Elucidating the Molecular Mechanisms of Action of CC-99282, a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent, Via Genome-Wide CRISPR Screen in a Preclinical Model of Non-... by Mo, Zhongying, Groocock, Lynda, Wood, Scott, Jankeel, Diana, Janardhanan, Preethi, Mendy, Derek, Angelo, Michael, Jang, In Sock, Fontanillo, Celia, Wang, Kai, Rolfe, Mark, Lopez-Girona, Antonia

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CC-99282 is a Novel Cereblon (CRBN) E3 Ligase Modulator (CELMoD) Agent with Enhanced Tumoricidal Activity in Preclinical Models of Lymphoma by Carrancio, Soraya, Groocock, Lynda, Janardhanan, Preethi, Jankeel, Diana, Galasso, Ryan, Guarinos, Carla, Narla, Rama K., Groza, Matthew, Leisten, Jim, Pierce, Daniel W., Rolfe, Mark, Lopez-Girona, Antonia

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BMS-986458 a Potential First-in-Class, Highly Selective, Potent and Well Tolerated BCL6 Ligand Directed Degrader (LDD) Demonstrates Multi-Modal Anti-Tumor Efficacy for the Treatmen... by Groocock, Lynda, Deb, Gauri, Zhu, Jinyi, Gamez, Jim, Castiglioni, Paola, Sanchez-Castillo, Manuel, Schumacher, Justin, Rondan, Alicia Benitez, Jankeel, Diana, Martinez-Garcia, Karla, Wood, Scott, Christoforou, Andy, Guarinos, Carla, Zhang, Wei, Narla, Rama Krishna, Zapf, Christoph W., Carrancio, Soraya, Pierce, Daniel W., Rolfe, Mark, Bence, Neil, Lopez-Girona, Antonia, Mortensen, Deborah S.

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Multi-Omics Integration to Elucidate the Cis-Regulatory Network Re-Wiring upon NSD2 Degradation in t(4;14) Multiple Myeloma by Hu, Bo, Modi, Hardik, Jankeel, Diana, Edwards, Jacob T., Zhao, Junfei, Bjorklund, Chad C., Jain, Gaurav, Hagner, Patrick R., Ortiz, Maria, Mo, Zhongying, Fontanillo, Celia, Zapf, Christoph W., Lopez-Girona, Antonia, Bence, Neil, Wang, Kai, Gandhi, Anita K., Rolfe, Mark, Mortensen, Deborah S., Groocock, Lynda

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Abstract 3932: Pathway interaction and mechanistic synergy of CC-99282, a novel cereblon E3 ligase modulator (CELMoD) agent, with enhancer of zeste homolog 2 inhibitors (EZH2is) by Carrancio, Soraya, Fontanillo, Celia, Galasso, Ryan, Colombo, Martino, Wood, Scott, Guarinos, Carla, Panjkovich, Alejandro, Jankeel, Diana, Blattler, Adam, Janardhanan, Preethi, Groza, Matthew, Leisten, Jim, Narla, Rama Krishna, Lopez-Girona, Antonia, Pierce, Daniel W.

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SARS-CoV-2 acquisition and immune pathogenesis among school-aged learners in four diverse schools by Cooper, Dan M., Zulu, Michael Z., Jankeel, Allen, Ibraim, Izabela Coimbra, Ardo, Jessica, Kasper, Kirsten, Stephens, Diana, Meyer, Andria, Stehli, Annamarie, Condon, Curt, Londoño, Mary E., Schreiber, Casey M., Lopez, Nanette V., Camplain, Ricky L., Weiss, Michael, Golden, Charles, Radom-Aizik, Shlomit, Boden-Albala, Bernadette, Chau, Clayton, Messaoudi, Ilhem, Ulloa, Erlinda R.

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