Syntheses of 1-substituted-3-aminopyrazoles by Ji, Nan, Meredith, Erik, Liu, Donglei, Adams, Christopher M., Artman, Gerald D., Jendza, Keith C., Ma, Fupeng, Mainolfi, Nello, Powers, James J., Zhang, Chun

Get full text

Discovery of 4-((2 S ,4 S )-4-Ethoxy-1-((5-methoxy-7-methyl-1 H -indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable... by Mainolfi, Nello, Ehara, Takeru, Karki, Rajeshri G, Anderson, Karen, Mac Sweeney, Aengus, Liao, Sha-Mei, Argikar, Upendra A, Jendza, Keith, Zhang, Chun, Powers, James, Klosowski, Daniel W, Crowley, Maura, Kawanami, Toshio, Ding, Jian, April, Myriam, Forster, Cornelia, Serrano-Wu, Michael, Capparelli, Michael, Ramqaj, Rrezarta, Solovay, Catherine, Cumin, Frederic, Smith, Thomas M, Ferrara, Luciana, Lee, Wendy, Long, Debby, Prentiss, Melissa, De Erkenez, Andrea, Yang, Louis, Liu, Fang, Sellner, Holger, Sirockin, Finton, Valeur, Eric, Erbel, Paulus, Ostermeier, Daniela, Ramage, Paul, Gerhartz, Bernd, Schubart, Anna, Flohr, Stefanie, Gradoux, Nathalie, Feifel, Roland, Vogg, Barbara, Wiesmann, Christian, Maibaum, Jürgen, Eder, Jörg, Sedrani, Richard, Harrison, Richard A, Mogi, Muneto, Jaffee, Bruce D, Adams, Christopher M

Get full text

The Discovery of N‑(1-Methyl-5-(trifluoromethyl)‑1H‑pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)‑1H‑indole-1-carboxamide (Acrizanib), a VEGFR‑2 Inhibitor Specifica... by Adams, Christopher M, Anderson, Karen, Artman, Gerald, Bizec, Jean-Claude, Cepeda, Rosemarie, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo A, Hosagrahara, Vinayak P, Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Lee, Wendy, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik L, Miranda, Karl, Peng, Yao, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy M, Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun, Zhang, Yiqin

Get full text

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway by Karki, Rajeshri G, Powers, James, Mainolfi, Nello, Anderson, Karen, Belanger, David B, Liu, Donglei, Ji, Nan, Jendza, Keith, Gelin, Christine F, Mac Sweeney, Aengus, Solovay, Catherine, Delgado, Omar, Crowley, Maura, Liao, Sha-Mei, Argikar, Upendra A, Flohr, Stefanie, La Bonte, Laura R, Lorthiois, Edwige L, Vulpetti, Anna, Brown, Ann, Long, Debby, Prentiss, Melissa, Gradoux, Nathalie, de Erkenez, Andrea, Cumin, Frederic, Adams, Christopher, Jaffee, Bruce, Mogi, Muneto

Get full text

A Reliable Synthesis of 3-Amino-5-Alkyl and 5-Amino-3-Alkyl Isoxazoles by Johnson, Leland, Powers, James, Ma, Fupeng, Jendza, Keith, Wang, Bing, Meredith, Erik, Mainolfi, Nello

Get full text

Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists by Thomson, Christopher G., Boss, Kelly, Calhoun, Amy, Fridrich, Cary, Gardinier, Kevin M., Hall, Edward C., Jendza, Keith, Kirman, Louise, Labbé-Giguere, Nancy, Laumen, Kurt, Qian, Ming, Sanyal, Sanjit, Shultz, Michael D., Snajdrova, Radka, Tan, Kian, Wang, Kate Yaping, Yang, Fan, Gao, Feng, Hong, Tao, Dale, Elena, Kuzmiski, Brent, Ortuno, Danny, Palacios, Daniel S.

Get full text

The Discovery of N -(1-Methyl-5-(trifluoromethyl)-1 H -pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1 H -indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Spec... by Adams, Christopher M., Anderson, Karen, Artman, Gerald, Bizec, Jean-Claude, Cepeda, Rosemarie, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo A., Hosagrahara, Vinayak P., Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Lee, Wendy, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik L., Miranda, Karl, Peng, Yao, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy M., Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun, Zhang, Yiqin

Get full text

Discovery of TD-0212, an Orally Active Dual Pharmacology AT 1 Antagonist and Neprilysin Inhibitor (ARNI) by McKinnell, R Murray, Fatheree, Paul, Choi, Seok-Ki, Gendron, Roland, Jendza, Keith, Olson Blair, Brooke, Budman, Joe, Hill, Craig M, Hegde, Laxminarayan G, Yu, Cecile, McConn, Donavon, Hegde, Sharath S, Marquess, Daniel G, Klein, Uwe

Get full text

Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI) by McKinnell, R. Murray, Fatheree, Paul, Choi, Seok-Ki, Gendron, Roland, Jendza, Keith, Olson Blair, Brooke, Budman, Joe, Hill, Craig M, Hegde, Laxminarayan G, Yu, Cecile, McConn, Donavon, Hegde, Sharath S, Marquess, Daniel G, Klein, Uwe

Get full text

The Versatility of α-Chloropropargyl Phenyl Sulfide Affords High Stereo- and Regioselectivities in Indium-Promoted Coupling Reactions under Mild Conditions by Mitzel, Thomas M, Palomo, Carolyn, Jendza, Keith

Get full text