Quantitative evaluation of trastuzumab deruxtecan pharmacokinetics and pharmacodynamics in mouse models of varying degrees of HER2 expression by Vasalou, Christina, Proia, Theresa A., Kazlauskas, Laura, Przybyla, Anna, Sung, Matthew, Mamidi, Srinivas, Maratea, Kim, Griffin, Matthew, Sargeant, Rebecca, Urosevic, Jelena, Rosenbaum, Anton I., Yuan, Jiaqi, Aluri, Krishna C., Ramsden, Diane, Hariparsad, Niresh, Jones, Rhys D.O., Mettetal, Jerome T.

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PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based pharmaco... by Poulin, Patrick, Jones, Rhys D.O., Jones, Hannah M., Gibson, Christopher R., Rowland, Malcolm, Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, He, Handan, Vuppugalla, Ragini, Marathe, Punit, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Yates, James W.T.

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Applications of Quantitative Systems Pharmacology in Model‐Informed Drug Discovery: Perspective on Impact and Opportunities by Bradshaw, Erica L., Spilker, Mary E., Zang, Richard, Bansal, Loveleena, He, Handan, Jones, Rhys D.O., Le, Kha, Penney, Mark, Schuck, Edgar, Topp, Brian, Tsai, Alice, Xu, Christine, Nijsen, Marjoleen J.M.A., Chan, Jason R.

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The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models by Schuller, Alwin G, Barry, Evan R, Jones, Rhys D O, Henry, Ryan E, Frigault, Melanie M, Beran, Garry, Linsenmayer, David, Hattersley, Maureen, Smith, Aaron, Wilson, Joanne, Cairo, Stefano, Déas, Olivier, Nicolle, Delphine, Adam, Ammar, Zinda, Michael, Reimer, Corinne, Fawell, Stephen E, Clark, Edwin A, D'Cruz, Celina M

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PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 4: Prediction of plasma concentration–time profiles in human from in vivo preclinical data by using the... by Vuppugalla, Ragini, Marathe, Punit, He, Handan, Jones, Rhys D.O., Yates, James W.T., Jones, Hannah M., Gibson, Christopher R., Chien, Jenny Y., Ring, Barbara J., Adkison, Kimberly K., Ku, M. Sherry, Fischer, Volker, Dutta, Sandeep, Sinha, Vikash K., Björnsson, Thorir, Lavé, Thierry, Poulin, Patrick

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Models and Simulations for the Photometric LSST Astronomical Time Series Classification Challenge (PLAsTiCC) by Kessler, R., Narayan, G., Avelino, A., Bachelet, E., Biswas, R., Brown, P. J., Chernoff, D. F., Connolly, A. J., Dai, M., Daniel, S., Stefano, R. Di, Drout, M. R., Galbany, L., González-Gaitán, S., Graham, M. L., Hlo ek, R., Ishida, E. E. O., Guillochon, J., Jha, S. W., Jones, D. O., Mandel, K. S., Muthukrishna, D., O'Grady, A., Peters, C. M., Pierel, J. R., Ponder, K. A., Prša, A., Rodney, S., Villar, V. A.

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Cosmological Results from the RAISIN Survey: Using Type Ia Supernovae in the Near Infrared as a Novel Path to Measure the Dark Energy Equation of State by Jones, D. O., Mandel, K. S., Kirshner, R. P., Thorp, S., Challis, P. M., Avelino, A., Brout, D., Burns, C., Foley, R. J., Pan, Y.-C., Scolnic, D. M., Siebert, M. R., Chornock, R., Freedman, W. L., Friedman, A., Frieman, J., Galbany, L., Hsiao, E., Kelsey, L., Marion, G. H., Nichol, R. C., Nugent, P. E., Phillips, M. M., Rest, A., Riess, A. G., Sako, M., Smith, M., Wiseman, P., Wood-Vasey, W. M.

