Quality by design in formulation and process development for a freeze-dried, small molecule parenteral product: a case study by Mockus, Linas N., Paul, Timothy W., Pease, Nathan A., Harper, Nancy J., Basu, Prabir K., Oslos, Elizabeth A., Sacha, Gregory A., Kuu, Wei Y., Hardwick, Lisa M., Karty, Jacquelyn J., Pikal, Michael J., Hee, Eun, Khan, Mansoor A., Nail, Steven L.

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The Influence of Mannitol Hemihydrate on the Secondary Drying Dynamics of a Protein Formulation: A Case Study by Srinivasan, Jayasree M., Wegiel, Lindsay A., Hardwick, Lisa M., Nail, Steven L.

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Correlation of laboratory and production freeze drying cycles by Kuu, Wei Y., Hardwick, Lisa M., Akers, Michael J.

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A proposed rationale and test methodology for establishment of acceptance criteria for vacuum integrity testing of pharmaceutical freeze dryers by Hardwick, Lisa M., Nail, Steven L., Jarman, James, Hasler, Kai, Hense, Thomas

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Product mass transfer resistance directly determined during freeze-drying cycle runs using tunable diode laser absorption spectroscopy (TDLAS) and pore diffusion model by Kuu, Wei Y., O'Bryan, Kevin R., Hardwick, Lisa M., Paul, Timothy W.

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Rapid determination of dry layer mass transfer resistance for various pharmaceutical formulations during primary drying using product temperature profiles by Kuu, Wei Y., Hardwick, Lisa M., Akers, Michael J.

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Practical formulation and process development of freeze-dried products by SCHWEGMAN, J. Jeff, HARDWICK, Lisa M, AKERS, Michael J

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Determination of Shelf Heat Transfer Coefficients Along the Shelf Flow Path of a Freeze Dryer Using the Shelf Fluid Temperature Perturbation Approach by Kuu, Wei Y., Nail, Steven L., Hardwick, Lisa M.

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Practical Formulation and Process Development of Freeze-Dried Products by Schwegman, J. Jeff, Hardwick, Lisa M., Akers, Michael J.

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Practical Experiences in the Transfer and Scale-up of Freeze-Dried Products by Schwegman, J Jeff, Hardwick, Lisa M, Crawford, Donald, Hines, C Wesley

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Practical experiences in the transfer and scale-up of freeze-dried products: several key steps should be taken to ensure a successful transfer of a freeze-dried product from a clie... by Schwegman, J. Jeff, Hardwick, Lisa M, Crawford, Donald, Hines, C. Wesley, Jarman, James, Korte, Brad, Akers, Michael J

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Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study by Docherty, Annemarie B, Harrison, Ewen M, Green, Christopher A, Hardwick, Hayley E, Pius, Riinu, Norman, Lisa, Holden, Karl A, Read, Jonathan M, Dondelinger, Frank, Carson, Gail, Merson, Laura, Lee, James, Plotkin, Daniel, Sigfrid, Louise, Halpin, Sophie, Jackson, Clare, Gamble, Carrol, Horby, Peter W, Nguyen-Van-Tam, Jonathan S, Ho, Antonia, Russell, Clark D, Dunning, Jake, Openshaw, Peter JM, Baillie, J Kenneth, Semple, Malcolm G

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Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score by Knight, Stephen R, Ho, Antonia, Pius, Riinu, Buchan, Iain, Carson, Gail, Drake, Thomas M, Dunning, Jake, Fairfield, Cameron J, Gamble, Carrol, Green, Christopher A, Gupta, Rishi, Halpin, Sophie, Hardwick, Hayley E, Holden, Karl A, Horby, Peter W, Jackson, Clare, Mclean, Kenneth A, Merson, Laura, Nguyen-Van-Tam, Jonathan S, Norman, Lisa, Noursadeghi, Mahdad, Olliaro, Piero L, Pritchard, Mark G, Russell, Clark D, Shaw, Catherine A, Sheikh, Aziz, Solomon, Tom, Sudlow, Cathie, Swann, Olivia V, Turtle, Lance CW, Openshaw, Peter JM, Baillie, J Kenneth, Semple, Malcolm G, Docherty, Annemarie B, Harrison, Ewen M

