masa, Mackay, Michael, Allison, John, Butcher, Helen, Caputo, Daniela, Dewhurst, Eleanor, Furlong, Anita, Graves, Barbara, Gray, Jennifer, Ivers, Tasmin, Le Gresley, Emma, Linger, Rachel, Meloy, Sarah, Muldoon, Francesca, Ovington, Nigel, Papadia, Sofia, Stark, Hannah, Stirrups, Kathleen E., Townsend, Paul, Walker, Neil, Webster, Jennifer, Scholtes, Ingrid, Hein, Sabine, King, Rebecca, Bradley, John R., Smith, Kenneth G.C., Lee, Joo Hyeon, Gupta, Ravindra K.

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Genetic risk factors for pediatric-onset multiple sclerosis by Gianfrancesco, Milena A, Stridh, Pernilla, Shao, Xiaorong, Rhead, Brooke, Graves, Jennifer S, Chitnis, Tanuja, Waldman, Amy, Lotze, Timothy, Schreiner, Teri, Belman, Anita, Greenberg, Benjamin, Weinstock–Guttman, Bianca, Aaen, Gregory, Tillema, Jan M, Hart, Janace, Caillier, Stacy, Ness, Jayne, Harris, Yolanda, Rubin, Jennifer, Candee, Meghan, Krupp, Lauren, Gorman, Mark, Benson, Leslie, Rodriguez, Moses, Mar, Soe, Kahn, Ilana, Rose, John, Roalstad, Shelly, Casper, T Charles, Shen, Ling, Quach, Hong, Quach, Diana, Hillert, Jan, Hedstrom, Anna, Olsson, Tomas, Kockum, Ingrid, Alfredsson, Lars, Schaefer, Catherine, Barcellos, Lisa F, Waubant, Emmanuelle

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A novel liposomal adjuvant system, CAF01, promotes long-lived Mycobacterium tuberculosis -specific T-cell responses in human by van Dissel, Jaap T, Joosten, Simone A, Hoff, Søren T, Soonawala, Darius, Prins, Corine, Hokey, David A, O’Dee, Dawn M, Graves, Andrew, Thierry-Carstensen, Birgit, Andreasen, Lars V, Ruhwald, Morten, de Visser, Adriëtte W, Agger, Else Marie, Ottenhoff, Tom H.M, Kromann, Ingrid, Andersen, Peter

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