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Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer by Bradbury, Robert H., Acton, David G., Broadbent, Nicola L., Brooks, A. Nigel, Carr, Gregory R., Hatter, Glenn, Hayter, Barry R., Hill, Kathryn J., Howe, Nicholas J., Jones, Rhys D.O., Jude, David, Lamont, Scott G., Loddick, Sarah A., McFarland, Heather L., Parveen, Zaieda, Rabow, Alfred A., Sharma-Singh, Gorkhn, Stratton, Natalie C., Thomason, Andrew G., Trueman, Dawn, Walker, Graeme E., Wells, Stuart L., Wilson, Joanne, Wood, J. Matthew

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Photometric and Spectroscopic Properties of Type Ia Supernova 2018oh with Early Excess Emission from the Kepler 2 Observations by Li, W., Wang, X., Vinkó, J., Mo, J., Zhang, T., Wang, L., Zhang, J., Rui, L., Huang, F., Li, L., Zhao, X., Sai, H., Zhang, K., Wang, L., Howell, D. A., Burke, J., Tucker, B. E., Shaya, E., Margheim, S., Zenteno, A., Villar, A., Dimitriadis, G., Fox, O. D., Jones, D. O., Kasen, D. N., Piro, A. L., Rojas-Bravo, C., Shappee, B. J., Holoien, T. W.-S., Stanek, K. Z., Drout, M. R., Auchettl, K., Brown, J. S., Bose, S., Brimacombe, J., Holmbo, S., Muñoz, J. A., Mutel, R. L., Post, R. S., Shields, J., Tallon, D., Thompson, T. A., Vallely, P. J., Villanueva, S., Smartt, S. J., Smith, K. W., Chambers, K. C., Flewelling, H. A., Huber, M. E., Magnier, E. A., Waters, C. Z., Bulger, J., Lowe, T. B., Willman, M., Sárneczky, K., Bódi, A., Bognár, Zs, Csák, B., Hanyecz, O., Ignácz, B., Kalup, Cs, Sódor, A., Szabó, R., Bilinski, C., Hook, I. M., Inserra, C., Cartier, Régis, Gutiérrez, C. P., Hermes, J. J., Reding, J. S., Kaiser, B. C., Tonry, J. L., Heinze, A. N., Weiland, H., Barentsen, G., Gully-Santiago, M., Hedges, C., Cody, A. M., Howell, S., Coughlin, J., Cleve, J. E. Van, Vinícius de Miranda Cardoso, J., McCalmont-Everton, K. M., Peterson, C. A., Reedy, L. H., Osborne, D., Kohnert, L., Migliorini, L., Wheaton, A., Spencer, B., Castillo, G., Beerman, G., Gangopadhyay, R., Weschler, T., Nystrom, V., Moffatt, J., Packard, M., Muszynski, M., Flynn, S., Elsaesser, B.

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Results of the Photometric LSST Astronomical Time-series Classification Challenge (PLAsTiCC) by Hložek, R., Malz, A. I., Ponder, K. A., Dai, M., Narayan, G., Ishida, E. E. O., Jr, T. Allam, Bahmanyar, A., Bi, X., Biswas, R., Boone, K., Chen, S., Du, N., Erdem, A., Galbany, L., Garreta, A., Jha, S. W., Jones, D. O., Kessler, R., Lin, M., Liu, J., Lochner, M., Mahabal, A. A., Mandel, K. S., Margolis, P., Martínez-Galarza, J. R., McEwen, J. D., Muthukrishna, D., Nakatsuka, Y., Noumi, T., Oya, T., Peiris, H. V., Peters, C. M., Puget, J. F., Setzer, C. N., Siddhartha, Stefanov, S., Xie, T., Yan, L., Yeh, K.-H., Zuo, W.

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Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades by Davies, Michael, Jones, Rhys D.O., Grime, Ken, Jansson-Löfmark, Rasmus, Fretland, Adrian J., Winiwarter, Susanne, Morgan, Paul, McGinnity, Dermot F.

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Final Moments II: Observational Properties and Physical Modeling of CSM-Interacting Type II Supernovae by Jacobson-Galán, W.V, Dessart, L, Davis, K.W, Kilpatrick, C.D, Margutti, R, Foley, R.J, Chornock, R, Terreran, G, Hiramatsu, D, Newsome, M, Gonzalez, E. Padilla, Pellegrino, C, Howell, D.A, Filippenko, A.V, Anderson, J.P, Angus, C.R, Auchettl, K, Bostroem, K.A, Brink, T.G, Cartier, R, Coulter, D.A, de Boer, T, Drout, M.R, Earl, N, Ertini, K, Farah, J.R, Farias, D, Gall, C, Gao, H, Gerlach, M.A, Guo, F, Haynie, A, Hosseinzadeh, G, Ibik, A.L, Jha, S.W, Jones, D.O, Langeroodi, D, Lebaron, N, Magnier, E.A, Piro, A.L, Raimundo, S.I, Rest, A, Rest, S, Rich, R. Michael, Rojas-Bravo, C, Sears, H, Taggart, K, Villar, V.A, Wainscoat, R.J, Wang, X-F, Wasserman, A.R, Yan, S, Yang, Y, Zhang, J, Zheng, W