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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses by Wang, Beibei, Skelly, Donal, Pan, Daniel, Omo-Dare, Nicola, Koeckerling, David, Jenkin, Daniel, Fernandes da Costa, Cristiano, Malik, Tariq, Baillie, J. Kenneth, Klenerman, Paul, Pollard, Andrew J., Conlon, Christopher, Jeffery, Katie, Stafford, Lizzie, Chand, Meera, Green, Christoper A., Harrison, Ewen M., Wai Ho, Antonia Ying, Palmarini, Massimo, Price, Nicholas, Robertson, David L., Sigfrid, Louise, Sriskandan, Shiranee, Stuart, David, Swann, Olivia V., Tedder, Richard S., Turtle, Lance CW, Zambon, Maria, Pius, Riinu, Knight, Stephen R., Harrison, Janet, Jackson, Clare, Gamble, Carrol, Plotkin, Daniel, Lee, James, Wham, Murray, Shaw, Victoria, McDonald, Sarah E., Armstrong, Jane A., Ashworth, Milton, Barlow, Samantha L., Bullock, Katie, Davis, Christopher, Dunn, Chris, King, Katharine, Kiy, Robyn T., Lant, Suzannah, Latawiec, Diane, Mancini, Maria, Metelmann, Soeren, Penrice-Randal, Rebekah, Pilgrim, Jack, van Tonder, Libby, Murphy, Lee, Morrice, Kirstie, Gilchrist, Tammy, Aldera, Erin L., Barnass, Stella, Bernatoniene, Jolanta, Bothma, Pieter, Brittain-Long, Robin, Caruth, Vikki, Collini, Paul, Dawson, Chris, Dervisevic, Samir, Dushianthan, Ahilanadan, Evans, Cariad, Harvey, Daniel, Hawcutt, Daniel B., Hodgson, Luke, Hormis, Anil, Kerrison, Caroline, Larkin, Susan, Little, Jeff, Meda, Manjula, Moon, James, Mortimore, Katherine, Murphy, Michael, O’Shea, Matthew K., Otahal, Igor, Panchatsharam, Selva, Patel, Brij, Pepperell, Justin, Peters, Mark, Price, David, Reschreiter, Henrik, Ruge, Bobby, Saluja, Taranprit, Sizer, Jeremy, Shankar-Hari, Manu, Snelson, Catherine, Staines, Nikki, Twagira, Mary, Vincent-Smith, Lisa, Visuvanathan, Shico, Welters, Ingeborg, Wolverson, Adam, Yates, Bryan, Fry, Elizabeth E., Ren, Jingshan

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Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease. An International Multicenter Study by Drake, Thomas M, Docherty, Annemarie B, Harrison, Ewen M, Quint, Jennifer K, Adamali, Huzaifa, Agnew, Sarah, Babu, Suresh, Barber, Christopher M, Barratt, Shaney, Bendstrup, Elisabeth, Bianchi, Stephen, Villegas, Diego Castillo, Chaudhuri, Nazia, Chua, Felix, Coker, Robina, Chang, William, Crawshaw, Anjali, Crowley, Louise E, Dosanjh, Davinder, Fiddler, Christine A, Forrest, Ian A, George, Peter M, Gibbons, Michael A, Groom, Katherine, Haney, Sarah, Hart, Simon P, Heiden, Emily, Henry, Michael, Ho, Ling-Pei, Hoyles, Rachel K, Hutchinson, John, Hurley, Killian, Jones, Mark, Jones, Steve, Kokosi, Maria, Kreuter, Michael, MacKay, Laura S, Mahendran, Siva, Margaritopoulos, George, Molina-Molina, Maria, Molyneaux, Philip L, O'Brien, Aiden, O'Reilly, Katherine, Packham, Alice, Parfrey, Helen, Poletti, Venerino, Porter, Joanna C, Renzoni, Elisabetta, Rivera-Ortega, Pilar, Russell, Anne-Marie, Saini, Gauri, Spencer, Lisa G, Stella, Giulia M, Stone, Helen, Sturney, Sharon, Thickett, David, Thillai, Muhunthan, Wallis, Tim, Ward, Katie, Wells, Athol U, West, Alex, Wickremasinghe, Melissa, Woodhead, Felix, Hearson, Glenn, Howard, Lucy, Baillie, J Kenneth, Openshaw, Peter J M, Semple, Malcolm G, Stewart, Iain, Jenkins, R Gisli

