An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software by Shah, Pranav, Kerns, Edward, Nguyen, Dac-Trung, Obach, R Scott, Wang, Amy Q, Zakharov, Alexey, McKew, John, Simeonov, Anton, Hop, Cornelis E C A, Xu, Xin

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A Novel Reaction Mediated by Human Aldehyde Oxidase: Amide Hydrolysis of GDC-0834 by Sodhi, Jasleen K, Wong, Susan, Kirkpatrick, Donald S, Liu, Lichuan, Khojasteh, S. Cyrus, Hop, Cornelis E. C. A, Barr, John T, Jones, Jeffrey P, Halladay, Jason S

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Evaluation of Time Dependent Inhibition Assays for Marketed Oncology Drugs: Comparison of Human Hepatocytes and Liver Microsomes in the Presence and Absence of Human Plasma by Mao, Jialin, Tay, Suzanne, Khojasteh, Cyrus S., Chen, Yuan, Hop, Cornelis E. C. A., Kenny, Jane R.

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Opportunities and challenges using artificial intelligence in ADME/Tox by Bhhatarai, Barun, Walters, W. Patrick, Hop, Cornelis E. C. A., Lanza, Guido, Ekins, Sean

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Inter‐individual and inter‐regional variations in enteric drug metabolizing enzyme activities: Results with cryopreserved human intestinal mucosal epithelia (CHIM) from the small i... by Li, Albert P., Ho, Ming‐Chih D., Alam, Novera, Mitchell, Walter, Wong, Susan, Yan, Zhengyin, Kenny, Jane R., E. C. A. Hop, Cornelis

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Abundance of Phase 1 and 2 Drug-Metabolizing Enzymes in Alcoholic and Hepatitis C Cirrhotic Livers: A Quantitative Targeted Proteomics Study by Prasad, Bhagwat, Bhatt, Deepak Kumar, Johnson, Katherine, Chapa, Revathi, Chu, Xiaoyan, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Hop, Cornelis E.C.A., Mathias, Anita, Lai, Yurong, Liao, Mingxiang, Humphreys, William G., Kumer, Sean C., Unadkat, Jashvant D.

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Interindividual and Regional Variability in Drug Transporter Abundance at the Human Blood–Brain Barrier Measured by Quantitative Targeted Proteomics by Billington, Sarah, Salphati, Laurent, Hop, Cornelis E. C. A., Chu, Xiaoyan, Evers, Raymond, Burdette, Doug, Rowbottom, Christopher, Lai, Yurong, Xiao, Guangqing, Humphreys, W. Griffith, Nguyen, Tot Bui, Prasad, Bhagwat, Unadkat, Jashvant D.

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Chemical Structure and Concentration of Intratumor Catabolites Determine Efficacy of Antibody Drug Conjugates by Zhang, Donglu, Yu, Shang-Fan, Ma, Yong, Xu, Keyang, Dragovich, Peter S, Pillow, Thomas H, Liu, Luna, Del Rosario, Geoffrey, He, Jintang, Pei, Zhonghua, Sadowsky, Jack D, Erickson, Hans K, Hop, Cornelis E. C. A, Khojasteh, S. Cyrus

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Tissue distribution and retention drives efficacy of rapidly clearing VHL-based PROTACs by Zhang, Donglu, Ma, Bin, Dragovich, Peter S., Ma, Li, Chen, Shu, Chen, Eugene C., Ye, Xiaofen, Liu, Joyce, Pizzano, Jennifer, Bortolon, Elizabeth, Chan, Emily, Zhang, Xing, Chen, Yi-Chen, Levy, Elizabeth S., Yauch, Robert L., Khojasteh, S. Cyrus, Hop, Cornelis E. C. A.