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The Photometric LSST Astronomical Time-series Classification Challenge PLAsTiCC: Selection of a Performance Metric for Classification Probabilities Balancing Diverse Science Goals by Malz, A. I., Hlo ek, R., Allam, T., Bahmanyar, A., Biswas, R., Dai, M., Galbany, L., Ishida, E. E. O., Jha, S. W., Jones, D. O., Kessler, R., Lochner, M., Mahabal, A. A., Mandel, K. S., Martínez-Galarza, J. R., McEwen, J. D., Muthukrishna, D., Narayan, G., Peiris, H., Peters, C. M., Ponder, K., Setzer, C. N.

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Pharmacokinetic/Pharmacodynamic Analysis of Savolitinib plus Osimertinib in an EGFR Mutation-Positive, MET-Amplified Non-Small Cell Lung Cancer Model by Jones, Rhys D O, Petersson, Klas, Tabatabai, Areya, Bao, Larry, Tomkinson, Helen, Schuller, Alwin G

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Interspecies evaluation of a physiologically based pharmacokinetic model to predict the biodistribution dynamics of dendritic nanoparticles by Vasalou, Christina, Harding, Joanna, Jones, Rhys D O, Hariparsad, Niresh, McGinnity, Dermot F

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Discovery of N‑(4-{[5-Fluoro-7-(2-methoxyethoxy)­quinazolin-4-yl]amino}­phenyl)-2-[4-(propan-2-yl)‑1H‑1,2,3-triazol-1-yl]­acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for... by Kettle, Jason G, Anjum, Rana, Barry, Evan, Bhavsar, Deepa, Brown, Crystal, Boyd, Scott, Campbell, Andrew, Goldberg, Kristin, Grondine, Michael, Guichard, Sylvie, Hardy, Christopher J, Hunt, Tom, Jones, Rhys D. O, Li, Xiuwei, Moleva, Olga, Ogg, Derek, Overman, Ross C, Packer, Martin J, Pearson, Stuart, Schimpl, Marianne, Shao, Wenlin, Smith, Aaron, Smith, James M, Stead, Darren, Stokes, Steve, Tucker, Michael, Ye, Yang

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A pharmacokinetic–pharmacodynamic model for the MET tyrosine kinase inhibitor, savolitinib, to explore target inhibition requirements for anti‐tumour activity by Jones, Rhys D.O., Grondine, Mike, Borodovsky, Alexandra, San Martin, Maryann, DuPont, Michelle, D'Cruz, Celina, Schuller, Alwin, Henry, Ryan, Barry, Evan, Castriotta, Lillian, Anjum, Rana, Petersson, Klas, Sahota, Tarjinder, Ahmed, Ghada F.

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A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models by White, Michael J., Cheatham, Letitia, Wen, Shenghua, Scarfe, Graeme, Cidado, Justin, Reimer, Corinne, Hariparsad, Niresh, Jones, Rhys D. O., Drew, Lisa, McGinnity, Dermot F., Vasalou, Christina

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Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors by Banks, Erica, Grondine, Michael, Bhavsar, Deepa, Barry, Evan, Kettle, Jason G, Reddy, Venkatesh Pilla, Brown, Crystal, Wang, Haiyun, Mettetal, Jerome T, Collins, Teresa, Adeyemi, Oladipupo, Overman, Ross, Lawson, Deborah, Harmer, Alexander R, Reimer, Corinne, Drew, Lisa, Packer, Martin J, Cosulich, Sabina, Jones, Rhys DO, Shao, Wenlin, Wilson, David, Guichard, Sylvie, Fawell, Stephen, Anjum, Rana

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The Pharmacokinetic-Pharmacodynamic (PKPD) Relationships of AZD3229, a Novel and Selective Inhibitor of KIT, in a Range of Mouse Xenograft Models of GIST by Pilla Reddy, Venkatesh, Anjum, Rana, Grondine, Michael, Smith, Aaron, Bhavsar, Deepa, Barry, Evan, Guichard, Sylvie M, Shao, Wenlin, Kettle, Jason G, Brown, Crystal, Banks, Erica, Jones, Rhys D O

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