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Clinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study by Halpin, Sophie, Donohue, Chloe, Ladhani, Shamez, Horby, Peter W, Docherty, Annemarie B, Semple, Malcolm G, Openshaw, Peter J M, Bach, Benjamin, Chand, Meera, Harrison, Ewen M, Hiscox, Julian A, Horby, Peter W, Klenerman, Paul, Law, Andrew, Moore, Shona C, Palmarini, Massimo, Russell, Clark D, Solomon, Tom, Sriskandan, Shiranee, Stuart, David, Thomson, Emma C, Oosthuyzen, Wilna, Norman, Lisa, Pius, Riinu, Mclean, Kenneth A, Saviciute, Egle, Leeming, Gary, Hendry, Ross, Greenhalf, William, Ahmed, Katie A, Asiimwe, Innocent G, Brennan, Benjamin, Catterall, Benjamin WA, Clark, Jordan J, Cole, Sarah, Cox, Helen, Elliott, Angela, Foster, Terry, Greenhalf, Willliam, Jones, Trevor R, Murphy, Ellen G, Small, Benjamin, Subramaniam, Krishanthi S, Tanianis, Jolanta, Trochu, Erwan, van Tonder, Libby, Wilcock, Eve, Agranoff, Daniel, Angus, Brian, Atkinson, Dougal, Barlow, Gavin, Barrett, Nicholas, Bassford, Christopher, Beadsworth, Michael, Best, Nicola, Burden, Tom, Chukkambotla, Srikanth, Cupitt, Jason, Dark, Paul, Dushianthan, Ahilanadan, Dyer, Tristan, Evans, Cariad, Fegan, Christopher, Finn, Adam, Fullerton, Duncan, Goldsmith, Arthur, Hardy, Elaine, Havalda, Peter, Holme, Anita, Kendall, Jason, Kerrison, Caroline, Larkin, Susan, Leiner, Tamas, Lillie, Patrick, MacNaughton, Emily, McCullough, Katherine, Moore, Elinoor, Morgan, Patrick, Morris, Craig, Nelson, Mark, Panchatsharam, Selva, Pintus, Stefania, Prout, Rachel, Rousseau, Guy, Ryan, Brendan, Saluja, Taranprit, Shanmuga, Prad, Sharma, Anil, Sizer, Jeremy, Smith, Richard, Snelson, Catherine, Spittle, Nick, Stambach, Tom, Tridente, Ascanio, Ustianowski, Andrew, Waddy, Sam, Whittaker, Paul, Williams, Martin, Wiselka, Martin, Young, Peter

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Acute kidney injury in patients hospitalized with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study by Sullivan, Michael K, Lees, Jennifer S, Drake, Thomas M, Docherty, Annemarie B, Oates, Georgia, Hardwick, Hayley E, Russell, Clark D, Merson, Laura, Dunning, Jake, Nguyen-Van-Tam, Jonathan S, Openshaw, Peter, Harrison, Ewen M, Baillie, J Kenneth, Semple, Malcolm G, Ho, Antonia, Mark, Patrick B

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Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19 by Sidhu, Jasmin K, Siggins, Matthew K, Liew, Felicity, Russell, Clark D, Uruchurtu, Ashley S S, Davis, Christopher, Turtle, Lance, Moore, Shona C, Hardwick, Hayley E, Oosthuyzen, Wilna, Thomson, Emma C, Semple, Malcolm G, Baillie, J Kenneth, Openshaw, Peter J M, Thwaites, Ryan S

