Targeting SHP2 phosphatase in breast cancer overcomes RTK-mediated resistance to PI3K inhibitors by Heynen, Guus J J E, Lisek, Kamil, Vogel, Regina, Wulf-Goldenberg, Annika, Alcaniz, Joshua, Montaudon, Elodie, Marangoni, Elisabetta, Birchmeier, Walter

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Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma by Sun, Chong, Wang, Liqin, Huang, Sidong, Heynen, Guus J. J. E., Prahallad, Anirudh, Robert, Caroline, Haanen, John, Blank, Christian, Wesseling, Jelle, Willems, Stefan M., Zecchin, Davide, Hobor, Sebastijan, Bajpe, Prashanth K., Lieftink, Cor, Mateus, Christina, Vagner, Stephan, Grernrum, Wipawadee, Hofland, Ingrid, Schlicker, Andreas, Wessels, Lodewyk F. A., Beijersbergen, Roderick L., Bardelli, Alberto, Di Nicolantonio, Federica, Eggermont, Alexander M. M., Bernards, Rene

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From Pyrazolones to Azaindoles: Evolution of Active-Site SHP2 Inhibitors Based on Scaffold Hopping and Bioisosteric Replacement by Mostinski, Yelena, Heynen, Guus J. J. E, López-Alberca, Maria Pascual, Paul, Jerome, Miksche, Sandra, Radetzki, Silke, Schaller, David, Shanina, Elena, Seyffarth, Carola, Kolomeets, Yuliya, Ziebart, Nandor, de Schryver, Judith, Oestreich, Sylvia, Neuenschwander, Martin, Roske, Yvette, Heinemann, Udo, Rademacher, Christoph, Volkamer, Andrea, von Kries, Jens Peter, Birchmeier, Walter, Nazaré, Marc

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Cancer Stem Cells Regulate Cancer-Associated Fibroblasts via Activation of Hedgehog Signaling in Mammary Gland Tumors by Valenti, Giovanni, Quinn, Hazel M, Heynen, Guus J J E, Lan, Linxiang, Holland, Jane D, Vogel, Regina, Wulf-Goldenberg, Annika, Birchmeier, Walter

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PTPN11 Is a Central Node in Intrinsic and Acquired Resistance to Targeted Cancer Drugs by Prahallad, Anirudh, Heynen, Guus J.J.E., Germano, Giovanni, Willems, Stefan M., Evers, Bastiaan, Vecchione, Loredana, Gambino, Valentina, Lieftink, Cor, Beijersbergen, Roderick L., Di Nicolantonio, Federica, Bardelli, Alberto, Bernards, Rene

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The Corepressor CTBP2 Is a Coactivator of Retinoic Acid Receptor/Retinoid X Receptor in Retinoic Acid Signaling by Bajpe, Prashanth Kumar, Heynen, Guus J. J. E., Mittempergher, Lorenza, Grernrum, Wipawadee, de Rink, Iris A., Nijkamp, Wouter, Beijersbergen, Roderick L., Bernards, Rene, Huang, Sidong

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Resistance to targeted cancer drugs through hepatocyte growth factor signaling by Heynen, Guus JJE, Fonfara, Aldona, Bernards, René

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Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma by Heynen, Guus J J E, Nevedomskaya, Ekaterina, Palit, Sander, Jagalur Basheer, Noorjahan, Lieftink, Cor, Schlicker, Andreas, Zwart, Wilbert, Bernards, Rene, Bajpe, Prashanth Kumar

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SUMOylation inhibition overcomes proteasome inhibitor resistance in multiple myeloma by Heynen, Guus J. J. E., Baumgartner, Francis, Heider, Michael, Patra, Upayan, Holz, Maximilian, Braune, Jan, Kaiser, Melanie, Schäffer, Isabell, Bamopoulos, Stefanos A., Ramberger, Evelyn, Murgai, Arunima, Ng, Yuen Lam Dora, Demel, Uta Margareta, Laue, Dominik, Liebig, Sven, Krüger, Josefine, Janz, Martin, Nogai, Axel, Schick, Markus, Mertins, Philipp, Müller, Stefan, Bassermann, Florian, Krönke, Jan, Keller, Ulrich, Wirth, Matthias

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Two Dot1 isoforms in Saccharomyces cerevisiae as a result of leaky scanning by the ribosome by Frederiks, Floor, Heynen, Guus J.J.E, van Deventer, Sjoerd J, Janssen, Hans, van Leeuwen, Fred

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Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer by Li, Hongde, Stokes, William, Chater, Emily, Roy, Rajat, de Bruin, Elza, Hu, Yili, Liu, Zhigang, Smit, Egbert F, Heynen, Guus JJE, Downward, Julian, Seckl, Michael J, Wang, Yulan, Tang, Huiru, Pardo, Olivier E

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Reduced NF1 expression confers resistance to EGFR inhibition in lung cancer by de Bruin, Elza C, Cowell, Catherine, Warne, Patricia H, Jiang, Ming, Saunders, Rebecca E, Melnick, Mary Ann, Gettinger, Scott, Walther, Zenta, Wurtz, Anna, Heynen, Guus J, Heideman, Daniëlle A M, Gómez-Román, Javier, García-Castaño, Almudena, Gong, Yixuan, Ladanyi, Marc, Varmus, Harold, Bernards, René, Smit, Egbert F, Politi, Katerina, Downward, Julian

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