Design, Synthesis and In-Vitro Biological Evaluation of Antofine and Tylophorine Prodrugs as Hypoxia-Targeted Anticancer Agents by Omran, Ziad, Guise, Chris P., Chen, Linwei, Rauch, Cyril, Abdalla, Ashraf N., Abdullah, Omeima, Sindi, Ikhlas A., Fischer, Peter M., Smaill, Jeff B., Patterson, Adam V., Liu, Yuxiu, Wang, Qingmin

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Subcellular Location of Tirapazamine Reduction Dramatically Affects Aerobic but Not Anoxic Cytotoxicity by Guise, Chris P, Abbattista, Maria R, Anderson, Robert F, Li, Dan, Taghipouran, Rana, Tsai, Angela, Lee, Su Jung, Smaill, Jeff B, Denny, William A, Hay, Michael P, Wilson, William R, Hicks, Kevin O, Patterson, Adam V

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The Role of Bystander Effects in the Antitumor Activity of the Hypoxia-Activated Prodrug PR-104 by Foehrenbacher, Annika, Patel, Kashyap, Abbattista, Maria R, Guise, Chris P, Secomb, Timothy W, Wilson, William R, Hicks, Kevin O

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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411NTR leading to therapeutic benefit by Singleton, Dean C., Mowday, Alexandra M., Guise, Chris P., Syddall, Sophie P., Bai, Sally Y., Li, Dan, Ashoorzadeh, Amir, Smaill, Jeff B., Wilson, William R., Patterson, Adam V.

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Identification of one-electron reductases that activate both the hypoxia prodrug SN30000 and diagnostic probe EF5 by Wang, Jingli, Guise, Chris P., Dachs, Gabi U., Phung, Yen, Hsu, Annie (Huai-Ling), Lambie, Neil K., Patterson, Adam V., Wilson, William R.

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Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A: A role for NADPH:cytochrome P450 oxidoreductase under hypoxia by Guise, Chris P., Wang, Anderson T., Theil, Anke, Bridewell, David J., Wilson, William R., Patterson, Adam V.

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Bioreductive prodrug PR-104 improves the tumour distribution and titre of the nitroreductase-armed oncolytic adenovirus ONYX-411 NTR leading to therapeutic benefit by Singleton, Dean C, Mowday, Alexandra M, Guise, Chris P, Syddall, Sophie P, Bai, Sally Y, Li, Dan, Ashoorzadeh, Amir, Smaill, Jeff B, Wilson, William R, Patterson, Adam V

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Abstract 2111: Identification of reductases capable of metabolic activation of hypoxia targeting prodrug SN30000 and hypoxia marker EF5 by Wang, Jingli, Guise, Chris P., Hsu, Huai-Ling, Hurley, Daniel, Wilson, William R., Patterson, Adam V.

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NITROREDUCTASE: A PRODRUG-ACTIVATING ENZYME FOR CANCER GENE THERAPY by Searle, Peter F, Chen, Ming-Jen, Hu, Longqin, Race, Paul R, Lovering, Andrew L, Grove, Jane I, Guise, Chris, Jaberipour, Mansooreh, James, Nicholas D, Mautner, Vivien, Young, Lawrence S, Kerr, David J, Mountain, Andrew, White, Scott A, Hyde, Eva I

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