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Gabapentin for chronic pelvic pain in women (GaPP2): a multicentre, randomised, double-blind, placebo-controlled trial by Horne, Andrew W, Vincent, Katy, Hewitt, Catherine A, Middleton, Lee J, Koscielniak, Magda, Szubert, Wojciech, Doust, Ann M, Daniels, Jane P, Abdi, Suraiya, Acharya, Santanu, Al-Inizi, Shamma, Ball, Elizabeth, Baranowski, Andrew, Bhal, Nadia, Bhatia, Kalsang, Bhattacharya, Siladitya, Birch, Judy V., Carpenter, Tyrone, Chalhoub, Tony, Cheong, Ying C., Clark, T. Justin, Cregg, Roman, Dada, Tunde D., Datta, Dib, Faraj, Radwan, Feltham, Max G., Gupta, Pratima, Hapangama, Dharani, Hardwick, Chris, Hughes, Jon, Khatri, Pinky, Kumar, Geeta, Leighton, Lisa J., Majumder, Kingshuk, MacFarlane, Gary J., Mortimer, Alex, Odedra, Smita, Ramsay, Bruce, Raza, Amer, Rea, William, Roy, Somendra, Sajid, Afia, Saraswat, Lucky, Shah, Ahmar, Sivasamy, Jambulingam, Srivastava, Rashmi, Stubbs, Clive, Swaminathan, Ajay, Thampi, Premila, Thanoon, Omar, Thomas, Tony, Tracey, Irene, Underwood, Martyn, Willocks, Clare, Williams, Amanda C de C., Wood, Simon, Zondervan, Krina

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Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study by Knight, Stephen R, Holden, Karl A, Merson, Laura, Russell, Clark D, Solomon, Tom, Carson, Gail, Olliaro, Piero, Semple, Malcolm G, Alex, Beatrice, Bach, Benjamin, Dunning, Jake, da Silva Filipe, Ana, Horby, Peter W, Law, Andrew, Price, Nicholas, Rambaut, Andrew, Robertson, David L, Scott, Janet T, de Silva, Thushan, Sigfrid, Louise, Tedder, Richard S, Thwaites, Ryan S, Turtle, Lance CW, Andrikopoulos, Petros, Liggi, Sonia, Sands, Caroline, Fairfield, Cameron J, Shaw, Catherine A, Dalton, Jo, Girvan, Michelle, Hendry, Ross, Greenhalf, William, McDonald, Sarah E, Booth, Laura, Catterall, Benjamin WA, Clarke, Emily A, Dincarslan, Oslem, Dyer, Philip, Gunning, Philip, Hartley, Catherine, Jensen, Rebecca L, Jones, Christopher B, Khandaker, Shadia, Lefteri, Daniella, Livoti, Lucia A, Middleton, Joanna, Reynolds, Will, Ridley, P. Matthew, Shaw, Victoria E, Tanianis-Hughes, Jolanta, Trochu, Erwan, Flaherty, Lisa, Massey, Hannah, Aldera, Erin L., Alegria, Ana, Barnass, Stella, Barrett, Nicholas, Basude, Sneha, Baxter, David, Beadsworth, Michael, Best, Nicola, Burden, Tom, Chukkambotla, Srikanth, Cutino-Moguel, Maria-Teresa, Douthwaite, Sam, Fullerton, Duncan, Garg, Atul, Hawcutt, Daniel B, Jennings, Paul, Kaliappan, Agilan, Kasipandian, Vidya, Koduri, Gouri, Laird, Steven, Leiner, Tamas, Little, Jeff, McEwen, Ruth, Morris, Craig, Moses, Samuel, Norris, Lillian, Panchatsharam, Selva, Pattison, Natalie, Peters, Mark, Price, David, Prout, Rachel, Richardson, Neil, Rousseau, Guy, Ryan, Brendan, Sharma, Anil, Stambach, Tom, Stewart, Richard, Thompson, Robert, Tridente, Ascanio, Vuylsteke, Alan, Waddy, Sam, Wake, Rachel, Wilson, Lawrence, Wiselka, Martin, Wootton, Daniel G, Workman, Andrew, Young, Peter

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