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Transporter Expression in Liver Tissue from Subjects with Alcoholic or Hepatitis C Cirrhosis Quantified by Targeted Quantitative Proteomics by Wang, Li, Collins, Carol, Kelly, Edward J, Chu, Xiaoyan, Ray, Adrian S, Salphati, Laurent, Xiao, Guangqing, Lee, Caroline, Lai, Yurong, Liao, Mingxiang, Mathias, Anita, Evers, Raymond, Humphreys, William, Hop, Cornelis E C A, Kumer, Sean C, Unadkat, Jashvant D

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Strategy for CYP3A Induction Risk Assessment from Preclinical Signal to Human: a Case Example of a Late-Stage Discovery Compound by Mao, Jialin, Fan, Peter, Wong, Susan, Wang, Jianshuang, Ismaili, Moulay Hicham Alaoui, Dean, Brian, Hop, Cornelis E. C. A., Wright, Matthew, Chen, Yuan

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Physiologically Based Pharmacokinetic Modeling to Predict Drug-Drug Interactions Involving Inhibitory Metabolite: A Case Study of Amiodarone by Chen, Yuan, Mao, Jialin, Hop, Cornelis E.C.A.

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High-throughput liquid chromatography/mass spectrometry method for the quantitation of small molecules using accurate mass technologies in supporting discovery drug screening by Ding, Xiao, Ghobarah, Hesham, Zhang, Xiaolin, Jaochico, Allan, Liu, Xingrong, Deshmukh, Gauri, Liederer, Bianca M., Hop, Cornelis E. C. A., Dean, Brian

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A Comparison of Total and Plasma Membrane Abundance of Transporters in Suspended, Plated, Sandwich-Cultured Human Hepatocytes Versus Human Liver Tissue Using Quantitative Targeted... by Kumar, Vineet, Salphati, Laurent, Hop, Cornelis E C A, Xiao, Guangqing, Lai, Yurong, Mathias, Anita, Chu, Xiaoyan, Humphreys, W Griffith, Liao, Mingxiang, Heyward, Scott, Unadkat, Jashvant D

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Antitumor Activity of Targeted and Cytotoxic Agents in Murine Subcutaneous Tumor Models Correlates with Clinical Response by WONG, Harvey, CHOO, Edna F, GOULD, Stephen E, ALICKE, Bruno, XIAO DING, LA, Hank, MCNAMARA, Erin, THEIL, Frank-Peter, TIBBITTS, Jay, FRIEDMAN, Lori S, HOP, Cornelis E. C. A

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Determination of GDC-0449, a small-molecule inhibitor of the Hedgehog signaling pathway, in human plasma by solid phase extraction-liquid chromatographic-tandem mass spectrometry by Ding, X., Chou, B., Graham, R.A., Cheeti, S., Percey, S., Matassa, L.C., Reuschel, S.A., Meng, M., Liu, S., Voelker, T., Lum, B.L., Rudewicz, P.J., Hop, C.E.C.A.

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Quantitative Transporter Proteomics by Liquid Chromatography with Tandem Mass Spectrometry: Addressing Methodologic Issues of Plasma Membrane Isolation and Expression-Activity Rela... by Kumar, Vineet, Prasad, Bhagwat, Patilea, Gabriela, Gupta, Anshul, Salphati, Laurent, Evers, Raymond, Hop, Cornelis E. C. A, Unadkat, Jashvant D.

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Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans by Takahashi, Ryan H, Choo, Edna F, Ma, Shuguang, Wong, Susan, Halladay, Jason, Deng, Yuzhong, Rooney, Isabelle, Gates, Mary, Hop, Cornelis E.C.A, Khojasteh, S. Cyrus, Dresser, Mark J, Musib, Luna

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Comparative Assessment of In Vitro–In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs by Poulin, Patrick, Hop, Cornelis E.C.A., Ho, Quynh, Halladay, Jason S., Haddad, Sami, Kenny, Jane R.

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Immolation of p‑Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody–Drug Conjugates with Phenol-Containing Payloads by Zhang, Donglu, Le, Hoa, Cruz-Chuh, Josefa dela, Bobba, Sudheer, Guo, Jun, Staben, Leanna, Zhang, Chenghong, Ma, Yong, Kozak, Katherine R, Lewis Phillips, Gail D, Vollmar, Breanna S, Sadowsky, Jack D, Vandlen, Richard, Wei, BinQing, Su, Dian, Fan, Peter, Dragovich, Peter S, Khojasteh, S. Cyrus, Hop, Cornelis E. C. A, Pillow, Thomas H

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