Fragment-to-Lead Medicinal Chemistry Publications in 2022 by Woodhead, Andrew J., Erlanson, Daniel A., de Esch, Iwan J. P., Holvey, Rhian S., Jahnke, Wolfgang, Pathuri, Puja

Get full text

C-H functionalisation tolerant to polar groups could transform fragment-based drug discovery (FBDD) by Chessari, Gianni, Grainger, Rachel, Holvey, Rhian S, Ludlow, R. Frederick, Mortenson, Paul N, Rees, David C

Get full text

Fragment-Based Discovery of Allosteric Inhibitors of SH2 Domain-Containing Protein Tyrosine Phosphatase‑2 (SHP2) by Day, James E. H., Berdini, Valerio, Castro, Joan, Chessari, Gianni, Davies, Thomas G., Day, Philip J., St. Denis, Jeffrey D., Fujiwara, Hideto, Fukaya, Satoshi, Hamlett, Christopher C. F., Hearn, Keisha, Hiscock, Steven D., Holvey, Rhian S., Ito, Satoru, Kandola, Navrohit, Kodama, Yasuo, Liebeschuetz, John W., Martins, Vanessa, Matsuo, Kenichi, Mortenson, Paul N., Muench, Sandra, Nakatsuru, Yoko, Ochiiwa, Hiroaki, Palmer, Nicholas, Peakman, Torren, Price, Amanda, Reader, Michael, Rees, David C., Rich, Sharna J., Shah, Alpesh, Shibata, Yoshihiro, Smyth, Tomoko, Twigg, David G., Wallis, Nicola G., Williams, Glyn, Wilsher, Nicola E., Woodhead, Andrew, Shimamura, Tadashi, Johnson, Christopher N.

Get full text

Selective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design by Holvey, Rhian S., Valkov, Eugene, Neal, David, Stewart, Murray, Abell, Chris

Get full text

Selective Targeting of the TPX2 Site of Importin-[alpha] Using Fragment-Based Ligand Design by Holvey, Rhian S, Valkov, Eugene, Neal, David, Stewart, Murray, Abell, Chris

Get full text

Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction by Chessari, Gianni, Hardcastle, Ian R, Ahn, Jong Sook, Anil, Burcu, Anscombe, Elizabeth, Bawn, Ruth H, Bevan, Luke D, Blackburn, Timothy J, Buck, Ildiko, Cano, Celine, Carbain, Benoit, Castro, Juan, Cons, Ben, Cully, Sarah J, Endicott, Jane A, Fazal, Lynsey, Golding, Bernard T, Griffin, Roger J, Haggerty, Karen, Harnor, Suzannah J, Hearn, Keisha, Hobson, Stephen, Holvey, Rhian S, Howard, Steven, Jennings, Claire E, Johnson, Christopher N, Lunec, John, Miller, Duncan C, Newell, David R, Noble, Martin E. M, Reeks, Judith, Revill, Charlotte H, Riedinger, Christiane, St. Denis, Jeffrey D, Tamanini, Emiliano, Thomas, Huw, Thompson, Neil T, Vinković, Mladen, Wedge, Stephen R, Williams, Pamela A, Wilsher, Nicola E, Zhang, Bian, Zhao, Yan

Get full text

A safe and reliable procedure for the iododeamination of aromatic and heteroaromatic amines in a continuous flow reactor by Malet-Sanz, Laia, Madrzak, Julia, Holvey, Rhian S., Underwood, Toby

Get full text

Abstract 1039: Fragment-based drug discovery to identify small molecule allosteric inhibitors of SHP2 by Day, Philip J., Berdini, Valerio, Castro, Juan, Chessari, Gianni, Davies, Thomas G., Day, James E., Fukaya, Satoshi, Hamlett, Chris, Hearn, Keisha, Hiscock, Steve, Holvey, Rhian, Ito, Satoru, Kodama, Yasuo, Matsuo, Kenichi, Nakatsuru, Yoko, Palmer, Nick, Price, Amanda, Shimamura, Tadashi, Denis, Jeffrey D.St, Wallis, Nicola G., Williams, Glyn, Johnson, Christopher N.

Get full text