Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk by Mirams, Gary R., Cui, Yi, Sher, Anna, Fink, Martin, Cooper, Jonathan, Heath, Bronagh M., McMahon, Nick C., Gavaghan, David J., Noble, Denis

Get full text

Localisation and functional significance of ryanodine receptors during β-adrenoceptor stimulation in the guinea-pig sino-atrial node by Rigg, Lauren, Heath, Bronagh M, Cui, Yi, Terrar, Derek A

Get full text

The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing... by Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

Get full text

Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition by Skidmore, John, Atcha, Zeenat, Boucherat, Emmanuelle, Castelletti, Laura, Chen, Deborah W., Coppo, Frank T., Cutler, Leanne, Dunsdon, Rachel M., Heath, Bronagh M., Hutchings, Rio, Hurst, David N., Javed, Sahar, Martin, Samuel, Maskell, Emma S.L., Norton, David, Pemberton, Darrel J., Redshaw, Sally, Rutter, Richard, Sehmi, Sanjeet S., Scoccitti, Tiziana, Temple, Hannah E., Theobald, Pam, Ward, Robert W., Wilson, David M.

Get full text

Modulation of the hyperpolarization-activated current (If) by calcium and calmodulin in the guinea-pig sino-atrial node by RIGG, Lauren, MATTICK, Paul A. D, HEATH, Bronagh M, TERRAR, Derek A

Get full text

Use of the dog isolated cardiac Purkinje fibre assay to investigate a compound with in vivo proarrhythmic activity by Graham, Sara G., Wilson, Carol M., Cui, Yi, Heath, Bronagh M.

Get full text

The discovery of 2-fluoro-N-3-fluoro-4-5-((4-morpholinobutyl)amino)-1,3, 4-oxadiazol-2-ylphenylbenzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing eff... by SKIDMORE, John, ATCHA, Zeenat, HURST, David N, JAVED, Sahar, MARTIN, Samuel, MASKELL, Emma S. L, NORTON, David, PEMBERTON, Darrel J, REDSHAW, Sally, RUTTER, Richard, SEHMI, Sanjeet S, SCOCCITTI, Tiziana, BOUCHERAT, Emmanuelle, TEMPLE, Hannah E, THEOBALD, Pam, WARD, Robert W, WILSON, David M, CASTELLETTI, Laura, CHEN, Deborah W, COPPO, Frank T, CUTLER, Leanne, DUNSDON, Rachel M, HEATH, Bronagh M, HUTCHINGS, Rio

Get full text

Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics by Vargas, Hugo M., Bass, Alan S., Breidenbach, Alexander, Feldman, Hal S., Gintant, Gary A., Harmer, Alexander R., Heath, Bronagh, Hoffmann, Peter, Lagrutta, Armando, Leishman, Derek, McMahon, Nick, Mittelstadt, Scott, Polonchuk, Liudmila, Pugsley, Michael K., Salata, Joseph J., Valentin, Jean-Pierre

Get full text

WITHDRAWN: Scientific review and recommendations on preclinical cardiovascular safety evaluation of biologics by Vargas, Hugo M., Bass, Alan S., Breidenbach, Alexander, Feldman, Hal S., Gintant, Gary A., Harmer, Alexander, Heath, Bronagh, Hoffmann, Peter, Lagrutta, Armando, Leishmann, Derek, McMahon, Nick, Mittelstadt, Scott, Polonchuk, Liudmila, Pugsley, Michael K., Salata, Joseph J., Valentin, Jean-Pierre

Get full text